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Development of a microfluidic device for the in situ production of singlet oxygen for chemical and biological applications (2012)
Thesis
Lumley, E. K. (2012). Development of a microfluidic device for the in situ production of singlet oxygen for chemical and biological applications. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219891

Cancer cells are derived from cells that are termed, and recognised as being 'self', meaning that the immune system does not target them. Many treatments target the tumour through its requirement for large quantities of nutrients. However, this cause... Read More about Development of a microfluidic device for the in situ production of singlet oxygen for chemical and biological applications.

Microfluidic modules for pre-concentration of [¹⁸F]fluoride in positron emission tomography (PET) radiotracer synthesis (2012)
Thesis
De Leonardis, F. (2012). Microfluidic modules for pre-concentration of [¹⁸F]fluoride in positron emission tomography (PET) radiotracer synthesis. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4214123

lPositron Emission Tomography (PET) is a non-invasive imaging method which enables to obtain both molecular and biochemical information of physiological processes in vivo, which means that PET imaging shows the chemical functioning of organs and tiss... Read More about Microfluidic modules for pre-concentration of [¹⁸F]fluoride in positron emission tomography (PET) radiotracer synthesis.

Integrated DNA extraction and amplification using electrokinetic pumping in a microfluidic device (2011)
Journal Article
Parton, J., Birch, C., Kemp, C., Haswell, S. J., Pamme, N., & Shaw, K. J. (2012). Integrated DNA extraction and amplification using electrokinetic pumping in a microfluidic device. Analytical Methods, 4(1), 96-100. https://doi.org/10.1039/c1ay05552f

An integrated system employing anion exchange for the extraction of DNA from biological samples prior to polymerase chain reaction DNA amplification has been developed, based on microfluidic methodology utilising electrokinetic pumping. In this syste... Read More about Integrated DNA extraction and amplification using electrokinetic pumping in a microfluidic device.

Microfluidic platforms for performing surface-based clinical assays (2011)
Journal Article
Tarn, M. D., & Pamme, N. (2011). Microfluidic platforms for performing surface-based clinical assays. Expert review of molecular diagnostics, 11(7), 711-720. https://doi.org/10.1586/ERM.11.59

The need for fast, specific and portable diagnostic systems for clinical assays has, in recent years, led to an explosion of research into microfluidic chip-based immunoassays towards rapid point-of-care analysis. Such devices exploit small dimension... Read More about Microfluidic platforms for performing surface-based clinical assays.

On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers (2011)
Journal Article
De Leonardis, F., Pascali, G., Salvadori, P. A., Watts, P., & Pamme, N. (2011). On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers. Journal of Chromatography A, 1218(29), 4714-4719. https://doi.org/10.1016/j.chroma.2011.05.062

Microfluidic approaches have demonstrated a relevant impact on radiochemical reactions involving Positron Emission Tomography (PET) nuclides, due to shorter reaction times and smaller precursor quantities. However, little attention has been given to... Read More about On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers.

Cell sorting by endocytotic capacity in a microfluidic magnetophoresis device (2011)
Journal Article
Robert, D., Pamme, N., Conjeaud, H., Gazeau, F., Iles, A., & Wilhelm, C. (2011). Cell sorting by endocytotic capacity in a microfluidic magnetophoresis device. Lab on a chip, 11(11), 1902-1910. https://doi.org/10.1039/c0lc00656d

Magnetically labelled cells are finding a wealth of applications for in vitro analysis as well as in vivo treatments. Sorting of cells into subpopulations based on their magnetite loading is an important step in such procedures. Here, we study the so... Read More about Cell sorting by endocytotic capacity in a microfluidic magnetophoresis device.

Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup (2011)
Journal Article
Rodríguez-Villarreal, A. I., Tarn, M. D., Madden, L. A., Lutz, J. B., Greenman, J., Samitier, J., & Pamme, N. (2011). Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup. Lab on a chip, 11(7), 1240-1248. https://doi.org/10.1039/c0lc00464b

The continuous flow focussing and manipulation of particles and cells are important factors in microfluidic applications for performing accurate and reproducible procedures downstream. Many particle focussing methods require complex setups or channel... Read More about Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup.

Continuous flow processes on single magnetic and diamagnetic particles in microfluidic devices (2011)
Thesis
Tarn, M. D. (2011). Continuous flow processes on single magnetic and diamagnetic particles in microfluidic devices. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211533

Magnetic microparticles have seen increasing interest in (bio)chemical processes in recent years due to their various surface functionalities, high surface-to-volume ratio, small sizes, and ease of manipulation via magnetic fields. However, conventio... Read More about Continuous flow processes on single magnetic and diamagnetic particles in microfluidic devices.

Microscreening toxicity system based on living magnetic yeast and gradient chips (2010)
Journal Article
García-Alonso, J., Fakhrullin, R. F., Paunov, V. N., Shen, Z., Hardege, J. D., Pamme, N., …Greenway, G. M. (2011). Microscreening toxicity system based on living magnetic yeast and gradient chips. Analytical and Bioanalytical Chemistry, 400(4), 1009-1013. https://doi.org/10.1007/s00216-010-4241-3

There is an increasing demand for easy and cost-effective methods to screen the toxicological impact of the growing number of chemical mixtures being generated by industry. Such a screening method has been developed using viable, genetically modified... Read More about Microscreening toxicity system based on living magnetic yeast and gradient chips.

