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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition (2012)
Journal Article
Monteiro dos Santos Pires, I., Olcina, M. M., Anbalagan, S., Pollard, J. R., Reaper, P. M., Charlton, P. A., …Hammond, E. M. (2012). Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. The British journal of cancer / Cancer Research Campaign, 107(2), (291-299). doi:10.1038/bjc.2012.265. ISSN 0007-0920

Background:Most solid tumours contain regions of sub-optimal oxygen concentration (hypoxia). Hypoxic cancer cells are more resistant to radiotherapy and represent the most aggressive fraction of a tumour. It is therefore essential that strategies con... Read More

Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy (2012)
Journal Article
Anbalagan, S., Monteiro dos Santos Pires, I., Blick, C., Hill, M. A., Ferguson, D. J. P., Chan, D. A., & Hammond, E. M. (2012). Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 103(3), (388-393). doi:10.1016/j.radonc.2012.04.001. ISSN 0167-8140

Background and purpose: For patients diagnosed with advanced renal cell carcinoma (RCC), there are few therapeutic options. Radiation therapy is predominantly used to treat metastasis and has not proven effective in the adjuvant setting for renal can... Read More