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Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2 (2011)
Journal Article
Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M., Williams, C. M., …Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), 416-424. https://doi.org/10.1182/blood-2010-10-312199

Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not cl... Read More about Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.

PKCα regulates platelet granule secretion and thrombus formation in mice (2009)
Journal Article
Konopatskaya, O., Gilio, K., Harper, M. T., Zhao, Y., Cosemans, J. M. E. M., Karim, Z. A., …Poole, A. W. (2009). PKCα regulates platelet granule secretion and thrombus formation in mice. Journal of Clinical Investigation, 119(2), 399-407. https://doi.org/10.1172/JCI34665

Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members of this family, including the... Read More about PKCα regulates platelet granule secretion and thrombus formation in mice.