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All Outputs (4)

Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei (2018)
Thesis
Alshegifi, M. (2018). Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221223

Trypanosoma brucei is a medically important protozoan parasite that causes African sleeping sickness in humans. Although disease treatment is possible, it is hindered by the limited availability of effective drugs and the rapid emergence of drug resi... Read More about Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei.

Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells (2018)
Thesis
Ethaeb, A. M. (2018). Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220989

Tissue factor (TF) is the main initiator of blood coagulation. In addition to its procoagulant property, TF has the ability to regulate various functions within cells including proliferation, angiogenesis and apoptosis. These outcomes appear to depen... Read More about Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells.

Targeted activation of dendritic cells via the CD40 receptor (2018)
Thesis
Wingham, B. (2018). Targeted activation of dendritic cells via the CD40 receptor. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4224089

Dendritic cell (DC) activation underpins the patient immune response in multiple cancers, including ovarian cancer. While DCs are detected within the margins of ovarian tumours, DC populations are maintained in an immature state, displaying low level... Read More about Targeted activation of dendritic cells via the CD40 receptor.

The generation of an immunosuppressive microenvironment by soluble factors in head and neck squamous cell carcinoma (2018)
Thesis
Roberts, E. R. (2018). The generation of an immunosuppressive microenvironment by soluble factors in head and neck squamous cell carcinoma. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220880

Tumour infiltrating lymphocytes (TIL) in head neck squamous cell carcinoma (HNSCC) are enriched in Treg, a finding confirmed in the current study, which is thought to be a contributing factor to immunosuppression and tumour evasion. Soluble factors r... Read More about The generation of an immunosuppressive microenvironment by soluble factors in head and neck squamous cell carcinoma.