Skip to main content

Research Repository

Advanced Search

All Outputs (56)

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol) (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol). Cochrane Database of Systematic Reviews, 2021(1), Article CD013839. https://doi.org/10.1002/14651858.CD013839

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of through-knee amputation compared to above-knee amputation on clinical and rehabilitation outcomes and complication rates in... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol).

Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers (2021)
Journal Article
Johnson, M. J., Huang, C., Chen, H., Jones, L., & Twiddy, M. (2021). Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003438

Objectives: Men living with prostate cancer have supportive and palliative needs. However, few studies detail unmet needs (vs quality of life measurement) or include data from those with advanced disease. We aimed to identify unmet needs of people li... Read More about Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers.

Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis. Environmental Health Perspectives, 128(12), 126002-1-126002-32. https://doi.org/10.1289/EHP7171

Background: Microplastics (MPs) have contaminated all compartments of the marine environment including biota such as seafood; ingestion from such sources is one of the two major uptake routes identified for human exposure. Objectives: The objectives... Read More about Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis.

Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis. SN Applied Sciences, 2(12), Article 1950. https://doi.org/10.1007/s42452-020-03749-0

Microplastics (MPs) are an emerging contaminant ubiquitous in the environment. There is growing concern regarding potential human health effects, a major human exposure route being dietary uptake. We have undertaken a systematic review (SR) and meta-... Read More about Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis.

Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services (2020)
Journal Article
Hess, S., Meads, D., Twiddy, M., Mason, S., Czoski-Murray, C., & Minton, J. (2021). Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services. Journal of Choice Modelling, 38, Article 100252. https://doi.org/10.1016/j.jocm.2020.100252

Choice modelling techniques have established themselves as a key analysis tool in health economics and have been used to understand patient and practitioner preferences across a wide variety of settings. A key interest in recent years has been the in... Read More about Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services.

Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search (2020)
Journal Article
Coleman, S., Wright, J. M., Nixon, J., Schoonhoven, L., Twiddy, M., & Greenhalgh, J. (2020). Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search. BMC Medical Research Methodology, 20(1), 217. https://doi.org/10.1186/s12874-020-01084-x

BACKGROUND: Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the first step in a realist eval... Read More about Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search.

Microplastic contamination of drinking water: a systematic review. (2020)
Journal Article
Danopoulos, E., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of drinking water: a systematic review. PLoS ONE, 15(7 July), Article e0236838. https://doi.org/10.1371/journal.pone.0236838

Background Microplastics (MPs) are omnipresent in the environment, including the human food chain; a likely important contributor to human exposure is drinking water. Objective To undertake a systematic review of MP contamination of drinking water... Read More about Microplastic contamination of drinking water: a systematic review..

high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study (2020)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Twiddy, M., …Chetter, I. C. (2020). high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study. BMJ open, 10(7), Article e038825. https://doi.org/10.1136/bmjopen-2020-038825

Introduction: The first-line recommended treatment for patients with intermittent claudication (IC), is a supervised exercise programme (SEP), which includes a minimum of 2 hours exercise per week over a 12-week period. However, provision, uptake, an... Read More about high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study.

Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial (2020)
Journal Article
Cardozo, W., Baker, R., Berger, C., Chapman, S., Codd, R., Coyne, P., …Brown, J. (in press). Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial. British journal of surgery, https://doi.org/10.1002/bjs.11703

Abstract Background Approximately 30,000 people per annum undergo major, emergency abdominal, gastrointestinal surgery, of which 36% (~10,800) are carried out for emergency colorectal pathology. Approximately 14% of all patients requiring emergency... Read More about Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial.

Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT (2020)
Journal Article
Davidson, B., Gurusamy, K., Corrigan, N., Croft, J., Ruddock, S., Pullan, A., …de Wilt, J. H. (2020). Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT. Health Technology Assessment, 24(21), 1-66. https://doi.org/10.3310/hta24210

Background: Although surgical resection has been considered the only curative option for colorectal liver metastases, thermal ablation has recently been suggested as an alternative curative treatment. There have been no adequately powered trials comp... Read More about Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT.

Information design for bowel cancer detection: The impact of using information visualisation to help patients prepare for colonoscopy screening (2019)
Journal Article
dos Santos Lonsdale, M., Ni, L. C., Gu, C., & Twiddy, M. (2019). Information design for bowel cancer detection: The impact of using information visualisation to help patients prepare for colonoscopy screening. Information Design Journal, 25(2), 125-156. https://doi.org/10.1075/idj.25.2.01lon

© 2019 John Benjamins Publishing Company. All rights reserved. Colorectal cancer is one of the most commonly occurring cancers in the world, and colonoscopy is the most sensitive procedure to detect it. Colonoscopy success depends on the quality of b... Read More about Information design for bowel cancer detection: The impact of using information visualisation to help patients prepare for colonoscopy screening.

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol (2019)
Journal Article
Wright, C., Hart, S. P., Allgar, V., English, A., Swan, F., Dyson, J., …Crooks, M. G. (2019). A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol. ERJ Open Research, 5(4), Article 0186. https://doi.org/10.1183/23120541.00186-2019

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now av... Read More about A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol.

Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study (2019)
Journal Article
Burton, W., Twiddy, M., Sahota, P., Brown, J., & Bryant, M. (2019). Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study. BMC public health, 19(1), Article 1074. https://doi.org/10.1186/s12889-019-7410-0

© 2019 The Author(s). Background: Children's centres in the UK provide a setting for public health programmes; offering support to families living in the most disadvantaged areas where obesity prevalence is at its highest. Health, Exercise and Nutrit... Read More about Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study.

Patient and public involvement in health research in low and middle-income countries: a systematic review (2019)
Journal Article
Cook, N., Siddiqi, N., Twiddy, M., & Kenyon, R. (2019). Patient and public involvement in health research in low and middle-income countries: a systematic review. BMJ open, 9(5), Article e026514. https://doi.org/10.1136/bmjopen-2018-026514

Objectives: Patient and public involvement (PPI) is argued to lead to higher quality health research, which is more relatable to and helps empower the public. We synthesised the evidence to look for examples of PPI in health research in low/middle-in... Read More about Patient and public involvement in health research in low and middle-income countries: a systematic review.

High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis (2018)
Journal Article
Forester, N. D., Lowes, S., Mitchell, E., & Twiddy, M. (2019). High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis. European journal of surgical oncology, 45(4), 519-527. https://doi.org/10.1016/j.ejso.2018.12.008

© 2018 Introduction: Provide evidence to support evolving management strategies for high-risk (B3) breast lesions by assessing risk of carcinoma in subgroups of B3 lesions using systematic review and meta-analysis. Methods: Databases identified obser... Read More about High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis.

TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial (2018)
Journal Article
Edginton, E., Walwyn, R., Twiddy, M., Wright-Hughes, A., Tubeuf, S., Reed, S., …Cottrell, D. (2018). TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial. Journal of Child and Adolescent Mental Health, 30(3), 167-182. https://doi.org/10.2989/17280583.2018.1532433

Background: Parenting programmes are recommended for conduct disorders in 5–11 year olds, but ineffective for 25–33%. A feasibility trial was needed to determine whether a confirmatory trial of second-line, manualised short-term psychoanalytic child... Read More about TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial.

Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial (2018)
Journal Article
Gurusamy, K., Corrigan, N., Croft, J., Twiddy, M., Morris, S., Woodward, N., …Davidson, B. R. (2018). Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial. Trials, 19(1), https://doi.org/10.1186/s13063-018-2499-5

Background:Although surgical resection has been considered the only curative option for colorectal livermetastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment. A prospective randomised trial is required to... Read More about Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial.

Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol (2018)
Journal Article
Harji, D., Marshall, H., Gordon, K., Crow, H., Hiley, V., Burke, D., …Sagar, P. (2018). Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol. BMJ open, 8(2), Article e018618. https://doi.org/10.1136/bmjopen-2017-018618

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Acute colorectal surgery forms a significant prop... Read More about Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol.

A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement (2018)
Journal Article
Twiddy, M., Czoski Murray, C. J., Mason, S. J., Meads, D., Wright, J. M., Mitchell, E. D., & Minton, J. (2018). A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement. BMJ open, 8(1), e019099. https://doi.org/10.1136/bmjopen-2017-019099

Abstract Objective Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation is patchy and a variety of service models are in use. The slow uptake in the UK and Europe is due to... Read More about A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement.

TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial (2017)
Journal Article
Edginton, E., Walwyn, R., Burton, K., Cicero, R., Graham, L., Reed, S., …Cottrell, D. (2017). TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial. Trials, 18(1), Article 431. https://doi.org/10.1186/s13063-017-2166-2

Background: The National Institute for Health and Care Excellence (NICE) recommends evidence-based parenting programmes as a first-line intervention for conduct disorders (CD) in children aged 5–11 years. As these are not effective in 25–33% of cases... Read More about TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial.