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Statistical design and analysis in trials of proportionate interventions: a systematic review (2019)
Journal Article
Candlish, J., Teare, M. D., Cohen, J., & Bywater, T. (2019). Statistical design and analysis in trials of proportionate interventions: a systematic review. Trials, 20(1), Article 151. https://doi.org/10.1186/s13063-019-3206-x

Background: In proportionate or adaptive interventions, the dose or intensity can be adjusted based on individual need at predefined decision stages during the delivery of the intervention. The development of such interventions may require an evaluat... Read More about Statistical design and analysis in trials of proportionate interventions: a systematic review.

Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial (2018)
Journal Article
Hutchinson, A., Rees, S., Young, A., Maraveyas, A., Date, K., & Johnson, M. J. (2019). Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial. Palliative medicine, 33(5), 510-517. https://doi.org/10.1177/0269216318815377

Background: Cancer patients have a four- to fivefold greater risk of thrombosis than the general population. Recommended treatment for cancer-associated thrombosis is 3–6 months of low-molecular-weight heparin. The ‘select-d’ trial is an open-label,... Read More about Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial.

Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling (2018)
Journal Article
Goodacre, S., Horspool, K., Shephard, N., Pollard, D., Hunt, B. J., Fuller, G., …Cohen, J. (2018). Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling. Health Technology Assessment, 22(47), V-229. https://doi.org/10.3310/hta22470

Background Pulmonary embolism (PE) is a leading cause of death in pregnancy and post partum, but the symptoms of PE are common in normal pregnancy. Simple diagnostic tests are needed to select women for diagnostic imaging. Objective To estimate the... Read More about Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling.

Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial (2018)
Journal Article
Reddington, M., Walters, S. J., Cohen, J., Baxter, S. K., & Cole, A. (2018). Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial. BMJ open, 8(7), Article e021631. https://doi.org/10.1136/bmjopen-2018-021631

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. Objective To investigate the feasibility of undertaking a definitive randomised controlled trial (RCT). Setting This was a pilot, pragmatic superiority RCT with... Read More about Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial.

CAMERA - complete assessment of elderly patients with cancer: A non-randomised feasibility study (2018)
Journal Article
Jackson, G., Gabe, R., Johnson, M., Date, K., Harman, D., Maraveyas, A., …Lind, M. J. (2019). CAMERA - complete assessment of elderly patients with cancer: A non-randomised feasibility study. Journal of Geriatric Oncology, 10(1), 175-177. https://doi.org/10.1016/j.jgo.2018.07.005

One of the primary risk factors in the development of cancer is older age. The demographic shift to an ageing population has given rise to an increased number of older patients with cancer. The extreme heterogeneity within this population renders app... Read More about CAMERA - complete assessment of elderly patients with cancer: A non-randomised feasibility study.

Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review (2018)
Journal Article
Orange, S. T., Northgraves, M. J., Marshall, P., Madden, L. A., & Vince, R. V. (2018). Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review. International journal of surgery, 56, 328-333. https://doi.org/10.1016/j.ijsu.2018.04.054

The Enhanced Recovery after Surgery (ERAS) model integrates several elements of perioperative care into a standardised clinical pathway for surgical patients. ERAS programmes aim to reduce the rate of complications, improve surgical recovery, and lim... Read More about Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review.

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: Study protocol for a randomised controlled trial (2018)
Journal Article
Pye, C., Chatters, R., Cohen, J., Brian, K., Cheong, Y. C., Laird, S., …Metwally, M. (2018). Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: Study protocol for a randomised controlled trial. BMJ open, 8(5), e020755. https://doi.org/10.1136/bmjopen-2017-020755

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Endometrial trauma commonly known as endometrial... Read More about Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: Study protocol for a randomised controlled trial.

Remote or on-site visits were feasible for the initial setup meetings with hospitals in a multicenter surgical trial: an embedded randomized trial (2018)
Journal Article
Jefferson, L., Fairhurst, C., Brealey, S., Coleman, E., Cook, L., Hewitt, C., …Dias, J. (2018). Remote or on-site visits were feasible for the initial setup meetings with hospitals in a multicenter surgical trial: an embedded randomized trial. Journal of clinical epidemiology, 100, 13-21. https://doi.org/10.1016/j.jclinepi.2018.04.011

© 2018 Elsevier Inc. Objectives: To investigate the effects, costs, and feasibility of providing on-site compared with remote meetings to set up hospital sites in a multicenter, surgical randomized controlled trial. Study Design and Setting: Hospital... Read More about Remote or on-site visits were feasible for the initial setup meetings with hospitals in a multicenter surgical trial: an embedded randomized trial.

United Kingdom Frozen Shoulder Trial (UK FROST), multi-centre, randomised, 12 month, parallel group, superiority study to compare the clinical and cost-effectiveness of Early Structured Physiotherapy versus manipulation under anaesthesia versus arthroscopic capsular release for patients referred to secondary care with a primary frozen shoulder: study protocol for a randomised controlled trial. (2017)
Journal Article
Brealey, S., Armstrong, A., Brooksbank, A., Carr, A., Charalambous, C., Cooper, C., …Rangan, A. (2017). United Kingdom Frozen Shoulder Trial (UK FROST), multi-centre, randomised, 12 month, parallel group, superiority study to compare the clinical and cost-effectiveness of Early Structured Physiotherapy versus manipulation under anaesthesia versus arthroscopic capsular release for patients referred to secondary care with a primary frozen shoulder: study protocol for a randomised controlled trial. Trials, 18(1), Article 614. https://doi.org/10.1186/s13063-017-2352-2

Background: Frozen shoulder (also known as adhesive capsulitis) occurs when the capsule, or the soft tissue envelope around the ball and socket shoulder joint, becomes scarred and contracted, making the shoulder tight, painful and stiff. It affects a... Read More about United Kingdom Frozen Shoulder Trial (UK FROST), multi-centre, randomised, 12 month, parallel group, superiority study to compare the clinical and cost-effectiveness of Early Structured Physiotherapy versus manipulation under anaesthesia versus arthroscopic capsular release for patients referred to secondary care with a primary frozen shoulder: study protocol for a randomised controlled trial..

Tissue factor-bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer (2017)
Journal Article
Date, K., Ettelaie, C., & Maraveyas, A. (2017). Tissue factor-bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer. Journal of thrombosis and haemostasis : JTH, 15(12), 2289-2299. https://doi.org/10.1111/jth.13871

© 2017 International Society on Thrombosis and Haemostasis Summary: Cancer is associated with an increased risk of venous thromboembolism (VTE); the exact mechanisms for the induction of VTE remain to be fully elucidated, but it is widely acknowledge... Read More about Tissue factor-bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer.

Aetiological investigations in early developmental impairment: Are they worth it? (2017)
Journal Article
Hart, A. R., Sharma, R., Atherton, M., Alabed, S., Simpson, S., Barfield, S., …Connolly, D. J. (2017). Aetiological investigations in early developmental impairment: Are they worth it?. Archives of Disease in Childhood, 102(11), 1004-1013. https://doi.org/10.1136/archdischild-2017-312843

Objective To study the frequency a diagnosis is made in children with early developmental impairment (EDI), and the contribution made to diagnosis by specific investigations. Design Retrospective case note review. Setting Community, neurodisability... Read More about Aetiological investigations in early developmental impairment: Are they worth it?.

Does early intervention improve outcomes in physiotherapy management of lumbar radicular syndrome? A mixed-methods study protocol (2017)
Journal Article
Reddington, M., Walters, S. J., Cohen, J., & Baxter, S. (2017). Does early intervention improve outcomes in physiotherapy management of lumbar radicular syndrome? A mixed-methods study protocol. BMJ open, 7(3), Article e014422. https://doi.org/10.1136/bmjopen-2016-014422

© Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-And-licensing/. Introduction Lumbar radicular syndrome (LRS) can be a... Read More about Does early intervention improve outcomes in physiotherapy management of lumbar radicular syndrome? A mixed-methods study protocol.

