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All Outputs (4)

Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells (2021)
Journal Article
Adeniran, O. I., Mohammad, M. A., Featherby, S., Maraveyas, A., Boa, A. N., & Ettelaie, C. (2021). Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells. Frontiers in Bioscience-Landmark, 26(10), 752-764. https://doi.org/10.52586/4985

Introduction: The restriction of prolyl-protein cis/trans isomerase 1 (Pin1) activity has been shown to prevent the release of tissue factor (TF) leading to the accumulation of the latter protein within the cell. This study tested the ability of nove... Read More about Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells.

De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions (2021)
Journal Article
Ettelaie, C., Featherby, S., Rondon, A. M. R., Greenman, J., Versteeg, H. H., & Maraveyas, A. (2021). De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions. Cancers, 13(15), Article 3837. https://doi.org/10.3390/cancers13153837

In this study, the role of de-palmitoylation of tissue factor (TF) in the decryption of its activity was explored. TF-tGFP constructs were prepared by mutagenesis-substitution at Cys245 to prevent or mimic palmitolyation. Additionally, to reduce TF d... Read More about De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions.

Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms (2021)
Journal Article
Madkhali, Y., Rondon, A. M., Featherby, S., Maraveyas, A., Greenman, J., & Ettelaie, C. (2021). Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms. Cancers, 13(15), Article 3718. https://doi.org/10.3390/cancers13153718

Procoagulant activity of tissue factor (TF) in response to injury or inflammation is accompanied with cellular signals which determine the fate of cells. However, to prevent excessive signalling, TF is rapidly dissipated through release into microves... Read More about Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms.

Investigation of the effects of anticoagulants on tissue factor mediated cellular processes (2021)
Thesis
Featherby, S. (2021). Investigation of the effects of anticoagulants on tissue factor mediated cellular processes. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223521

Thrombotic complications are common in cancer patients and are amongst the leading causes of morbidity and mortality. Recently, it was reported that treatment of cancer patients with the low molecular weight heparin (LMWH) family of anticoagulants ca... Read More about Investigation of the effects of anticoagulants on tissue factor mediated cellular processes.