All Outputs (5)

Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor (2025)
Journal Article
Featherby, S. J., Faulkner, E. C., Maraveyas, A., & Ettelaie, C. (2025). Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor. Cancers, 17(4), Article 644. https://doi.org/10.3390/cancers17040644

Background: Interactions between tissue factor (TF) and β1-integrin induce cell signals, but the molecular mechanisms are not completely understood. The extracellular domain of TF and EGF4-βTD domains of β1-integrin were hypothesised to be the most l... Read More about Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor.

Tissue factor signalling modifies the expression and regulation of G1/S checkpoint regulators: Implications during injury and prolonged inflammation (2024)
Journal Article
Featherby, S., Faulkner, E., & Ettelaie, C. (2025). Tissue factor signalling modifies the expression and regulation of G1/S checkpoint regulators: Implications during injury and prolonged inflammation. Molecular Medicine Reports, 31(2), Article 39. https://doi.org/10.3892/mmr.2024.13404

Tissue factor (TF) possesses additional physiological functions beyond initiating the coagulation cascade. Cellular signals initiated by cellular TF or on contact with TF-containing microvesicles, contribute to wound healing through regulating a numb... Read More about Tissue factor signalling modifies the expression and regulation of G1/S checkpoint regulators: Implications during injury and prolonged inflammation.

Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis (2024)
Thesis
Faulkner, E. C. Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866422

Introduction
Older age is the main risk factor for idiopathic pulmonary fibrosis (IPF). Ageing-related changes in lung blood (pulmonary and bronchial) and lymphatic vessels are implicated in IPF pathophysiology, based on reports of their altered den... Read More about Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis.

A Patient's Guide to Pulmonary Fibrosis, Second Edition (2022)
Other
Jagielka, K., Hockin, E., Faulkner, E. C., Hart, S., & Nikitenko, L. L. (2022). A Patient's Guide to Pulmonary Fibrosis, Second Edition. [print]

Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis (2022)
Preprint / Working Paper
Faulkner, E. C., Moverley, A. A., Hart, S. P., & Nikitenko, L. L. Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis

Increasing age is the main risk factor for chronic lung diseases (CLD) including idiopathic pulmonary fibrosis (IPF). Halting or reversing progression of IPF remains an unmet clinical need due to limited knowledge of underlying mechanisms. In particu... Read More about Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis.