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All Outputs (48)

Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights (2012)
Journal Article
Van Hoeck, V., Leroy, J. L. M. R., Arias Alvarez, M., Rizos, D., Gutierrez-Adan, A., Schnorbusch, K., …Sturmey, R. G. (2013). Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights. Reproduction, 145(1), 33-44. https://doi.org/10.1530/REP-12-0174

Elevated plasma nonesterified fatty acid (NEFA) concentrations are associated with negative energy balance and metabolic disorders such as obesity and type II diabetes. Such increased plasma NEFA concentrations induce changes in the microenvironment... Read More about Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights.

Variable imprinting of the MEST gene in human preimplantation embryos (2012)
Journal Article
Huntriss, J. D., Hemmings, K. E., Hinkins, M., Rutherford, A. J., Sturmey, R. G., Elder, K., & Picton, H. M. (2013). Variable imprinting of the MEST gene in human preimplantation embryos. European Journal of Human Genetics, 21(1), 40-47. https://doi.org/10.1038/ejhg.2012.102

There is evidence that expression and methylation of the imprinted paternally expressed gene 1/mesoderm-specific transcript homologue (PEG1/MEST) gene may be affected by assisted reproductive technologies (ARTs) and infertility. In this study, we sou... Read More about Variable imprinting of the MEST gene in human preimplantation embryos.

Role of transient receptor potential channels in mammalian oviduct and uterine epithelia (2011)
Thesis
Ghavideldarestani, M. (2011). Role of transient receptor potential channels in mammalian oviduct and uterine epithelia. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4213385

Calcium is an important secondary messenger and plays a major role in cell function, including proliferation, cell growth, secretion and death .It also plays a critical role in uterine smooth muscle contraction and embryo implantation. This thesis is... Read More about Role of transient receptor potential channels in mammalian oviduct and uterine epithelia.

Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology (2011)
Journal Article
Van Hoeck, V., Sturmey, R. G., Bermejo-Alvarez, P., Rizos, D., Gutierrez-Adan, A., Leese, H. J., …Leroy, J. L. M. R. (2011). Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. PLoS ONE, 6(8), e23183. https://doi.org/10.1371/journal.pone.0023183

Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduc... Read More about Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology.

Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability (2010)
Journal Article
Sturmey, R. G., Bermejo-Alvarez, P., Gutierrez-Adan, A., Rizos, D., Leese, H. J., & Lonergan, P. (2010). Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability. Molecular Reproduction and Development, 77(3), 285-296. https://doi.org/10.1002/mrd.21145

The ratio of male/female embryos may be modified by environmental factors such as maternal diet in vivo and the composition of embryo culture media in vitro. We have used amino acid profiling, a noninvasive marker of developmental potential to compar... Read More about Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability.

Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy (2009)
Journal Article
Sturmey, R. G., Wild, C. P., & Hardie, L. J. (2009). Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy. Mutagenesis, 24(3), 253-258. https://doi.org/10.1093/mutage/gep004

Barrett's oesophagus (BO) carries an increased risk of progression to oesophageal adenocarcinoma. Chromoendoscopy with methylene blue (MB) can be used to facilitate identification of BO and target areas for biopsy. If photoexcited, MB can generate re... Read More about Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy.

DNA damage and metabolic activity in the preimplantation embryo (2008)
Journal Article
Sturmey, R. G., Hawkhead, J. A., Barker, E. A., & Leese, H. J. (2009). DNA damage and metabolic activity in the preimplantation embryo. Human Reproduction, 24(1), 81-91. https://doi.org/10.1093/humrep/den346

BACKGROUND: Embryos with greater viability have a lower or 'quieter' amino acid metabolism than those which arrest. We have hypothesized this is due to non-viable embryos possessing greater cellular/molecular damage and consuming more nutrients, such... Read More about DNA damage and metabolic activity in the preimplantation embryo.

The effects of hypo- and hyperglycemia during lipolysis-like conditions on bovine oocyte maturation, subsequent embryo developmental and glucose metabolism
Conference Proceeding
Sturmey, R., Andries, S., Bols, P., De Bie, J., Desmet, K., Leroy, J., & Marei, W. The effects of hypo- and hyperglycemia during lipolysis-like conditions on bovine oocyte maturation, subsequent embryo developmental and glucose metabolism.

Abstract of a conference paper presented at the 31st meeting of the European Embryo Transfer Associaton, 11-12 September 2015, Ghent, Belgium.