Magnetic forces for surface-based bioanalysis in microfluidic devices (2010)
Thesis
Peyman, S. A. (2010). Magnetic forces for surface-based bioanalysis in microfluidic devices. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4213006

Biochemical analysis is a critical part of clinical diagnostics, forensic science and environmental monitoring. Typically, this form of analysis involves the use of bioanalytical procedures which are extremely sensitive and highly specific. However,... Read More about Magnetic forces for surface-based bioanalysis in microfluidic devices.

Rapid, multistep on-chip DNA hybridisation in continuous flow on magnetic particles (2010)
Journal Article
Vojtíšek, M., Iles, A., & Pamme, N. (2010). Rapid, multistep on-chip DNA hybridisation in continuous flow on magnetic particles. Biosensors & bioelectronics, 25(9), 2172-2176. https://doi.org/10.1016/j.bios.2010.01.034

DNA hybridisation is an important tool for bioanalytical research and clinical diagnostics; conventional methods, however, require long incubation times and numerous washing steps, rendering the procedure time consuming and labour intensive. In this... Read More about Rapid, multistep on-chip DNA hybridisation in continuous flow on magnetic particles.

The importance of particle type selection and temperature control for on-chip free-flow magnetophoresis (2009)
Journal Article
Tarn, M. D., Peyman, S. A., Robert, D., Iles, A., Wilhelm, C., & Pamme, N. (2009). The importance of particle type selection and temperature control for on-chip free-flow magnetophoresis. Journal of Magnetism and Magnetic Materials, 321(24), 4115-4122. https://doi.org/10.1016/j.jmmm.2009.08.016

Free-flow magnetophoresis is becoming a popular technique for the separation and manipulation of magnetic particles and materials in microsystems. A wide variety of magnetic particles are commercially available that differ greatly in size and in magn... Read More about The importance of particle type selection and temperature control for on-chip free-flow magnetophoresis.

Mobile magnetic particles as solid-supports for rapid surface-based bioanalysis in continuous flow (2009)
Journal Article
Peyman, S. A., Iles, A., & Pamme, N. (2009). Mobile magnetic particles as solid-supports for rapid surface-based bioanalysis in continuous flow. Lab on a chip, 9(21), 3110-3117. https://doi.org/10.1039/b904724g

An extremely versatile microfluidic device is demonstrated in which multi-step (bio) chemical procedures can be performed in continuous flow. The system operates by generating several co-laminar flow streams, which contain reagents for specific (bio)... Read More about Mobile magnetic particles as solid-supports for rapid surface-based bioanalysis in continuous flow.

Diamagnetic repulsion—A versatile tool for label-free particle handling in microfluidic devices (2009)
Journal Article
Peyman, S. A., Kwan, E. Y., Margarson, O., Iles, A., & Pamme, N. (2009). Diamagnetic repulsion—A versatile tool for label-free particle handling in microfluidic devices. Journal of Chromatography A, 1216(52), 9055-9062. https://doi.org/10.1016/j.chroma.2009.06.039

We report the exploration of diamagnetic repulsion forces for the selective manipulation of microparticles inside microfluidic devices. Diamagnetic materials such as polymers are repelled from magnetic fields, an effect greatly enhanced by suspending... Read More about Diamagnetic repulsion—A versatile tool for label-free particle handling in microfluidic devices.

On-chip diamagnetic repulsion in continuous flow (2009)
Journal Article
Tarn, M. D., Hirota, N., Iles, A., & Pamme, N. (2009). On-chip diamagnetic repulsion in continuous flow. Science and Technology of Advanced Materials, 10(1), 014611 - 014611. https://doi.org/10.1088/1468-6996/10/1/014611

We explore the potential of a microfluidic continuous flow particle separation system based on the repulsion of diamagnetic materials from a high magnetic field. Diamagnetic polystyrene particles in paramagnetic manganese (II) chloride solution were... Read More about On-chip diamagnetic repulsion in continuous flow.

Rapid on-chip multi-step (bio)chemical procedures in continuous flow - manoeuvring particles through co-laminar reagent streams (2008)
Journal Article
Peyman, S. A., Iles, A., & Pamme, N. (2008). Rapid on-chip multi-step (bio)chemical procedures in continuous flow - manoeuvring particles through co-laminar reagent streams. Chemical communications : Chem comm / the Royal Society of Chemistry, 1220-1222. https://doi.org/10.1039/b716532c

We introduce a novel and extremely versatile microfluidic platform in which tedious multi-step biochemical processes can be performed in continuous flow within a fraction of the time required for conventional methods.

Simultaneous bioassays in a microfluidic channel on plugs of different magnetic particles (2007)
Journal Article
Bronzeau, S., & Pamme, N. (2008). Simultaneous bioassays in a microfluidic channel on plugs of different magnetic particles. Analytica Chimica Acta, 609(1), 105-112. https://doi.org/10.1016/j.aca.2007.11.035

Magnetic particles coated with specific biomolecules are often used as solid supports for bioassays but conventional test tube based techniques are time consuming and labour intensive. An alternative is to work on magnetic particle plugs immobilised... Read More about Simultaneous bioassays in a microfluidic channel on plugs of different magnetic particles.