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All Outputs (116)

Molecular mechanisms of environmental adaptation in the Western Canaries Lizard (Gallotia galloti) (2025)
Thesis
Gilbert, E. (2025). Molecular mechanisms of environmental adaptation in the Western Canaries Lizard (Gallotia galloti) [Doctorate thesis, University of Hull]. https://hull-repository.worktribe.com/output/5461963

This research aims to elucidate evolutionary and plastic molecular processes that allows Gallotia galloti to inhabit a range of environmental conditions. It specifically investigates evolutionary processes in promoter regions of environmentally-adapt... Read More about Molecular mechanisms of environmental adaptation in the Western Canaries Lizard (Gallotia galloti).

Exploiting tissue on-chip technology to predict treatment responses in HNSCC (2025)
Thesis
Greaves, J.-L. (2025). Exploiting tissue on-chip technology to predict treatment responses in HNSCC [Masters by Research thesis, University of Hull]. https://hull-repository.worktribe.com/output/5462236

Culture models have advanced significantly in recent years, especially for studying disease in 3-dimensions. However, these models have rarely been used to correlate in vitro response with the clinical response in diseases like head and neck cancer (... Read More about Exploiting tissue on-chip technology to predict treatment responses in HNSCC.

Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System (2025)
Thesis
Barry, A. (2025). Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System [Doctoral thesis, University of Hull]. https://hull-repository.worktribe.com/output/5133792

Glioblastoma (GBM) is the most common primary malignancy in the central nervous system and the most devastating, with a median survival of 18 months from diagnosis. The development of models to research and understand GBM tumourigenesis and progressi... Read More about Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System.

The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing (2025)
Thesis
Rodriguez-Barucg, Q. (2025). The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing [Doctoral thesis, University of Hull]. https://hull-repository.worktribe.com/output/5126336

This thesis investigates the role of environmentally relevant concentrations of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI), in wound healing. While SSRIs are effective in treating psychiatric conditions, their inc... Read More about The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing.

Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events (2025)
Thesis
Papachristofi, V. (2025). Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events [Doctoral thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/5038856

The modern environment in which we live is replete with chemicals that have accumulated to levels that have been proposed to impact various aspects of physiology. The impact of a selection of these environmental contaminants on the physiology of earl... Read More about Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events.

The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue (2025)
Thesis
Golebiewski, P. (2025). The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue [Masters by Research thesis, University of Hull]. https://hull-repository.worktribe.com/output/5087881

Thyroid cancer (TC) is the most common endocrine malignancy globally. While surgery and radioactive iodine (RAI) therapy generally yield favourable outcomes, prognosis worsens in RAI-refractory or resistant cases, highlighting the need for alternativ... Read More about The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue.

Development of Multimodal Imaging Agents for Thrombosis (2025)
Thesis
Gil, H. (2025). Development of Multimodal Imaging Agents for Thrombosis [Doctoral thesis, University of Hull]. https://hull-repository.worktribe.com/output/5088352

Quantum dots (QDs) are colloidal nanoparticles with unique optical and electronic characteristics attributed to quantum confinement effects, making them ideal for fluorescence imaging of biological systems. This thesis investigates the synthesis and... Read More about Development of Multimodal Imaging Agents for Thrombosis.

Novel urinary biomarkers for the non-invasive detection of endometriosis. (2025)
Thesis
Draper, H. (2025). Novel urinary biomarkers for the non-invasive detection of endometriosis. [Doctorate thesis, Hull York Medical School, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5178894

Introduction: Endometriosis affects 190 million women worldwide, yet there are no accurate non-invasive diagnostic tests that have been shown able to alleviate the average 8-year diagnostic delay. Phosphoglycerate mutase 1 (PGAM1) has been identified... Read More about Novel urinary biomarkers for the non-invasive detection of endometriosis..

Determination of the role of WSB-1 in breast cancer and metastasis to the bone (2024)
Thesis
Lovell, S. (2024). Determination of the role of WSB-1 in breast cancer and metastasis to the bone [Masters by Research thesis, University of Hull]. https://hull-repository.worktribe.com/output/5086180

Breast cancer is the second most common cause of female-related deaths in the United Kingdom with metastatic spread the main reason for treatment failure and cancer-related deaths. The bone is the most frequent site of secondary cancer, significantly... Read More about Determination of the role of WSB-1 in breast cancer and metastasis to the bone.

Insights into Polymicrobial Communities in Wound Infections (2024)
Thesis
Kadam, S. (2024). Insights into Polymicrobial Communities in Wound Infections [Doctoral thesis, Hull York Medical School, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5178990

Delayed wound healing, particularly in patients with comorbidities like diabetes, represents a significant health and economic burden, often resulting in a reduced quality of life for these patients. Infection is a key factor in delayed wound healing... Read More about Insights into Polymicrobial Communities in Wound Infections.

Effects of an immunostimulatory bispecific antibody on gene expression of head & neck tumour biopsies maintained in a microfluidic device (2024)
Thesis
Owen, J. (2024). Effects of an immunostimulatory bispecific antibody on gene expression of head & neck tumour biopsies maintained in a microfluidic device [Masters by Research thesis, University of Hull]. https://hull-repository.worktribe.com/output/4867150

Head and Neck Squamous cell carcinoma (HNSCC) is the seventh most prevalent cancer worldwide with approximately 880,000 new diagnoses per year. HNSCC includes malignant lesions originating in the pharynx, larynx, nasopharynx, oral cavity and aero-dig... Read More about Effects of an immunostimulatory bispecific antibody on gene expression of head & neck tumour biopsies maintained in a microfluidic device.

An investigation into the TRPV1-CGRP signalling pathway in vessel development (2024)
Thesis
Bates, A. (2024). An investigation into the TRPV1-CGRP signalling pathway in vessel development [PhD thesis, University of Hull]. https://hull-repository.worktribe.com/output/4865918

TRPV1 is a non-selective cation channel which is activated through various different factors including, but not limited to, raised temperature and acidic pH. It has been linked in the past to endothelial cell proliferation in acidic conditions, but a... Read More about An investigation into the TRPV1-CGRP signalling pathway in vessel development.

Understanding demulcent activity (2024)
Thesis
Ahmad, B. (2024). Understanding demulcent activity [Doctoral thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/4790538

A demulcent is defined in the oxford dictionary as a soothing agent that protects mucous membranes and relieves irritation by forming a protective film (Ireland, 2020). There is no scientific or clinical evidence supporting this mode of action. We th... Read More about Understanding demulcent activity.

Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis (2024)
Thesis
Faulkner, E. C. (2024). Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis [Doctorate thesis, University of Hull]. https://hull-repository.worktribe.com/output/4866422

Introduction
Older age is the main risk factor for idiopathic pulmonary fibrosis (IPF). Ageing-related changes in lung blood (pulmonary and bronchial) and lymphatic vessels are implicated in IPF pathophysiology, based on reports of their altered den... Read More about Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis.

Investigation into the role of the epigenetic target CBX2 in Glioblastoma (2024)
Thesis
Beattie, H. (2024). Investigation into the role of the epigenetic target CBX2 in Glioblastoma [Masters by Research thesis, University of Hull]. https://hull-repository.worktribe.com/output/4866108

Glioblastoma (GBM) has been identified as an extremely difficult tumour to treat owing to issues of heterogeneity, as well as the aggressive nature of the tumours’ growth. Despite current treatments using a combination of methods, treatment resistanc... Read More about Investigation into the role of the epigenetic target CBX2 in Glioblastoma.

Identification of tumour anitgens that may facilitate effective cancer detection and treatment (2024)
Thesis
Mohamed, E. (2024). Identification of tumour anitgens that may facilitate effective cancer detection and treatment [Doctorate thesis, University of Hull]. https://hull-repository.worktribe.com/output/4866442

Tumour antigens (TAs) play a crucial role in terms of cancer diagnosis and targets for therapy. As TAs are normally expressed in restricted tissues such as testis, sensitivity and specificity may not be ideal, but they could still represent good biom... Read More about Identification of tumour anitgens that may facilitate effective cancer detection and treatment.

Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products (2024)
Thesis
Doyle, B. (2024). Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products [Doctoral thesis, University of Hull]. https://hull-repository.worktribe.com/output/4587910

Upon entering the body, any given xenobiotic can undergo metabolism which facilitates its excretion from the body. When metabolised, a compound typically has the same effects of the initial drug/nutraceutical, however this is not always the case and... Read More about Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products.

Is the PEGylation of indium phosphide/zinc sulphide quantum dots the first step in creating a platelet biocompatible multimodal imaging agent? (2024)
Thesis
Booth, Z. (2024). Is the PEGylation of indium phosphide/zinc sulphide quantum dots the first step in creating a platelet biocompatible multimodal imaging agent? [Doctoral thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/4790560

Background:
Indium phosphide/zinc sulphide (InP/ZnS) quantum dots (QDs) are semiconductive nanoparticles that have received growing focus due to the perception that they are safer than heavy metal based QDs. InP/ZnS QDs possess a highly fluorescent... Read More about Is the PEGylation of indium phosphide/zinc sulphide quantum dots the first step in creating a platelet biocompatible multimodal imaging agent?.

The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease (2024)
Thesis
Nickolay, T. (2024). The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease [Doctoral thesis, University of Hull and University of York]. https://hull-repository.worktribe.com/output/4659878

This thesis investigates the utility of cardiopulmonary exercise testing (CPET) in assessing and managing patients with coronary artery disease (CAD), particularly focusing on the significance of oxygen pulse (O2Pulse) inflections as a marker for myo... Read More about The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease.