Hyperbaric oxygen restores the antioxidant defence mechansim following exercise in patients with intermittent claudication

Abidia, A; Kuhan, G; Laden, G; Bahia, H; Chetter, Ian; Greenman, J; McCollum, P

Detection of nitric oxide in tissue samples by ESI-MS (2009)
Journal Article
Shen, Z., Webster, A., Welham, K. J., Dyer, C. E., Greenman, J., & Haswell, S. J. (2010). Detection of nitric oxide in tissue samples by ESI-MS. Analyst, 135(2), 302-305. https://doi.org/10.1039/b917643h

A novel method to determine nitric oxide (NO) in biological tissue samples with minimal interference from the cellular detritus is described. Methylpiperazinobenzenediamine, consisting of an o-phenylenediamine and a methyl piperazine group, was chose... Read More about Detection of nitric oxide in tissue samples by ESI-MS.

Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing (2009)
Journal Article
Dou, Y., Haswell, S., Greenman, J., & Wadhawan, J. (2009). Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing. Electrochemistry communications, 11(10), 1976-1981. https://doi.org/10.1016/j.elecom.2009.08.032

The detection of hydrogen peroxide is detailed using horseradish peroxidase and anthraquinone. Both species are immobilized on a glassy carbon electrode substrate. This dual immobilization gives rise to lower detection limits compared with the situat... Read More about Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing.

Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser (2009)
Journal Article
Oakley, J. A., Robinson, S., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser. Analytica Chimica Acta, 652(1-2), 239-244. https://doi.org/10.1016/j.aca.2009.07.063

An integrated gel supported micro-fluidic system is reported, in which PCR products can be efficiently injected into a capillary electrophoresis device. The gel supported system is designed to provide greater stability to reagents during long periods... Read More about Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser.

COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines (2009)
Journal Article
O'Kane, S. L., Eagle, G. L., Greenman, J., Lind, M. J., & Cawkwell, L. (2010). COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. Lung Cancer, 67(2), 160-165. https://doi.org/10.1016/j.lungcan.2009.04.008

BACKGROUND Although malignant pleural mesothelioma is a rare tumour, its incidence is increasing. The prognosis remains very poor with an average survival of 10 months from diagnosis. The choice of chemotherapy regimens for mesothelioma patients is l... Read More about COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines.

CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds (2009)
Journal Article
Khan, A., Nicholson, G., McRobbie, G., Greenman, J., Pannecouque, C., Daelemans, D., …Archibald, S. J. (2009). CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds. Antiviral research, 82(2), A59-A60. https://doi.org/10.1016/j.antiviral.2009.02.141

AMD3100 is a bis-azamacrocyclic compound that has been demonstrated to be a highly effective antagonist of the CXCR4 chemokine receptor. The two azamacrocyclic rings have been shown to interact with aspartate residues on the receptor via hydrogen bon... Read More about CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds.

The use of carrier RNA to enhance DNA extraction from microfluidic-based silica monoliths (2009)
Journal Article
Shaw, K. J., Thain, L., Dyer, C., Docker, P. T., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). The use of carrier RNA to enhance DNA extraction from microfluidic-based silica monoliths. Analytica Chimica Acta, 652(1-2), 231-233. https://doi.org/10.1016/j.aca.2009.03.038

DNA extraction was carried out on silica-based monoliths within a microfluidic device. Solid-phase DNA extraction methodology was applied in which the DNA binds to silica in the presence of a chaotropic salt, such as guanidine hydrochloride, and is e... Read More about The use of carrier RNA to enhance DNA extraction from microfluidic-based silica monoliths.

Development of a bi-functional silica monolith for electro-osmotic pumping and DNA clean-up/extraction using gel-supported reagents in a microfluidic device (2009)
Journal Article
Oakley, J. A., Shaw, K. J., Docker, P. T., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). Development of a bi-functional silica monolith for electro-osmotic pumping and DNA clean-up/extraction using gel-supported reagents in a microfluidic device. Lab on a chip, 9(11), 1596-1600. https://doi.org/10.1039/b820553a

A silica monolith used to support both electro-osmotic pumping (EOP) and the extraction/elution of DNA coupled with gel-supported reagents is described. The benefits of the combined EOP extraction/elution system were illustrated by combining DNA extr... Read More about Development of a bi-functional silica monolith for electro-osmotic pumping and DNA clean-up/extraction using gel-supported reagents in a microfluidic device.

Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes (2009)
Journal Article
Khan, A., Nicholson, G., McRobbie, G., Pannecouque, C., De Clercq, E., Ullom, R., …Greenman, J. (2009). Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes. Journal of the American Chemical Society, 131(10), 3416-3417. https://doi.org/10.1021/ja807921k

A new copper(II) containing bis-macrocyclic CXCR4 chemokine receptor antagonist is shown to have improved binding properties to the receptor protein in comparison to the drug AMD3100 (Plerixafor, Mozobil). The interaction of the metallodrug has been... Read More about Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes.

pH testing for detecting the position of nasogastric tubes in adults and children (2009)
Journal Article
Kalia, S., Hall, J., El-Habbal, M., Imrie, C., Arabiat, D. H., Shields, L., …Elliott, B. (2009). pH testing for detecting the position of nasogastric tubes in adults and children. Cochrane Database of Systematic Reviews, 28126. https://doi.org/10.1002/14651858.cd007660

This is the protocol for a review and there is no abstract. The objectives are as follows: Our objective is to determine if there is sufficient evidence to recommend the use of pH testing (the intervention under scrutiny) for verification of correct... Read More about pH testing for detecting the position of nasogastric tubes in adults and children.

Simple practical approach for sample loading prior to DNA extraction using a silica monolith in a microfluidic device (2009)
Journal Article
Shaw, K. J., Docker, P. T., Haswell, S. J., Joyce, D. A., Dyer, C. E., Greenman, J., & Greenway, G. M. (2009). Simple practical approach for sample loading prior to DNA extraction using a silica monolith in a microfluidic device. Lab on a chip, 9(23), 3430-3432. https://doi.org/10.1039/b913309g

A novel DNA loading methodology is presented for performing DNA extraction on a microfluidic system. DNA in a chaotropic salt solution was manually loaded onto a silica monolith orthogonal to the subsequent flow of wash and elution solutions. DNA was... Read More about Simple practical approach for sample loading prior to DNA extraction using a silica monolith in a microfluidic device.

Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity (2008)
Journal Article
Li, C., Collier, M. E. W., Frentzou, G. A., Greenman, J., & Ettelaie, C. (2008). Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity. Cancer Immunology, Immunotherapy, 57(9), 1347-1355. https://doi.org/10.1007/s00262-008-0469-6

Aims We previously reported that overexpression of tissue factor (TF) protected HT29 tumour cells from cellular cytotoxicity through a mechanism requiring the presence of the cytoplasmic domain of TF. In this investigation the mechanism of TF-mediate... Read More about Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity.

Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer? (2008)
Journal Article
Alhamarneh, O., Amarnath, S. M. P., Stafford, N. D., & Greenman, J. (2008). Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?. Head & neck, 30(2), 251-261. https://doi.org/10.1002/hed.20739

Advances in the treatment modalities for head and neck squamous cell carcinoma (HNSCC) over the last 20 years involving surgery, radiotherapy, chemotherapy, and immunotherapy are not fully reflected in increases in the 5-year survival rates, mainly d... Read More about Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?.

Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies (2008)
Journal Article
Dyer, C. E., Greenman, J., Haswell, S. J., & Hattersley, S. M. (2008). Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies. Lab on a chip, 8(11), 1842-1846. https://doi.org/10.1039/b809345h

A microfluidic based experimental methodology has been developed that offers a biomimetic microenvironment in which pseudo in vivo tissue studies can be carried out under in vitro conditions. Using this innovative technique, which utilizes the inhere... Read More about Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies.

Heat shock proteins in vascular disease - a review (2005)
Journal Article
Mehta, T., Greenman, J., Ettelaie, C., Venkatasubramaniam, A., Chetter, I., & McCollum, P. (2005). Heat shock proteins in vascular disease - a review. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 29(4), 395-402. https://doi.org/10.1016/j.ejvs.2005.01.005

Introduction There is growing evidence that heat shock proteins (HSPs), a family of stress-inducible proteins may be involved in the pathogenesis of atherosclerotic vascular diseases. Here, we systematically review the evidence behind this notion.... Read More about Heat shock proteins in vascular disease - a review.

Hyperbaric oxygen restores the antioxidant defence mechansim following exercise in patients with intermittent claudication (2001)
Journal Article
Abidia, A., Kuhan, G., Laden, G., Bahia, H., Chetter, I., Greenman, J., & McCollum, P. (2001). Hyperbaric oxygen restores the antioxidant defence mechansim following exercise in patients with intermittent claudication. Undersea and Hyperbaric Medical Society meeting abstracts, 28(32), 0 - 0

BACKGROUND: Intermittent claudication represents a minor ischaemia reperfusion episode. Exposure to hyperbaric oxygen during such episodes is a concern to many vascular surgeons because of the theoretical risk of generating excess free radicals. We a... Read More about Hyperbaric oxygen restores the antioxidant defence mechansim following exercise in patients with intermittent claudication.

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