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Regulation of cell survival by sphingosine-1-phosphate receptor S1P 1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1 (2013)
Journal Article
Rutherford, C., Childs, S., Ohotski, J., McGlynn, L., Riddick, M., MacFarlane, S., …Palmer, T. M. (2013). Regulation of cell survival by sphingosine-1-phosphate receptor S1P 1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), Article e927. https://doi.org/10.1038/cddis.2013.455

Although the ability of bioactive lipid sphingosine-1-phosphate (S1P) to positively regulate anti-apoptotic/pro-survival responses by binding to S1P1 is well known, the molecular mechanisms remain unclear. Here we demonstrate that expression of S1P1... Read More about Regulation of cell survival by sphingosine-1-phosphate receptor S1P 1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.