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Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome (2012)
Journal Article
Sathyapalan, T., Shepherd, J., Coady, A., Kilpatrick, E. S., & Atkin, S. L. (2012). Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 97(11), 3951-3955. https://doi.org/10.1210/jc.2012-2279

Background: It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome (PCOS). Statins are considered to have a pleiotropic effect other than their lipid-lowering effect. These effects may be mediated in part by redu... Read More about Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome.

Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis (2012)
Journal Article
Fahim, A., Crooks, M., Wilmot, R., Campbell, A. P., Morice, A., & Hart, S. (2012). Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis. Respirology : official journal of the Asian Pacific Society of Respirology, 17(8), 1247-1252. https://doi.org/10.1111/j.1440-1843.2012.02231.x

Background and objective: Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer.... Read More about Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis.

Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels (2012)
Journal Article
Zeng, B., Eastmond, S., Elsenussi, S. E., Boa, A. N., Xu, S., Elsenussi, S. E., …Boa, A. (2012). Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels. British Journal of Pharmacology, 167(6), 1232-1243. https://doi.org/10.1111/j.1476-5381.2012.02058.x

BACKGROUND: Fenamate analogues, econazole and 2-APB are inhibitors of TRPM2 channels, which have been used as research tools. However, these compounds have different chemical structures and therapeutic applications. Here we aimed to investigate the p... Read More about Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels.

Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei (2012)
Journal Article
Peña-Diaz, P., Pelosi, L., Ebikeme, C., Colasante, C., Gao, F., Bringaud, F., & Voncken, F. (2012). Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei. Journal of Biological Chemistry, 287(50), 41861-41874. https://doi.org/10.1074/jbc.M112.404699

Trypanosoma brucei is a kinetoplastid parasite of medical and veterinary importance. Its digenetic life cycle alternates between the bloodstream form in the mammalian host and the procyclic form (PCF) in the bloodsucking insect vector, the tsetse fly... Read More about Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei.

Aortic augmentation index is independently associated with N-terminal pro b-type natriuretic peptide in patients with peripheral arterial disease (2012)
Journal Article
Shahin, Y., & Chetter, I. (2012). Aortic augmentation index is independently associated with N-terminal pro b-type natriuretic peptide in patients with peripheral arterial disease. Vascular and endovascular surgery, 46(8), 648-653. https://doi.org/10.1177/1538574412462634

Objectives: To investigate the relationship of aortic augmentation index (AIx) with N-terminal pro B-type natriuretic peptide (NTproBNP) plasma levels in patients with peripheral arterial disease (PAD) with normal left ventricular (LV) function. Meth... Read More about Aortic augmentation index is independently associated with N-terminal pro b-type natriuretic peptide in patients with peripheral arterial disease.

Embracing a culture in conducting research requires more than nurses' enthusiasm (2012)
Journal Article
Loke, J. C., Laurenson, M. C., & Lee, K. W. (2014). Embracing a culture in conducting research requires more than nurses' enthusiasm. Nurse education today, 34(1), (132-137). doi:10.1016/j.nedt.2012.09.006. ISSN 0260-6917

Aims This study explored the perceptions of clinical nurses about their research knowledge and experiences to highlight any gaps in nurse education in supporting research activities in healthcare organisations. Background Nurses' research activities... Read More about Embracing a culture in conducting research requires more than nurses' enthusiasm.

Minimally clinically important difference in chronic breathlessness: every little helps (2012)
Journal Article
Oxberry, S. G., Bland, J. M., Clark, A. L., Cleland, J. G., & Johnson, M. (2012). Minimally clinically important difference in chronic breathlessness: every little helps. American Heart Journal, 164(2), (229-235). doi:10.1016/j.ahj.2012.05.003. ISSN 0002-8703

ObjectivesThe aim of the study was to determine the minimally clinically important difference (MCID) for breathlessness due to chronic heart failure (CHF). BackgroundThe measurement of breathlessness is difficult because it is subjective and multifac... Read More about Minimally clinically important difference in chronic breathlessness: every little helps.

Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx (2012)
Journal Article
Zeng, B., Chen, G., & Xu, S. Z. (2012). Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx. Biochemical Pharmacology, 84(8), (1024-1035). doi:10.1016/j.bcp.2012.07.013. ISSN 1873-2968

STIM1 is a Ca 2+ sensing molecule. Once the Ca 2+ stores are depleted, STIM1 moves towards the plasma membrane (PM) (translocation), forms puncta (clustering), and triggers store-operated Ca 2+ entry (SOCE). Although this process has been regarded as... Read More about Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx.

Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels (2012)
Journal Article
Jiang, H., Zeng, B., Chen, G., Bot, D., Eastmond, S., Elsenussi, S. E., …Xu, S. (2012). Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels. Biochemical Pharmacology, 83(7), 923-931. doi:10.1016/j.bcp.2012.01.014

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used anti-inflammatory therapeutic agents,among which the fenamate analogues play important roles in regulating intracellular Ca<sup>2+</sup> transient and ion channels. However, the eff... Read More about Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels.

Response of face-selective brain regions to trustworthiness and gender of faces (2012)
Journal Article
Mattavelli, G., Andrews, T. J., Asghar, A. U., Towler, J. R., & Young, A. W. (2012). Response of face-selective brain regions to trustworthiness and gender of faces. Neuropsychologia, 50(9), (2205-2211). doi:10.1016/j.neuropsychologia.2012.05.024. ISSN 0028-3932

Neuropsychological and neuroimaging studies have demonstrated a role for the amygdala in processing the perceived trustworthiness of faces, but it remains uncertain whether its responses are linear (with the greatest response to the least trustworthy... Read More about Response of face-selective brain regions to trustworthiness and gender of faces.

Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies (2012)
Journal Article
Fahim, A., Chong, M. C., Crooks, M. G., & Hart, S. P. (2012). Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies. Lung, 190(4), 451-458. doi:10.1007/s00408-012-9390-z

PurposeIdiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies... Read More about Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies.

Functional evolution of the feeding system in rodents (2012)
Journal Article
Cox, P. G., Rayfield, E. J., Fagan, M. J., Herrel, A., Pataky, T. C., & Jeffery, N. (2012). Functional evolution of the feeding system in rodents. PloS one, 7(4), e36299. https://doi.org/10.1371/journal.pone.0036299

The masticatory musculature of rodents has evolved to enable both gnawing at the incisors and chewing at the molars. In particular, the masseter muscle is highly specialised, having extended anteriorly to originate from the rostrum. All living rodent... Read More about Functional evolution of the feeding system in rodents.

Volume conduction effects in brain network inference from electroencephalographic recordings using phase lag index (2012)
Journal Article
Peraza, L. R., Asghar, A., Green, G., & Halliday, D. M. (2012). Volume conduction effects in brain network inference from electroencephalographic recordings using phase lag index. Journal of neuroscience methods, 207(2), (189-199). doi:10.1016/j.jneumeth.2012.04.007. ISSN 0165-0270

In this paper, we test the performance of a synchronicity estimator widely applied in Neuroscience, phase lag index (PLI), for brain network inference in EEG. We implement the four sphere head model to simulate the volume conduction problem present i... Read More about Volume conduction effects in brain network inference from electroencephalographic recordings using phase lag index.

Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer (2012)
Journal Article
Hodgkinson, V. C., Agarwal, V., ElFadl, D., Fox, J. N., McManus, P. L., Mahapatra, T. K., …Cawkwell, L. (2012). Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer. Journal of Proteomics, 75(9), (2745-2752). doi:10.1016/j.jprot.2012.03.049. ISSN 1874-3919

Neoadjuvant chemotherapy is used to treat oestrogen receptor-positive breast cancer however chemo-resistance is a major obstacle in this molecular subtype. The ability to predict tumour response would allow chemotherapy administration to be directed... Read More about Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer.

The role of systematic reviews of qualitative evidence in evaluating interventions: a case study (2012)
Journal Article
Lorenc, T., Pearson, M., Jamal, F., Cooper, C., & Garside, R. (2012). The role of systematic reviews of qualitative evidence in evaluating interventions: a case study. Research Synthesis Methods, 3(1), 1-10. doi:10.1002/jrsm.1036

Systematic reviews of qualitative evidence have been widely used to provide information on the context and implementation of interventions, and their potential barriers and facilitators. However, such reviews face a number of methodological challenge... Read More about The role of systematic reviews of qualitative evidence in evaluating interventions: a case study.

Evolution of an endovenous laser ablation practice for varicose veins (2012)
Journal Article
Samuel, N., Wallace, T., Carradice, D., Smith, G., Mazari, F., & Chetter, I. (2013). Evolution of an endovenous laser ablation practice for varicose veins. Phlebology, 28(5), 248-256. https://doi.org/10.1258/phleb.2011.011103

Objective We aimed to assess the evolution of an endovenous laser ablation (EVLA) practice in the management of varicose veins in a university teaching hospital vascular surgical unit, over five years. Methods This was a retrospective review of a pro... Read More about Evolution of an endovenous laser ablation practice for varicose veins.

Are emotions perceptual experiences of value? (2012)
Journal Article
Whiting, D. (2012). Are emotions perceptual experiences of value?. Ratio, 25(1), 93-107. https://doi.org/10.1111/j.1467-9329.2011.00518.x

A number of emotion theorists hold that emotions are perceptions of value. In this paper I say why they are wrong. I claim that in the case of emotion there is nothing that can provide the perceptual modality that is needed if the perceptual theory i... Read More about Are emotions perceptual experiences of value?.