All Outputs (15)

Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport (2022)
Book Chapter
Voelzmann, A., & Sanchez-Soriano, N. (2022). Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport. In A. Vagnoni (Ed.), Axonal Transport (429-449). Humana Press. https://doi.org/10.1007/978-1-0716-1990-2_23

The use of primary neuronal cultures generated from Drosophila tissue provides a powerful model for studies of transport mechanisms. Cultured fly neurons provide similarly detailed subcellular resolution and applicability of pharmacology or fluoresce... Read More about Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport.

Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons (2021)
Journal Article
Hahn, I., Voelzmann, A., Parkin, J., Fülle, J. B., Slater, P. G., Lowery, L. A., Sanchez-Soriano, N., & Prokop, A. (2021). Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons. PLoS Genetics, 17(7), Article e1009647. https://doi.org/10.1371/journal.pgen.1009647

The formation and maintenance of microtubules requires their polymerisation, but little is known about how this polymerisation is regulated in cells. Focussing on the essential microtubule bundles in axons of Drosophila and Xenopus neurons, we show t... Read More about Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons.

Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age-A nd combination-specific phenotypic profiles in Drosophila (2020)
Journal Article
West, R. J., Sharpe, J. L., Voelzmann, A., Munro, A. L., Hahn, I., Baines, R. A., & Pickering-Brown, S. (2020). Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age-A nd combination-specific phenotypic profiles in Drosophila. Acta Neuropathologica Communications, 8(1), Article 158. https://doi.org/10.1186/s40478-020-01028-y

A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this expansion is... Read More about Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age-A nd combination-specific phenotypic profiles in Drosophila.

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex (2019)
Journal Article
Qu, Y., Hahn, I., Lees, M., Parkin, J., Voelzmann, A., Dorey, K., Rathbone, A., Friel, C. T., Allan, V. J., Okenve-Ramos, P., Sanchez-Soriano, N., & Prokop, A. (2019). Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex. eLife, 8, Article e50319. https://doi.org/10.7554/eLife.50319

Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmenta... Read More about Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex.

The model of local axon homeostasis - Explaining the role and regulation of microtubule bundles in axon maintenance and pathology (2019)
Journal Article
Hahn, I., Voelzmann, A., Liew, Y. T., Costa-Gomes, B., & Prokop, A. (2019). The model of local axon homeostasis - Explaining the role and regulation of microtubule bundles in axon maintenance and pathology. Neural Development, 14(1), Article 11. https://doi.org/10.1186/s13064-019-0134-0

Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them key lesi... Read More about The model of local axon homeostasis - Explaining the role and regulation of microtubule bundles in axon maintenance and pathology.

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements (2018)
Journal Article
Sociale, M., Wulf, A. L., Breiden, B., Klee, K., Thielisch, M., Eckardt, F., Sellin, J., Bülow, M. H., Löbbert, S., Weinstock, N., Voelzmann, A., Schultze, J., Sandhoff, K., & Bauer, R. (2018). Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Cell reports, 22(4), 967-978. https://doi.org/10.1016/j.celrep.2017.12.090

Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular energy state via transcriptional regulators. Here, we identify a role of ceramide synthase (CerS) Schlank, a multiple transmembrane protein containing a catalyt... Read More about Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements.

Debris buster is a Drosophila scavenger receptor essential for airway physiology (2017)
Journal Article
Wingen, A., Carrera, P., Ekaterini Psathaki, O., Voelzmann, A., Paululat, A., & Hoch, M. (2017). Debris buster is a Drosophila scavenger receptor essential for airway physiology. Developmental Biology, 430(1), 52-68. https://doi.org/10.1016/j.ydbio.2017.08.018

Scavenger receptors class B (SR-B) are multifunctional transmembrane proteins, which in vertebrates participate in lipid transport, pathogen clearance, lysosomal delivery and intracellular sorting. Drosophila has 14 SR-B members whose functions are s... Read More about Debris buster is a Drosophila scavenger receptor essential for airway physiology.

Drosophila Short stop as a paradigm for the role and regulation of spectraplakins (2017)
Journal Article
Voelzmann, A., Liew, Y. T., Qu, Y., Hahn, I., Melero, C., Sánchez-Soriano, N., & Prokop, A. (2017). Drosophila Short stop as a paradigm for the role and regulation of spectraplakins. Seminars in Cell & Developmental Biology, 69, 40-57. https://doi.org/10.1016/j.semcdb.2017.05.019

Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true members of three protein families: plakins, spectrins and Gas2-like proteins. Spectraplakin genes encode at least 7 characteristic functional domains which a... Read More about Drosophila Short stop as a paradigm for the role and regulation of spectraplakins.

Ohgata, the single Drosophila ortholog of human cereblon, regulates insulin signaling-dependent organismic growth (2016)
Journal Article
Wakabayashi, S., Sawamura, N., Voelzmann, A., Broemer, M., Asahi, T., & Hoch, M. (2016). Ohgata, the single Drosophila ortholog of human cereblon, regulates insulin signaling-dependent organismic growth. Journal of Biological Chemistry, 291(48), 25120-25132. https://doi.org/10.1074/jbc.M116.757823

Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that is highly conserved in animals and plants. CRBN proteins have been implicated in various biological processes such as development, metabolism, learning, and memory format... Read More about Ohgata, the single Drosophila ortholog of human cereblon, regulates insulin signaling-dependent organismic growth.

A conceptual view at microtubule plus end dynamics in neuronal axons (2016)
Journal Article
Voelzmann, A., Hahn, I., Pearce, S. P., Sánchez-Soriano, N., & Prokop, A. (2016). A conceptual view at microtubule plus end dynamics in neuronal axons. Brain Research Bulletin, 126(3), 226-237. https://doi.org/10.1016/j.brainresbull.2016.08.006

Axons are the cable-like protrusions of neurons which wire up the nervous system. Polar bundles of microtubules (MTs) constitute their structural backbones and are highways for life-sustaining transport between proximal cell bodies and distal synapse... Read More about A conceptual view at microtubule plus end dynamics in neuronal axons.

Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking (2016)
Journal Article
Voelzmann, A., Okenve-Ramos, P., Qu, Y., Chojnowska-Monga, M., del Caño-Espinel, M., Prokop, A., & Sanchez-Soriano, N. (2016). Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking. eLife, 5, Article e14694. https://doi.org/10.7554/elife.14694

The mechanisms regulating synapse numbers during development and ageing are essential for normal brain function and closely linked to brain disorders including dementias. Using Drosophila, we demonstrate roles of the microtubule-associated protein Ta... Read More about Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking.

Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif (2016)
Journal Article
Voelzmann, A., Wulf, A. L., Eckardt, F., Thielisch, M., Brondolin, M., Pesch, Y. Y., Sociale, M., Bauer, R., & Hoch, M. (2016). Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif. FEBS Letters, 590(7), 971-981. https://doi.org/10.1002/1873-3468.12125

Drosophila Ceramide Synthase (CerS) Schlank regulates both ceramide synthesis and fat metabolism. Schlank contains a catalytic lag1p motif and, like many CerS in other species, a homeodomain of unknown function. Here, we show that the Drosophila CerS... Read More about Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif.

Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling (2014)
Journal Article
Mass, E., Wachten, D., Aschenbrenner, A. C., Voelzmann, A., & Hoch, M. (2014). Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling. Developmental Cell, 28(6), 711-726. https://doi.org/10.1016/j.devcel.2014.02.012

Calcineurin is a heteromeric Ca²⁺-dependent serine/threonine phosphatase. It dephosphorylates the transcription factor nuclear factor of activated Tcells (NFAT) in the cytoplasm, which subsequently undergoes nuclear translocation. NFAT reg... Read More about Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling.

Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS (2011)
Journal Article
Voelzmann, A., & Bauer, R. (2011). Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS. Gene Expression Patterns, 11(8), 501-510. https://doi.org/10.1016/j.gep.2011.08.006

Schlank is a member of the highly conserved ceramide synthase family and controls growth and body fat in Drosophila. Ceramide synthases are key enzymes in the sphingolipid de novo synthesis pathway. Ceramide synthase proteins and the (dihydro)ceramid... Read More about Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS.

Ceramide synthases in mammalians, worms, and insects: Emerging schemes (2010)
Journal Article
Voelzmann, A., & Bauer, R. (2010). Ceramide synthases in mammalians, worms, and insects: Emerging schemes. BioMolecular Concepts, 1(5-6), 411-422. https://doi.org/10.1515/bmc.2010.028

The ceramide synthase (CerS) gene family comprises a group of highly conserved transmembrane proteins, which are found in all studied eukaryotes. The key feature of the CerS proteins is their role in ceramide synthase activity. Therefore, their origi... Read More about Ceramide synthases in mammalians, worms, and insects: Emerging schemes.