All Outputs (31)

Morphine for chronic breathlessness (MABEL) in the UK: a health economic evaluation of a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial (2025)
Journal Article
Atter, M. J., Hall, P., Evans, R., Norrie, J., Cohen, J., Williams, B., Chaudhuri, N., Bajwah, S., Higginson, I., Pearson, M., Currow, D., Stewart, G., Fallon, M., & Johnson, M. (2025). Morphine for chronic breathlessness (MABEL) in the UK: a health economic evaluation of a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial. BMJ open, 15, e102124. https://doi.org/10.1136/bmjopen-2025-102124

Objectives: To compare costs and health consequences and to assess the cost-effectiveness of using low-dose oral long-acting morphine in people with chronic breathlessness.
Design: Within-trial planned cost-consequences and cost-effectiveness analy... Read More about Morphine for chronic breathlessness (MABEL) in the UK: a health economic evaluation of a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial.

Morphine for chronic breathlessness (MABEL) in the UK: a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial (2025)
Journal Article
Johnson, M. J., Williams, B., Keerie, C., Tuck, S., Hart, S., Bajwah, S., Chaudhuri, N., Pearson, M., Cohen, J., Evans, R. A., Currow, D. C., Higginson, I. J., Hall, P., Atter, M., Norrie, J., Fallon, M. T., Hart, S., Barrett, S., Bayes, H., …Jones, A. (2025). Morphine for chronic breathlessness (MABEL) in the UK: a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial. The lancet. Respiratory medicine, 13(11), 967-977. https://doi.org/10.1016/S2213-2600%2825%2900205-X

Background: The effectiveness of opioids for breathlessness seen in laboratory-based studies has not been replicated in clinical trials. We aimed to assess the effectiveness of oral morphine for breathlessness in long-term conditions. Methods: This p... Read More about Morphine for chronic breathlessness (MABEL) in the UK: a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial.

Phase II randomised controlled basket feasibility trial of a personalised, remotely delivered exercise programme on disease-free survival among early-stage, high-risk cancers: CANFit study protocol (2025)
Journal Article
Bullock, A. F., Cohen, J., Huang, C., Jackson, G., Lind, M., Pearson, M., Richardson, G., Saxton, J., Twiddy, M., Wilson, C., & Forbes, C. (2025). Phase II randomised controlled basket feasibility trial of a personalised, remotely delivered exercise programme on disease-free survival among early-stage, high-risk cancers: CANFit study protocol. BMJ open, 15(9), e100044. https://doi.org/10.1136/bmjopen-2025-100044

INTRODUCTION: Evidence suggests a 38% risk reduction in breast and bowel cancer-specific mortality with higher levels of exercise, however, most of this evidence is observational. More clinical trials are needed to build strong evidence for exercise'... Read More about Phase II randomised controlled basket feasibility trial of a personalised, remotely delivered exercise programme on disease-free survival among early-stage, high-risk cancers: CANFit study protocol.

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), e002327. https://doi.org/10.1136/bmjresp-2024-002327

Introduction Breathlessness is common and impairs the quality of life of people with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic interstitial lung diseases (ILD). We report the findings of a multicentre, fast-track (wait-list), mixed-met... Read More about Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial.

Exploring patients’ and carers’ experiences, understandings and expectations of COPD exacerbations: an interview study (2024)
Journal Article
Hutchinson, A., Russell, R., Cummings, H., Usmani, O., MacFadyen, S., Cohen, J., Morris, T., Muellerova, H., Xu, Y., Hellens, G., Roy, K., & Crooks, M. G. (2025). Exploring patients’ and carers’ experiences, understandings and expectations of COPD exacerbations: an interview study. BJGP Open, 9(2), 26. https://doi.org/10.3399/BJGPO.2024.0026

Background: Chronic obstructive pulmonary disease (COPD) exacerbations are clinically significant events that affect millions of people globally. Aim: To explore patients’ and carers’ experiences, understanding, and expectations of, as well as their... Read More about Exploring patients’ and carers’ experiences, understandings and expectations of COPD exacerbations: an interview study.

Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study (2024)
Journal Article
Cuthbert, J. J., Soyiri, I., Lomax, S. J., Turgoose, J., Fuat, A., Cohen, J., & Clark, A. L. (2024). Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study. Heart, 110(12), 854-862, 323577. https://doi.org/10.1136/heartjnl-2023-323577

Background Loop diuretics are commonly prescribed in the community, not always to patients with a recorded diagnosis of heart failure (HF). The rate of HF events in patients prescribed loop diuretics without a diagnosis of HF is unknown. Methods This... Read More about Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study.

A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol (2024)
Journal Article
Northgraves, M., Cohen, J., Harvey, J., Huang, C., Palmieri, C., Pinder, S., Roy, P., Reynia, S., Soares, M., & Cain, H. (2024). A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol. PLoS ONE, 19(3), e0300339. https://doi.org/10.1371/journal.pone.0300339

Background
The Oncotype DX® Breast Recurrence Score assay can guide recommendations made to patients with oestrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer regarding post-surgery adjuvant the... Read More about A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol.

Modified-release morphine or placebo for chronic breathlessness: the MABEL trial protocol (2023)
Journal Article
Date, K., Williams, B., Cohen, J., Chaudhuri, N., Bajwah, S., Pearson, M., Higginson, I., Norrie, J., Keerie, C., Tuck, S., Hall, P., Currow, D., Fallon, M., & Johnson, M. (2023). Modified-release morphine or placebo for chronic breathlessness: the MABEL trial protocol. ERJ Open Research, 9(4), 00167. https://doi.org/10.1183/23120541.00167-2023

Chronic breathlessness, a persistent and disabling symptom despite optimal treatment of underlying causes, is a frightening symptom with serious and widespread impact on patients and their carers. Clinical guidelines support the use of morphine for t... Read More about Modified-release morphine or placebo for chronic breathlessness: the MABEL trial protocol.

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., Pearson, M., Morice, A., Turgoose, J., Faruqi, S., Watt, M., Morris, T., & Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT (2023)
Journal Article
Pollux, P. M. J., Surr, C., Cohen, J., Huang, C., Wolverson, E., Mountain, P., Turner, R., Hawkesford-Webb, E., Winter, B., & Hudson, J. M. (2023). The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT. Pilot and Feasibility Studies, 9(1), 34. https://doi.org/10.1186/s40814-023-01256-8

Background: Cognitive problems associated with dementia affect a large proportion of older adults living in residential care. Knowledge of cognitive impairments is important for providing person-centred care (PCC). The impact of specific cognitive im... Read More about The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT.

Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol (2023)
Journal Article
Baldwin, Z.-A., Busby, S., Allsup, D., Cohen, J., & Bamidele, O. (2023). Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol. PLoS ONE, 18(3), e0282458. https://doi.org/10.1371/journal.pone.0282458

Introduction Haematological malignancies are a heterogenous group of blood and lymphatic cancers. Survivorship care is a similarly diverse term concerning patients’ health and wellbeing from diagnosis to end of life. Survivorship care for patients wi... Read More about Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol.

Reflections of experts by experience and research team members on research and development about a sensitive issue that attracts stigma (2023)
Journal Article
Howlett, H., Catterick, M., Onukwugha, F., Charlotte., Roberts, H., Karen., Dyson, J., Cheyenne., Smith, L., & Cohen, J. (2023). Reflections of experts by experience and research team members on research and development about a sensitive issue that attracts stigma. Research for All, 7(1). https://doi.org/10.14324/RFA.07.1.02

To reduce the number of alcohol-exposed pregnancies in antenatal care in the UK, the CHAMPION study objective was to design appropriate training and resources to develop the midwifery skills and confidence required to have an effective conversation a... Read More about Reflections of experts by experience and research team members on research and development about a sensitive issue that attracts stigma.

Co-designed weight management intervention for women recovering from oestrogen-receptor positive breast cancer (2022)
Journal Article
Saxton, J. M., Pickering, K., Wane, S., Humphreys, H., Crank, H., Anderson, A. S., Cain, H., Cohen, J., Copeland, R. J., Gray, J., Hargreaves, J., McNally, R. J. Q., & Wilson, C. (2022). Co-designed weight management intervention for women recovering from oestrogen-receptor positive breast cancer. BMC Cancer, 22(1), 1202. https://doi.org/10.1186/s12885-022-10287-y

Background: Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, particularly in women with oestrogen receptor-positive (ER +) disease. The aim of this study was to co-design (with... Read More about Co-designed weight management intervention for women recovering from oestrogen-receptor positive breast cancer.

The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study (2022)
Journal Article
Saxton, J., Pickering, K., Wane, S., Crank, H., Anderson, A., Cain, H., Cohen, J., Copeland, R., Gray, J., Hargreaves, J., McNally, R., & Wilson, C. (2022). The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study. BMC Cancer, 22(1), 1189. https://doi.org/10.1186/s12885-022-10238-7

Background: Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, notably in women with oestrogen-receptor positive disease. The aim of this qualitative study was to investigate the... Read More about The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study.

Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings (2022)
Journal Article
Hutchinson, A., Allgar, V., Cohen, J., Currow, D. C., Griffin, S., Hart, S., Hird, K., Hodge, A., Mason, S., Northgraves, M., Reeve, J., Swan, F., & Johnson, M. J. (2022). Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings. ERJ Open Research, 8(4), 00257-2022. https://doi.org/10.1183/23120541.00257-2022

Introduction: One-fifth of emergency department presentations by ambulance are due to acute-on-chronic breathlessness. We explored the feasibility of an evaluation-phase, cluster randomised controlled trial (cRCT) of the effectiveness and cost-effect... Read More about Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings.

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol (2022)
Journal Article
Northgraves, M., Allsup, D., Cohen, J., Huang, C., Turgoose, J., & Ali, S. (2022). A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol. PLoS ONE, 17(2), e0263195. https://doi.org/10.1371/journal.pone.0263195

Background
Acute leukaemias (AL) are aggressive but potentially curable blood cancers that can potentially affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking... Read More about A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

Tenotomy for diabetic foot ulcers: a scoping survey of current practice (2022)
Journal Article
Hitchman, L., Nandhra, S., Gooday, C., Cowan, C., Bowling, F., Nixon, J., Pickard, J., Cohen, J., Atkin, L., Rudarakanchana, N., Collings, R., Kavarthapu, V., Shalhoub, J., Games, F., & Russell, D. (2022). Tenotomy for diabetic foot ulcers: a scoping survey of current practice. Journal of Vascular Societies Great Britain and Ireland, 1(2), 54-58. https://doi.org/10.54522/jvsgbi.2022.006

Background: Diabetes mellitus is one of the fastest growing health crises of our time. One of the major complications is diabetic foot ulcers, many of which fail to heal. Tenotomy – transection of tendon fibres – may help to redistribute pressure in... Read More about Tenotomy for diabetic foot ulcers: a scoping survey of current practice.

Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review (2022)
Journal Article
Metwally, M., Chatters, R., Pye, C., Dimairo, M., White, D., Walters, S., Cohen, J., Young, T., Cheong, Y., Laird, S., Mohiyiddeen, L., Chater, T., Pemberton, K., Turtle, C., Hall, J., Taylor, L., Brian, K., Sizer, A., & Hunter, H. (2022). Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review. Health Technology Assessment, 26(10), vii-122. https://doi.org/10.3310/JNZT9406

Background: In vitro fertilisation is a widely used reproductive technique that can be undertaken with or without intracytoplasmic sperm injection. The endometrial scratch procedure is an in vitro fertilisation ‘add-on’ that is sometimes provided pri... Read More about Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review.

A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI (2021)
Journal Article
Metwally, M., Chatters, R., Dimairo, M., Walters, S., Pye, C., White, D., Bhide, P., Chater, T., Cheong, Y., Choudhary, M., Child, T., Drakeley, A., Evbuomwan, I., Gelbaya, T., Grace, J., Harris, P., Laird, S., da Silva, S. M., Mohiyiddeen, L., …Cohen, J. (2021). A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI. Human Reproduction, 36(7), 1841-1853. https://doi.org/10.1093/humrep/deab041

STUDY QUESTION: What is the clinical-effectiveness and safety of the endometrial scratch (ES) procedure compared to no ES, prior to usual first time in vitro fertilisation (IVF) treatment? SUMMARY ANSWER: ES was safe but did not improve pregnancy out... Read More about A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI.

A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol (2021)
Journal Article
Northgraves, M., Cohen, J., Allgar, V., Currow, D., Hart, S., Hird, K., Hodge, A., Johnson, M., Mason, S., Swan, F., & Hutchinson, A. (2021). A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol. ERJ Open Research, 7(1), 00955-2020. https://doi.org/10.1183/23120541.00955-2020

Introduction: Chronic breathlessness, persistent and disabling despite optimal treatment of underlying causes, is a prevalent and frightening symptom and is associated with many emergency presentations and admission to hospital. Breathlessness manage... Read More about A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol.