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Preface (2021)
Book Chapter
Sahebkar, A., & Sathyapalan, T. (2021). Preface. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases : Pharmacology, Molecular Targets, and Therapeutic Benefits (v). Cham: Springer Verlag. https://doi.org/10.1007/978-3-030-73234-9

Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14663

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age and is associated with increased body weight. Objective: To review the literature on the effect of different pharmacological interventions on t... Read More about Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials.

Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study (2021)
Journal Article
Deshmukh, H., Shah, N., Papageorgiou, M., Abdalla, M. A., Lhaf, F., Aye, M., & Sathyapalan, T. (2022). Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study. Bone, 155, Article 116285. https://doi.org/10.1016/j.bone.2021.116285

Introduction: There is conflicting data on the effect of polycystic ovary syndrome (PCOS) on bone mineral density (BMD) and fracture risk. Recent genetic data suggest that men may also carry genetic risk factors for PCOS; the associations of these fa... Read More about Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study.

Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes. Frontiers in Molecular Biosciences, 8, Article 744459. https://doi.org/10.3389/fmolb.2021.744459

Background and Purpose: Patients with type 2 diabetes (T2D) have increased risk of cardiovascular disease (CVD), encompassing myocardial infarction, stroke, and peripheral vascular disease. We hypothesized that those biomarkers indicative of acute is... Read More about Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes.

Hypoglycemia-induced changes in complement pathways in type 2 diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Diboun, I., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Hypoglycemia-induced changes in complement pathways in type 2 diabetes. Atherosclerosis, 46, 35-45. https://doi.org/10.1016/j.athplu.2021.11.002

Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothes... Read More about Hypoglycemia-induced changes in complement pathways in type 2 diabetes.

Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14636

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD). Ob... Read More about Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis.

Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Kahal, H., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia. Cells, 10(11), Article 3109. https://doi.org/10.3390/cells10113109

Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elic-its a similar response with inflammatory and oxidative-stress responses c... Read More about Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia.

Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14623

Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterized by insulin resistance and is a major risk factor for type 2 diabetes mellitus (T2DM). The objective was to review th... Read More about Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review (2021)
Journal Article
Safarzadeh, S., Shirban, F., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2022). The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review. Phytotherapy Research, 36(1), 243-265. https://doi.org/10.1002/ptr.7308

Cancer therapy-induced oral mucositis (OM) is one of the most troublesome morbidities after radio-chemotherapy. Age, nutritional status, tumor type, oral hygiene, and treatment method are the determinants for OM incidence. In addition, oxygen-free ra... Read More about The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review.

The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease (2021)
Journal Article
Lashgari, N. A., Roudsari, N. M., Momtaz, S., Sathyapalan, T., Abdolghaffari, A. H., & Sahebkar, A. (2021). The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease. Journal of Neuroimmunology, 361, Article 577758. https://doi.org/10.1016/j.jneuroim.2021.577758

Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and oxidative stress play key etiopathological role. The pathology of PD brain is characterized by inclusions of aggregated α-synuclein (α-SYN) in the cytoplasmic region o... Read More about The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease.

Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract (2021)
Journal Article
Korani, S., Rashidi, K., Hamelian, M., Jalalvand, A. R., Tajehmiri, A., Korani, M., …Sahebkar, A. (2021). Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract. Bioinorganic Chemistry and Applications, 2021, Article 7019130. https://doi.org/10.1155/2021/7019130

Background. Wound healing is a complex process of replacing devitalized cellular structures and tissues with healthy cells and tissue. Nanotechnology has been increasingly proposed as a novel platform to treat wounds and skin regeneration. The aim of... Read More about Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract.

Association of microRNAs With Embryo Development and Fertilization in Women Undergoing Subfertility Treatments: A Pilot Study (2021)
Journal Article
Butler, A. E., Cunningham, T. K., Ramachandran, V., Diboun, I., Halama, A., Sathyapalan, T., …Atkin, S. L. (2021). Association of microRNAs With Embryo Development and Fertilization in Women Undergoing Subfertility Treatments: A Pilot Study. Frontiers in Reproductive Health, 3, Article 719326. https://doi.org/10.3389/frph.2021.719326

Objective: Small non-coding RNAs, known as microRNAs (miRNAs), have emerging regulatory functions within the ovary that have been related to fertility. This study was undertaken to determine if circulating miRNAs reflect the changes associated with t... Read More about Association of microRNAs With Embryo Development and Fertilization in Women Undergoing Subfertility Treatments: A Pilot Study.

Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study (2021)
Journal Article
Holmes, P., Bell, H. E., Bozkurt, K., Catarig, A. M., Clark, A., Machell, A., & Sathyapalan, T. (2021). Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study. Diabetes Therapy, https://doi.org/10.1007/s13300-021-01141-8

Introduction: Once-weekly (OW) semaglutide was associated with clinically relevant improvements in glycaemic control and body weight versus comparators in the SUSTAIN randomised controlled trials (RCTs). SURE UK, which is one of a series of individua... Read More about Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study.

Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit (2021)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Choudhary, P., Christian, P., …Sathyapalan, T. (in press). Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit. British Journal of Diabetes, https://doi.org/10.15277/bjd.2021.308

Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Choudhary, P., Narendran, P., Shah, N., Barnes, D., …Sathyapalan, T. (2021). Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit. Diabetes Care, 44(11), e190-e191. https://doi.org/10.2337/dc21-1181

Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders (2021)
Journal Article
Koushki, K., Shahbaz, S. K., Keshavarz, M., Bezsonov, E. E., Sathyapalan, T., & Sahebkar, A. (2021). Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders. Biomolecules, 11(9), Article 1289. https://doi.org/10.3390/biom11091289

Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-lo... Read More about Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders.

Impact of severe hypoglycemia on the heat shock and related protein response (2021)
Journal Article
Atkin, A. S., Moin, A. S. M., Nandakumar, M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Impact of severe hypoglycemia on the heat shock and related protein response. Scientific reports, 11(1), Article 17057. https://doi.org/10.1038/s41598-021-96642-8

Heat shock proteins contribute to diabetes-induced complications and are affected by glycemic control. Our hypothesis was that hypoglycemia-induced heat shock and related protein changes would be amplified in type 2 diabetes (T2D). This prospective,... Read More about Impact of severe hypoglycemia on the heat shock and related protein response.

Implications on the Therapeutic Potential of Statins via Modulation of Autophagy (2021)
Journal Article
Gorabi, A. M., Kiaie, N., Aslani, S., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Implications on the Therapeutic Potential of Statins via Modulation of Autophagy. Oxidative Medicine and Cellular Longevity, 2021, Article 9599608. https://doi.org/10.1155/2021/9599608

Statins, which are functionally known as 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) inhibitors, are lipid-lowering compounds widely prescribed in patients with cardiovascular diseases (CVD). Several biological and therapeutic functions have been attri... Read More about Implications on the Therapeutic Potential of Statins via Modulation of Autophagy.

The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes (2021)
Journal Article
Yaribeygi, H., Farrokhi, F. R., Abdalla, M. A., Sathyapalan, T., Banach, M., Jamialahmadi, T., & Sahebkar, A. (2021). The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes. Journal of Diabetes Research, 2021, Article 6518221. https://doi.org/10.1155/2021/6518221

Glucagon-like peptide-1 receptor (GLP-1R) agonists are a class of newly introduced antidiabetic medications that potentially lower blood glucose by several molecular pathways. DPP-4 inhibitors are the other type of novel antidiabetic medications whic... Read More about The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes.

Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers (2021)
Journal Article
Marsden, A. J., Riley, D. R., Birkett, S., Rodriguez-Barucg, Q., Guinn, B. A., Carroll, S., …Beltran-Alvarez, P. (in press). Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers. Amino acids, https://doi.org/10.1007/s00726-021-03024-5

Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily av... Read More about Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity. Frontiers in endocrinology, 12, Article 658304. https://doi.org/10.3389/fendo.2021.658304

Objective: Detailed proteomic analysis in a cohort of patients with differing severity of COVID-19 disease identified biomarkers within the complement and coagulation cascades as biomarkers for disease severity has been reported; however, it is uncle... Read More about Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection? (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?. Frontiers in endocrinology, 12, Article 665134. https://doi.org/10.3389/fendo.2021.665134

Introduction: Neuropilin-1(NRP1) is a cofactor that enhances SARS-CoV-2 coronavirus cell infectivity when co-expressed with angiotensin-converting enzyme 2(ACE2). The Renin-Angiotensin System (RAS) is activated in type 2 diabetes (T2D); therefore, th... Read More about Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?.

Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., …Sathyapalan, T. (2021). Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study. Diabetes, Obesity and Metabolism, 23(10), 2261-2268. https://doi.org/10.1111/dom.14467

Aim: To identify the baseline demographic and clinical characteristics associated with diabetes-related distress (DRD) and factors associated with improvement in DRD after initiating use of the FreeStyle Libre (FSL) in people living with type 1 diabe... Read More about Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study.

High-fidelity simulation and virtual reality: An evaluation of medical students' experiences (2021)
Journal Article
Macnamara, A. F., Bird, K., Rigby, A., Sathyapalan, T., & Hepburn, D. (2021). High-fidelity simulation and virtual reality: An evaluation of medical students' experiences. BMJ Simulation & Technology Enhanced Learning, 7(6), 528-535. https://doi.org/10.1136/bmjstel-2020-000625

Background: Simulation technology is widely used in medical education, providing an environment in which students can develop and practise a multitude of skills that are relevant to clinical practice, without the risk of harm to patients. Methods: We... Read More about High-fidelity simulation and virtual reality: An evaluation of medical students' experiences.

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype (2021)
Journal Article
Li, J. V., Ashrafian, H., Sarafian, M., Homola, D., Rushton, L., Barker, G., …Holmes, E. (2021). Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype. Microbiome, 9(1), Article 139. https://doi.org/10.1186/s40168-021-01086-x

Background: Bariatric surgery, used to achieve effective weight loss in individuals with severe obesity, modifies the gut microbiota and systemic metabolism in both humans and animal models. The aim of the current study was to understand better the m... Read More about Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype.

The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Mohammed, I., Atkin, S., Reid, M., & Sathyapalan, T. (2021). The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study. Frontiers in Physiology, 12, Article 652559. https://doi.org/10.3389/fphys.2021.652559

Purpose: Free androgen index (FAI) and anti-Mullerian hormone (AMH) are independently associated with polycystic ovary syndrome (PCOS). This study aimed to describe the relationship between these two markers and health-related quality of life (HR-QoL... Read More about The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study.

The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery (2021)
Journal Article
Jamialahmadi, T., Nematy, M., Jangjoo, A., Goshayeshi, L., Abdalla, M. A., Akhlaghi, S., …Sahebkar, A. (in press). The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, https://doi.org/10.1007/s40519-021-01151-2

Background: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hepatic fibrosis are the most detrimental hepatic abnormalities associated with increased body weight with devastating clinical outcomes. Therefore, there... Read More about The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery.

Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches (2021)
Journal Article
Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (in press). Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches. Mini-Reviews in Medicinal Chemistry, 22(2), 312-321. https://doi.org/10.2174/1389557521666210505112834

Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favoura... Read More about Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches.

Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia (2021)
Journal Article
Moin, A. S. M., Kahal, H., Al-Qaissi, A., Kumar, N., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia. BMJ Open Diabetes Research and Care, 9(1), Article e002211. https://doi.org/10.1136/bmjdrc-2021-002211

Introduction Hypoglycemia in type 2 diabetes (T2D) may increase risk for Alzheimer’s disease (AD), but no data on changes in AD-related proteins with differing degrees of hypoglycemia exist. We hypothesized that milder prolonged hypoglycemia would ca... Read More about Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia.

Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials (2021)
Journal Article
Gorabi, A. M., Razi, B., Aslani, S., Abbasifard, M., Imani, D., Sathyapalan, T., & Sahebkar, A. (2021). Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials. Cytokine, 143, Article 155541. https://doi.org/10.1016/j.cyto.2021.155541

It has been suggested that curcumin has the potential for lowering inflammation. In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and... Read More about Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials.

Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms (2021)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms. Oxidative Medicine and Cellular Longevity, 2021, Article 9959320. https://doi.org/10.1155/2021/9959320

Glucagon-like peptide 1 receptor agonists and dipeptidyl-peptidase 4 inhibitors are medications used for managing diabetes, mimicking the metabolic effects of incretin hormones. Recent evidence suggests that these medications have antioxidative poten... Read More about Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms.

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis (2021)
Journal Article
Aalami, A. H., Abdeahad, H., Mesgari, M., Sathyapalan, T., & Sahebkar, A. (2021). Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis. Biomed research international, 2021, Article 5557309. https://doi.org/10.1155/2021/5557309

Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis,... Read More about Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis.

Plasma heat shock protein response to euglycemia in type 2 diabetes (2021)
Journal Article
Atkin, A. S., Moin, A. S., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Plasma heat shock protein response to euglycemia in type 2 diabetes. BMJ Open Diabetes Research and Care, 9(1), Article e002057. https://doi.org/10.1136/bmjdrc-2020-002057

Introduction Glucose variability is associated with mortality and macrovascular diabetes complications. The mechanisms through which glucose variability mediates tissue damage are not well understood, although cellular oxidative stress is likely invo... Read More about Plasma heat shock protein response to euglycemia in type 2 diabetes.

Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training (2021)
Journal Article
Jerobin, J., Ramanjaneya, M., Bettahi, I., Parammal, R., Siveen, K. S., Alkasem, M., …Abou-Samra, A. B. (2021). Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training. Lipids in Health and Disease, 20(1), Article 34. https://doi.org/10.1186/s12944-021-01463-3

Background: Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid ho... Read More about Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training.

The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review (2021)
Book Chapter
Gharibpour, F., Shirban, F., Bagherniya, M., Nosouhian, M., Sathyapalan, T., & Sahebkar, A. (2021). The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review. In G. E. Barreto, & A. Sahebkar (Eds.), Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health (225-248). Cham: Springer Verlag. https://doi.org/10.1007/978-3-030-64872-5_16

Candida albicans is part of the healthy flora in the oral cavity. It can also cause opportunistic infection, which can be deleterious. The most typical type of chronic oral candidiasis is denture stomatitis, and C. albicans is identified as the most... Read More about The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review.

Impact of curcumin on fatty acid metabolism (2021)
Journal Article
Nosrati-Oskouie, M., Aghili-Moghaddam, N. S., Sathyapalan, T., & Sahebkar, A. (in press). Impact of curcumin on fatty acid metabolism. Phytotherapy Research, https://doi.org/10.1002/ptr.7105

Free fatty acids (FFAs) and fatty acid synthesis (FAS) activity have significantly contributed to disease states such as insulin resistance, obesity, type 2 diabetes, myocardial infarction, blood pressure, and several types of cancer. Currently, seve... Read More about Impact of curcumin on fatty acid metabolism.

Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes. Frontiers in endocrinology, 12, Article 651009. https://doi.org/10.3389/fendo.2021.651009

Introduction: Patients with severe COVID-19 infections have coagulation abnormalities indicative of a hypercoagulable state, with thromboembolic complications and increased mortality. Platelets are recognized as mediators of inflammation, releasing p... Read More about Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19 (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Diboun, I., Atkin, S. L., & Butler, A. E. (in press). Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19. Scientific reports, 11(1), Article 6428. https://doi.org/10.1038/s41598-021-85760-y

Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS). The objective was to determine the circulatory biomarkers for macrophage activation at baselin... Read More about Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19.

The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update (2021)
Journal Article
Navashenaq, J. G., Shabgah, A. G., Hedayati-Moghadam, M., Ariaee, N., Mohammadi, H., Hemmatzadeh, M., …Sahebkar, A. (2021). The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update. Life Sciences, 269, https://doi.org/10.1016/j.lfs.2021.119083

© 2021 Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the late stages of the disease, it can be associated with several complications. Although the exact etiology of RA is unknown, various studies have been p... Read More about The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update.

Correction to: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome (Journal of Translational Medicine, (2020), 18, 1, (490), 10.1186/s12967-020-02669-2) (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Correction to: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome (Journal of Translational Medicine, (2020), 18, 1, (490), 10.1186/s12967-020-02669-2). Journal of Translational Medicine, 19(1), Article 106. https://doi.org/10.1186/s12967-021-02782-w

© 2021, The Author(s). An amendment to this paper has been published and can be accessed via the original article.

Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis (2021)
Journal Article
Karimi, L., Makvandi, S., Vahedian-Azimi, A., Sathyapalan, T., & Sahebkar, A. (2021). Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis. Journal of Pregnancy, 2021, 1-33. https://doi.org/10.1155/2021/8870129

Background. Based on what is known at this time, pregnant women are at an increased risk of severe illness from COVID-19 compared to nonpregnant women. Additionally, pregnant women with COVID-19 might have an increased risk of adverse pregnancy outco... Read More about Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis.

Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Diboun, I., Elrayess, M. A., Butler, A. E., & Atkin, S. L. (in press). Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome. Scientific reports, 11(1), Article 5320. https://doi.org/10.1038/s41598-021-84586-y

© 2021, The Author(s). Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulatio... Read More about Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome.

Depression, Anxiety, and Stress Among Patients with COVID-19: A Cross-Sectional Study (2021)
Book Chapter
Moayed, M. S., Vahedian-Azimi, A., Mirmomeni, G., Rahimi-Bashar, F., Goharimoghadam, K., Pourhoseingholi, M. A., …Sahebkar, A. (2021). Depression, Anxiety, and Stress Among Patients with COVID-19: A Cross-Sectional Study. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (229-236). Cham: Springer. https://doi.org/10.1007/978-3-030-59261-5_19

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Aim: Patients with confirmed COVID-19 infection can develop several psychological consequences. Epidemiological data on mental health... Read More about Depression, Anxiety, and Stress Among Patients with COVID-19: A Cross-Sectional Study.

The Immune Response and Effectiveness of COVID-19 Therapies (2021)
Book Chapter
Tavasolian, F., Hatam, G. R., Mosawi, S. H., Saadi, M. I., Abdollahi, E., Jamialahmadi, T., …Sahebkar, A. (2021). The Immune Response and Effectiveness of COVID-19 Therapies. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (115-126). Cham: Springer. https://doi.org/10.1007/978-3-030-59261-5_10

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly pathogenic with r... Read More about The Immune Response and Effectiveness of COVID-19 Therapies.

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2021). Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?. Frontiers in endocrinology, 12, Article 638621. https://doi.org/10.3389/fendo.2021.638621

© Copyright © 2021 Moin, Sathyapalan, Butler and Atkin. Background: Women with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the... Read More about Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?.

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals (2021)
Journal Article
Hosseini, S. A., Zahedipour, F., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (in press). Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals. BioFactors, https://doi.org/10.1002/biof.1713

Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokin... Read More about Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals.

Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models (2021)
Journal Article
Mohammadi, S., Abdollahi, E., Nezamnia, M., Esmaeili, S. A., Tavasolian, F., Sathyapalan, T., & Sahebkar, A. (2021). Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models. International immunopharmacology, 90, Article 107195. https://doi.org/10.1016/j.intimp.2020.107195

Since half of the genes are inherited from the paternal side, the maternal immune system has to tolerate the presence of foreign paternal antigens. Regulatory T cells facilitate the development and maintenance of peripheral tissue tolerance of the fe... Read More about Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models.

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2021). The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/2042018821989238

© The Author(s), 2021. Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Metabolic consequences associated with PCOS include, but are not limited to, insulin resistance (IR), type 2... Read More about The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.

Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme (2021)
Journal Article
Afshari, A. R., Motamed-Sanaye, A., Sabri, H., Soltani, A., Karkon-Shayan, S., Radvar, S., …Sahebkar, A. (2021). Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme. Current medicinal chemistry, 28(24), 4877-4892. https://doi.org/10.2174/0929867328666210113165805

The current standard of care in glioblastoma multiforme (GBM), as the most morbid brain tumor, is not adequate, despite substantial progress in cancer therapy. Among patients receiving current standard treatments, including surgery, irradiation, and... Read More about Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme.

Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice (2021)
Journal Article
Shah, N., Abdalla, M. A., Deshmukh, H., & Sathyapalan, T. (2021). Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/20420188211042145

Diabetes mellitus (DM) is a chronic, progressive, and multifaceted illness resulting in significant physical and psychological detriment to patients. As of 2019, 463 million people are estimated to be living with DM worldwide, out of which 90% have t... Read More about Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice.

siRNA Therapeutics: Future Promise for Neurodegenerative Diseases (2021)
Journal Article
Amiri, A., Barreto, G., Sathyapalan, T., & Sahebkar, A. (2021). siRNA Therapeutics: Future Promise for Neurodegenerative Diseases. Current Neuropharmacology, 19(11), 1896-1911. https://doi.org/10.2174/1570159X19666210402104054

Neurodegenerative diseases (ND), as a group of central nervous system (CNS) disorders, are among the most prominent medical problems of the 21st century. They are often associated with considerable disability, motor dysfunction and dementia and are m... Read More about siRNA Therapeutics: Future Promise for Neurodegenerative Diseases.

Cardiac Injury in COVID-19: A Systematic Review (2021)
Book Chapter
Moayed, M. S., Rahimi-Bashar, F., Vahedian-Azimi, A., Sathyapalan, T., Guest, P. C., Jamialahmadi, T., & Sahebkar, A. (2021). Cardiac Injury in COVID-19: A Systematic Review. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (325-333). Cham: Springer. https://doi.org/10.1007/978-3-030-59261-5_29

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Coronavirus 2019 (COVID-19) is responsible for the current pandemic which has already resulted in considerable mortality worldwide. Th... Read More about Cardiac Injury in COVID-19: A Systematic Review.

Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms (2021)
Book Chapter
Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases (401-410). Cham: Springer. https://doi.org/10.1007/978-3-030-73234-9_26

Diabetes mellitus is a growing health challenge globally which is increasing in epidemic proportion. Naturally occurring pharmacological agents are more likely to provide beneficial therapeutic effects without undesirable side effects compared to the... Read More about Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms.