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All Outputs (111)

Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery (2024)
Journal Article
Cai, Y., Pascoletti, G., Zioupos, P., Budair, B., Zanetti, E. M., Ringrose, T. J., & Junaid, S. (2024). Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery. Life, 14(3), Article 328. https://doi.org/10.3390/life14030328

Introduction: Flatfoot is a condition commonly seen in children; however, there is general disagreement over its incidence, characterization and correction. Painful flatfoot accompanied with musculoskeletal and soft tissue problems requires surgery t... Read More about Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery.

The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis (2022)
Journal Article
Talbott, H. G., Wilkins, R. A., Redmond, A. C., Brockett, C. L., & Mengoni, M. (2022). The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis. Clinical biomechanics, 99, Article 105745. https://doi.org/10.1016/j.clinbiomech.2022.105745

Background: Subchondral bone cysts are a common presentation in ankle haemarthropathy. The relationship with ankle joint health has however not previously been investigated. The aim of this study was to assess the influence of subchondral bone cysts... Read More about The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis.

Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation? (2021)
Journal Article
Bates, K. T., Wang, L., Dempsey, M., Broyde, S., Fagan, M. J., & Cox, P. G. (2021). Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?. Interface, 18(180), Article 20210324. https://doi.org/10.1098/rsif.2021.0324

Measures of attachment or accommodation area on the skeleton are a popular means of rapidly generating estimates of muscle proportions and functional performance for use in large-scale macroevolutionary studies. Herein, we provide the first evaluatio... Read More about Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?.

Morphological variation of the hemophilic talus (2021)
Journal Article
Talbott, H. G., Wilkins, R. A., Redmond, A. C., Brockett, C. L., & Mengoni, M. (2021). Morphological variation of the hemophilic talus. Clinical Anatomy, 34(6), 941-947. https://doi.org/10.1002/ca.23757

Flattening of the trochlear tali is clinically observed as structural and functional changes advance in patients with hemarthropathy of the ankle. However, the degree of this flattening has not yet been quantified, and distribution of the morphologic... Read More about Morphological variation of the hemophilic talus.

Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809) (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809). Proceedings of the Royal Society B: Biological Sciences, 288(1950), Article 20202809. https://doi.org/10.1098/rspb.2021.0831

Further analysis of our finite element (FE) models, as part of ongoing work, has revealed a systematic error running through all 30 models in our original analysis. In all 30 FE models, the force magnitudes applied to represent maximum isometric cont... Read More about Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809).

Evolutionary biomechanics: hard tissues and soft evidence? (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Evolutionary biomechanics: hard tissues and soft evidence?. Proceedings of the Royal Society B: Biological Sciences, 288(1945), Article 20202809. https://doi.org/10.1098/rspb.2020.2809

Biomechanical modelling is a powerful tool for quantifying the evolution of functional performance in extinct animals to understand key anatomical innovations and selective pressures driving major evolutionary radiations. However, the fossil record i... Read More about Evolutionary biomechanics: hard tissues and soft evidence?.

The biomechanical role of the chondrocranium and the material properties of cartilage (2020)
Journal Article
Jones, M. E. H., Gröning, F., Aspden, R. M., Dutel, H., Sharp, A., Moazen, M., …Evans, S. E. (2020). The biomechanical role of the chondrocranium and the material properties of cartilage. Vertebrate Zoology, 70(4), 699-715. https://doi.org/10.26049/VZ70-4-2020-10

The chondrocranium is the cartilage component of the vertebrate braincase. Among jawed vertebrates it varies greatly in structure, mineralisation, and in the extent to which it is replaced by bone during development. In mammals, birds, and some bony... Read More about The biomechanical role of the chondrocranium and the material properties of cartilage.

Viscoelastically active sutures – A stitch in time? (2020)
Journal Article
France, L. A., & Fancey, K. S. (2021). Viscoelastically active sutures – A stitch in time?. Materials Science and Engineering: C, 121, Article 111695. https://doi.org/10.1016/j.msec.2020.111695

We present results to show that a commercially available polypropylene suture filament (Ethicon Prolene), following annealing and tensile creep can, after creep load removal, release viscoelastically stored energy over a period of several weeks. Spec... Read More about Viscoelastically active sutures – A stitch in time?.

Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation (2020)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2020). Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation. Computer Methods and Programs in Biomedicine, 196, Article 105677. https://doi.org/10.1016/j.cmpb.2020.105677

Background and objective: NF-κB can be activated by the canonical and non-canonical pathways. These two pathways interplay via the TRAF1|NIK complex after stimulation by TNF. However existing mathematical models of two pathways are inadequate. In thi... Read More about Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation.

Multi-beat averaging reveals u waves are ubiquitous and standing tall at elevated heart rates following exercise (2020)
Journal Article
Al-Karadi, M. S., & Langley, P. (2020). Multi-beat averaging reveals u waves are ubiquitous and standing tall at elevated heart rates following exercise. Sensors, 20(14), 1-12. https://doi.org/10.3390/s20144029

The reporting of U wave abnormalities is clinically important, but the measurement of this small electrocardiographic (ECG) feature is extremely difficult, especially in challenging recording conditions, such as stress exercise, due to contaminating... Read More about Multi-beat averaging reveals u waves are ubiquitous and standing tall at elevated heart rates following exercise.

Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering (2020)
Journal Article
Jaganathan, S. K., & Mani, M. P. (in press). Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering. Journal of Industrial Textiles, Article 152808372090680. https://doi.org/10.1177/1528083720906809

In the recent decade, the growth of medical textiles is enormous and it paves the sustained development in the quality of life. In this research, an electrospun textile scaffold comprising polyurethane impregnated with Alternanthera sessilis oil was... Read More about Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering.

Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method (2020)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & Pérez del Palomar, A. (2020). Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method. Computer Methods and Programs in Biomedicine, 191, Article 105397. https://doi.org/10.1016/j.cmpb.2020.105397

Background and objective: Craniofacial asymmetry is a common growth disorder often caused by unilateral chewing. Although an early orthodontic treatment would avoid surgical procedures later in life, the uncertainty of defining the accurate sagittal... Read More about Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method.

P014 | THE INFLUENCE OF SUBCHONDRAL BONE CYSTS ON TISSUE PRESSURES IN THE TIBIOTALAR JOINT (2020)
Journal Article
Talbott, H., Wilkins, R., Redmond, A., Brockett, C., & Mengoni, M. (2020). P014 | THE INFLUENCE OF SUBCHONDRAL BONE CYSTS ON TISSUE PRESSURES IN THE TIBIOTALAR JOINT. Haemophilia, 26(S2), https://doi.org/10.1111/hae.13911

Introduction: Subchondral bone cysts are an indicator of late stage haemophilic joint disease (HJD); however, the implication of these cysts on joint health is little understood. The aim of this study was to assess, computationally, the influence... Read More about P014 | THE INFLUENCE OF SUBCHONDRAL BONE CYSTS ON TISSUE PRESSURES IN THE TIBIOTALAR JOINT.

Galaxy and Mass Assembly (GAMA): Defining passive galaxy samples and searching for the UV upturn (2019)
Journal Article
Phillipps, S., Ali, S. S., Bremer, M. N., de Propris, R., Sansom, A. E., Cluver, M. E., …Wang, L. (2020). Galaxy and Mass Assembly (GAMA): Defining passive galaxy samples and searching for the UV upturn. Monthly notices of the Royal Astronomical Society, 492(2), 2128-2139. https://doi.org/10.1093/mnras/stz3552

© 2019 The Author(s) We use data from the GAMA and GALEX surveys to demonstrate that the UV upturn, an unexpected excess of ultraviolet flux from a hot stellar component, seen in the spectra of many early-type galaxies, arises from processes internal... Read More about Galaxy and Mass Assembly (GAMA): Defining passive galaxy samples and searching for the UV upturn.

An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein (2019)
Journal Article
Jothi, L., Jaganathan, S. K., & Nageswaran, G. (2020). An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein. Materials Chemistry and Physics, 242, Article 122514. https://doi.org/10.1016/j.matchemphys.2019.122514

In this work, a novel label-free electrochemical immunosensor for the detection of alpha-fetoprotein (AFP) is fabricated for early diagnosis and prognostics of liver cancer. A porous graphene nanoribbon (PGNR) was synthesized via chemical reduction m... Read More about An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein.

Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering (2019)
Journal Article
Mani, M. P., Jiang, H., Mani, M. P., & Jaganathan, S. K. (2019). Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering. International Journal of Nanomedicine, 14, 8149-8159. https://doi.org/10.2147/IJN.S214646

Introduction: Recently several new approaches were emerging in bone tissue engineering to develop a substitute for remodelling the damaged tissue. In order to resemble the native extracellular matrix (ECM) of the human tissue, the bone scaffolds must... Read More about Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering.

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head (2019)
Journal Article
Dutel, H., Galland, M., Tafforeau, P., Long, J. A., Fagan, M. J., Janvier, P., …Herbin, M. (2019). Neurocranial development of the coelacanth and the evolution of the sarcopterygian head. Nature, 569, 556–559. https://doi.org/10.1038/s41586-019-1117-3

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lu... Read More about Neurocranial development of the coelacanth and the evolution of the sarcopterygian head.

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More about Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway.

The effect of beat interval on ventricular repolarisation in atrial fibrillation (2019)
Conference Proceeding
Al-Karadi, M. S., Wilkinson, A. J., & Langley, P. (2019). The effect of beat interval on ventricular repolarisation in atrial fibrillation. . https://doi.org/10.22489/CinC.2018.294

© 2018 Creative Commons Attribution. Atrial fibrillation (AF) is characterised by rapid beat interval changes. The aim of the study was to investigate the effect of such changes on ECG ventricular repolarisation characteristics. In 10 AF recordings b... Read More about The effect of beat interval on ventricular repolarisation in atrial fibrillation.

Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. https://doi.org/10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More about Bite force and cranial bone strain in four species of lizards.