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Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel (2013)
Journal Article
Beltran-Alvarez, P., Espejo, A., Schmauder, R., Beltran, C., Mrowka, R., Linke, T., …Brugada, R. (2013). Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel. FEBS Letters, 587(19), 3159-3165. https://doi.org/10.1016/j.febslet.2013.07.043

The α-subunit of the cardiac voltage-gated sodium channel (Na V1.5) plays a central role in cardiomyocyte excitability. We have recently reported that NaV1.5 is post-translationally modified by arginine methylation. Here, we aimed to identify the enz... Read More about Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel.

A Missense Mutation in the Sodium Channel β2 Subunit Reveals SCN2B as a New Candidate Gene for Brugada Syndrome (2013)
Journal Article
Riuró, H., Beltran-Alvarez, P., Tarradas, A., Selga, E., Campuzano, O., Vergés, M., …Brugada, R. (2013). A Missense Mutation in the Sodium Channel β2 Subunit Reveals SCN2B as a New Candidate Gene for Brugada Syndrome. Human Mutation, 34(7), 961-966. https://doi.org/10.1002/humu.22328

Brugada Syndrome (BrS) is a familial disease associated with sudden cardiac death. A 20%-25% of BrS patients carry genetic defects that cause loss-of-function of the voltage-gated cardiac sodium channel. Thus, 70%-75% of patients remain without a gen... Read More about A Missense Mutation in the Sodium Channel β2 Subunit Reveals SCN2B as a New Candidate Gene for Brugada Syndrome.

A Novel Missense Mutation, I890T, in the Pore Region of Cardiac Sodium Channel Causes Brugada Syndrome (2013)
Journal Article
Tarradas, A., Selga, E., Beltran-Alvarez, P., Pérez-Serra, A., Riuró, H., Picó, F., …Brugada, R. (2013). A Novel Missense Mutation, I890T, in the Pore Region of Cardiac Sodium Channel Causes Brugada Syndrome. PLoS ONE, 8(1), Article e53220. https://doi.org/10.1371/journal.pone.0053220

Brugada syndrome (BrS) is a life-threatening, inherited arrhythmogenic syndrome associated with autosomal dominant mutations in SCN5A, the gene encoding the cardiac Na+ channel alpha subunit (Nav1.5). The aim of this work was to characterize the func... Read More about A Novel Missense Mutation, I890T, in the Pore Region of Cardiac Sodium Channel Causes Brugada Syndrome.

The cardiac sodium channel is post-translationally modified by arginine methylation (2011)
Journal Article
Beltran-Alvarez, P., Pagans, S., & Brugada, R. (2011). The cardiac sodium channel is post-translationally modified by arginine methylation. Journal of Proteome Research, 10(8), 3712-3719. https://doi.org/10.1021/pr200339n

The α subunit of the cardiac sodium channel (Na v1.5) is an essential protein in the initial depolarization phase of the cardiomyocyte action potential. Post-translational modifications such as phosphorylation are known to regulate Na v1.5 function.... Read More about The cardiac sodium channel is post-translationally modified by arginine methylation.

A systematic screen for proteing-lipid interactions in Saccharomyces cerevisiae (2010)
Journal Article
Gallego, O., Betts, M. J., Gvozdenovic-Jeremic, J., Maeda, K., Matetzki, C., Aguilar-Gurrieri, C., …Gavin, A. C. (2010). A systematic screen for proteing-lipid interactions in Saccharomyces cerevisiae. Molecular Systems Biology, 6(1), Article 430. https://doi.org/10.1038/msb.2010.87

Proteing-metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog proteing-lipid interactions in yeast. We used arrays of 56 metabolites to measure lipid-binding fingerprints of 172 p... Read More about A systematic screen for proteing-lipid interactions in Saccharomyces cerevisiae.