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Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism (2006)
Journal Article
Nikitenko, L. L., Blucher, N., Fox, S. B., Bicknell, R., Smith, D. M., & Rees, M. C. (2006). Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism. Journal of cell science, 119(5), 910-922. https://doi.org/10.1242/jcs.02783

Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are related peptides with distinct pharmacological profiles. Calcitonin-receptor-like receptor (CRLR, now known as CL) can function as either an AM receptor or a CGRP receptor, when cotra... Read More about Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism.

Adrenomedullin and tumour angiogenesis (2005)
Journal Article
Nikitenko, L. L., Fox, S. B., Kehoe, S., Rees, M. C., & Bicknell, R. (2006). Adrenomedullin and tumour angiogenesis. The British Journal of Cancer, 94(1), 1-7. https://doi.org/10.1038/sj.bjc.6602832

The angiogenic activity of peptide adrenomedullin (AM) was first shown in 1998 . Since then, a number of reports have confirmed the ability of AM to induce the growth and migration of isolated vascular endothelial and smooth muscle cells in vitro and... Read More about Adrenomedullin and tumour angiogenesis.

Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2 (2005)
Journal Article
Carroll, V. A., Nikitenko, L. L., Bicknell, R., & Harris, A. L. (2005). Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(4), 736-741. https://doi.org/10.1161/01.ATV.0000157980.15710.2b

Objective - The thrombolytic therapy drug, Reteplase, is a domain deletion mutant of tissue plasminogen activator (tPA), comprising the kringle 2 and protease (K2P) domains. Some kringle domains of hemostatic proteins are antiangiogenic and promote a... Read More about Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2.

Adrenomedullin: Multiple functions in human pregnancy (2004)
Journal Article
Wilson, C., Nikitenko, L. L., Sargent, I. L., & Rees, M. C. (2004). Adrenomedullin: Multiple functions in human pregnancy. Angiogenesis, 7(3), 203-212. https://doi.org/10.1007/s10456-004-4183-5

Adrenomedullin is a 52 amino acid peptide originally isolated from human phaeochromocytoma in 1993. It was initially demonstrated to have profound effects on the vasculature including vasodilatation and subsequently promotion of angiogenesis. Since t... Read More about Adrenomedullin: Multiple functions in human pregnancy.

Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. (2003)
Journal Article
Nikitenko, L. L., Smith, D. M., Bicknell, R., & Rees, M. C. (2003). Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. FASEB Journal, 17(11), 1499-1501. https://doi.org/10.1096/fj.02-0993fje

Adrenomedullin is a 52 amino acid peptide that shows a remarkable range of effects on the vasculature that include inter alia, vasodilatation, regulation of permeability, inhibition of endothelial cell apoptosis, and promotion of angiogenesis. Recent... Read More about Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia..

Adrenomedullin and the microvasculature (2002)
Journal Article
Nikitenko, L. L., Smith, D. M., Hague, S., Wilson, C. R., Bicknell, R., & Rees, M. C. (2002). Adrenomedullin and the microvasculature. Trends in Pharmacological Sciences, 23(3), 101-103. https://doi.org/10.1016/S0165-6147%2800%2901983-0

The peptide adrenomedullin shows a remarkable range of effects on the vasculature that include vasodilatation, regulation of vascular smooth muscle cell proliferation, inhibition of endothelial apoptosis and promotion of angiogenesis. It is becoming... Read More about Adrenomedullin and the microvasculature.

Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus (2001)
Journal Article
Nikitenko, L. L., Brown, N. S., Smith, D. M., MacKenzie, I. Z., Bicknell, R., & Rees, M. C. (2001). Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus. Molecular Human Reproduction, 7(7), 655-664. https://doi.org/10.1093/molehr/7.7.655

The calcitonin receptor-like receptor (CRLR) can function as a receptor for either calcitonin gene-related peptide (CGRP) or adrenomedullin (AM), depending upon co-expression with members of a novel family of receptor activity-modifying proteins (RAM... Read More about Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus.

Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium (2000)
Journal Article
Nikitenko, L. L., MacKenzie, I. Z., Rees, M. C., & Bicknell, R. (2000). Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium. Molecular Human Reproduction, 6(9), 811-819. https://doi.org/10.1093/molehr/6.9.811

Human endometrium is a mucosa served by a microvascular blood supply that involves benign angiogenesis under the control of ovarian steroids throughout reproductive life. Adrenomedullin is a multifunctional 52-amino acid peptide involved in numerous... Read More about Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium.

Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens (2000)
Journal Article
Nikitenko, L. L., Lloyd, B. H., Rudland, P. S., Fear, S., & Barraclough, R. (2000). Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens. International journal of cancer. Journal international du cancer, 86(2), 219-228. https://doi.org/10.1002/%28SICI%291097-0215%2820000415%2986%3A2%3C219%3A%3AAID-IJC11%3E3.0.CO%3B2-7

Rodent S 100A4 (p9Ka) induces a metastatic phenotype in benign rat mammary tumour cells and cooperates with the neu oncogene to produce metastatic tumours in a transgenic mouse model system. Human S 100A4 possesses similar metastasis-inducing propert... Read More about Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens.

Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy (1998)
Journal Article
Nikitenko, L., Morgan, G., Kolesnikov, S. I., & Wooding, F. B. (1998). Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy. Journal of Histochemistry and Cytochemistry, 46(5), 679-688. https://doi.org/10.1177/002215549804600513

The fetus must transport considerable and increasing amounts of calcium across the placental trophoblast epithelium to support growth and development and bone formation. Active calcium transport across epithelia has been shown to correlate with calbi... Read More about Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy.