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Acute coronary syndromes, platelets and the endothelium (2019)
Thesis
Rossington, J. A. (2019). Acute coronary syndromes, platelets and the endothelium. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4222365

ABSTRACT Background: Acute coronary syndromes (ACS) are medical emergencies. Platelet and endothelial function are fundamental to the pathophysiology; and implicated in secondary conditions such as no reflow (NR). Guidelines support the administrati... Read More about Acute coronary syndromes, platelets and the endothelium.

A novel interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in platelets (2018)
Thesis
Khalil, J. S. (2018). A novel interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in platelets. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221504

Platelet activation initiates a series of events, such as shape change, degranulation and aggregation, which results in the formation of a haemostatic plug and arrest of blood loss at the sites of vascular damage. Shape change is accompanied by remod... Read More about A novel interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in platelets.

Energy metabolism of platelets (2017)
Thesis
Aibibula, M. (2017). Energy metabolism of platelets. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221806

Undesired platelet activation is associated with a number of diseases characterised by metabolic imbalance, such as hyperlipidaemia. Changes in platelet energy metabolism associated with disease states are unclear. This thesis presents a detailed inv... Read More about Energy metabolism of platelets.

Association of type 1 inositol 1,4,5-trisphosphate receptor (IP₃R1) with protein kinase A and A-kinase Anchoring Protein 9 (AKAP9) in platelets (2017)
Thesis
Trivedi, A. N. (2017). Association of type 1 inositol 1,4,5-trisphosphate receptor (IP₃R1) with protein kinase A and A-kinase Anchoring Protein 9 (AKAP9) in platelets. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4219204

Cyclic adenosine monophsphoate (cAMP) signalling is thought to regulate inositol-1,4,5 trisphosphate (IP₃)-mediated calcium (Ca²⁺) mobilisation in platelets through protein kinase A (PKA)-mediated phosphorylation, leading to inhibition of inositol-1,... Read More about Association of type 1 inositol 1,4,5-trisphosphate receptor (IP₃R1) with protein kinase A and A-kinase Anchoring Protein 9 (AKAP9) in platelets.

The role of scavenger receptors in oxidised low-density lipoprotein induced platelet hyperactivity (2016)
Thesis
Woodward, C. (2016). The role of scavenger receptors in oxidised low-density lipoprotein induced platelet hyperactivity. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4218666

Increased platelet hyperactivity is a common consequence of hyperlipidemia and is associated with increased risk of acute coronary syndromes. Platelet interaction with oxidised low-density lipoprotein (oxLDL) is believed to play a crucial role in pla... Read More about The role of scavenger receptors in oxidised low-density lipoprotein induced platelet hyperactivity.

PDE3A signalling in blood platelets (2016)
Thesis
Law, R. (2016). PDE3A signalling in blood platelets. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4218467

Cyclic 3’, 5’ adenosine monophosphate (cAMP) signalling downstream of prostacyclin (PGI₂) is a key inhibitory pathway in blood platelets. This pathway is dynamically regulated by phosphodiesterase 3A (PDE3A), which hydrolyses cAMP into metabolically... Read More about PDE3A signalling in blood platelets.

Phosphoproteomic analysis of platelet signalling cascades by flow cytometry (2014)
Thesis
Spurgeon, B. E. J. (2014). Phosphoproteomic analysis of platelet signalling cascades by flow cytometry. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216373

The activation of blood platelets is a critical haemostatic response that serves to prevent haemorrhage, but unregulated platelet activation is associated with arterial thrombosis. Endothelial-derived inhibitors prostacyclin (PGI₂) and nitric oxide (... Read More about Phosphoproteomic analysis of platelet signalling cascades by flow cytometry.

The role of glucocorticoids in platelet function (2014)
Thesis
Banerjee, S. (2014). The role of glucocorticoids in platelet function. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216471

Platelets are pivotal in regulating haemostasis, but can precipitate atherothrombosis associated to cardiovascular diseases. The synthetic glucocorticoid prednisolone is widely used as an anti-inflammatory and immunosuppressive drug. Previously it wa... Read More about The role of glucocorticoids in platelet function.

GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS (2013)
Thesis
Kahal, H. (2013). GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4215983

Studies investigating atherothrombotic risk in women with polycystic ovary syndrome (PCOS), in particular platelet function and carotid intima-media wall thickness (cIMT), have been confounded by not adequately accounting for obesity. Liraglutide is... Read More about GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS.

The influence of oxidised low density lipoproteins on platelet activation (2013)
Thesis
Wraith, K. S. (2013). The influence of oxidised low density lipoproteins on platelet activation. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4214678

The oxidation of low density lipoproteins (LDL) may contribute to platelet hyperactivity and thrombotic events in cardiovascular diseases. Although these pathological particles are known to stimulate platelet activation, the exact signalling mechanis... Read More about The influence of oxidised low density lipoproteins on platelet activation.

Regulation of blood platelet function by nitric oxide (2013)
Thesis
Wake, J. D. (2013). Regulation of blood platelet function by nitric oxide. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4214507

Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix resulting in platelet activation and aggregation to form a haemostatic plug. This self-amplifying mechanism requires a tight control to prevent uncontrolled platelet... Read More about Regulation of blood platelet function by nitric oxide.

Adiponectin : a novel circulating anti-thrombotic factor in humans? (2011)
Thesis
Yousaf, T. A. (2011). Adiponectin : a novel circulating anti-thrombotic factor in humans?. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4212180

Adiponectin is an adipocyte-derived pro-inflammatory adipokine that regulates metabolic homeostasis, although it has been reported to modulate platelet function and thrombosis. In this study the effects of globular adiponectin (gAd), a novel platelet... Read More about Adiponectin : a novel circulating anti-thrombotic factor in humans?.

Regulation of blood platelet function by the AGC family of protein kinases (2010)
Thesis
Aburima, A. A. (2010). Regulation of blood platelet function by the AGC family of protein kinases. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4212803

Upon vascular injury, platelets aggregate at the site of blood vessel injury to form a hemostatic plug maintaining the physiological integrity of the vascular system. Platelets respond to a variety of extracellular stimuli to undergo a rapid aggregat... Read More about Regulation of blood platelet function by the AGC family of protein kinases.