Skip to main content

Research Repository

Advanced Search

All Outputs (49)

Practical considerations of dissolved oxygen levels for platelet function under hypoxia (2021)
Journal Article
Kusanto, B., Gordon, A., Naylor-Adamson, L., Atkinson, L., Coupland, C., Booth, Z., …Arman, M. (2021). Practical considerations of dissolved oxygen levels for platelet function under hypoxia. International Journal of Molecular Sciences, 22(24), Article 13223. https://doi.org/10.3390/ijms222413223

Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing bloo... Read More about Practical considerations of dissolved oxygen levels for platelet function under hypoxia.

Anatomy in Ancient China: How Acupuncture Meridians Were First Identified (2021)
Journal Article
Shaw, V., & Winder, I. C. (2021). Anatomy in Ancient China: How Acupuncture Meridians Were First Identified. Acupuncture in Physiotherapy : Journal of the Acupuncture Association of Chartered Physiotherapists, 33(2), Article 11-18

Acupuncture meridians are usually considered esoteric structures which serve as conduits for invisible Qi or life force. We argue, however, that the earliest texts describing meridians, the Mawangdui medical manuscripts, are in fact an anatomical atl... Read More about Anatomy in Ancient China: How Acupuncture Meridians Were First Identified.

The vertebral artery blood supply to the brain and its relationship with cognition across the taxonomic classes: Mammalia and Aves (2021)
Presentation / Conference
Lunn, A., Winder, I. C., & Shaw, V. (2021, July). The vertebral artery blood supply to the brain and its relationship with cognition across the taxonomic classes: Mammalia and Aves. Poster presented at Anatomical Society Summer Meeting 2021: Cutting Edge Anatomy, Glasgow

Human brains require the most energy per unit of mass of any animal and also have the largest cortical neuron count, which is afforded by having the largest primate brain and abiding by economic scaling rules. Cortical neuron count is one of the most... Read More about The vertebral artery blood supply to the brain and its relationship with cognition across the taxonomic classes: Mammalia and Aves.

The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures (2021)
Presentation / Conference
Shaw, V., & Winder, I. C. (2021, January). The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures. Presented at Anatomical Society Virtual Winter Meeting: Vision and Visualisation, Newcastle

Complying with the constraints on class size created by social distancing meant that in Bangor, it was not possible to have in-person cadaveric teaching this year. This had the biggest impact on the second-year Medical Sciences students, and the firs... Read More about The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures.

Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells (2020)
Journal Article
Beeby, E., Magalhães, M., Lemos, M. F. L., Pires, I. M., & Cabral, C. (in press). Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells. Journal of Ethnopharmacology, Article 113515. https://doi.org/10.1016/j.jep.2020.113515

Ethnopharmacological relevance: The past few years have witnessed an increasing interest in essential oils (EOs) as potential therapeutic agents against a wide variety of pathologies, including cancer. EOs extracted from Ridolfia segetum (L.) Moris (... Read More about Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells.

Measurement of Glutathione as a Tool for Oxidative Stress Studies by High Performance Liquid Chromatography (2020)
Journal Article
Nuhu, F., Gordon, A., Sturmey, R., Seymour, A. M., & Bhandari, S. (2020). Measurement of Glutathione as a Tool for Oxidative Stress Studies by High Performance Liquid Chromatography. Molecules, 25(18), Article 4196. https://doi.org/10.3390/molecules25184196

Background: Maintenance of the ratio of glutathione in the reduced (GSH) and oxidised (GSSG) state in cells is important in redox control, signal transduction and gene regulation, factors that are altered in many diseases. The accurate and reliable d... Read More about Measurement of Glutathione as a Tool for Oxidative Stress Studies by High Performance Liquid Chromatography.

Hiding in Plain Sight-Ancient Chinese Anatomy (2020)
Journal Article
Shaw, V., Diogo, R., & Winder, I. C. (2020). Hiding in Plain Sight-Ancient Chinese Anatomy. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, https://doi.org/10.1002/ar.24503

For thousands of years, scientists have studied human anatomy by dissecting bodies. Our knowledge of their findings is limited, however, both by the subsequent loss of many of the oldest texts, and by a tendency towards a Eurocentric perspective in m... Read More about Hiding in Plain Sight-Ancient Chinese Anatomy.

Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells (2020)
Journal Article
Beeby, E., Magalhães, M., Poças, J., Collins, T., Lemos, M., Barros, L., …Pires, I. M. (2020). Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells. Journal of Ethnopharmacology, 258, Article 112803. https://doi.org/10.1016/j.jep.2020.112803

Ethnopharmacological relevance: Despite advances in modern therapeutic strategies, cancer remains the second leading cause of death worldwide. Therefore, there is a constant need to develop more efficient anticancer targeting strategies. The anticanc... Read More about Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells.

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., …Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Weight, height, and midupper arm circumference are associated with haemoglobin levels in adolescent girls living in rural India: A cross‐sectional study (2019)
Journal Article
Ahankari, A. S., Tata, L., & Fogarty, A. (2019). Weight, height, and midupper arm circumference are associated with haemoglobin levels in adolescent girls living in rural India: A cross‐sectional study. Maternal & child nutrition, https://doi.org/10.1111/mcn.12908

We aimed to explore the association of physical parameters with haemoglobin (Hb) levels to test the hypothesis that impaired physical development is associated with anaemia. A cross‐sectional survey study recruited adolescent girls (13 to 17 years) l... Read More about Weight, height, and midupper arm circumference are associated with haemoglobin levels in adolescent girls living in rural India: A cross‐sectional study.

Dynamic electric field alignment of metal-organic framework micro- rods (2019)
Journal Article
Cheng, F., Young, A. J., Bouillard, J. G., Kemp, N. T., Guillet-Nicolas, R., Hall, C. H., …Chin, J. M. (2019). Dynamic electric field alignment of metal-organic framework micro- rods. Journal of the American Chemical Society, 141(33), 12989-12993. https://doi.org/10.1021/jacs.9b06320

Alignment of Metal Organic Framework (MOF) crystals has previously been performed via careful control of oriented MOF growth on substrates, as well as by dynamic magnetic alignment. We show here that microrod crystals of the MOF NU-1000 can also be d... Read More about Dynamic electric field alignment of metal-organic framework micro- rods.

A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects (2019)
Journal Article
Ghobaei Namhil, Z., Kemp, C., Verrelli, E., Iles, A., Pamme, N., Adawi, A. M., & Kemp, N. (2019). A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects. Physical chemistry chemical physics : PCCP, 21(2), 681-691. https://doi.org/10.1039/c8cp05510f

A significant impediment to the use of impedance spectroscopy in bio-sensing is the electrode polarization effect that arises from the movement of free ions to the electrode-solution interface, forming an electrical double layer (EDL). The EDL screen... Read More about A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects.

Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion (2018)
Journal Article
Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., …Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582

© 2018 American Chemical Society. Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many... Read More about Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion.

Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press (2018)
Journal Article
Orange, S. T., Metcalfe, J. W., Vince, R. V., Marshall, P., Madden, L. A., & Liefeith, A. (2020). Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press. Journal of strength and conditioning research, 34(3), 728-737. https://doi.org/10.1519/JSC.0000000000002715

This study examined the test-retest reliability of the GymAware PowerTool (GYM) to measure velocity and power in the free-weight back squat and bench press. Twenty-nine academy rugby league players (age: 17.6 ± 1.0 years; body mass: 87.3 ± 20.8 kg) c... Read More about Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press.

Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press (2018)
Journal Article
Orange, S. T., Metcalfe, J. W., Liefeith, A., Marshall, P., Madden, L. A., Fewster, C. R., & Vince, R. V. (2019). Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press. Journal of strength and conditioning research, 33(9), 2398-2408. https://doi.org/10.1519/JSC.0000000000002574

Orange, ST, Metcalfe, JW, Liefeith, A, Marshall, P, Madden, LA, Fewster, CR, and Vince, RV. Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press. J Strength Cond Res 33(9): 2398-2408,... Read More about Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press.

A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei (2018)
Journal Article
Colasante, C., Zheng, F., Kemp, C., & Voncken, F. (2018). A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei. Molecular and Biochemical Parasitology, 221, 36-51. https://doi.org/10.1016/j.molbiopara.2018.03.003

The procyclic form of the human parasite Trypanosoma brucei harbors one single, large mitochondrion containing all tricarboxylic acid (TCA) cycle enzymes and respiratory chain complexes present also in higher eukaryotes. Metabolite exchange among sub... Read More about A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei.

WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer (2018)
Journal Article
Poujade, F., Mannion, A., Brittain, N., Theodosi, A., Beeby, E., Leszczynska, K. B., …Pires, I. M. (2018). WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer. The British Journal of Cancer, 118(9), 1229-1237. https://doi.org/10.1038/s41416-018-0056-3

© 2018 Cancer Research UK. Background: Metastatic spread is responsible for the majority of cancer-associated deaths. The tumour microenvironment, including hypoxia, is a major driver of metastasis. The aim of this study was to investigate the role o... Read More about WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer.

Risk factors for maternal anaemia and low birth weight in pregnant women living in rural India: a prospective cohort study (2017)
Journal Article
Ahankari, A. S., Myles, P. R., Dixit, J. V., Tata, L. J., & Fogarty, A. W. (2017). Risk factors for maternal anaemia and low birth weight in pregnant women living in rural India: a prospective cohort study. Public health, 151, 63-73. https://doi.org/10.1016/j.puhe.2017.06.023

© 2017 The Royal Society for Public Health Objective The aim of this prospective study was to estimate the prevalence and risk factors for maternal anaemia and low birth weight (LBW) in pregnant women living in Maharashtra state, India. Study design... Read More about Risk factors for maternal anaemia and low birth weight in pregnant women living in rural India: a prospective cohort study.