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All Outputs (17)

Simplification or simulation: power calculation in clinical trials (2021)
Journal Article
Huang, C., Li, P., & Martin, C. R. (2022). Simplification or simulation: power calculation in clinical trials. Contemporary clinical trials, 113, Article 106663. https://doi.org/10.1016/j.cct.2021.106663

Background and objectives: A justifiable sample size is essential at trial design stage. Generally this task is completed by forming the main research question into a statistical procedure and then implementing the published formulae or software pack... Read More about Simplification or simulation: power calculation in clinical trials.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations. The Cochrane database of systematic reviews, 2021(12), CD013839. https://doi.org/10.1002/14651858.CD013839.pub2

BACKGROUND: Diabetes and vascular disease are the leading causes of lower limb amputation. Currently, 463 million adults are living with diabetes, and 202 million with peripheral vascular disease, worldwide. When a lower limb amputation is considered... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations.

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. (2021)
Journal Article
Danopoulos, E., Twiddy, M., West, R., & Rotchell, J. M. (in press). A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. Journal of hazardous materials, Article 127861. https://doi.org/10.1016/j.jhazmat.2021.127861

Humans are exposed to microplastics (MPs) daily via ingestion and inhalation. It is not known whether this results in adverse health effects and, if so, at what levels of exposure. Without epidemiological studies, human cell in vitro MP toxicological... Read More about A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells..

A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers (2021)
Journal Article
Hitchman, L., Totty, J., Lathan, R., Sidapra, M., Smith, G., Carradice, D., & Chetter, I. (2021). A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers. British journal of surgery, 108(supp.6), Article 1031. https://doi.org/10.1093/bjs/znab259.1127

Aim The purpose of this mixed methods feasibility study was to assess the feasibility of delivering ESWT to patients with DFUs. It also aimed to explore any potential clinical effect of ESWT on wound healing and investigate whether ESWT may offer an... Read More about A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers.

The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience (2021)
Journal Article
Chen, H., Twiddy, M., Jones, L., & Johnson, M. J. (2021). The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience. European Journal of Cancer Care, 30(6), Article e13503. https://doi.org/10.1111/ecc.13503

Objective: The objective of this study is to explore the specific information and communication needs of men affected by prostate cancer to inform the development of educational materials for clinicians. Methods: This is a qualitative descriptive stu... Read More about The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience.

The Tokophobia Severity Scale (TSS): measurement model, power and sample size considerations (2021)
Journal Article
Martin, C. R., Jones, C., Huang, C., Jomeen, J., Boubert, L., & Marshall, C. A. (in press). The Tokophobia Severity Scale (TSS): measurement model, power and sample size considerations. Journal of reproductive and infant psychology, https://doi.org/10.1080/02646838.2021.1931070

Objective: To examine the measurement model of the Tokophobia Severity Scale and consider issues of statistical power and sample size from the original instrument development study. Background: Fear of childbirth (FoC) and tokophobia represents an ar... Read More about The Tokophobia Severity Scale (TSS): measurement model, power and sample size considerations.

A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol (2021)
Journal Article
Twiddy, M., Hazara, A., Bhandari, S., & Allgar, V. (in press). A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol. Clinical and Experimental Nephrology, https://doi.org/10.1007/s10157-021-02072-1

Background: Incremental haemodialysis/haemodiafiltration (HD) may help reduce early mortality rates in patients starting HD. This mixed-method feasibility study aims to test the acceptability, tolerance and safety of a novel incremental HD regime, an... Read More about A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol.

An Updated Systematic Review and Meta-Analysis of Home-based Exercise Programmes for Individuals with Intermittent Claudication. (2021)
Journal Article
Pymer, S., Ibeggazene, S., Palmer, J., Tew, G., Ingle, L., Smith, G., …Harwood, A. (2021). An Updated Systematic Review and Meta-Analysis of Home-based Exercise Programmes for Individuals with Intermittent Claudication. Journal of vascular surgery, 74(6), 2076-2085.e20

Objectives: Supervised exercise programmes (SEP) are effective for improving walking distance in patients with intermittent claudication (IC) but provision and uptake rates are sub-optimal. Access to such programmes has also been halted by the Corona... Read More about An Updated Systematic Review and Meta-Analysis of Home-based Exercise Programmes for Individuals with Intermittent Claudication..

Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum (2021)
Journal Article
Robles, J. A., Simpson, S. A., Coulman, E., Gallagher, D., Jewell, K., Cohen, D., …Playle, R. (2021). Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum. International journal of obesity, 45(8), 1728-1739. https://doi.org/10.1038/s41366-021-00835-0

Objective: To assess whether a weight management intervention for pregnant women with obesity was effective in reducing body mass index (BMI) 12 months after giving birth. Methods: Pragmatic, cluster randomised controlled trial (RCT) with embedded co... Read More about Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum.

Do patient characteristics matter when calculating sample size for eczema clinical trials? (2021)
Journal Article
Howells, L., Gran, S., Chalmers, J. R., Stuart, B., Santer, M., Bradshaw, L., …Thomas, K. S. (2021). Do patient characteristics matter when calculating sample size for eczema clinical trials?. Skin Health and Disease, 1(3), Article e42. https://doi.org/10.1002/ski2.42

Background: The Patient-Oriented Eczema Measure (POEM) is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To ensure that the statistical significance of clinical trial results is meani... Read More about Do patient characteristics matter when calculating sample size for eczema clinical trials?.

The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review (2021)
Journal Article
Simms, M., Parker, P., Rigby, A., Whybrow, P., & Twiddy, M. (in press). The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review. Ultrasound, https://doi.org/10.1177/1742271X21995212

Background: The use of multiparametric magnetic resonance imaging (mpMRI) within active surveillance of prostate cancer programmes is identified by the UK National Institute for Health and Care Excellence (NICE guideline NG 131 2019) as having a role... Read More about The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review.

Domiciliary Cough Monitoring for the Prediction of COPD Exacerbations (2021)
Journal Article
Crooks, M. G., den Brinker, A. C., Thackray-Nocera, S., van Dinther, R., Wright, C. E., & Morice, A. H. (2021). Domiciliary Cough Monitoring for the Prediction of COPD Exacerbations. Lung, 199(2), 131-137. https://doi.org/10.1007/s00408-021-00435-9

Introduction: Acute exacerbations of COPD (AE-COPD) are a leading cause of health service utilisation and are associated with morbidity and mortality. Identifying the prodrome of AE-COPD by monitoring symptoms and physiological parameters (telemonito... Read More about Domiciliary Cough Monitoring for the Prediction of COPD Exacerbations.

Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It? (2021)
Journal Article
Sykes, D. L., Holdsworth, L., Jawad, N., Gunasekera, P., Morice, A. H., & Crooks, M. G. (2021). Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?. Lung, 199(2), 113-119. https://doi.org/10.1007/s00408-021-00423-z

© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature. The enduring impact of COVID-19 on patients has been examined in recent studies, leading to the description of Long-COVID. We report the l... Read More about Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?.

The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres (2021)
Journal Article
Burton, W., Sahota, P., Twiddy, M., Brown, J., & Bryant, M. (in press). The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres. Prevention Science, https://doi.org/10.1007/s11121-021-01205-y

Background Poor participant engagement threatens the potential impact and cost effectiveness of public health programmes preventing meaningful evaluation and wider application. Although barriers and levers to engagement with public health programmes... Read More about The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres.

Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study (2021)
Journal Article
Brown, J. M., Croft, J., Poad, H., Bell, R., Collinson, M., Gordon, K., …Goodwin, L. (2021). Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study. Journal of Clinical Oncology, 39(3), 202-214. https://doi.org/10.1200/JCO.20.01665

PURPOSE: High-grade nonmuscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease. Treatments include intravesical maintenance Bacillus Calmette-Guerin (mBCG) and radical cystectomy (RC). We wanted to understand whether a randomized trial co... Read More about Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol) (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol). Cochrane Database of Systematic Reviews, 2021(1), Article CD013839. https://doi.org/10.1002/14651858.CD013839

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of through-knee amputation compared to above-knee amputation on clinical and rehabilitation outcomes and complication rates in... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol).

Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers (2021)
Journal Article
Johnson, M. J., Huang, C., Chen, H., Jones, L., & Twiddy, M. (2021). Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003438

Objectives: Men living with prostate cancer have supportive and palliative needs. However, few studies detail unmet needs (vs quality of life measurement) or include data from those with advanced disease. We aimed to identify unmet needs of people li... Read More about Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers.