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A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity (2010)
Journal Article
Tuncel, S., Dumoulin, F., Gailer, J., Sooriyaarachchi, M., Atilla, D., Durmuş, M., Bouchu, D., Savoie, H., Boyle, R. W., & Ahsen, V. (2011). A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity. Dalton Transactions : an international journal of inorganic chemistry, 40(16), 4067-4079. https://doi.org/10.1039/c0dt01260b

Three Zn(II) phthalocyanines substituted by hydroxyl-terminated tetraethylene glycol chains have been synthesized. In order to evaluate the potential of these highly water-soluble phthalocyanines as type II-photosensitisers for photodynamic therapy,... Read More about A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity.

Dipyrrin complexes and their uses as self assembling materials (2010)
Thesis
Benstead, M. (2010). Dipyrrin complexes and their uses as self assembling materials. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4210942

Several series of BODIPYs bearing mesogenic substituents were synthesised and their fluorescence and liquid crystal properties were characterized. Each compound prepared consisted of one BODIPY fluorophore and one, two or three mesogenic units based... Read More about Dipyrrin complexes and their uses as self assembling materials.

Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy (2010)
Thesis
Bullous, A. (2010). Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211381

Photodynamic therapy is a novel cancer treatment, involving the combination of light, photosensitiser and molecular oxygen to produce cytotoxic species. Currently, commercially available photosensitisers, including Photofrin and Foscan, only exhibit... Read More about Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy.

Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action (2010)
Journal Article
Smith, K., Malatesti, N., Cauchon, N., Hunting, D., Lecomte, R., van Lier, J. E., Greenman, J., & Boyle, R. W. (2011). Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action. Immunology, 132(2), 256-265. https://doi.org/10.1111/j.1365-2567.2010.03359.x

Two cationic porphyrins bearing an isothiocyanate group for conjugation to monocolonal antibodies have been synthesized. The two porphyrins conjugated efficiently to three monoclonal antibodies (anti-CD104, anti-CD146 and anti-CD326), which recognize... Read More about Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action.

Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species (2010)
Journal Article
Josefsen, L. B., Aylott, J. W., Beeby, A., Warburton, P., Boyle, J. P., Peers, C., & Boyle, R. W. (2010). Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species. Photochemical & photobiological sciences : an international journal, 9(6), 801-811. https://doi.org/10.1039/c0pp00004c

Reactive oxygen species (ROS) have for some time been implicated in the onset and progression of medical conditions including cancer, ageing, heart disease and Alzheimer's disease. Recently, it has been postulated that ROS play a much more subtle rol... Read More about Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species.

Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives (2010)
Journal Article
Jha, S., Silversides, J. D., Boyle, R. W., & Archibald, S. J. (2010). Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives. CrystEngComm RSC, 12(6), 1730-1739. https://doi.org/10.1039/b924683e

Hydantoins have been known as medicinally active compounds since the 1940s and thiohydantoin derivatives are currently undergoing clinical trials as potent androgen receptor antagonist drugs. Control of solid state properties including the formation... Read More about Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives.

Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies (2010)
Journal Article
Alonso, C. M. A., Palumbo, A., Bullous, A. J., Pretto, F., Neri, D., & Boyle, R. W. (2010). Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies. Bioconjugate chemistry, 21(2), 302-313. https://doi.org/10.1021/bc9003537

Synthesis of three new cationic thiol-reactive maleimide-porphyrin derivatives and their use in site-specific conjugation to monoclonal antibodies is reported. The selective reactivity toward thiols is demonstrated using competition experiments, wher... Read More about Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies.