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Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease (2016)
Journal Article
Berthaume, M. A., Perry, D. C., Dobson, C. A., Witzel, U., Clarke, N. M., & Fagan, M. J. (2016). Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease. Clinical Anatomy, 29(6), 759-772. https://doi.org/10.1002/ca.22690

Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. The etiology of the disease remains largely unknown, but the mechanism is believed to be vascular and/or biom... Read More about Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease.

Integrating user-centred design in the development of a silent speech interface based on permanent magnetic articulography (2015)
Book Chapter
Cheah, L. A., Gilbert, J. M., Gonzalez, J. A., Bai, J., Ell, S. R., Fagan, M. J., …Rychenko, S. I. (2015). Integrating user-centred design in the development of a silent speech interface based on permanent magnetic articulography. In Biomedical Engineering Systems and Technologies; Communications in Computer and Information Science (324-337). Springer Verlag. https://doi.org/10.1007/978-3-319-27707-3_20

Abstract: A new wearable silent speech interface (SSI) based on Permanent Magnetic Articulography (PMA) was developed with the involvement of end users in the design process. Hence, desirable features such as appearance, port-ability, ease of use and... Read More about Integrating user-centred design in the development of a silent speech interface based on permanent magnetic articulography.

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z., Gustafson, J., Cunningham, M. L., …Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126. https://doi.org/10.1016/j.jbiomech.2015.11.012

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More about Intracranial pressure changes during mouse development.

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance (2015)
Journal Article
Toro-Ibacache, V., Fitton, L. C., Fagan, M. J., & O'Higgins, P. (2016). Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance. Journal of anatomy, 228(1), 70-84. https://doi.org/10.1111/joa.12384

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investi... Read More about Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance.

A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease (2015)
Journal Article
Ji, B., Genever, P. G., & Fagan, M. J. (2016). A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease. International journal for numerical methods in biomedical engineering, 32(3), e02735. https://doi.org/10.1002/cnm.2735

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have... Read More about A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease.

Mechanical properties of calvarial bones in a mouse model for craniosynostosis (2015)
Journal Article
Moazen, M., Peskett, E., Babbs, C., Pauws, E., & Fagan, M. J. (2015). Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PLoS ONE, 10(5), e0125757. https://doi.org/10.1371/journal.pone.0125757

The mammalian cranial vault largely consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Premature closure of the cranial sutures, craniosynostosis, can lead to serious clinical pathology unle... Read More about Mechanical properties of calvarial bones in a mouse model for craniosynostosis.

Foam pads properties and their effects on posturography in participants of different weight (2015)
Journal Article
Fagan, M., & Gosselin, G. (2015). Foam pads properties and their effects on posturography in participants of different weight. Chiropractic & manual therapies, 23(2), Article ARTN 2. https://doi.org/10.1186/s12998-014-0045-4

Background: Foam pads are increasingly used on force platforms during balance assessments in order to produce increased instability thereby permitting the measurement of enhanced posturographic parameters. A variety of foam pads providing different m... Read More about Foam pads properties and their effects on posturography in participants of different weight.

Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis (2014)
Journal Article
Watson, P. J., Fagan, M. J., & Dobson, C. A. (2015). Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 229(1), 9-19. https://doi.org/10.1177/0954411914564476

Biomechanical analysis of juvenile pelvic growth can be used in the evaluation of medical devices and investigation of hip joint disorders. This requires access to scan data of healthy juveniles, which are not always freely available. This article an... Read More about Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis.

Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model (2014)
Journal Article
Ji, B., Yang, Q., Genever, P. G., & Fagan, M. J. (2014). Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model. Bio-medical materials and engineering, 24(6), 3373-3378. https://doi.org/10.3233/BME-141160

Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentia... Read More about Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model.

Masticatory biomechanics in the rabbit: a multi-body dynamics analysis (2014)
Journal Article
Watson, P. J., Gröning, F., Curtis, N., Fitton, L. C., Herrel, A., McCormack, S. W., & Fagan, M. J. (2014). Masticatory biomechanics in the rabbit: a multi-body dynamics analysis. Journal of the Royal Society interface / the Royal Society, 11(99), Article 20140564. https://doi.org/10.1098/rsif.2014.0564

Multi-body dynamics is a powerful engineering tool which is becoming increasingly popular for the simulation and analysis of skull biomechanics. This paper presents the first application of multi-body dynamics to analyse the biomechanics of the rabbi... Read More about Masticatory biomechanics in the rabbit: a multi-body dynamics analysis.

The biomechanical function of periodontal ligament fibres in orthodontic tooth movement (2014)
Journal Article
McCormack, S. W., Witzel, U., Watson, P. J., Fagan, M. J., & Gröning, F. (2014). The biomechanical function of periodontal ligament fibres in orthodontic tooth movement. PLoS ONE, 9(7), e102387. https://doi.org/10.1371/journal.pone.0102387

Orthodontic tooth movement occurs as a result of resorption and formation of the alveolar bone due to an applied load, but the stimulus responsible for triggering orthodontic tooth movement remains the subject of debate. It has been suggested that th... Read More about The biomechanical function of periodontal ligament fibres in orthodontic tooth movement.

In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri (2014)
Journal Article
Porro, L. B., Ross, C. F., Iriarte-Diaz, J., O'Reilly, J. C., Evans, S. E., & Fagan, M. J. (2014). In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri. The journal of experimental biology, 217(11), 1983-1992. https://doi.org/10.1242/jeb.096362

In vivo bone strain data are the most direct evidence of deformation and strain regimes in the vertebrate cranium during feeding and can provide important insights into skull morphology. Strain data have been collected during feeding across a wide ra... Read More about In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri.

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease (2014)
Journal Article
Ji, B., Genever, P. G., Patton, R. J., & Fagan, M. J. (2014). Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease. International journal for numerical methods in biomedical engineering, 30(11), 1085-1102. https://doi.org/10.1002/cnm.2645

Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM-in... Read More about Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease.

Effects of cervical muscle fatigue on the perception of the subjective vertical and horizontal (2014)
Journal Article
Gosselin, G., & Fagan, M. J. (2014). Effects of cervical muscle fatigue on the perception of the subjective vertical and horizontal. SpringerPlus, 3(1), Article 78. https://doi.org/10.1186/2193-1801-3-78

Introduction: Cervical functional capacity outcome measures that are simple and reliable are urgently needed in order permit accurate assessment/reassessment during treatments and rehabilitation. Induced neck muscle fatigue has been shown to alter fu... Read More about Effects of cervical muscle fatigue on the perception of the subjective vertical and horizontal.

Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls (2014)
Journal Article
Curtis, N., Witzel, U., & Fagan, M. J. (2014). Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls. Folia primatologica, 85(2), 77-87. https://doi.org/10.1159/000357526

Cranial sutures are an essential part of the growing skull, allowing bones to increase in size during growth, with their morphology widely believed to be dictated by the forces and displacements that they experience. The zygomaticotemporal suture in... Read More about Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls.

A predator-prey based mathematical model of the bone remodelling cycle: Exploring the relationship between the model parameters and biochemical factors (2014)
Journal Article
Ji, B., Yang, Q., Genever, P. G., Patton, R. J., & Fagan, M. J. (2014). A predator-prey based mathematical model of the bone remodelling cycle: Exploring the relationship between the model parameters and biochemical factors. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228(10), 1035-1042. https://doi.org/10.1177/0954411914554633

© IMechE 2014. Bone remodelling is a vital process which enables bone to repair, renew and optimize itself. Disorders in the bone remodelling process are inevitably manifested in bone-related diseases, such as hypothyroidism, primary hyperparathyroid... Read More about A predator-prey based mathematical model of the bone remodelling cycle: Exploring the relationship between the model parameters and biochemical factors.

The effects of cervical muscle fatigue on balance - A study with elite amateur rugby league players (2014)
Journal Article
Gosselin, G., & Fagan, M. J. (2014). The effects of cervical muscle fatigue on balance - A study with elite amateur rugby league players. Journal of sports science & medicine, 13(2), 329-337

Neck muscle fatigue has been shown to alter an individual’s balance in a similar way to that reported in subjects suffering from neck pain or subjects that have suffered a neck injury. The main purpose of the present study was to quantify the effects... Read More about The effects of cervical muscle fatigue on balance - A study with elite amateur rugby league players.

Erratum: Cranial sutures work collectively to distribute strain throughout the reptile skull (Journal of The Royal Society Interface (2013) 10 (2013044) DOI: 10.1098/rsif.2013.0442) (2013)
Journal Article
Curtis, N., Jones, M. E., Evans, S. E., O'Higgins, P., & Fagan, M. J. (2013). Erratum: Cranial sutures work collectively to distribute strain throughout the reptile skull (Journal of The Royal Society Interface (2013) 10 (2013044) DOI: 10.1098/rsif.2013.0442). Journal of the Royal Society interface / the Royal Society, 10(87), Article 2013044. https://doi.org/10.1098/rsif.2013.0584

Figure 4 was presented incorrectly, with (a) and (b) displaying the same bite position. The corrected figure below shows different bite positions for (a) and (b) as was initially intended.

The importance of accurate muscle modelling for biomechanical analyses: A case study with a lizard skull (2013)
Journal Article
Gröning, F., Jones, M. E., Curtis, N., Herrel, A., O'Higgins, P., Evans, S. E., & Fagan, M. J. (2013). The importance of accurate muscle modelling for biomechanical analyses: A case study with a lizard skull. Journal of the Royal Society interface / the Royal Society, 10(84), Article 20130216. https://doi.org/10.1098/rsif.2013.0216

Computer-based simulation techniques such as multi-body dynamics analysis are becoming increasingly popular in the field of skull mechanics. Multi-body models can be used for studying the relationships between skull architecture, muscle morphology an... Read More about The importance of accurate muscle modelling for biomechanical analyses: A case study with a lizard skull.

Cranial sutures work collectively to distribute strain throughout the reptile skull (2013)
Journal Article
Curtis, N., Fagan, M. J., Evans, S. E., Jones, M. E. H., & O'Higgins, P. (2013). Cranial sutures work collectively to distribute strain throughout the reptile skull. Journal of the Royal Society interface / the Royal Society, 10(86), 1-9. https://doi.org/10.1098/rsif.2013.0442

The skull is composed of many bones that come together at sutures. These sutures are important sites of growth, and as growth ceases some become fused while others remain patent. Their mechanical behaviour and how they interact with changing form and... Read More about Cranial sutures work collectively to distribute strain throughout the reptile skull.