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All Outputs (3)

Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse (2010)
Journal Article
Matsakas, A., Otto, A., Elashry, M. I., Brown, S. C., & Patel, K. (2010). Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse. Rejuvenation Research, 13(6), 717-727. https://doi.org/10.1089/rej.2010.1065

Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse a... Read More about Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse.

Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise (2010)
Journal Article
Matsakas, A., Mouisel, E., Amthor, H., & Patel, K. (2010). Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise. Journal of Muscle Research and Cell Motility, 31(2), 111-125. https://doi.org/10.1007/s10974-010-9214-9

Myostatin-deficient mice (MSTN (-/-)) display excessive muscle mass and this is associated with a profound loss of oxidative metabolic properties. In this study we analysed the effect of two endurance-based exercise regimes, either a forced high-impa... Read More about Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise.

A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity (2010)
Journal Article
Otto, A., Macharia, R., Matsakas, A., Valasek, P., Mankoo, B. S., & Patel, K. (2010). A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity. Developmental Biology, 343(1-2), 51-62. https://doi.org/10.1016/j.ydbio.2010.04.014

The major component of skeletal muscle is the myofibre. Genetic intervention inducing over-enlargement of myofibres beyond a certain threshold through acellular growth causes a reduction in the specific tension generating capacity of the muscle. Howe... Read More about A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.