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All Outputs (3)

Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells (2019)
Thesis
Adeniran, O. I. (2019). Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222358

Most standard anticancer drugs are non-selective in their cytotoxicity towards cancerous versus normal cells. Therefore, there is a need for the development of selective and targeted anticancer agents. Previous studies have reported upregulation of t... Read More about Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells.

Chemically modified sporopollenin as a solid support for heterogeneous catalysts (2019)
Thesis
Abimbade, S. F. (2019). Chemically modified sporopollenin as a solid support for heterogeneous catalysts. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222418

Application of the principles of ‘Green Chemistry’ has been a focus in recent years in the synthesis of fine chemicals, and solid-phase catalysts are useful tools in that endeavour compared to stoichiometric reagents. Another important principle of ‘... Read More about Chemically modified sporopollenin as a solid support for heterogeneous catalysts.

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites (2019)
Journal Article
Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators... Read More about N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.