All Outputs (602)

Detection of microplastics in human lung tissue using μFTIR spectroscopy (2022)
Journal Article
Jenner, L. C., Rotchell, J. M., Bennett, R. T., Cowen, M., Tentzeris, V., & Sadofsky, L. (2022). Detection of microplastics in human lung tissue using μFTIR spectroscopy. The Science of the total environment, 831, Article 154907. https://doi.org/10.1016/j.scitotenv.2022.154907

Airborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity, especially indoors. Respiratory symptoms and disease following exposure to occupational levels of MP... Read More about Detection of microplastics in human lung tissue using μFTIR spectroscopy.

FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis (2022)
Journal Article
Blissett, R., Blissett, D., Levrat-Guillen, F., Deshmukh, H., Wilmot, E. G., Ryder, R. E., …Sathyapalan, T. (2022). FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis. BMJ Open Diabetes Research and Care, 10(2), Article e002580. https://doi.org/10.1136/bmjdrc-2021-002580

INTRODUCTION: This study aims to estimate the budget impact of increased uptake of the FreeStyle Libre Flash Glucose Monitoring system in people with type 1 diabetes mellitus (T1DM) in the UK. RESEARCH DESIGN AND METHODS: A budget impact model was de... Read More about FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis.

A scoping review of risk-stratified bowel screening: current evidence, future directions (2022)
Journal Article
Cairns, J. M., Greenley, S., Bamidele, O., & Weller, D. (2022). A scoping review of risk-stratified bowel screening: current evidence, future directions. Cancer Causes and Control, https://doi.org/10.1007/s10552-022-01568-9

Purpose: In this scoping review, we examined the international literature on risk-stratified bowel screening to develop recommendations for future research, practice and policy. Methods: Six electronic databases were searched from inception to 18 Oct... Read More about A scoping review of risk-stratified bowel screening: current evidence, future directions.

A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results (2022)
Journal Article
Bamidele, O. O., Green, T., Tookey, S., Walabyeki, J., & Macleod, U. (2022). A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results. European Journal of Cancer Care, https://doi.org/10.1111/ecc.13574

Objective: This study explored women's perspectives on the acceptability of including new cancer information with an all-clear breast or cervical screening result letter (using ovarian cancer as a case study). Methods: In 2016, six focus group discus... Read More about A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results.

Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women (2022)
Journal Article
Ramanjaneya, M., Abdalhakam, I., Bettahi, I., Bensila, M., Jerobin, J., Aye, M. M., …Abou-Samra, A. B. (2022). Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women. Frontiers in endocrinology, 12, Article 740703. https://doi.org/10.3389/fendo.2021.740703

Background: The complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, al... Read More about Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women.

Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project) (2022)
Journal Article
Crowther, L., Pearson, M., Cummings, H., & Crooks, M. G. (2022). Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project). BMJ Open Respiratory Research, 9(1), Article e001155. https://doi.org/10.1136/bmjresp-2021-001155

Short-acting beta agonist (SABA) overuse (≥3 canisters annually) is associated with worse asthma outcomes and accounts for the majority of greenhouse gas emissions from asthma inhalers in England. Reducing SABA overuse aligns with the National Health... Read More about Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project).

The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication (2022)
Journal Article
Ibeggazene, S., Cai, P. L., Smith, G. E., Ibbegazene, S., Stirrup, A., Pymer, S., …Chetter, I. C. (in press). The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication. Vascular, https://doi.org/10.1177/17085381211059665

Background: The screening and diagnosis of intermittent claudication is a challenging process and often relies on the expertise of specialist vascular clinicians. We sought to investigate the diagnostic performance of the Edinburgh Claudication Quest... Read More about The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication.

Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present (2022)
Journal Article
Jenner, L., Sadofsky, L., Danopoulos, E., Chapman, E., White, D., Jenkins, R., & Rotchell, J. M. (2022). Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present. Atmosphere, 13(2), Article 265. https://doi.org/10.3390/atmos13020265

Atmospheric microplastics (MPs) have been consistently captured within air samples on a global scale. Locations with high human activity are reported to have high MP levels. An urban sampling site in the Humber region (U.K.) has been sampled over a 1... Read More about Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present.

Do guidelines influence breathlessness management in advanced lung diseases? A multinational survey of respiratory medicine and palliative care physicians (2022)
Journal Article
Krajnik, M., Hepgul, N., Wilcock, A., Jassem, E., Bandurski, T., Tanzi, S., …Walker, F. (2022). Do guidelines influence breathlessness management in advanced lung diseases? A multinational survey of respiratory medicine and palliative care physicians. BMC Pulmonary Medicine, 22(1), Article 41. https://doi.org/10.1186/s12890-022-01835-0

Background: Respiratory medicine (RM) and palliative care (PC) physicians’ management of chronic breathlessness in advanced chronic obstructive pulmonary disease (COPD), fibrotic interstitial lung disease (fILD) and lung cancer (LC), and the influenc... Read More about Do guidelines influence breathlessness management in advanced lung diseases? A multinational survey of respiratory medicine and palliative care physicians.

Geographical distance and reduced access to palliative radiotherapy: Systematic review and meta-analysis (2022)
Journal Article
Chand, C. P., Greenley, S., Macleod, U., Lind, M., Barton, R., & Kelly, C. (2022). Geographical distance and reduced access to palliative radiotherapy: Systematic review and meta-analysis. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003356

Background: Palliative radiotherapy (PRT) is an effective way of reducing symptoms caused by advanced incurable cancer. Several studies have investigated factors that contribute to inequalities in access to PRT; distance to a radiotherapy centre has... Read More about Geographical distance and reduced access to palliative radiotherapy: Systematic review and meta-analysis.

Barriers and facilitators to accessing and utilising post-treatment psychosocial support by Black men treated for prostate cancer—a systematic review and qualitative synthesis (2022)
Journal Article
Bamidele, O. O., Alexis, O., Ogunsanya, M., Greenley, S., Worsley, A., & Mitchell, E. D. (2022). Barriers and facilitators to accessing and utilising post-treatment psychosocial support by Black men treated for prostate cancer—a systematic review and qualitative synthesis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, https://doi.org/10.1007/s00520-021-06716-6

Purpose: To synthesise findings from published studies on barriers and facilitators to Black men accessing and utilising post-treatment psychosocial support after prostate cancer (CaP) treatment. Methods: Searches of Medline, Embase, PsycInfo, Coch... Read More about Barriers and facilitators to accessing and utilising post-treatment psychosocial support by Black men treated for prostate cancer—a systematic review and qualitative synthesis.

A new classification system for the anatomical variations of the human circle of Willis: A systematic review (2021)
Journal Article
Ayre, J. R., Bazira, P. J., Abumattar, M., Makwana, H. N., & Sanders, K. A. (2022). A new classification system for the anatomical variations of the human circle of Willis: A systematic review. Journal of anatomy, 240(6), 1187-1204. https://doi.org/10.1111/joa.13616

The circle of Willis (CoW) is an anastomotic arterial network located on the base of the brain. Studies have shown that it demonstrates considerable anatomical variation in humans. This systematic review aimed to identify and catalogue the described... Read More about A new classification system for the anatomical variations of the human circle of Willis: A systematic review.

Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14663

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age and is associated with increased body weight. Objective: To review the literature on the effect of different pharmacological interventions on t... Read More about Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations. The Cochrane database of systematic reviews, 2021(12), CD013839. https://doi.org/10.1002/14651858.CD013839.pub2

BACKGROUND: Diabetes and vascular disease are the leading causes of lower limb amputation. Currently, 463 million adults are living with diabetes, and 202 million with peripheral vascular disease, worldwide. When a lower limb amputation is considered... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations.

Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study (2021)
Journal Article
Deshmukh, H., Shah, N., Papageorgiou, M., Abdalla, M. A., Lhaf, F., Aye, M., & Sathyapalan, T. (2022). Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study. Bone, 155, Article 116285. https://doi.org/10.1016/j.bone.2021.116285

Introduction: There is conflicting data on the effect of polycystic ovary syndrome (PCOS) on bone mineral density (BMD) and fracture risk. Recent genetic data suggest that men may also carry genetic risk factors for PCOS; the associations of these fa... Read More about Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study.

Practical considerations of dissolved oxygen levels for platelet function under hypoxia (2021)
Journal Article
Kusanto, B., Gordon, A., Naylor-Adamson, L., Atkinson, L., Coupland, C., Booth, Z., …Arman, M. (2021). Practical considerations of dissolved oxygen levels for platelet function under hypoxia. International Journal of Molecular Sciences, 22(24), Article 13223. https://doi.org/10.3390/ijms222413223

Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing bloo... Read More about Practical considerations of dissolved oxygen levels for platelet function under hypoxia.

Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia (2021)
Journal Article
Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., …Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272

Bacterial infections are a major cause of morbidity and mortality in chronic lymphocytic leukemia (CLL), and infection risk increases in patients treated with the Bruton’s tyrosine kinase (Btk) inhibitor, ibrutinib. Btk and related kinases (like Tec)... Read More about Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia.

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. (2021)
Journal Article
Danopoulos, E., Twiddy, M., West, R., & Rotchell, J. M. (in press). A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. Journal of hazardous materials, Article 127861. https://doi.org/10.1016/j.jhazmat.2021.127861

Humans are exposed to microplastics (MPs) daily via ingestion and inhalation. It is not known whether this results in adverse health effects and, if so, at what levels of exposure. Without epidemiological studies, human cell in vitro MP toxicological... Read More about A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells..

Isolation and characterisation of graves’ disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device (2021)
Journal Article
Foster, H., Wade, M., England, J., Greenman, J., & Green, V. (2021). Isolation and characterisation of graves’ disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device. Organs-on-a-Chip, 3, Article 100011. https://doi.org/10.1016/j.ooc.2021.100011

Abstract This report demonstrates the ability of a microfluidic device to maintain human Graves' disease tissue enabling the isolation and characterisation of Graves' disease specific exosomes. Graves' disease (n = 7) and non-Graves’ disease (Hashim... Read More about Isolation and characterisation of graves’ disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device.

Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14636

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD). Ob... Read More about Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis.