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A retrospective cohort study in severe asthma describing commonly measured biomarkers: Eosinophil count and IgE levels (2017)
Journal Article
Haughney, J., Morice, A., Blyth, K. G., Lee, A. J., Coutts, A., McKnight, E., & Pavord, I. (2018). A retrospective cohort study in severe asthma describing commonly measured biomarkers: Eosinophil count and IgE levels. Respiratory medicine, 134, 117-123. https://doi.org/10.1016/j.rmed.2017.12.001

© 2017 Elsevier Ltd Background Identifying asthma patients suitable for biologic therapy includes the assessment of blood biomarkers (IgE and eosinophils (EOS)). How they relate to each other is unclear. Methods This retrospective, database study use... Read More about A retrospective cohort study in severe asthma describing commonly measured biomarkers: Eosinophil count and IgE levels.

Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma? (2017)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2017). Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?. European respiratory journal, 50(6), Article 1701366. https://doi.org/10.1183/13993003.01366-2017

Copyright © ERS 2017. Little is known of the long-term symptom profile in uncontrolled asthma and whether symptoms can predict distinct phenotypes. The primary objective of these analyses was to assess diurnal profile of cough and wheeze in an uncont... Read More about Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?.

Does FeNO Predict Clinical Characteristics in Chronic Cough? (2017)
Journal Article
Sadeghi, M. H., Wright, C. E., Hart, S., Crooks, M., & Morice, A. H. (2018). Does FeNO Predict Clinical Characteristics in Chronic Cough?. Lung, 196(1), 59-64. https://doi.org/10.1007/s00408-017-0074-6

© 2017, The Author(s). Purpose: To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. Methods: We have studied consecutive patients attending a sp... Read More about Does FeNO Predict Clinical Characteristics in Chronic Cough?.

Pharmacology of cough in palliative care (2017)
Journal Article
Morice, A. H., & Shanks, G. (2017). Pharmacology of cough in palliative care. Current opinion in supportive and palliative care, 11(3), 147-151. https://doi.org/10.1097/SPC.0000000000000279

© 2017 Wolters Kluwer Health, Inc. All rights reserved. Purpose of review Cough is a common and distressing symptom. It has a marked decrement on quality-of-life particularly in the arena of palliative care where coexisting symptoms such as pain may... Read More about Pharmacology of cough in palliative care.

A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial (2017)
Journal Article
Birring, S. S., Wijsenbeek, M. S., Agrawal, S., van den Berg, J. W., Stone, H., Maher, T. M., …Morice, A. (2017). A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial. The lancet. Respiratory medicine, 5(10), 806-815. https://doi.org/10.1016/S2213-2600%2817%2930310-7

Background Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher dr... Read More about A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial.

Theobromine for the treatment of persistent cough: A randomised, multicentre, double-blind, placebo-controlled clinical trial (2017)
Journal Article
Morice, A. H., McGarvey, L., Pavord, I. D., Higgins, B., Chung, K. F., & Birring, S. S. (2017). Theobromine for the treatment of persistent cough: A randomised, multicentre, double-blind, placebo-controlled clinical trial. Journal of thoracic disease, 9(7), 1864-1872. https://doi.org/10.21037/jtd.2017.06.18

© Journal of Thoracic Disease. Background: To investigate the effect of BC1036 on health-related quality of life (QOL) in subjects with persistent cough. The secondary objective was to investigate the effect of BC1036 on subjective cough severity. Me... Read More about Theobromine for the treatment of persistent cough: A randomised, multicentre, double-blind, placebo-controlled clinical trial.

The emerging role of the eosinophil and its measurement in chronic cough (2017)
Journal Article
Sadeghi, M. H., & Morice, A. H. (2017). The emerging role of the eosinophil and its measurement in chronic cough. Open Respiratory Medicine Journal, 11, 17-30. https://doi.org/10.2174/1874306401711010017

© 2017 Sadeghi & Morice. Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastrooesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these condi... Read More about The emerging role of the eosinophil and its measurement in chronic cough.

Cough hypersensitivity syndrome: A few more steps forward (2017)
Journal Article
Song, W. J., & Morice, A. H. (2017). Cough hypersensitivity syndrome: A few more steps forward. Allergy Asthma and Immunology Research, 9(5), 394-402. https://doi.org/10.4168/aair.2017.9.5.394

© The Korean Academy of Asthma, Allergy and Clinical Immunology. Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high... Read More about Cough hypersensitivity syndrome: A few more steps forward.

A new way to look at acute cough in the pharmacy (2017)
Journal Article
Morice, A. H. (2017). A new way to look at acute cough in the pharmacy. Pharmaceutical Journal, 9(4), https://doi.org/10.1211/CP.2017.20202484

© 2017 Royal Pharmaceutical Society. All rights reserved. Cough is the most common symptom for which people seek medical advice, and patients with cough frequently present to community pharmacy. Cough can be either acute or chronic. Acute cough, defi... Read More about A new way to look at acute cough in the pharmacy.

Point prevalence and epidemiological characteristics of chronic cough in the general adult population: The Korean National Health and Nutrition Examination Survey 2010-2012 (2017)
Journal Article
Kang, M. G., Song, W. J., Kim, H. J., Won, H. K., Sohn, K. H., Kang, S. Y., …Cho, S. H. (2017). Point prevalence and epidemiological characteristics of chronic cough in the general adult population: The Korean National Health and Nutrition Examination Survey 2010-2012. Medicine, 96(13), Article e6486. https://doi.org/10.1097/MD.0000000000006486

© 2017 the Author(s). Cough is frequently self-limiting, but may persist longer in certain individuals. Most of previous studies on the epidemiology of chronic cough have only measured period prevalence, and thus have afforded limited information on... Read More about Point prevalence and epidemiological characteristics of chronic cough in the general adult population: The Korean National Health and Nutrition Examination Survey 2010-2012.

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation (2017)
Journal Article
Crooks, M. G., den Brinker, A., Hayman, Y., Williamson, J. D., Innes, A., Wright, C. E., …Morice, A. H. (2017). Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation. Lung, 195(3), 289-294. https://doi.org/10.1007/s00408-017-9996-2

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deteriorat... Read More about Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation.

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? (2017)
Journal Article
Hayman, Y. A., Sadofsky, L. R., Williamson, J. D., Hart, S. P., & Morice, A. H. (2017). The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?. Ers Monograph, 3(1), 00026-2016. https://doi.org/10.1183/23120541.00026-2016

Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR. The proposed mechanis... Read More about The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?.

Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study (2017)
Journal Article
Morjaria, J. B., Morice, A. H., Morice, A., Rigby, A., & Morjaria, J. (2017). Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study. Lung, 195(3), 281-288. https://doi.org/10.1007/s00408-017-9990-8

Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory event... Read More about Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study.