All Outputs (3)

Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer (2022)
Thesis
Dobrowinski, W. (2022). Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4291232

Epigenetics is the study of the change in gene expression patterns that are not caused by direct alterations in the DNA nucleotide sequence but instead are as a result of the dynamic remodelling of the chromatin state. Regulation of the chromatin lan... Read More about Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer.

The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth (2022)
Journal Article
Bilton, L. J., Warren, C., Humphries, R. M., Kalsi, S., Waters, E., Francis, T., …Wade, M. A. (2022). The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth. Cancers, 14(14), Article 3491. https://doi.org/10.3390/cancers14143491

Chromobox 2 (CBX2) is a chromatin-binding component of polycomb repressive complex 1, which causes gene silencing. CBX2 expression is elevated in triple-negative breast cancer (TNBC), for which there are few therapeutic options. Here, we aimed to inv... Read More about The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth.

Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model (2022)
Thesis
Hosni Ep Ben Daoud, I. (2022). Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4224543

Glioblastoma (GBM) is a deadly disease with poor prognosis. The gold standard treatment is surgery followed by chemoradiotherapy almost always including Temozolomide. Despite extensive research for new therapeutic approaches relapse after treatment s... Read More about Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model.