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All Outputs (26)

The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents (2008)
Thesis
Sparke, A. E. (2008). The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212783

Multimodality imaging agents have the potential to be detected in both MRI and optical imaging experiments allowing for visualisation of biological systems from the cellular level up to the whole body. Lanthanide complexes have shown great promise as... Read More about The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents.

Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy (2007)
Thesis
Frentzou, G. A. (2007). Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215164

Recently it has been demonstrated that tissue factor (TF) plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Card... Read More about Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy.

Metabolic remodeling in the aging heart (2005)
Journal Article
Sample, J., Cleland, J. G. F., & Seymour, A. L. (2006). Metabolic remodeling in the aging heart. Journal of Molecular and Cellular Cardiology, 40(1), (56-63). doi:10.1016/j.yjmcc.2005.09.018. ISSN 0022-2828

The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the... Read More about Metabolic remodeling in the aging heart.

Studies of ischaemia and reperfusion in cardiac hypertrophy (2002)
Thesis
Richardson, S. .. (2002). Studies of ischaemia and reperfusion in cardiac hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4217972

Cardiac hypertrophy may be associated with an enhanced susceptibility to ischaemic/reperfusion injury but the mechanisms remain unresolved. There is evidence for an increased dependence on glucose metabolism in cardiac hypertrophy, which may be benef... Read More about Studies of ischaemia and reperfusion in cardiac hypertrophy.

Semiquantitative analysis of collagen types in the hypertrophied left ventricle (2001)
Journal Article
Seymour, A. (2001). Semiquantitative analysis of collagen types in the hypertrophied left ventricle. Journal of anatomy, 198(1), 83 - 92

Cardiac fibrosis is a characteristic feature of left ventricular hypertrophy. The aim of this study was to develop a simple and accurate method to analyse collagen accumulation, taking into account the variation in cardiac muscle fibre orientation an... Read More about Semiquantitative analysis of collagen types in the hypertrophied left ventricle.

Biochemical adaptations in cardiac hypertrophy (2001)
Thesis
Clarke, S. J. (2001). Biochemical adaptations in cardiac hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222088

Cardiac hypertrophy is the adaptive response of the heart to chronic overload. The metabolic adaptations that occur during hypertrophy are initially beneficial, but can ultimately deteriorate into heart failure. The mechanisms underlying this are unk... Read More about Biochemical adaptations in cardiac hypertrophy.