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Laparoscopic versus Open Colorectal Surgery in the Acute Setting (LaCeS Trial): A multicentre, randomised controlled feasibility trial. (2020)
Journal Article
Harji, D., Marshall, H., Gordon, K., Twiddy, M., Pullan, A., Meads, D., …Brown, J. (in press). Laparoscopic versus Open Colorectal Surgery in the Acute Setting (LaCeS Trial): A multicentre, randomised controlled feasibility trial. British journal of surgery, https://doi.org/10.1002/bjs.11703

Abstract Background Approximately 30,000 people per annum undergo major, emergency abdominal, gastrointestinal surgery, of which 36% (~10,800) are carried out for emergency colorectal pathology. Approximately 14% of all patients requiring emergency... Read More about Laparoscopic versus Open Colorectal Surgery in the Acute Setting (LaCeS Trial): A multicentre, randomised controlled feasibility trial..

Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention (2020)
Journal Article
Vaughan, D., Kretz, O., Alqallaf, A., Mitchell, R., von der Heide, J., Vaiyapuri, S., …Patel, K. (in press). Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention. European Journal of Translational Myology, 30(2), 276-285. https://doi.org/10.4081/ejtm.0.8904

Duchenne Muscular Dystrophy is a devastating disease caused by the absence of a functional rod-shaped cytoplasmic protein called dystrophin. Several avenues are being developed aimed to restore dystrophin expression in boys affected by this X-linked... Read More about Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention.

Title: A systematic review and meta-analysis of studies comparing burden from lung cancer and chronic obstructive pulmonary disease (COPD) (2020)
Journal Article
Luckett, T., San Martin, A., Currow, D. C., Johnson, M. J., Barnes-Harris, M. M. M., & Phillips, J. L. (in press). Title: A systematic review and meta-analysis of studies comparing burden from lung cancer and chronic obstructive pulmonary disease (COPD). Palliative medicine,

Background Chronic obstructive pulmonary disease (COPD) and lung cancer are both life-limiting diseases that confer burden in the form of symptoms and impacts on functioning and quality of life. Comparing burden between these diseases is of interest... Read More about Title: A systematic review and meta-analysis of studies comparing burden from lung cancer and chronic obstructive pulmonary disease (COPD).

Patients’ and caregivers’ experiences of driving with chronic breathlessness before and after regular low-dose sustained-release morphine: A qualitative study (2020)
Journal Article
Ferreira, D. H., Boland, J. W., Kochovska, S., Honson, A., Phillips, J. L., & Currow, D. C. (in press). Patients’ and caregivers’ experiences of driving with chronic breathlessness before and after regular low-dose sustained-release morphine: A qualitative study. Palliative medicine, https://doi.org/10.1177/0269216320929549

Background: Chronic breathlessness is a disabling syndrome that profoundly impacts patients’ and caregivers’ lives. Driving is important for most people, including those with advanced disease. Regular, low-dose, sustained-release morphine safely red... Read More about Patients’ and caregivers’ experiences of driving with chronic breathlessness before and after regular low-dose sustained-release morphine: A qualitative study.

Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective (2020)
Journal Article
Turner, A., Veysey, M., Keely, S., Scarlett, C. J., Lucock, M., & Beckett, E. L. (2020). Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective. International Journal of Environmental Research and Public Health, 17(11), https://doi.org/10.3390/ijerph17114094

Intense sweeteners (IS) are often marketed as a healthier alternative to sugars, with the potential to aid in combating the worldwide rise of diabetes and obesity. However, their use has been counterintuitively associated with impaired glucose homeos... Read More about Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective.

Identification of patients with potential palliative care needs: a systematic review of screening tools in primary care (2020)
Journal Article
ElMokhallalati, Y., Bradley, S. H., Chapman, E., Ziegler, L., Murtagh, F. E., Johnson, M. J., & Bennett, M. I. (in press). Identification of patients with potential palliative care needs: a systematic review of screening tools in primary care. Palliative medicine, https://doi.org/10.1177/0269216320929552

Background Despite increasing evidence of the benefits of early access to palliative care, many patients do not receive palliative care in a timely manner. A systematic approach in primary care can facilitate earlier identification of patients with... Read More about Identification of patients with potential palliative care needs: a systematic review of screening tools in primary care.

The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial (2020)
Journal Article
Huang, C. (in press). The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial. International Journal of Drug Policy,

Background: This study examined the effects of the iPlayClean anti-doping intervention on attitudes towards doping and susceptibility, and whether delivery mode affected the results. Methods: A total of 1,081 high-level UK athletes (14-18 years old... Read More about The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial.

The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial (2020)
Journal Article
Nicholls, A., Morley, D., Thompson, M. A., Huang, C., Abt, G., Rothwell, M., …Ntoumanis, N. (in press). The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial. International Journal of Drug Policy,

Background: This study examined the effects of the iPlayClean anti-doping intervention on attitudes towards doping and susceptibility, and whether delivery mode affected the results. Methods: A total of 1,081 high-level UK athletes (14-18 years old... Read More about The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial.

