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Is swimming safe in heart failure? : a systematic review (2017)
Journal Article
Shah, P. M., Pellicori, P., Macnamara, A., Urbinati, A., & Clark, A. L. (2017). Is swimming safe in heart failure? : a systematic review. Cardiology in review, 25(6), 321-325. https://doi.org/10.1097/CRD.0000000000000154

It is not clear whether swimming is safe in patients with chronic heart failure. Ten studies examining the hemodynamic effects of acute water immersion (WI) (155 patients; average age 60 years; 86% male; mean left ventricular ejection fraction (LVEF)... Read More

The use of ofatumumab in the treatment of B-cell malignancies (2017)
Journal Article
Soe, Z. N., & Allsup, D. (2017). The use of ofatumumab in the treatment of B-cell malignancies. Future oncology, 13(29), 2611-2628. https://doi.org/10.2217/fon-2017-0275

Ofatumumab has been extensively studied in the treatment of B-cell malignancies. Currently, it has been approved for the treatment of chronic lymphocytic leukemia in a number of different situations. However, there is still no compelling evidence con... Read More

“Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program (2017)
Journal Article
Harwood, A., Broadbent, E., Totty, J. P., Smith, G. E., & Chetter, I. C. (2017). “Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program. Journal of Vascular Nursing, 35(3), 131-135. https://doi.org/10.1016/j.jvn.2017.03.001

© 2017 Society for Vascular Nursing, Inc. Intermittent claudication (IC) is a common condition which has severe impacts on quality of life, physical function, and mental health. Supervised exercise is the recommended first-line treatment for patients... Read More

Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial (2017)
Journal Article
Collett, L., Howard, D. R., Munir, T., McParland, L., Oughton, J. B., Rawstron, A. C., …Hillmen, P. (2017). Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial. Trials, 18(1), https://doi.org/10.1186/s13063-017-2138-6

Background Treatment of chronic lymphocytic leukaemia (CLL) has seen a substantial improvement over the last few years. Combination immunochemotherapy, such as fludarabine, cyclophosphamide and rituximab (FCR), is now standard first-line therapy. How... Read More

Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment (2017)
Journal Article
Medlock, J., Das, A. A. K., Madden, L. A., Allsup, D. J., & Paunov, V. N. (2017). Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment. Chemical Society Reviews, 46(16), 5110-5127. https://doi.org/10.1039/c7cs00179g

Cancer incidence and mortality have both increased in the last decade and are predicted to continue to rise. Diagnosis and treatment of cancers are often hampered by the inability to specifically target neoplastic cells. Bioimprinting is a promising... Read More

A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma (2017)
Journal Article
Pratt, G., Yap, C., Oldreive, C., Slade, D., Bishop, R., Griffiths, M., …Stankovic, T. (2018). A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma. British journal of haematology, 182(3), 429-433. https://doi.org/10.1111/bjh.14793

The effect of caloric restriction on the forelimb skeletal muscle fibers of the hypertrophic myostatin null mice (2017)
Journal Article
Elashry, M. I., Matsakas, A., Wenisch, S., Arnhold, S., & Patel, K. (2017). The effect of caloric restriction on the forelimb skeletal muscle fibers of the hypertrophic myostatin null mice. Acta Histochemica, 119(5), 582-591. https://doi.org/10.1016/j.acthis.2017.06.002

Skeletal muscle mass loss has a broad impact on body performance and physical activity. Muscle wasting occurs due to genetic mutation as in muscular dystrophy, age-related muscle loss (sarcopenia) as well as in chronic wasting disorders as in cancer... Read More

Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF) (2017)
Journal Article
Vancauwenberghe, E., Noyer, L., Derouiche, S., Lemonnier, L., Gosset, P., Sadofsky, L. R., …Roudbaraki, M. (2017). Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Molecular Carcinogenesis, 56(8), 1851-1867. https://doi.org/10.1002/mc.22642

Previous studies showed the effects of resveratrol (RES) on several cancer cells, including prostate cancer (PCa) cell apoptosis without taking into consideration the impact of the tumor microenvironment (TME). The TME is composed of cancer cells, en... Read More

Dialkylcarbamoyl Chloride Dressings in the Prevention of Surgical Site Infections after Nonimplant Vascular Surgery (2017)
Journal Article
Carradice, D., Chetter, I. C., Totty, J. P., Wallace, T., Bua, N., Pan, D., & Smith, G. E. (2017). Dialkylcarbamoyl Chloride Dressings in the Prevention of Surgical Site Infections after Nonimplant Vascular Surgery. Annals of vascular surgery, 44, 387-392. https://doi.org/10.1016/j.avsg.2017.03.198

© 2017 Elsevier Inc. Background Dressings coated with dialkylcarbamoyl chloride (DACC) are highly hydrophobic and irreversibly bind multiple types of bacteria, trapping them in the dressing and reducing the number of organisms at the wound surface. W... Read More

Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure (2017)
Journal Article
Kotecha, D., Flather, M. D., Altman, D. G., Holmes, J., Rosano, G., Wikstrand, J., …Cleland, J. G. (2017). Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure. Journal of the American College of Cardiology, 69(24), 2885-2896. https://doi.org/10.1016/j.jacc.2017.04.001

Background The relationship between mortality and heart rate remains unclear for patients with heart failure with reduced ejection fraction in either sinus rhythm or atrial fibrillation (AF). Objectives This analysis explored the prognostic importan... Read More

Genistein crosses the bioartificial oviduct and alters secretion composition (2017)
Journal Article
Simintiras, C. A., & Sturmey, R. G. (2017). Genistein crosses the bioartificial oviduct and alters secretion composition. Reproductive Toxicology, 71, (63-70). doi:10.1016/j.reprotox.2017.04.010. ISSN 0890-6238

The dietary derived isoflavone and oestrogen analogue, genistein, is known to perturb fundamental reproductive events such as implantation and embryo cleavage. However the question of whether genistein is able to traverse the oviduct epithelial monol... Read More

Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure (2017)
Journal Article
Fröhlich, H., Torres, L., Täger, T., Schellberg, D., Corletto, A., Kazmi, S., …Frankenstein, L. (2017). Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure. Clinical Research in Cardiology, 106(9), 711-721. https://doi.org/10.1007/s00392-017-1115-0

© 2017, Springer-Verlag Berlin Heidelberg. Aims: Beta-blockers are recommended for the treatment of chronic heart failure (CHF). However, it is disputed whether beta-blockers exert a class effect or whether there are differences in efficacy between a... Read More

Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study (2017)
Journal Article
Pellicori, P., Clark, A. L., Kallvikbacka-Bennett, A., Zhang, J., Urbinati, A., Monzo, L., …Cleland, J. G. (2017). Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study. European journal of heart failure, 19(7), 883-892. https://doi.org/10.1002/ejhf.825

Background: Jugular venous distension, reflecting raised right atrial pressure (RAP), is a classical sign of congestive heart failure (CHF), but its clinical assessment can be difficult. Methods: RAP was measured non-invasively using near-infrared sp... Read More

Long-term outcomes of a randomized clinical trial of supervised exercise, percutaneous transluminal angioplasty or combined treatment for patients with intermittent claudication due to femoropopliteal disease (2017)
Journal Article
Mazari, F. A., Khan, J. A., Samuel, N., Smith, G., Carradice, D., McCollum, P., & Chetter, I. (2017). Long-term outcomes of a randomized clinical trial of supervised exercise, percutaneous transluminal angioplasty or combined treatment for patients with intermittent claudication due to femoropopliteal disease. Journal of vascular surgery, 65(4), 1239-1240. doi:10.1016/j.jvs.2017.02.014

Background: To compare the long-term outcomes of angioplasty (PTA), supervised exercise (SEP) and combined treatment (PTA+SEP) in patients with intermittent claudication (IC) due to femoropopliteal disease. Methods: Patients recruited to PTA, SEP and... Read More

The effects of short-term omission of daily medication on the pathophysiology of heart failure (2017)
Journal Article
Dovancescu, S., Pellicori, P., Mabote, T., Torabi, A., Clark, A. L., & Cleland, J. G. (2017). The effects of short-term omission of daily medication on the pathophysiology of heart failure. European journal of heart failure, 19(5), 643-649. https://doi.org/10.1002/ejhf.748

Aims Pharmacological therapies for heart failure (HF) aim to improve congestion, symptoms, and prognosis. Failing to take medication is a potential cause of worsening HF. Characterizing the effects of short-term medication omission could inform the d... Read More

Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure (2017)
Journal Article
Fröhlich, H., Raman, N., Täger, T., Schellberg, D., Goode, K. M., Kazmi, S., …Frankenstein, L. (2017). Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure. International journal of cardiology, 238, 97-104. https://doi.org/10.1016/j.ijcard.2017.03.028

© 2017 Elsevier B.V. Background In patients with chronic heart failure (CHF) increasing levels of total serum cholesterol are associated with improved survival – while statin usage is not. The impact of statin treatment on the “reverse epidemiology”... Read More

Maternal metabolic stress may affect oviduct gatekeeper function (2017)
Journal Article
Jordaens, L., van Hoeck, V., Maillo, V., Gutiérrez-Adán, A., Marei, W., Vlaeminck, B., …Leroy, J. L. M. R. (2017). Maternal metabolic stress may affect oviduct gatekeeper function. Reproduction, 153(6), (759-773). doi:10.1530/rep-16-0569. ISSN 1470-1626

We hypothesized that elevated non-esterified fatty acids (NEFA) modify in vitro bovine oviduct epithelial cell (BOEC) metabolism and barrier function. Hereto, BOECs were studied in a polarized system with 24h-treatments at day 9: 1) CONTROL (0µM NEFA... Read More

TRPV1 polymorphisms influence capsaicin cough sensitivity in men (2017)
Journal Article
Sadofsky, L. R., Cantero-Recasens, G., Wright, C., Valverde, M. A., & Morice, A. H. (2017). TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Journal of thoracic disease, 9(3), 839-840. doi:10.21037/jtd.2017.03.50

Capsaicin, the hot component of chilli peppers, is a well-known tussive agent, which is regularly used as a tool to study cough and antitussives (1). Capsaicin is known to activate the transient receptor potential vanilloid 1 (TRPV1) cation channel w... Read More

What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan? (2017)
Journal Article
Pellicori, P., Urbinati, A., Shah, P., MacNamara, A., Kazmi, S., Dierckx, R., …Clark, A. L. (2017). What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?. European journal of heart failure, 19(6), 768-778. https://doi.org/10.1002/ejhf.788

Aims The PARADIGM-HF trial showed that sacubitril–valsartan, an ARB–neprilysin inhibitor, is more effective than enalapril for some patients with heart failure (HF). It is uncertain what proportion of patients with HF would be eligible for sacubitril... Read More

Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling (2017)
Journal Article
Zhang, J., Wong, K., Clark, A. L., & Cleland, J. G. (2017). Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling. International journal of cardiology, 233, 67-72. https://doi.org/10.1016/j.ijcard.2017.01.127

Background The relation between changes in NT-proBNP and renal function has commonly been studied using multiple regressions, which may ignore the complexity of relations between related variables. Methods and results Data were collected from patient... Read More