Skip to main content

Research Repository

Advanced Search

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration (2011)
Journal Article
Zech, T., Calaminus, S., Caswell, P., Spence, H. J., Carnell, M., Insall, R. H., …Machesky, L. M. (2012). The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. Journal of cell science, 124(22), 3753-3759. doi:10.1242/jcs.080986

The actin cytoskeleton provides scaffolding and physical force to effect fundamental processes such as motility, cytokinesis and vesicle trafficking. The Arp2/3 complex nucleates actin structures and contributes to endocytic vesicle invagination and... Read More about The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration.

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis (2011)
Journal Article
Carnell, M., Zech, T., Calaminus, S. D., Ura, S., Hagedorn, M., Johnston, S. A., …Insall, R. H. (2011). Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. Journal of Cell Biology, 193(5), (831-839). doi:10.1083/jcb.201009119. ISSN 0021-9525

WASP and SCAR homologue (WASH) is a recently identified and evolutionarily conserved regulator of actin polymerization. In this paper, we show that WASH coats mature Dictyostelium discoideum lysosomes and is essential for exocytosis of indigestible m... Read More about Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis.