All Outputs (66)

Calcific tendinopathy of the shoulder: a cohort study of clinical management and scoping review of treatment options (2025)
Thesis
Ashton, F. (2025). Calcific tendinopathy of the shoulder: a cohort study of clinical management and scoping review of treatment options [Doctoral thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/5465422

Aim
The James Lind Alliance (JLA) priority setting exercise for shoulder surgery identified a research need to define the role of early surgery in the management of newly diagnosed patients with calcific tendinopathy of the shoulder. This thesis wil... Read More about Calcific tendinopathy of the shoulder: a cohort study of clinical management and scoping review of treatment options.

Iron Therapy in Peritoneal Dialysis: A Systematic Review and Meta-Analysis with Insights from a National Questionnaire Survey (2025)
Thesis
Spencer, S. (2025). Iron Therapy in Peritoneal Dialysis: A Systematic Review and Meta-Analysis with Insights from a National Questionnaire Survey [Masters by Research thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/5429805

Abstract
1.1 Background and Objectives
Anaemia and iron deficiency are common in people undergoing peritoneal dialysis (PD), contributing to increased morbidity and mortality. While oral iron is often used due to its accessibility, it may be poorly... Read More about Iron Therapy in Peritoneal Dialysis: A Systematic Review and Meta-Analysis with Insights from a National Questionnaire Survey.

Navigating Destabilisation: Experiences of homelessness, health, and belonging in trans people’s lives (2025)
Thesis
Busby, S. (2025). Navigating Destabilisation: Experiences of homelessness, health, and belonging in trans people’s lives [Doctoral thesis, The University of Hull and the University of York]. https://hull-repository.worktribe.com/output/5430423

Background:
Trans people in the UK experience a disproportionate level of homelessness compared to the general population, with one third of trans people experiencing homelessness during their life. Most current data in this area is quantitative and... Read More about Navigating Destabilisation: Experiences of homelessness, health, and belonging in trans people’s lives.

Patient Reported Outcome Measures for Mental Health: Development and Pragmatic Evaluation in the NHS (2025)
Thesis
Blenkiron, P. (2025). Patient Reported Outcome Measures for Mental Health: Development and Pragmatic Evaluation in the NHS [Doctoral thesis by publication, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5287979

Background: Patient-reported outcome measures (PROMs) are standardised questionnaires or interviews that elicit subjective reports of health. They have growing potential for improving patient-centred care and decision making. The National Institute f... Read More about Patient Reported Outcome Measures for Mental Health: Development and Pragmatic Evaluation in the NHS.

Functional Morphology and Masticatory Biomechanics of British Red Squirrels (2025)
Thesis
Chandler, K. (2025). Functional Morphology and Masticatory Biomechanics of British Red Squirrels [Doctoral thesis, Hull York Medical School, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5244785

British red squirrels Sciurus vulgaris exist in fragmented populations, with the spread of invasive grey squirrels Sciurus carolinensis the leading cause. Populations are isolated, occupying different habitats, consuming different diets and little ge... Read More about Functional Morphology and Masticatory Biomechanics of British Red Squirrels.

Azithromycin, Oesophageal Function, and Cough in Chronic Respiratory Disease (2025)
Thesis
Sykes, D. (2025). Azithromycin, Oesophageal Function, and Cough in Chronic Respiratory Disease [Doctoral thesis, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5287949

Chronic cough is a disabling feature of many chronic respiratory diseases and is now recognised as a distinct disease. Despite being amongst the commonest causes for healthcare contact, there are no licenced treatments for chronic cough in the UK. Th... Read More about Azithromycin, Oesophageal Function, and Cough in Chronic Respiratory Disease.

Macrophage phagocytosis of tumour cells is modulated by trained innate immunity (2025)
Thesis
Chatzis, A. (2025). Macrophage phagocytosis of tumour cells is modulated by trained innate immunity [Doctoral thesis, Hull York Medical School, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5244384

Cancer represents the second leading cause of death having long-lasting socioeconomic impact. There is an increasing need to better understand disease pathogenesis to inform the development of therapeutic approaches and to address the timely question... Read More about Macrophage phagocytosis of tumour cells is modulated by trained innate immunity.

Exploring Medical Communication & Media Influence on Public Health Perceptions During the COVID-19 Pandemic (2025)
Thesis
Rees, K. D. C. (2025). Exploring Medical Communication & Media Influence on Public Health Perceptions During the COVID-19 Pandemic [Doctoral thesis, Hull York Medical School, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5244847

Background
The COVID-19 pandemic marked the first global health crisis to unfold in a highly connected digital media environment. Understanding how social and mainstream media shaped public health communication during this period is crucial for impr... Read More about Exploring Medical Communication & Media Influence on Public Health Perceptions During the COVID-19 Pandemic.

Can Tissue-On-Chip Technology provide a platform for investigating differences in Extracellular Vesicle miRNA content between Thyroid Pathologies? (2025)
Thesis
Haigh, T. (2025). Can Tissue-On-Chip Technology provide a platform for investigating differences in Extracellular Vesicle miRNA content between Thyroid Pathologies? [Doctoral thesis, Hull York Medical School, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5182708

This study uses an established method to maintain human thyroid tissue ex vivo on a tissue-on-chip device, allowing for the collection, isolation and interrogation of the small extracellular vesicles (sEVs) released directly from thyroid tissue. The... Read More about Can Tissue-On-Chip Technology provide a platform for investigating differences in Extracellular Vesicle miRNA content between Thyroid Pathologies?.

Investigating the impact of α-synuclein and PD-L1 deletion on platelet function (2025)
Thesis
Sennett, C. (2025). Investigating the impact of α-synuclein and PD-L1 deletion on platelet function [Doctoral thesis, University of Hull and University of York]. https://hull-repository.worktribe.com/output/5182732

Platelet proteomic studies suggest that platelets express over 1,000 proteins, most of which have no known function in platelets. This thesis investigates two such proteins, α-synuclein and Programmed Death Ligand 1 (PD-L1), and their roles in essent... Read More about Investigating the impact of α-synuclein and PD-L1 deletion on platelet function.

Combined Head-Mounted Display Virtual Reality and Electroencephalography in the Study of Working Memory (2024)
Thesis
Durnin, A. (2024). Combined Head-Mounted Display Virtual Reality and Electroencephalography in the Study of Working Memory [Doctoral thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/5005212

Modern head-mounted display virtual reality (HMD-VR) is used to present immersive virtual environments which reduce external distractions during research. Working memory load (WML) is commonly measured using electroencephalography (EEG), which non-in... Read More about Combined Head-Mounted Display Virtual Reality and Electroencephalography in the Study of Working Memory.

Human Brain Responses to Fast-Moving Consumer Goods Using Electroencephalography (2024)
Thesis
Aksoy, M. (2024). Human Brain Responses to Fast-Moving Consumer Goods Using Electroencephalography [Doctorate thesis, University of Hull]. https://hull-repository.worktribe.com/output/4910116

The utilisation of brain monitoring methods in the field of neuroscience provides an opportunity to go beyond subjective data collection methods such as questionnaires, focus groups, and interviews. Using these monitoring methods allows researchers i... Read More about Human Brain Responses to Fast-Moving Consumer Goods Using Electroencephalography.

Delayed left ventricular remodelling and optimal medical therapy in patients with heart failure with reduced ejection fraction. A systematic review (2024)
Thesis
Whittaker, L. W. (2024). Delayed left ventricular remodelling and optimal medical therapy in patients with heart failure with reduced ejection fraction. A systematic review [Masters thesis, HYMS]. https://hull-repository.worktribe.com/output/5182805

Introduction
International guidelines recommend implantable cardioverter-defibrillators (ICDs) for patients with heart failure and a reduced ejection fraction (HFrEF) to reduce the risk of sudden cardiac death (SCD) if patient’s left ventricular eje... Read More about Delayed left ventricular remodelling and optimal medical therapy in patients with heart failure with reduced ejection fraction. A systematic review.

A proof of concept study evaluating the role of emerging ultrasound technologies in the active surveillance of localised prostate cancer (2024)
Thesis
Parker, P. C. (2024). A proof of concept study evaluating the role of emerging ultrasound technologies in the active surveillance of localised prostate cancer [Doctorate thesis, University of Hull]. https://hull-repository.worktribe.com/output/4866373

Background
Although one in eight men will develop some form of prostate cancer (PCa) within their lifetime, not all PCa is of high-risk of progression. In such cases active surveillance (AS) provides an alternative to radical treatment (Hamdy et al.... Read More about A proof of concept study evaluating the role of emerging ultrasound technologies in the active surveillance of localised prostate cancer.

Understanding demulcent activity (2024)
Thesis
Ahmad, B. (2024). Understanding demulcent activity [Doctoral thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/4790538

A demulcent is defined in the oxford dictionary as a soothing agent that protects mucous membranes and relieves irritation by forming a protective film (Ireland, 2020). There is no scientific or clinical evidence supporting this mode of action. We th... Read More about Understanding demulcent activity.

Parenteral nutrition and venting gastrostomy in the management of malignant bowel obstruction (2024)
Thesis
Patterson, M. J. (2024). Parenteral nutrition and venting gastrostomy in the management of malignant bowel obstruction [Doctoral thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/4711450

Background: Malignant bowel obstruction (MBO) is a distressing complication of gastrointestinal, gynaecological and other cancers causing severe pain, intractable nausea and vomiting, anorexia, and death. There are no agreed best approaches for sympt... Read More about Parenteral nutrition and venting gastrostomy in the management of malignant bowel obstruction.

Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty (2024)
Thesis
Randall, J. (2024). Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty [Doctoral thesis, University of Hull and University of York]. https://hull-repository.worktribe.com/output/4659916

Aim
Non-anaemic iron deficiency although identified as a potential area for improving patient outcome in the literature, its effect on patient outcomes post-surgery is an under researched topic, with numerous gaps in the published literature. The ai... Read More about Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty.

The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables (2024)
Thesis
Kassianides, X. (2024). The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables [Doctoral thesis, University of Hull and University of York]. https://hull-repository.worktribe.com/output/4659777

Background: Modern intravenous iron preparations (e.g. ferric derisomaltose (FDI), ferric carboxymaltose (FCM)) are commonly used in non-dialysis-dependent chronic kidney disease (CKD) patients. Despite similar efficacy and safety in terms of previou... Read More about The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables.

The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation (2024)
Thesis
Greaves, J. (2024). The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation [Masters thesis, Hull York Medical School]. https://hull-repository.worktribe.com/output/4609527

The proper activation and subsequent differentiation of naive CD4+ T cells into effector T helper and regulatory T cells is vital for directing an appropriate adaptive immune response to specific infections. Recent evidence has identified long non-co... Read More about The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation.

Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis (2024)
Thesis
Muscutt, E. W. (2024). Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis [Doctoral thesis, University of Hull and University of York]. https://hull-repository.worktribe.com/output/4557553

Visceral leishmaniasis (VL) causes immune and haematological dysfunction and is fatal in >95% of cases if left untreated. While macrophages are vital for efficient Leishmania parasite clearance, parasite-macrophage interactions are critical for VL pr... Read More about Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis.