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The toxic effect of cytostatics on primary cilia frequency and multiciliation (2019)
Journal Article
Filipová, A., Diaz Garcia, D., Bezrouk, A., Čížková, D., Dvořák, J., Filip, S., …Šinkorová, Z. (2019). The toxic effect of cytostatics on primary cilia frequency and multiciliation. Journal of Cellular and Molecular Medicine, 23(8), 5728-5736. https://doi.org/10.1111/jcmm.14487

The primary cilium is considered as a key component of morphological cellular stability. However, cancer cells are notorious for lacking primary cilia in most cases, depending upon the tumour type. Previous reports have shown the effect of starvation... Read More about The toxic effect of cytostatics on primary cilia frequency and multiciliation.

Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2. (2019)
Journal Article
Wilkinson, H. N., Clowes, C., Banyard, K. L., Matteuci, P., Mace, K., & Hardman, M. J. (2019). Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2. Journal of Investigative Dermatology, 139(5), 1171-1181.e6. https://doi.org/10.1016/j.jid.2019.01.005

Cellular senescence can be broadly defined as a stable, yet essentially irreversible, loss of proliferative capacity. Historically, senescence is described as a negative outcome of advanced cellular age. It is now clear, however, that senescence repr... Read More about Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2..

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall (2018)
Journal Article
Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2019). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, 30(3), 383-391. https://doi.org/10.1111/jce.13805

Introduction: K2p3.1, also known as TASK-1, is a twin-pore acid-sensitive repolarizing K+ channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibition... Read More about K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall.

Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease (2018)
Journal Article
Bature, F., Guinn, B., Pang, D., The Luton, Dunstable, Milton Keynes General Practise consortium, , & Pappas, Y. (2018). Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease. Journal of Alzheimer's Disease Reports, 2(1), 207-212. https://doi.org/10.3233/adr-180064

We set out to investigate the insights general practitioners (GPs) have into the early signs and symptoms of Alzheimer's disease (AD), factors that may be responsible for the late diagnosis, as well as their recommendations for early diagnosis of AD.... Read More about Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease.

Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design (2018)
Journal Article
Bature, F., Pang, D., Robinson, A., Polson, N., Pappas, Y., & Guinn, B. (2018). Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design. Current Alzheimer Research, 15(8), 723-730. https://doi.org/10.2174/1567205015666180404155358

Objective Evidence suggests that individuals with Alzheimer’s disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study aimed to identify patterns in signs and symptoms preceding the clinical diagnosis o... Read More about Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design.

WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer (2018)
Journal Article
Poujade, F., Mannion, A., Brittain, N., Theodosi, A., Beeby, E., Leszczynska, K. B., …Pires, I. M. (2018). WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer. The British journal of cancer / Cancer Research Campaign, 118(9), 1229-1237. https://doi.org/10.1038/s41416-018-0056-3

© 2018 Cancer Research UK. Background: Metastatic spread is responsible for the majority of cancer-associated deaths. The tumour microenvironment, including hypoxia, is a major driver of metastasis. The aim of this study was to investigate the role o... Read More about WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer.

The Role of Chemokines in Thyroid Carcinoma (2017)
Journal Article
Yapa, S., Mulla, O., Green, V., England, J., & Greenman, J. (2017). The Role of Chemokines in Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 27(11), 1347-1359. https://doi.org/10.1089/thy.2016.0660

© Copyright 2017, Mary Ann Liebert, Inc. 2017. The global incidence of thyroid cancer is increasing, and metastatic spread to the lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process... Read More about The Role of Chemokines in Thyroid Carcinoma.

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression (2014)
Journal Article
Mura, M., Hopkins, T. G., Michael, T., Abd-Latip, N., Weir, J., Aboagye, E., …Blagden, S. P. (2015). LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene, 34(39), 5025-5036. https://doi.org/10.1038/onc.2014.428

RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP... Read More about LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.

Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei (2012)
Journal Article
Peña-Diaz, P., Pelosi, L., Ebikeme, C., Colasante, C., Gao, F., Bringaud, F., & Voncken, F. (2012). Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei. Journal of Biological Chemistry, 287(50), 41861-41874. https://doi.org/10.1074/jbc.M112.404699

Trypanosoma brucei is a kinetoplastid parasite of medical and veterinary importance. Its digenetic life cycle alternates between the bloodstream form in the mammalian host and the procyclic form (PCF) in the bloodsucking insect vector, the tsetse fly... Read More about Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei.

Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation (2009)
Journal Article
Colasante, C., Peña Diaz, P., Clayton, C., & Voncken, F. (2009). Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation. Molecular and Biochemical Parasitology, 167(2), 104-117. https://doi.org/10.1016/j.molbiopara.2009.05.004

The mitochondrial carrier family (MCF) is a group of structurally conserved proteins that mediate the transport of a wide range of metabolic intermediates across the mitochondrial inner membrane. In this paper, an overview of the mitochondrial carrie... Read More about Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation.