All Outputs (111)

Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome (2015)
Journal Article
Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome. Open heart, 2(1), e000302. https://doi.org/10.1136/openhrt-2015-000302

Objective To assess the effect of catheter ablation on atrial fibrillation (AF) symptoms and quality of life (QoL). Methods Patients with AF scheduled for ablation were recruited. Pulmonary vein isolation (PVI) was performed and complex fractionated... Read More about Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome.

A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease (2015)
Journal Article
Ji, B., Genever, P. G., & Fagan, M. J. (2016). A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease. International journal for numerical methods in biomedical engineering, 32(3), e02735. https://doi.org/10.1002/cnm.2735

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have... Read More about A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease.

Mechanical properties of calvarial bones in a mouse model for craniosynostosis (2015)
Journal Article
Moazen, M., Peskett, E., Babbs, C., Pauws, E., & Fagan, M. J. (2015). Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PLoS ONE, 10(5), e0125757. https://doi.org/10.1371/journal.pone.0125757

The mammalian cranial vault largely consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Premature closure of the cranial sutures, craniosynostosis, can lead to serious clinical pathology unle... Read More about Mechanical properties of calvarial bones in a mouse model for craniosynostosis.

Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity (2015)
Journal Article
Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity. Medical engineering & physics, 37(2), 251-255. https://doi.org/10.1016/j.medengphy.2014.12.008

Background Lead V₁ is routinely analysed due to its large amplitude AF waveform. V₁ correlates strongly with right atrial activity but only moderately with left atrial activity. Posterior lead V₉ correlates strongest with left atrial activity. Aims (... Read More about Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity.

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso (2015)
Journal Article
Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., …Zhang, H. (2015). A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso. PLoS Computational Biology, 11(1), Article e1004026. https://doi.org/10.1371/journal.pcbi.1004026

Rapid atrial arrhythmias such as atrial fibrillation (AF) predispose to ventricular arrhythmias, sudden cardiac death and stroke. Identifying the origin of atrial ectopic activity from the electrocardiogram (ECG) can help to diagnose the early onset... Read More about A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso.

Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls (2015)
Journal Article
Langley, P., Bourke, J. P., & Giacopelli, D. (2015). Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls. Acta Cardiologica, 70(6), 672-677. https://doi.org/10.2143/AC.70.6.3120179

© 2015, Acta Cardiologica. All rights reserved. Objective The aim of this study is to characterize the observable segment of the atrial repolarization (Ta wave) of the standard ECG during sinus rhythm in paroxysmal atrial fibrillation (PAF) patients... Read More about Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls.

Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model (2014)
Journal Article
Ji, B., Yang, Q., Genever, P. G., & Fagan, M. J. (2014). Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model. Bio-medical materials and engineering, 24(6), 3373-3378. https://doi.org/10.3233/BME-141160

Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentia... Read More about Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model.

Non-invasive estimation of left atrial dominant frequency in atrial fibrillation from different electrode sites: Insight from body surface potential mapping (2014)
Journal Article
Bojarnejad, M., Blake, J. R., Bourke, J., Shepherd, E., Murray, A., & Langley, P. (2014). Non-invasive estimation of left atrial dominant frequency in atrial fibrillation from different electrode sites: Insight from body surface potential mapping. Journal of atrial fibrillation, 7(3), 6-10

© 2014, CardioFront LLC. All rights reserved. The dominant driving sources of atrial fibrillation are often found in the left atrium, but the expression of left atrial activation on the body surface is poorly understood. Using body surface potential... Read More about Non-invasive estimation of left atrial dominant frequency in atrial fibrillation from different electrode sites: Insight from body surface potential mapping.

Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation (2014)
Journal Article
Di Marco, L. Y., Raine, D., Bourke, J. P., & Langley, P. (2014). Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation. Computers in biology and medicine, 54, 172-179. https://doi.org/10.1016/j.compbiomed.2014.09.005

Background Non-invasive tools to help identify patients likely to benefit from catheter ablation (CA) of atrial fibrillation (AF) would facilitate personalised treatment planning. Aim To investigate atrial waveform organisation through recurrence plo... Read More about Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation.

Masticatory biomechanics in the rabbit: a multi-body dynamics analysis (2014)
Journal Article
Watson, P. J., Gröning, F., Curtis, N., Fitton, L. C., Herrel, A., McCormack, S. W., & Fagan, M. J. (2014). Masticatory biomechanics in the rabbit: a multi-body dynamics analysis. Journal of the Royal Society interface / the Royal Society, 11(99), Article 20140564. https://doi.org/10.1098/rsif.2014.0564

Multi-body dynamics is a powerful engineering tool which is becoming increasingly popular for the simulation and analysis of skull biomechanics. This paper presents the first application of multi-body dynamics to analyse the biomechanics of the rabbi... Read More about Masticatory biomechanics in the rabbit: a multi-body dynamics analysis.

Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components (2014)
Journal Article
Di Maria, C., Liu, C., Zheng, D., Murray, A., & Langley, P. (2014). Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components. Physiological Measurement, 35(8), 1649-1664. https://doi.org/10.1088/0967-3334/35/8/1649

This study presents a systematic comparison of different approaches to the automated selection of the principal components (PC) which optimise the detection of maternal and fetal heart beats from non-invasive maternal abdominal recordings. A public d... Read More about Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components.

Recurring patterns in stationary intervals of abdominal uterine electromyograms during gestation (2014)
Journal Article
Di Marco, L. Y., Di Maria, C., Tong, W., Taggart, M. J., Robson, S. C., & Langley, P. (2014). Recurring patterns in stationary intervals of abdominal uterine electromyograms during gestation. Medical and Biological Engineering and Computing, 52(8), 707-716. https://doi.org/10.1007/s11517-014-1174-6

Abdominal uterine electromyograms (uEMG) studies have focused on uterine contractions to describe the evolution of uterine activity and preterm birth (PTB) prediction. Stationary, non-contracting uEMG has not been studied. The aim of the study was to... Read More about Recurring patterns in stationary intervals of abdominal uterine electromyograms during gestation.

In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri (2014)
Journal Article
Porro, L. B., Ross, C. F., Iriarte-Diaz, J., O'Reilly, J. C., Evans, S. E., & Fagan, M. J. (2014). In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri. The journal of experimental biology, 217(11), 1983-1992. https://doi.org/10.1242/jeb.096362

In vivo bone strain data are the most direct evidence of deformation and strain regimes in the vertebrate cranium during feeding and can provide important insights into skull morphology. Strain data have been collected during feeding across a wide ra... Read More about In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri.

Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls (2014)
Journal Article
Curtis, N., Witzel, U., & Fagan, M. J. (2014). Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls. Folia primatologica, 85(2), 77-87. https://doi.org/10.1159/000357526

Cranial sutures are an essential part of the growing skull, allowing bones to increase in size during growth, with their morphology widely believed to be dictated by the forces and displacements that they experience. The zygomaticotemporal suture in... Read More about Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls.

Erratum: Cranial sutures work collectively to distribute strain throughout the reptile skull (Journal of The Royal Society Interface (2013) 10 (2013044) DOI: 10.1098/rsif.2013.0442) (2013)
Journal Article
Curtis, N., Jones, M. E., Evans, S. E., O'Higgins, P., & Fagan, M. J. (2013). Erratum: Cranial sutures work collectively to distribute strain throughout the reptile skull (Journal of The Royal Society Interface (2013) 10 (2013044) DOI: 10.1098/rsif.2013.0442). Journal of the Royal Society interface / the Royal Society, 10(87), Article 2013044. https://doi.org/10.1098/rsif.2013.0584

Figure 4 was presented incorrectly, with (a) and (b) displaying the same bite position. The corrected figure below shows different bite positions for (a) and (b) as was initially intended.

