All Outputs (25)

MRI contrast agent delivery using spore capsules: controlled release in blood plasma (2009)
Journal Article
Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, 6442-6444. https://doi.org/10.1039/b909551a

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is sl... Read More about MRI contrast agent delivery using spore capsules: controlled release in blood plasma.

Phosphatidylglycerol lipids enhance folding of an α helical membrane protein (2008)
Journal Article
Seddon, A. M., Lorch, M., Ces, O., Templer, R. H., Macrae, F., & Booth, P. J. (2008). Phosphatidylglycerol lipids enhance folding of an α helical membrane protein. Journal of Molecular Biology, 380(3), 548-556. https://doi.org/10.1016/j.jmb.2008.05.001

Membrane lipids are increasingly being recognised as active participants in biological events. The precise roles that individual lipids or global properties of the lipid bilayer play in the folding of membrane proteins remain to be elucidated, Here,... Read More about Phosphatidylglycerol lipids enhance folding of an α helical membrane protein.

Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes (2008)
Journal Article
Lorch, M., & Lopez, J. J. (2008). Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes. Journal of Biological Chemistry, 283(12), 7813-7822. https://doi.org/10.1074/jbc.M707480200

Magic angle spinning (MAS) NMR has been used to investigate the location and orientation of five serotonin receptor 1a agonists (serotonin, buspirone, quipazine, 8-OH-DPAT, and LY-163,165) in single component model lipid and brain lipid membranes. Th... Read More about Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes.

Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR (2007)
Journal Article
Pfleger, N., Lorch, M., Woerner, A. C., Shastri, S., & Glaubitz, C. (2008). Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR. Journal of Biomolecular NMR, 40(1), 15-21. https://doi.org/10.1007/s10858-007-9203-5

The proteorhodopsin family consists of hundreds of homologous retinal containing membrane proteins found in bacteria in the photic zone of the oceans. They are colour tuned to their environment and act as light-driven proton pumps with a potential en... Read More about Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR.

Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence (2007)
Journal Article
Basting, D., Lorch, M., Lehner, I., & Glaubitz, C. (2008). Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence. FASEB Journal, 22(2), 365-373. https://doi.org/10.1096/fj.07-9162com

Efflux pumps of the small multidrug resistance family bind cationic, lipophilic antibiotics and transport them across the membrane in exchange for protons. The transport cycle must involve various conformational states of the protein needed for subst... Read More about Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence.