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All Outputs (30)

Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics (2023)
Working Paper
Manolis, D., Hasan, S., Ettelaie, C., Maraveyas, A., O'Brien, D., Kessler, B., …Nikitenko, L. Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics

Background G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) signalling is implicated in skin-related and cardiovascular diseases, migraine and cancer. However, beyond its agonists and receptor activity-modifying proteins (RA... Read More about Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics.

Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis (2022)
Working Paper
Faulkner, E. C., Moverley, A. A., Hart, S. P., & Nikitenko, L. L. Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis

Increasing age is the main risk factor for chronic lung diseases (CLD) including idiopathic pulmonary fibrosis (IPF). Halting or reversing progression of IPF remains an unmet clinical need due to limited knowledge of underlying mechanisms. In particu... Read More about Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis.

Rapid realist review: Anxiolytic effects of music therapy on mechanically ventilated patients (2021)
Working Paper
Watson, H., & Marshall, P. Rapid realist review: Anxiolytic effects of music therapy on mechanically ventilated patients

Aims To review the literature focusing on anxiety and music therapy as a non-pharmacological anxiolytic for patients receiving mechanical ventilation and to determine the contexts, mechanisms and outcomes of what works for whom and under what circu... Read More about Rapid realist review: Anxiolytic effects of music therapy on mechanically ventilated patients.

How reproducible should research software be? (2021)
Working Paper
Harrison, S., Dasgupta, A., Waldman, S., Henderson, A., & Lovell, C. (2021). How reproducible should research software be?

How reproducible should research software be? In this article, we attempt to answer this question by defining four levels of reproducibility, suggesting criteria to help you decide which level your research software should be at, and recommended prac... Read More about How reproducible should research software be?.

The Horizon Run 5 Cosmological Hydrodynamic Simulation: Probing Galaxy Formation from Kilo- to Giga-parsec Scales (2020)
Working Paper
Lee, J., Shin, J., Snaith, O. N., Kim, Y., Few, C. G., Devriendt, J., …Park, C. The Horizon Run 5 Cosmological Hydrodynamic Simulation: Probing Galaxy Formation from Kilo- to Giga-parsec Scales

Horizon Run 5 (HR5) is a cosmological hydrodynamical simulation which captures the properties of the Universe on a Gpc scale while achieving a resolution of 1kpc. Inside the simulation box we zoom-in on a high-resolution cuboid region with a volume o... Read More about The Horizon Run 5 Cosmological Hydrodynamic Simulation: Probing Galaxy Formation from Kilo- to Giga-parsec Scales.

Impact of Minimum Unit Pricing on Alcohol-Related Emergency Department Attendances in Scotland: A Natural Experiment Study (2020)
Working Paper
So, V., Millard, A. D., Katikireddi, S. V., Deluca, P., Drummond, C., Eadie, D., …Leyland, A. H. Impact of Minimum Unit Pricing on Alcohol-Related Emergency Department Attendances in Scotland: A Natural Experiment Study

Background: Minimum Unit Pricing (MUP) was introduced in Scotland at 50p per unit (8g) of alcohol on 1st May 2018 to reduce alcohol consumption and associated harms. We assessed its impact on alcohol-related emergency department (ED) attendances, dri... Read More about Impact of Minimum Unit Pricing on Alcohol-Related Emergency Department Attendances in Scotland: A Natural Experiment Study.

The effectiveness and characteristics of mHealth interventions to increase adolescent’s use of sexual and reproductive health services in Sub-Saharan Africa: protocol for a systematic review (2020)
Working Paper
Onukwugha, F., Smith, L., Kaseje, . D., Wafula, . C., Kaseje, . M., Were, V., … Magadi, . M. The effectiveness and characteristics of mHealth interventions to increase adolescent’s use of sexual and reproductive health services in Sub-Saharan Africa: protocol for a systematic review

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos (2019)
Working Paper
Muller, B., Lewis, N., Adeniyi, T., Leese, H. J., Brison, D., & Sturmey, R. G. Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos

Background Mitochondria provide the major source of ATP for mammalian oocyte maturation and early embryo development. Oxygen Consumption Rate (OCR) is an established measure of mitochondrial function. OCR by mammalian oocytes and embryos has generall... Read More about Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos.

The Mälardalen University Visiting Professorship in Systemic Innovation: A Report to the Swedish Knowledge Foundation (2017)
Working Paper
Midgley, G. The Mälardalen University Visiting Professorship in Systemic Innovation: A Report to the Swedish Knowledge Foundation

Executive Summary: Over a period of a year (1.4.16 to 31.3.17), the Swedish Knowledge Foundation funded a Visiting Professorship in Systemic Innovation based at Mälardalen University (MDH), Eskilstuna, Sweden. The position was taken by Gerald Midgle... Read More about The Mälardalen University Visiting Professorship in Systemic Innovation: A Report to the Swedish Knowledge Foundation.

Evaluating how System Health Assessment can Trigger Anticipatory Action for Resilience (2017)
Working Paper
Lowe, D., Oliver, P., Midgley, G., & Yearworth, M. Evaluating how System Health Assessment can Trigger Anticipatory Action for Resilience

In 2014 the Defence Science and Technology Laboratory developed and implemented a novel approach to assess the system by which the United Kingdom Ministry of Defence delivers infrastructure projects and services. This approach brought together existi... Read More about Evaluating how System Health Assessment can Trigger Anticipatory Action for Resilience.

Effective and meaningful engagement of older people in health care interventions using co-methodologies: an integrative literature review (protocol) (2017)
Working Paper
Cowdell, F., Taylor, E., Sykes, M., & Dyson, J. Effective and meaningful engagement of older people in health care interventions using co-methodologies: an integrative literature review (protocol)

Review question How can older people most effectively and most meaningfully be engaged in health care intervention design, development or delivery using co-methodologies?

A systematic review examining reducing unplanned hospital admissions in adults with cancer (2017)
Working Paper
Walabyeki, J., Macleod, U., Johnson, M., Dyson, J., Oliver, S., Allgar, V., …Hammond, T. A systematic review examining reducing unplanned hospital admissions in adults with cancer

Review question: 1. What interventions have been tested and have successfully reduced unplanned hospital admissions in adults with cancer? 2. What are the factors associated with unplanned hospital admissions in adults with cancer?

Emerging Trends and New Frontiers in Community Operational Research (2017)
Working Paper
Johnson, M. P., Midgley, G., & Chichirau, G. Emerging Trends and New Frontiers in Community Operational Research

Community operational research (COR), and its disciplinary relation, community-based operations research, have an increasingly high profile within multiple domains that benefit from empirical and analytic approaches to problem solving. Many of these... Read More about Emerging Trends and New Frontiers in Community Operational Research.

What is Systemic Innovation? (2017)
Working Paper
Midgley, G., & Lindhult, E. What is Systemic Innovation?

The term ‘systemic innovation’ is increasing in use. However, there is no consensus on its meaning: four different ways of using the term can be identified in the literature. Most people simply define it as a type of innovation where value can only b... Read More about What is Systemic Innovation?.

Systemic lean intervention: enhancing lean with community operational research (2016)
Working Paper
Ufua, D. E., Papadopoulos, T., & Midgley, G. Systemic lean intervention: enhancing lean with community operational research

This paper discusses how the theory and methodology of Community OR can enhance Lean initiatives. We argue that Lean practice can benefit from going beyond just the involvement of organizational stakeholders: local communities can be swept into the p... Read More about Systemic lean intervention: enhancing lean with community operational research.

Systemic evaluation of a community environmental management programme (2016)
Working Paper
Foote, J., Ahuriri-Driscoll, A., Hepi, M., Midgley, G., & Earl-Goulet, J. Systemic evaluation of a community environmental management programme

Community environmental management (CEM) involves achieving environmental objectives through the facilitation of community partnerships, local dialogues, consultations and participative decision making. This is increasingly seen as a solution to some... Read More about Systemic evaluation of a community environmental management programme.