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All Outputs (9)

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z., Gustafson, J., Cunningham, M. L., …Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126. https://doi.org/10.1016/j.jbiomech.2015.11.012

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More about Intracranial pressure changes during mouse development.

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance (2015)
Journal Article
Toro-Ibacache, V., Fitton, L. C., Fagan, M. J., & O'Higgins, P. (2016). Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance. Journal of anatomy, 228(1), 70-84. https://doi.org/10.1111/joa.12384

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investi... Read More about Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance.

Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation (2015)
Journal Article
Langley, P. (2015). Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation. Entropy, 17(9), 6397-6411. https://doi.org/10.3390/e17096397

A novel method of quantifying the effectiveness of the suppression of ventricular activity from electrocardiograms (ECGs) in atrial fibrillation is proposed. The temporal distribution of the energy of wavelet coefficients is quantified by wavelet ent... Read More about Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation.

Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome (2015)
Journal Article
Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome. Open heart, 2(1), e000302. https://doi.org/10.1136/openhrt-2015-000302

Objective To assess the effect of catheter ablation on atrial fibrillation (AF) symptoms and quality of life (QoL). Methods Patients with AF scheduled for ablation were recruited. Pulmonary vein isolation (PVI) was performed and complex fractionated... Read More about Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome.

A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease (2015)
Journal Article
Ji, B., Genever, P. G., & Fagan, M. J. (2016). A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease. International journal for numerical methods in biomedical engineering, 32(3), e02735. https://doi.org/10.1002/cnm.2735

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have... Read More about A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease.

Mechanical properties of calvarial bones in a mouse model for craniosynostosis (2015)
Journal Article
Moazen, M., Peskett, E., Babbs, C., Pauws, E., & Fagan, M. J. (2015). Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PLoS ONE, 10(5), e0125757. https://doi.org/10.1371/journal.pone.0125757

The mammalian cranial vault largely consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Premature closure of the cranial sutures, craniosynostosis, can lead to serious clinical pathology unle... Read More about Mechanical properties of calvarial bones in a mouse model for craniosynostosis.

Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity (2015)
Journal Article
Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity. Medical engineering & physics, 37(2), 251-255. https://doi.org/10.1016/j.medengphy.2014.12.008

Background Lead V₁ is routinely analysed due to its large amplitude AF waveform. V₁ correlates strongly with right atrial activity but only moderately with left atrial activity. Posterior lead V₉ correlates strongest with left atrial activity. Aims (... Read More about Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity.

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso (2015)
Journal Article
Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., …Zhang, H. (2015). A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso. PLoS Computational Biology, 11(1), Article e1004026. https://doi.org/10.1371/journal.pcbi.1004026

Rapid atrial arrhythmias such as atrial fibrillation (AF) predispose to ventricular arrhythmias, sudden cardiac death and stroke. Identifying the origin of atrial ectopic activity from the electrocardiogram (ECG) can help to diagnose the early onset... Read More about A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso.

Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls (2015)
Journal Article
Langley, P., Bourke, J. P., & Giacopelli, D. (2015). Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls. Acta Cardiologica, 70(6), 672-677. https://doi.org/10.2143/AC.70.6.3120179

© 2015, Acta Cardiologica. All rights reserved. Objective The aim of this study is to characterize the observable segment of the atrial repolarization (Ta wave) of the standard ECG during sinus rhythm in paroxysmal atrial fibrillation (PAF) patients... Read More about Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls.