Applications of radiation in photodiagnosis and photodynamic therapy (2020) Thesis Entract, G. (2020). Applications of radiation in photodiagnosis and photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222353 The application of radiation to porphyrin-based photosensitisers for the purposes of photodiagnosis and photodynamic therapy have been described in an effort to explore combined therapies, which seek to extend the use of photodynamic therapy beyond i... Read More about Applications of radiation in photodiagnosis and photodynamic therapy.
Porphyrin and metalloporphyrin agents for the personalised treatment and imaging of cancers (2019) Thesis Sandland, J. (2019). Porphyrin and metalloporphyrin agents for the personalised treatment and imaging of cancers. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4398472 The improvement of cancer medicine by utilizing the approach of personalised medicine has been investigated, principally, through the combination of diagnostic imaging (PET imaging) with treatment modalities (radiotherapy). Radiotherapy is key to bot... Read More about Porphyrin and metalloporphyrin agents for the personalised treatment and imaging of cancers.
Theranostic porphyrin conjugates for the combined treatment and diagnosis of cancer (2019) Thesis Yap, S. Y. (2019). Theranostic porphyrin conjugates for the combined treatment and diagnosis of cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221753 The development of theranostic agents capable of the combined treatment of diagnosis of disease has seen a growing interest within the research community. The combination of diagnostic and treatment modality onto a single construct will allow the car... Read More about Theranostic porphyrin conjugates for the combined treatment and diagnosis of cancer.
Near infrared fluorescence probes : towards applications in fluorescence guided surgery (2017) Thesis Cheng, H. Y. (2017). Near infrared fluorescence probes : towards applications in fluorescence guided surgery. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220740 Surgery has been a popular method for the treatment of cancers, in particular solid tumours; but the surgical margins for cancerous tissues are often indistinct and in most cases, the poor identification of residual cancer tissues can result in re-ex... Read More about Near infrared fluorescence probes : towards applications in fluorescence guided surgery.
Self-sterilising surfaces to combat healthcare associated infections (2017) Thesis Turner, C. L. (2017). Self-sterilising surfaces to combat healthcare associated infections. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4266419 The immobilisation of photosensitisers on polymeric supports for use in photodynamic antimicrobial chemotherapy has become increasingly popular. The immobilisation of photosensitisers on polymeric supports has been attempted previously by covalent at... Read More about Self-sterilising surfaces to combat healthcare associated infections.
A microfluidic approach to the study of cellular responses to oxidative stress (2015) Thesis Chandrabalan, K. (2015). A microfluidic approach to the study of cellular responses to oxidative stress. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4217617
Synthesis of water-soluble porphyrin-dendron conjugates for targeted photodynamic therapy (2013) Thesis Bryden, F. (2013). Synthesis of water-soluble porphyrin-dendron conjugates for targeted photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221329 The targeting of photosensitisers with tumour-associated biomolecules is widely used for improved photosensitiser tumour localisation during photodynamic therapy, allowing fewer side effects in comparison to conventional cancer treatments. In particu... Read More about Synthesis of water-soluble porphyrin-dendron conjugates for targeted photodynamic therapy.
Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours (2012) Thesis Smith, R. (2012). Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219918 To establish accurate and early stage tumour diagnosis, quantitative molecular imaging modalities such as positron emission tomography (PET) are being employed. Molecular probes containing a positron emitting isotope (e.g. ¹⁸F, ⁶⁴Cu) are designed to... Read More about Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours.
Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy (2010) Thesis Bullous, A. (2010). Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211381 Photodynamic therapy is a novel cancer treatment, involving the combination of light, photosensitiser and molecular oxygen to produce cytotoxic species. Currently, commercially available photosensitisers, including Photofrin and Foscan, only exhibit... Read More about Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy.
Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer (2008) Thesis Welch, C. J. (2008). Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208906 Porphyrin molecules are efficient generators of singlet oxygen and are used as photosensitisers in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting... Read More about Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer.
Synthesis of porphyrins and metalloporphyrins for biological applications (2005) Thesis Ita, S. (2005). Synthesis of porphyrins and metalloporphyrins for biological applications. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221109 Porphyrins are ideal candidates for PDT (Photodynamic therapy). Their ability to localise preferentially in diseased tissue allows specific targeting of cancerous tissue in certain areas. In recent years, linking photosensitisers to sugar moieties ha... Read More about Synthesis of porphyrins and metalloporphyrins for biological applications.
