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Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation (2017)
Journal Article
Davey, G. E., Dyson, P. J., Davey, C. A., Davey, G., Adhireksan, Z., Ma, Z., …Davey, C. (2017). Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation. Nature communications, 8(1), https://doi.org/10.1038/s41467-017-01680-4

© 2017 The Author(s). The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially the... Read More