The importance of accurate muscle modelling for biomechanical analyses: A case study with a lizard skull (2013)
Journal Article
Gröning, F., Jones, M. E., Curtis, N., Herrel, A., O'Higgins, P., Evans, S. E., & Fagan, M. J. (2013). The importance of accurate muscle modelling for biomechanical analyses: A case study with a lizard skull. Journal of the Royal Society interface / the Royal Society, 10(84), Article 20130216. https://doi.org/10.1098/rsif.2013.0216

Computer-based simulation techniques such as multi-body dynamics analysis are becoming increasingly popular in the field of skull mechanics. Multi-body models can be used for studying the relationships between skull architecture, muscle morphology an... Read More about The importance of accurate muscle modelling for biomechanical analyses: A case study with a lizard skull.

Cranial sutures work collectively to distribute strain throughout the reptile skull (2013)
Journal Article
Curtis, N., Fagan, M. J., Evans, S. E., Jones, M. E. H., & O'Higgins, P. (2013). Cranial sutures work collectively to distribute strain throughout the reptile skull. Journal of the Royal Society interface / the Royal Society, 10(86), 1-9. https://doi.org/10.1098/rsif.2013.0442

The skull is composed of many bones that come together at sutures. These sutures are important sites of growth, and as growth ceases some become fused while others remain patent. Their mechanical behaviour and how they interact with changing form and... Read More about Cranial sutures work collectively to distribute strain throughout the reptile skull.

Characteristics of atrial fibrillation cycle length predict restoration of sinus rhythm by catheter ablation (2013)
Journal Article
Di Marco, L. Y., Raine, D., Bourke, J. P., & Langley, P. (2013). Characteristics of atrial fibrillation cycle length predict restoration of sinus rhythm by catheter ablation. Heart rhythm : the official journal of the Heart Rhythm Society, 10(9), 1303-1310. https://doi.org/10.1016/j.hrthm.2013.06.007

Background Successful termination of atrial fibrillation (AF) during catheter ablation (CA) is associated with arrhythmia-free follow-up. Preablation factors such as mean atrial fibrillation cycle length (AFCL) predict the likelihood of AF terminatio... Read More about Characteristics of atrial fibrillation cycle length predict restoration of sinus rhythm by catheter ablation.

Accuracy of algorithms for detection of atrial fibrillation from short duration beat interval recordings (2012)
Journal Article
Langley, P., Dewhurst, M., Di Marco, L. Y., Adams, P., Dewhurst, F., Mwita, J. C., …Murray, A. (2012). Accuracy of algorithms for detection of atrial fibrillation from short duration beat interval recordings. Medical engineering & physics, 34(10), 1441-1447. https://doi.org/10.1016/j.medengphy.2012.02.002

Atrial fibrillation (AF) is characterised by highly variable beat intervals. The aims of the study were to assess the accuracy of AF detection algorithms from short analysis durations and to validate prospectively the accuracy on a large community-ba... Read More about Accuracy of algorithms for detection of atrial fibrillation from short duration beat interval recordings.

Comparison of body surface and intracardiac ECG recordings in patients with atrial fibrillation during electrophysiological studies (2012)
Journal Article
Bojarnejad, M., Blake, J., Bourke, J. P., Murray, A., & Langley, P. (2012). Comparison of body surface and intracardiac ECG recordings in patients with atrial fibrillation during electrophysiological studies. IFMBE proceedings, 39 IFMBE, 612-615. https://doi.org/10.1007/978-3-642-29305-4_160

Atrial fibrillation (AF) dominant frequency (DF) is thought to reflect the degree of organisation of underlying atrial activity (AA). Our aim was to evaluate the relationship between the DFs from the body surface electrocardiogram (ECG) and intracard... Read More about Comparison of body surface and intracardiac ECG recordings in patients with atrial fibrillation during electrophysiological studies.