Opioids for breathlessness: a narrative review (2020)
Journal Article
Johnson, M., & Currow, D. (in press). Opioids for breathlessness: a narrative review. BMJ supportive & palliative care,

ABSTRACT Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of management and should be optimised prior to use... Read More about Opioids for breathlessness: a narrative review.

Development of a Core Outcome Set to use in the Research and Assessment of Malignant Bowel Obstruction: protocol for the RAMBO study (2020)
Journal Article
Baddeley, E., Bravington, A., Johnson, M., Currow, D., Murtagh, F., Boland, E., …Boland, J. (2020). Development of a Core Outcome Set to use in the Research and Assessment of Malignant Bowel Obstruction: protocol for the RAMBO study. BMJ open, 10(6), https://doi.org/10.1136/bmjopen-2020-039154

Introduction: Studies regarding the management of malignant bowel obstruction (MBO) report conflicting findings. This is partly due to different outcome measures being used to evaluate severity of MBO and the response to treatments. Furthermore, curr... Read More about Development of a Core Outcome Set to use in the Research and Assessment of Malignant Bowel Obstruction: protocol for the RAMBO study.

Quality of life changes with duration of chronic breathlessness: a random sample of community-dwelling people. (2020)
Journal Article
Currow, D. C., Chang, S., Dal Grande, E., Ferreira, D. H., Kochovska, S., Kinchin PhD, I., …Ekstrom, M. (in press). Quality of life changes with duration of chronic breathlessness: a random sample of community-dwelling people. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2020.05.015

Introduction Chronic breathlessness is associated with poorer quality of life. This population study aimed to define dimensions of quality of life (QoL), and duration and dominant causes of breathlessness that most diminished QoL. Methods This... Read More about Quality of life changes with duration of chronic breathlessness: a random sample of community-dwelling people..

A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin: TOUCAN Phase II trial final (2020)
Journal Article
Jones, R., Crabb, S., Chester, J., Elliott, T., Huddart, R., Birtle, A., …Griffiths, G. (in press). A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin: TOUCAN Phase II trial final. BJU international, https://doi.org/10.1111/bju.15096

Objectives To assess the efficacy and tolerability of the dual epidermal growth factor receptor/vascular endothelial growth factor receptor inhibitor, vandetanib, in combination with carboplatin and gemcitabine in the first‐line treatment of patient... Read More about A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin: TOUCAN Phase II trial final.

Whole-genome sequencing of a sporadic primary immunodeficiency cohort (2020)
Journal Article
Thaventhiran, J. E. D., Primary Immunodeficiency Consortium for the NIHR Bioresource, , Lango Allen, H., Burren, O. S., Rae, W., Greene, D., …Smith, K. G. C. (in press). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, https://doi.org/10.1038/s41586-020-2265-1

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. Although the most severe forms of PID are identified in early child... Read More about Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Quality of life among caregivers of people with end-stage kidney disease managed with dialysis or comprehensive conservative care (2020)
Journal Article
Morton, R. L., Burns, A., Crail, S. M., McGeechan, K., Shah, K. K., & Murtagh, F. E. (2020). Quality of life among caregivers of people with end-stage kidney disease managed with dialysis or comprehensive conservative care. BMC Nephrology, 21(1), 160. https://doi.org/10.1186/s12882-020-01830-9

BACKGROUND: To measure health-related and care-related quality of life among informal caregivers of older people with end-stage kidney disease (ESKD), and to determine the association between caregiver quality of life and care recipient's treatment t... Read More about Quality of life among caregivers of people with end-stage kidney disease managed with dialysis or comprehensive conservative care.

Interventions to minimise doctors’ mental ill-health and its impacts on the workforce and patient care: the Care Under Pressure realist review (2020)
Journal Article
Carrieri, D., Pearson, M., Mattick, K., Papoutsi, C., Briscoe, S., Wong, G., & Jackson, M. (in press). Interventions to minimise doctors’ mental ill-health and its impacts on the workforce and patient care: the Care Under Pressure realist review. Health Services and Delivery Research, 8(19), 1-132. https://doi.org/10.3310/hsdr08190

Background The growing incidence of mental ill-health in health professionals, including doctors, is a global concern. Although a large body of literature exists on interventions that offer support, advice and/or treatment to sick doctors, it has no... Read More about Interventions to minimise doctors’ mental ill-health and its impacts on the workforce and patient care: the Care Under Pressure realist review.

Physical activity and nutrition interventions for older adults with cancer: a systematic review (2020)
Journal Article
Forbes, C. C., Swan, F., Greenley, S., Lind, M., & Johnson, M. J. (in press). Physical activity and nutrition interventions for older adults with cancer: a systematic review. Journal of cancer survivorship : research and practice, https://doi.org/10.1007/s11764-020-00883-x

Purpose: The aim of this review was to summarize the current literature for the effectiveness of activity and nutritional based interventions on health-related quality of life (HRQoL) in older adults living with and beyond cancer (LWBC). Methods: W... Read More about Physical activity and nutrition interventions for older adults with cancer: a systematic review.


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