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Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens (2023)
Journal Article
Richardson, S., Mayes, W. M., Faetsch, S., Hetjens, H., Teuchies, J., Walker, P., …Heise, S. (2023). Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens. The Science of the total environment, 891, Article 164280. https://doi.org/10.1016/j.scitotenv.2023.164280

Extended chemical analyses of fluvial sediments were undertaken to establish the key pollutant pressures and mixtures present across nine European Union inland waterways. A wide range of chemical components and physical parameters were investigated i... Read More about Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens.

Electrochemical quantification of D-glucose during the production of bioethanol from thermo-mechanically pre-treated wheat straw (2021)
Journal Article
Ward, R. A., Charlton, A., Welham, K. J., Baker, P., Zein, S. H., Tomkinson, J., …Wadhawan, J. D. (2021). Electrochemical quantification of D-glucose during the production of bioethanol from thermo-mechanically pre-treated wheat straw. Electrochemistry communications, 124, Article 106942. https://doi.org/10.1016/j.elecom.2021.106942

Mechanical pre-treatment (disc refining) of wheat straw, at both atmospheric and elevated pressure, is shown to be an efficient process to access fermentable monosaccharides, with the potential to integrate within the infrastructure of existing first... Read More about Electrochemical quantification of D-glucose during the production of bioethanol from thermo-mechanically pre-treated wheat straw.

An innovative method of extraction of coffee oil using an advanced microwave system: in comparison with conventional Soxhlet extraction method (2019)
Journal Article
Hibbert, S., Welham, K., & Zein, S. H. (2019). An innovative method of extraction of coffee oil using an advanced microwave system: in comparison with conventional Soxhlet extraction method. SN Applied Sciences, 1(11), Article 1467. https://doi.org/10.1007/s42452-019-1457-5

The production of energy and chemicals from waste biomass is an attractive alternative by comparison with first generation biofuels and fossil feedstocks. This paper investigates oil extraction from spent coffee grounds (SCG) by means of an advanced... Read More about An innovative method of extraction of coffee oil using an advanced microwave system: in comparison with conventional Soxhlet extraction method.

An investigation of the uptake of estradiol in the bivalve Mytilus spp. corresponding biological implications and the effect of the addition of Sporopollenin on bioavailability (2019)
Thesis
Harley, M. A. (2019). An investigation of the uptake of estradiol in the bivalve Mytilus spp. corresponding biological implications and the effect of the addition of Sporopollenin on bioavailability. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221927

There has been concern over the past two decades over estrogenic hormones such as 17 α-ethinylestradiol and 17 β-estradiol (E2) in fresh water and marine ecosystems and the risk to aquatic organisms even with low exposure levels. This study is to acc... Read More about An investigation of the uptake of estradiol in the bivalve Mytilus spp. corresponding biological implications and the effect of the addition of Sporopollenin on bioavailability.

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., …Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Background The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More about The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.

An investigation of glycidyl methacrylate terpolymers for mixed mode LC separations (2018)
Thesis
Alkarimi, A. A. (2018). An investigation of glycidyl methacrylate terpolymers for mixed mode LC separations. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4306322

Enhancing efficient separation techniques for use in proteomics or metabolomics is a growing area in recent years. Monolithic columns, as innovative separation materials have gained more attention and acceptance for proteomic and metabolic s... Read More about An investigation of glycidyl methacrylate terpolymers for mixed mode LC separations.

A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism (2016)
Journal Article
Vasiliadou, R., Esfahani, M. M. N., Brown, N. J., & Welham, K. J. (2016). A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism. Sensors, 16(9), Article ARTN 1418. https://doi.org/10.3390/s16091418

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler... Read More about A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism.

Development of a microfluidic approach to the analysis of carbamate pesticides in drinking water (2016)
Thesis
Algethami, J. S. G. (2016). Development of a microfluidic approach to the analysis of carbamate pesticides in drinking water. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223548

During the last decade, public concern over carbamate pesticide residues has increased remarkably and their accurate determination in environmental samples is gaining great importance. These compounds are present in environmental samples at low conce... Read More about Development of a microfluidic approach to the analysis of carbamate pesticides in drinking water.

Development of a microfluidic device with a screen printed electrode for studies on phase II metabolism (2015)
Thesis
Vasiliadou, R. (2015). Development of a microfluidic device with a screen printed electrode for studies on phase II metabolism. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222259

Simulating human metabolism by electrochemistry (EC) and mass spectrometry (MS) provides an alternative approach to the existing in vitro and in vivo methodologies. Herein, screen printed electrodes (SPEs) were investigated as potent electrochemical... Read More about Development of a microfluidic device with a screen printed electrode for studies on phase II metabolism.

Optimization preparation of the biosynthesis of silver nanoparticles using watermelon and study of its antibacterial activity (2014)
Journal Article
Alzahrani, E., & Welham, K. (in press). Optimization preparation of the biosynthesis of silver nanoparticles using watermelon and study of its antibacterial activity. International Journal of Basic and Applied Sciences, 3(4), 392. https://doi.org/10.14419/ijbas.v3i4.3358

The field of nanotechnology is the most active area of research in modern materials science. There is increased demand on nanoparticles because of their wide applicability in various areas; for example, electronics, catalysis, chemistry, energy and m... Read More about Optimization preparation of the biosynthesis of silver nanoparticles using watermelon and study of its antibacterial activity.

Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins (2013)
Journal Article
Alzahrani, E., & Welham, K. (2014). Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins. Analytical Methods, 6(2), 558-568. https://doi.org/10.1039/c3ay41442f

Protein identification by mass spectrometry forms the cornerstone of proteomics. Commonly, the identification of proteins is based on digestion of proteins into peptides using proteolytic enzymes. Cleavage of the disulphide bonds in proteins before e... Read More about Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins.

Preconcentration of milk proteins using octadecylated monolithic silica microchip (2013)
Journal Article
Alzahrani, E., & Welham, K. (2013). Preconcentration of milk proteins using octadecylated monolithic silica microchip. Analytica Chimica Acta, 798, 40-47. https://doi.org/10.1016/j.aca.2013.08.035

Sample preparation is a bottleneck in systems for chemical analysis and it is a required step in order to remove interference and preconcentrate the target analytes. Much research in recent years has focused on porous monolithic materials since they... Read More about Preconcentration of milk proteins using octadecylated monolithic silica microchip.

Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen (2013)
Journal Article
Kashuba, E., Eagle, G. L., Bailey, J., Evans, P., Welham, K. J., Allsup, D., & Cawkwell, L. (2013). Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen. Journal of Proteomics, 91, 478-485. https://doi.org/10.1016/j.jprot.2013.08.002

CLL is an incurable disease with variable prognosis. The hyper reactivity of the B-cell receptor (BCR) to unknown antigen ligation plays a pivotal role in CLL-cell survival. We aimed to investigate the BCR signalling pathway using proteomics to ident... Read More about Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen.

Investigation of monolithic materials for protein sample preparation (2012)
Thesis
Alzahrani, E. (2012). Investigation of monolithic materials for protein sample preparation. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4214634

Proteomics plays an important role in the recognition of diseases and the understanding of biological processes. Sample preparation is a bottleneck in systems for chemical analysis and it is a required step in proteomics in order to remove interferen... Read More about Investigation of monolithic materials for protein sample preparation.

Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’” (2011)
Journal Article
Zheng, S., Webster, A., Zheng, S., Welham, K. J., Dyer, C. E., Greenman, J., …Haswell, S. J. (2011). Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’”. Analyst, 136(2), 411-411. https://doi.org/10.1039/c0an00729c

Comment by Tsikas et al. (Analyst, 2011, DOI: 10.1039/c0an00411a) on the preliminary work by Shen and colleagues (Analyst, 2010, 135, 302) describing the use of ESI-MS/MS for the detection of methylpiperazinobenzenediamine, as a probe for NO in tissu... Read More about Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’”.

Identification of a female sex pheromone in Carcinus maenas (2011)
Journal Article
Hardege, J. D., Bartels-Hardege, H. D., Fletcher, N., Terschak, J. A., Harley, M., Smith, M. A., …Bublitz, R. (2011). Identification of a female sex pheromone in Carcinus maenas. Marine ecology progress series, 436, 177-189. https://doi.org/10.3354/meps09226

Despite major progress in our understanding of animal signaling systems, the identification of chemical signals in aquatic organisms is still in its infancy. Exemplary for this is the lack of structural knowledge of crustacean sex pheromones despite... Read More about Identification of a female sex pheromone in Carcinus maenas.

Design and evaluation of synthetic silica-based monolithic materials in shrinkable tube for efficient protein extraction (2011)
Journal Article
Alzahrani, E., & Welham, K. (2011). Design and evaluation of synthetic silica-based monolithic materials in shrinkable tube for efficient protein extraction. Analyst, 136(20), 4321-4327. https://doi.org/10.1039/c1an15447h

Sample pretreatment is a required step in proteomics in order to remove interferences and preconcentrate the samples. Much research in recent years has focused on porous monolithic materials since they are highly permeable to liquid flow and show hig... Read More about Design and evaluation of synthetic silica-based monolithic materials in shrinkable tube for efficient protein extraction.

Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis) (2011)
Journal Article
Velez, Z., Hubbard, P. C., Hardege, J. D., Welham, K. J., Barata, E. N., & Canário, A. V. M. (2011). Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis). Aquaculture, 314(1-4), 153-158. https://doi.org/10.1016/j.aquaculture.2011.01.025

Nocturnal animals often rely heavily on olfactory cues to locate their food. This is especially true for fish whose prey live buried in the substrate. The aim of the current study was to identify non-polar odorants released by the ragworm (Hediste di... Read More about Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis).

Detection of nitric oxide in tissue samples by ESI-MS (2009)
Journal Article
Shen, Z., Webster, A., Welham, K. J., Dyer, C. E., Greenman, J., & Haswell, S. J. (2010). Detection of nitric oxide in tissue samples by ESI-MS. Analyst, 135(2), 302-305. https://doi.org/10.1039/b917643h

A novel method to determine nitric oxide (NO) in biological tissue samples with minimal interference from the cellular detritus is described. Methylpiperazinobenzenediamine, consisting of an o-phenylenediamine and a methyl piperazine group, was chose... Read More about Detection of nitric oxide in tissue samples by ESI-MS.

Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome? (2009)
Journal Article
Smith, L., Qutob, O., Watson, M. B., Beavis, A. W., Potts, D., Welham, K. J., …Cawkwell, L. (2009). Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?. Neoplasia, 11(11), 1194-1207. https://doi.org/10.1593/neo.09902

PURPOSE: We aimed to identify putative predictive protein biomarkers of radioresistance. EXPERIMENTAL DESIGN: Three breast cancer cell lines (MCF7, MDA-MB-231, and T47D) were used as in vitro models to study radioresistance. Inherent radiosensitiviti... Read More about Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?.