All Outputs (111)

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. https://doi.org/10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More about The role of miniaturization in the evolution of the mammalian jaw and middle ear.

Validation of an algorithm to reveal the U wave in atrial fibrillation (2018)
Journal Article
Al-Karadi, M. S., Wilkinson, A. J., Caldwell, J., & Langley, P. (2018). Validation of an algorithm to reveal the U wave in atrial fibrillation. Scientific reports, 8(1), Article 11946. https://doi.org/10.1038/s41598-018-30493-8

Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U... Read More about Validation of an algorithm to reveal the U wave in atrial fibrillation.

Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering (2018)
Journal Article
Qi, J., Zhang, H., Wang, Y., Mani, M. P., & Jaganathan, S. K. (2018). Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering. International Journal of Nanomedicine, 13, 2777-2788. https://doi.org/10.2147/IJN.S151242

Introduction: Currently, the design of extracellular matrix (ECM) with nanoscale properties in bone tissue engineering is challenging. For bone tissue engineering, the ECM must have certain properties such as being nontoxic, highly porous, and should... Read More about Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering.

Simultaneous determination of ascorbic acid, dopamine and uric acid by a novel electrochemical sensor based on N2/Ar RF plasma assisted graphene nanosheets/graphene nanoribbons (2018)
Journal Article
Jothi, L., Neogi, S., Jaganathan, S. K., & Nageswaran, G. (2018). Simultaneous determination of ascorbic acid, dopamine and uric acid by a novel electrochemical sensor based on N2/Ar RF plasma assisted graphene nanosheets/graphene nanoribbons. Biosensors & bioelectronics, 105, 236-242. https://doi.org/10.1016/j.bios.2018.01.040

© 2018 Elsevier B.V. A novel nitrogen/argon (N2/Ar) radio frequency (RF) plasma functionalized graphene nanosheet/graphene nanoribbon (GS/GNR) hybrid material (N2/Ar/GS/GNR) was developed for simultaneous determination of ascorbic acid (AA), dopamine... Read More about Simultaneous determination of ascorbic acid, dopamine and uric acid by a novel electrochemical sensor based on N2/Ar RF plasma assisted graphene nanosheets/graphene nanoribbons.

The biomechanical role of the chondrocranium and sutures in a lizard cranium (2017)
Journal Article
Jones, M. E. H., Gröning, F., Dutel, H., Sharp, A., Fagan, M. J., & Evans, S. E. (2017). The biomechanical role of the chondrocranium and sutures in a lizard cranium. Journal of the Royal Society interface / the Royal Society, 14(137), Article 20170637. https://doi.org/10.1098/rsif.2017.0637

The role of soft tissues in skull biomechanics remains poorly understood. Not least, the chondrocranium, the portion of the braincase which persists as cartilage with varying degrees of mineralization. It also remains commonplace to overlook the biom... Read More about The biomechanical role of the chondrocranium and sutures in a lizard cranium.

Heart sound classification from unsegmented phonocardiograms (2017)
Journal Article
Langley, P., & Murray, A. (2017). Heart sound classification from unsegmented phonocardiograms. Physiological Measurement, 38(8), 1658-1670. https://doi.org/10.1088/1361-6579/aa724c

Objective Most algorithms for automated analysis of phonocardiograms (PCG) require segmentation of the signal into the characteristic heart sounds. The aim was to assess the feasibility for accurate classification of heart sounds on short, unsegmente... Read More about Heart sound classification from unsegmented phonocardiograms.

Form-function relationships in dragonfly mandibles under an evolutionary perspective (2017)
Journal Article
Blanke, A., Schmitz, H., Patera, A., Dutel, H., & Fagan, M. J. (2017). Form-function relationships in dragonfly mandibles under an evolutionary perspective. Journal of the Royal Society interface / the Royal Society, 14(128), Article 20161038. https://doi.org/10.1098/rsif.2016.1038

© 2017 The Author(s). Functional requirements may constrain phenotypic diversification or foster it. For insect mouthparts, the quantification of the relationship between shape and function in an evolutionary framework remained largely unexplored. He... Read More about Form-function relationships in dragonfly mandibles under an evolutionary perspective.

Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs. A computational study (2017)
Journal Article
Alday, E. A. P., Colman, M. A., Langley, P., & Zhang, H. (2017). Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs. A computational study. PLoS Computational Biology, 13(3), e1005270. https://doi.org/10.1371/journal.pcbi.1005270

Atrial tachy-arrhytmias, such as atrial fibrillation (AF), are characterised by irregular electrical activity in the atria, generally associated with erratic excitation underlain by re-entrant scroll waves, fibrillatory conduction of multiple wavelet... Read More about Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs. A computational study.

Accuracy of pulse interval timing in ambulatory blood pressure measurement (2016)
Journal Article
Kane, S. A., Blake, J. R., McArdle, F. J., Langley, P., & Sims, A. J. (2016). Accuracy of pulse interval timing in ambulatory blood pressure measurement. Scientific reports, 6(1), Article 37472. https://doi.org/10.1038/srep37472

Blood pressure (BP) monitors rely on pulse detection. Some blood pressure monitors use pulse timings to analyse pulse interval variability for arrhythmia screening, but this assumes that the pulse interval timings detected from BP cuffs are accurate... Read More about Accuracy of pulse interval timing in ambulatory blood pressure measurement.

Morphological evolution of the mammalian jaw adductor complex (2016)
Journal Article
Lautenschlager, S., Gill, P., Luo, Z., Fagan, M. J., & Rayfield, E. J. (2017). Morphological evolution of the mammalian jaw adductor complex. Biological Reviews, 92(4), 1910-1940. https://doi.org/10.1111/brv.12314

The evolution of the mammalian jaw during the transition from non-mammalian synapsids to crown mammals is a key event in vertebrate history and characterised by the gradual reduction of its individual bones into a single element and the concomitant t... Read More about Morphological evolution of the mammalian jaw adductor complex.

A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs (2016)
Journal Article
Sivaraman, J., Uma, G., Langley, P., Umapathy, M., Venkatesan, S., & Palanikumar, G. (2016). A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs. Computer Methods and Programs in Biomedicine, 137, 341-351. https://doi.org/10.1016/j.cmpb.2016.10.005

© 2016 Elsevier Ireland Ltd Background The interaction between the PTa and PP interval dynamics from the surface ECG is seldom explained. Mathematical modeling of these intervals is of interest in finding the relationship between the heart rate and r... Read More about A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs.

The atrial T wave: The elusive electrocardiographic wave exposed by a case of shifting atrial pacemaker (2016)
Journal Article
Langley, P., & Caldwell, J. (2016). The atrial T wave: The elusive electrocardiographic wave exposed by a case of shifting atrial pacemaker. Journal of Electrocardiology, 49(4), 557-559. https://doi.org/10.1016/j.jelectrocard.2016.05.003

The atrial T wave (Ta wave) is the body surface manifestation of atrial repolarisation and, unlike the P wave (atrial depolarisation), is little recognised. We report the case of a patient with shifting pacemaker which clearly demonstrates the effect... Read More about The atrial T wave: The elusive electrocardiographic wave exposed by a case of shifting atrial pacemaker.

Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review (2016)
Journal Article
Kane, S. A., Blake, J. R., McArdle, F. J., Langley, P., & Sims, A. J. (2016). Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review. Open heart, 3(1), e000362. https://doi.org/10.1136/openhrt-2015-000362

Background: Atrial Fibrillation (AF) affects around 2% of the population and early detection is beneficial, allowing patients to begin potentially life-saving anticoagulant therapies. Blood pressure (BP) monitors may offer an opportunity to screen fo... Read More about Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review.

Abnormal heart sounds detected from short duration unsegmented phonocardiograms by wavelet entropy (2016)
Journal Article
Langley, P., & Murray, A. (2016). Abnormal heart sounds detected from short duration unsegmented phonocardiograms by wavelet entropy. Computing in cardiology, 43, 545-548. https://doi.org/10.22489/cinc.2016.156-268

© 2016 CCAL. Segmentation of the characteristic heart sounds is thought to be an essential requirement for the automatic classification of phonocardiograms. The aim of this work was to test the feasibility of classification using short duration, unse... Read More about Abnormal heart sounds detected from short duration unsegmented phonocardiograms by wavelet entropy.

A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study (2016)
Journal Article
Clewett, C. J., Langley, P., Bateson, A. D., Asghar, A., & Wilkinson, A. J. (2016). A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study. Health Technology Letters, 3(1), 2-5. https://doi.org/10.1049/htl.2015.0037

Hypoglycaemia unawareness is a common condition associated with increased risk of severe hypoglycaemia. The purpose of the authors' study was to develop a simple to use, home-based and non-invasive hypoglycaemia warning system based on electroencepha... Read More about A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study.

Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study (2016)
Journal Article
Moazen, M., Leonidou, A., Pagkalos, J., Marghoub, A., Fagan, M. J., & Tsiridis, E. (2016). Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study. Journal of Arthroplasty, 31(8), 1849-1856. https://doi.org/10.1016/j.arth.2016.02.013

© 2016 Elsevier Inc. Background Lack of fracture movement could be a potential cause of periprosthetic femoral fracture (PFF) fixation failures. This study aimed to test whether the use of distal far cortical locking screws reduces the overall stiffn... Read More about Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study.

The U wave in atrial fibrillation (2016)
Journal Article
Langley, P., Bourke, J. P., & Murray, A. (2016). The U wave in atrial fibrillation. Computing in cardiology, 42, 833-836. https://doi.org/10.1109/cic.2015.7411040

The U wave in ECGs of patients is difficult to observe because it is hidden under the atrial fibrillatory wave. Measurement and characteristics of the U wave in atrial fibrillation have not previously been described. Beat averaging was used to reveal... Read More about The U wave in atrial fibrillation.

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z., Gustafson, J., Cunningham, M. L., …Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126. https://doi.org/10.1016/j.jbiomech.2015.11.012

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More about Intracranial pressure changes during mouse development.

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance (2015)
Journal Article
Toro-Ibacache, V., Fitton, L. C., Fagan, M. J., & O'Higgins, P. (2016). Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance. Journal of anatomy, 228(1), 70-84. https://doi.org/10.1111/joa.12384

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investi... Read More about Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance.

Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation (2015)
Journal Article
Langley, P. (2015). Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation. Entropy, 17(9), 6397-6411. https://doi.org/10.3390/e17096397

A novel method of quantifying the effectiveness of the suppression of ventricular activity from electrocardiograms (ECGs) in atrial fibrillation is proposed. The temporal distribution of the energy of wavelet coefficients is quantified by wavelet ent... Read More about Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation.