All Outputs (24)

Development of fluorine-18 radiolabelled peptides for targeted imaging of the CXCR4 chemokine receptor (2021)
Thesis
Plater, J. Development of fluorine-18 radiolabelled peptides for targeted imaging of the CXCR4 chemokine receptor. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223832

The chemokine receptor CXCR4 has been shown to be over-expressed in multiple cancer types and is often linked to a poor prognosis, making it a significant target of interest for both imaging and therapeutics. Early diagnosis, imaging and identificati... Read More about Development of fluorine-18 radiolabelled peptides for targeted imaging of the CXCR4 chemokine receptor.

Characterisation of targeted imaging and theranostic agents for cancer and fibrosis (2018)
Thesis
Thompson, J. A. Characterisation of targeted imaging and theranostic agents for cancer and fibrosis. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4221539

Positron emission tomography (PET) imaging is a non-invasive modality that permits the characterisation of biological processes at the molecular level. Integrin αvβ6 and the chemokine receptor CXCR4 are important receptors in the pathogenesis of vari... Read More about Characterisation of targeted imaging and theranostic agents for cancer and fibrosis.

Development of radiolabeled fatty acid derivatives for imaging cardiac metabolism using PET and SPECT (2018)
Thesis
Al-Ali, Z. S. A. Development of radiolabeled fatty acid derivatives for imaging cardiac metabolism using PET and SPECT. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223957

Cardiac diseases are the leading cause of death worldwide. To address this problem, a better understanding of biochemical reasons underlying heart pathologies is needed. Fatty acid oxidation (FAO) plays a significant role in cardiac energy production... Read More about Development of radiolabeled fatty acid derivatives for imaging cardiac metabolism using PET and SPECT.

Development and evaluation of CXCR4 receptor targeted probes for medical imaging applications (2017)
Thesis
Lee, R. E. Development and evaluation of CXCR4 receptor targeted probes for medical imaging applications. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224548

The chemokine receptor CXCR4 has been shown to be overexpressed in over 23 different types of cancers, making it an attractive target for therapeutic and imaging agents. Molecular imaging techniques, such as positron emission tomography (PET) and sin... Read More about Development and evaluation of CXCR4 receptor targeted probes for medical imaging applications.

A spectroscopic and imaging investigation of sporopollenin-metal interactions (2017)
Thesis
Alkhatib, F. M. A spectroscopic and imaging investigation of sporopollenin-metal interactions. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4220724

The main objective has been the determination of the nature of the interaction of metal complexes and salts with the surface of sporopollenin exine capsules (SEC) and other naturally occurring spore exines. These natural materials derived from plant... Read More about A spectroscopic and imaging investigation of sporopollenin-metal interactions.

Development of optimised MRI contrast agents for copper(I) click reactions (2017)
Thesis
Aloraibi, F. K. M. Development of optimised MRI contrast agents for copper(I) click reactions. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224113

This research has been focused on synthesising three gadolinium(III) 1,4,7-triacetic acid-1,4,7,10-tetraazacyclododecane (DO3A) macrocyclic complexes (Gd6, Gd7, Gd8) as potential T1 MRI contrast agents. Alkyne derivativised chelators were synthesised... Read More about Development of optimised MRI contrast agents for copper(I) click reactions.

Probing cardiac metabolism in uraemic cardiomyopathy (2017)
Thesis
Atkinson, R. Probing cardiac metabolism in uraemic cardiomyopathy. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4220698

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). Uraemic cardiomyopathy (UCM) is characterised by structural and cellular remodelling including left ventricular hypertrophy (LVH), metabolic re... Read More about Probing cardiac metabolism in uraemic cardiomyopathy.

Non-standard methodology in organic synthesis : mechanochemistry with macrocycles and sporopollenin (2016)
Thesis
Abdulwahaab, B. H. Non-standard methodology in organic synthesis : mechanochemistry with macrocycles and sporopollenin. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224065

Glyoxal-bridged bisaminal tetraazamacrocyclic derivatives of 1,4,7,10 tetraazacyclododecane (cyclen) and 1,4,8,11- tetraazacyclotetradecane (cyclam) can be N-functionalized to incorporate coordinating groups or for conjugation to biomolecules. Herein... Read More about Non-standard methodology in organic synthesis : mechanochemistry with macrocycles and sporopollenin.

Design and synthesis of iron oxide nanomaterials for biomedical applications (2016)
Thesis
Baghdadi, N. E. Design and synthesis of iron oxide nanomaterials for biomedical applications. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4219152

Nanotechnology products have huge potential to be a part of the developments in various fields, including functional materials, electronics and medicine. Using nanomaterials in medical applications has been successful for disease diagnosis and drug d... Read More about Design and synthesis of iron oxide nanomaterials for biomedical applications.

Positron emission tomography imaging probes targeting chemokine receptors (2016)
Thesis
Alzahrani, S. O. Positron emission tomography imaging probes targeting chemokine receptors. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4219878

Positron emission tomography (PET) is a highly sensitive nuclear medicine imaging technique. PET is used to accurately diagnose cancer and can detect early stage tumours. Molecular probes containing a positron emitting metal radioisotope (such as ⁶⁴C... Read More about Positron emission tomography imaging probes targeting chemokine receptors.

Synthesis of components to form linked multi-metal constructs : potential MRI/optical contrast agents (2015)
Thesis
Al-Yassiry, M. M. A. Synthesis of components to form linked multi-metal constructs : potential MRI/optical contrast agents. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4218927

Azamacrocyclic chelators with coordinating pendant arms can form complexes with lanthanide(lll) ions offering a high level of kinetic and thermodynamic stability. There are many potentially useful applications of these complexes in areas such as magn... Read More about Synthesis of components to form linked multi-metal constructs : potential MRI/optical contrast agents.

Synthesis and characterisation of novel azamacrocyclic chelators for biomedical applications : biological activity and radiolabelling (2015)
Thesis
Al-Zirgani, A. S. Z. Synthesis and characterisation of novel azamacrocyclic chelators for biomedical applications : biological activity and radiolabelling. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224050

Azamacrocyclic derivatives that contain nitrogen donors have been used for decades in analytical, industrial and medical applications. They are good hosts for metal ions, anions, neutral molecules and organic cation guests. Azamacrocyclic complexes t... Read More about Synthesis and characterisation of novel azamacrocyclic chelators for biomedical applications : biological activity and radiolabelling.

Metal oxide nanoparticles as potential MRI contrast agents (2015)
Thesis
Jones, N. E. Metal oxide nanoparticles as potential MRI contrast agents. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4218445

Magnetic resonance imaging (MRI) is a common medical imaging modality that does not require the administration of radiopharmaceuticals, as it relies on the inherent nuclear spin of the protons in the tissues and organs. However, it lacks sensitivity... Read More about Metal oxide nanoparticles as potential MRI contrast agents.

Interaction between the Alzheimer's peptide, beta-amyloid and lipid membrane (2015)
Thesis
Saurabh, R. Interaction between the Alzheimer's peptide, beta-amyloid and lipid membrane. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4218383

Alzheimer’s disease (AD) is a neurodegenerative disorder. The patho-physiological effects of amyloid beta (Aβ) may be mediated by Aβ-membrane interaction. However, the molecular mechanism of interaction between Aβ and neuronal membrane remains unknow... Read More about Interaction between the Alzheimer's peptide, beta-amyloid and lipid membrane.

Synthesis and biological evaluation of CXCR4 chemokine receptor antagonists (2014)
Thesis
Nicholson, K. L. Synthesis and biological evaluation of CXCR4 chemokine receptor antagonists. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4222198

The CXCR4 chemokine receptor is known to be overexpressed in many types of cancer as well as being involved in several stages of metastasis, which is responsible for the majority of deaths in cancer patients. Molecular imaging techniques, such as pos... Read More about Synthesis and biological evaluation of CXCR4 chemokine receptor antagonists.

Positron emission tomography imaging agents with gallium-68 : bifunctional chelators and multimodality (2013)
Thesis
Burke, B. P. Positron emission tomography imaging agents with gallium-68 : bifunctional chelators and multimodality. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4220631

Positron emission tomography (PET) as a nuclear medicine technique offers very high sensitivity compared with other imaging modalities. PET is often combined with computed tomography (CT) to offer structural information. Incorporation of a positron e... Read More about Positron emission tomography imaging agents with gallium-68 : bifunctional chelators and multimodality.

Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours (2012)
Thesis
Smith, R. Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4219918

To establish accurate and early stage tumour diagnosis, quantitative molecular imaging modalities such as positron emission tomography (PET) are being employed. Molecular probes containing a positron emitting isotope (e.g. ¹⁸F, ⁶⁴Cu) are designed to... Read More about Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours.

Polyacrylamide nanoparticle delivery systems in photodynamic therapy (2011)
Thesis
Kuruppuarachchi, M. Polyacrylamide nanoparticle delivery systems in photodynamic therapy. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4213126

In treating many diseases, including cancer and bacterial infections, drug resistance has emerged as a major obstacle limiting the therapeutic efficacy of chemotherapeutic agents. One area which may prove to be particularly attractive is Photodynamic... Read More about Polyacrylamide nanoparticle delivery systems in photodynamic therapy.

The use of enzymes, isomerisable lipid analogues and small molecules to modulate the structure and dynamics of lipid bilayer (2010)
Thesis
Batchelor, R. The use of enzymes, isomerisable lipid analogues and small molecules to modulate the structure and dynamics of lipid bilayer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4211370

A series of experiments were carried out to assess the effects and interactions of isomerisable lipid analogues, small molecules, and enzyme catalysed substrates on the structure and dynamics of lipid bilayers.

Modulation of Enzyme Activity Usin... Read More about The use of enzymes, isomerisable lipid analogues and small molecules to modulate the structure and dynamics of lipid bilayer.

CXCR4 chemokine receptor antagonists : new metallodrugs (2009)
Thesis
Khan, A. CXCR4 chemokine receptor antagonists : new metallodrugs. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4216132

Chemokine receptors are a target of growing interest for new therapeutic drugs, as their role in multiple disease states has been demonstrated. The CXCR4/ CXCL12 pairing has been implicated in HIV and cancer, as well as chronic inflammatory diseases,... Read More about CXCR4 chemokine receptor antagonists : new metallodrugs.