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Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine (2008)
Journal Article
Sadofsky, L. R., Campi, B., Trevisani, M., Compton, S. J., & Morice, A. H. (2008). Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Experimental Lung Research, 34(10), 681-693. https://doi.org/10.1080/01902140802339623

American guidelines, unlike European guidelines, support the use of antihistamines as a first line of treatment for some causes of chronic cough. Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsa... Read More about Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine.

General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial (2008)
Journal Article
Chetter, I. (2008). General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial. Lancet, 372(9656), 2132-2142. https://doi.org/10.1016/S0140-6736%2808%2961699-2

BackgroundThe effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with th... Read More about General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial.

Quality of life in patients with lower limb ischemia; revised suggestions for analysis (2008)
Journal Article
Gulati, S., Coughlin, P. A., Hatfield, J., & Chetter, I. C. (2009). Quality of life in patients with lower limb ischemia; revised suggestions for analysis. Journal of vascular surgery, 49(1), 122-126. https://doi.org/10.1016/j.jvs.2008.08.011

Background: Quality of life (QoL) is a crucial outcome measure in patients with lower limb ischemia (LLI). The Short Form 36 (SF36) has been proposed as the gold standard instrument for generic QoL analysis in patients with LLI. The Short Form 8 (SF8... Read More about Quality of life in patients with lower limb ischemia; revised suggestions for analysis.

The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply (2008)
Journal Article
Birring, S. S., Mann, V. M., Matos, S., Yousaf, N., Wood, C., Fleming, T., …Pavord, I. D. (2008). The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply. European respiratory journal, 32(2), 530-531. https://doi.org/10.1183/09031936.00060808

K. McGuinness and colleagues request further details regarding the validation of the Leicester Cough Monitor (LCM) over 24 h. This was not possible during our study because of limitations in battery life 1. Therefore, we compared automated and manual... Read More about The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply.

Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status (2008)
Journal Article
Bournazos, S., Rennie, J., Hart, S. P., Fox, K. A. A., & Dransfield, I. (2008). Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), 1491-1498. https://doi.org/10.1161/ATVBAHA.108.167601

OBJECTIVE: Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the... Read More about Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status.