A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero (2016)
Journal Article
Jarvis, D., Mooney, C., Cohen, J., Papaioannou, D., Bradburn, M., Sutton, A., & Griffiths, P. D. (2017). A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero. European Radiology, 27(6), 2367-2380. https://doi.org/10.1007/s00330-016-4563-4

© 2016, The Author(s). Objectives: This systematic review was undertaken to define the diagnostic performance of in utero MR (iuMR) imaging when attempting to confirm, exclude or provide additional information compared with the information provided b... Read More about A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero.

The test-retest reliability of four functional mobility tests in apparently healthy adults (2016)
Journal Article
Northgraves, M. J., Hayes, S. C., Marshall, P., Madden, L. A., & Vince, R. V. (2016). The test-retest reliability of four functional mobility tests in apparently healthy adults. Isokinetics and Exercise Science, 24(3), 171-179. https://doi.org/10.3233/ies-160614

Background: Simple field tests are often used to assess functional mobility in clinical settings. Despite having many benefits, these tests are susceptible to measurement error and individual variation. Objectives: To examine the test-retest and abso... Read More about The test-retest reliability of four functional mobility tests in apparently healthy adults.

DiPALS: Diaphragm pacing in patients with amyotrophic lateral sclerosis – A randomised controlled trial (2016)
Journal Article
McDermott, C. J., Bradburn, M. J., Maguire, C., Cooper, C. L., Baird, W. O., Baxter, S. K., …Shaw, P. J. (2016). DiPALS: Diaphragm pacing in patients with amyotrophic lateral sclerosis – A randomised controlled trial. Health Technology Assessment, 20(45), 1-218. https://doi.org/10.3310/hta20450

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in death, usually from respiratory failure, within 2–3 years of symptom onset. Non-invasive ventilation (NIV) is a treatment that when given to patients in respir... Read More about DiPALS: Diaphragm pacing in patients with amyotrophic lateral sclerosis – A randomised controlled trial.

The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma (2014)
Journal Article
Goodacre, S., Cohen, J., Bradburn, M., Stevens, J., Gray, A., Benger, J., & Coats, T. (in press). The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma. Health Technology Assessment, 18(22), 1-167. https://doi.org/10.3310/hta18220

Background: Magnesium sulphate, administered by the intravenous (i.v.) or inhaled (nebulised) route, has been proposed as a treatment for adults with acute severe asthma. Existing trials show mixed results and uncertain evidence of benefit. Objective... Read More about The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma.

Effect of lactate supplementation and sodium bicarbonate on 40-km cycling time trial performance (2014)
Journal Article
Northgraves., M. J., Peart., D. J., Jordan, C. A., & Vince, R. V. (2014). Effect of lactate supplementation and sodium bicarbonate on 40-km cycling time trial performance. Journal of strength and conditioning research, 28(1), 273-280. https://doi.org/10.1519/JSC.0b013e3182986a4c

The use of nutritional supplements to improve sporting performance and increase training adaptations is commonplace among athletes and is an expanding market in terms of product choice and availability. The purpose of this study was to examine the ef... Read More about Effect of lactate supplementation and sodium bicarbonate on 40-km cycling time trial performance.

Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial (2013)
Journal Article
Goodacre, S., Cohen, J., Bradburn, M., Gray, A., Benger, J., & Coats, T. (2013). Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial. The lancet. Respiratory medicine, 1(4), 293-300. https://doi.org/10.1016/S2213-2600%2813%2970070-5

Background: Previous studies suggested intravenous or nebulised magnesium sulphate (MgSO4) might improve respiratory function in patients with acute asthma. We aimed to determine whether intravenous or nebulised MgSO4 improve symptoms of breathlessne... Read More about Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial.