Skip to main content

Research Repository

Advanced Search

Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I (2023)
Thesis
Bolanle, O. I. (2023). Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4420724

Despite the plethora of drugs currently available for managing coronary artery disease (CAD) patients with or without type 2 diabetes mellitus (T2DM), yet CAD frequently progresses, necessitating a coronary artery bypass graft (CABG) procedure using... Read More about Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I.

The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos (2023)
Thesis
Martin, F. (2023). The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4430667

Background: Blood-derived products are a growing area of therapeutic treatments for a diverse range of conditions, including hair loss, scarring, muscle injury, wounds, arthritis, and symptoms related to the menopause. Platelet-rich plasma (PRP) is o... Read More about The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos.

Investigating the impact of hyperglycaemia on early embryo environment and development (2019)
Thesis
Roussi, K. (2019). Investigating the impact of hyperglycaemia on early embryo environment and development. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4222139

The development of metabolic conditions has been associated with suboptimal nutrient provision to the embryo during pregnancy. Metabolic disorders have also been linked to subfertility; obese women produce fewer and smaller oocytes that are metabolic... Read More about Investigating the impact of hyperglycaemia on early embryo environment and development.

Novel aspects of mitochondrial biology in early embryos (2019)
Thesis
Muller, B. (2019). Novel aspects of mitochondrial biology in early embryos. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221758

Mitochondria play an essential role in early development through facilitating the production of energy required to undergo key physiological processes. Mitochondrial function in oocytes and embryos has been associated with viability and reproductive... Read More about Novel aspects of mitochondrial biology in early embryos.

Energy metabolism of platelets (2017)
Thesis
Aibibula, M. (2017). Energy metabolism of platelets. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221806

Undesired platelet activation is associated with a number of diseases characterised by metabolic imbalance, such as hyperlipidaemia. Changes in platelet energy metabolism associated with disease states are unclear. This thesis presents a detailed inv... Read More about Energy metabolism of platelets.

The effect of maternal overweight and obesity on the viability and metabolism of human oocytes and early embryos (2015)
Thesis
Leary, C. (2015). The effect of maternal overweight and obesity on the viability and metabolism of human oocytes and early embryos. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4217662

Overweight and obese (OWOB) women are reported to have a lower chance of becoming pregnant. The nutritional enrichment of the periconceptional environment apparent in obese women may be detrimental for embryo viability. This is the first study to exa... Read More about The effect of maternal overweight and obesity on the viability and metabolism of human oocytes and early embryos.

Metabolic regulation during early embryo development (2015)
Thesis
McKeegan, P. (2015). Metabolic regulation during early embryo development. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216544

The preimplantation embryo must satisfy dynamic changes in energy demand during development to the blastocyst stage. Energy is provided through regulated metabolic pathways including glycolysis, β-oxidation and oxidative phosphorylation. Oxygen consu... Read More about Metabolic regulation during early embryo development.

Role of transient receptor potential channels in mammalian oviduct and uterine epithelia (2011)
Thesis
Ghavideldarestani, M. (2011). Role of transient receptor potential channels in mammalian oviduct and uterine epithelia. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4213385

Calcium is an important secondary messenger and plays a major role in cell function, including proliferation, cell growth, secretion and death .It also plays a critical role in uterine smooth muscle contraction and embryo implantation. This thesis is... Read More about Role of transient receptor potential channels in mammalian oviduct and uterine epithelia.