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A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2024). A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 25(4), Article 2409. https://doi.org/10.3390/ijms25042409

Dysregulated Alzheimer’s disease (AD)-associated protein expression is reported in polycystic ovary syndrome (PCOS), paralleling the expression reported in type 2 diabetes (T2D). We hypothesized, however, that these proteins would not differ between... Read More about A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome.

Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation (2024)
Journal Article
Ssemmondo, E., Deshmukh, H., Wilmot, E. G., Adeleke, K. A., Shah, N., Walton, C., …Sathyapalan, T. (2024). Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation. Diabetes, Obesity and Metabolism, 26(4), 1340-1345. https://doi.org/10.1111/dom.15435

Aim: To understand the effect of intermittently scanned continuous glucose monitoring (isCGM) in people with diabetes with a ‘psychosocial’ indication for access. Methods: The study utilized baseline and follow-up data from the Association of British... Read More about Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation.

A Cross-Sectional Study of Alzheimer-Related Proteins in Women with Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2024). A Cross-Sectional Study of Alzheimer-Related Proteins in Women with Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 25(2), Article 1158. https://doi.org/10.3390/ijms25021158

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in women of reproductive age, and several risk factors found in PCOS are associated with an increased risk of Alzheimer's disease (AD). Proteins increased in AD have been reporte... Read More about A Cross-Sectional Study of Alzheimer-Related Proteins in Women with Polycystic Ovary Syndrome.

Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study (2024)
Journal Article
Deshmukh, H., Adeleke, K., Wilmot, E. G., Folwell, A., Barnes, D., Walker, N., …Sathyapalan, T. (2024). Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study. Diabetes, Obesity and Metabolism, 26(4), 1333-1339. https://doi.org/10.1111/dom.15434

Aims: To evaluate the clinical features and impact of flash glucose monitoring in older adults with type 1 diabetes (T1D) across age groups defined as young-old, middle-old, and old-old. Materials and Methods: Clinicians were invited to submit anonym... Read More about Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study.

Relationship between endocrine disrupting chemicals (phthalate metabolites, triclosan and bisphenols) and vitamin D in female subjects: An exploratory pilot study (2023)
Journal Article
Brennan, E., Butler, A. E., Nandakumar, M., Thompson, K., Sathyapalan, T., & Atkin, S. L. (2024). Relationship between endocrine disrupting chemicals (phthalate metabolites, triclosan and bisphenols) and vitamin D in female subjects: An exploratory pilot study. Chemosphere, 349, Article 140894. https://doi.org/10.1016/j.chemosphere.2023.140894

Introduction: Evidence suggests that endocrine disrupting chemicals (EDCs), commonly used in plastics and personal care products, may be associated with reduced levels of vitamin D. Therefore, this study examined the relationship between phthalate me... Read More about Relationship between endocrine disrupting chemicals (phthalate metabolites, triclosan and bisphenols) and vitamin D in female subjects: An exploratory pilot study.

Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis (2023)
Journal Article
Batten, L., Sathyapalan, T., & Palmer, T. M. (2023). Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis. International Journal of Molecular Sciences, 24(24), Article 17465. https://doi.org/10.3390/ijms242417465

This review will provide an overview of what is currently known about mechanisms linking poor glycaemic control with increased thrombotic risk. The leading causes of death in people with diabetes are strokes and cardiovascular disease. Significant mo... Read More about Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis.

Association of polychlorinated biphenyls with vitamin D in female subjects (2023)
Journal Article
Butler, A. E., Brennan, E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Association of polychlorinated biphenyls with vitamin D in female subjects. Environmental Research, 233, Article 116465. https://doi.org/10.1016/j.envres.2023.116465

Introduction: Polychlorinated biphenyls (PCBs) are known endocrine disrupters. A potentially causal association of PCBs with vitamin D has been reported. Higher body mass index (BMI) is associated with lower PCB levels whilst the strongest associatio... Read More about Association of polychlorinated biphenyls with vitamin D in female subjects.

The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial (2023)
Journal Article
Deshmukh, H., Papageorgiou, M., Wells, L., Akbar, S., Strudwick, T., Deshmukh, K., …Sathyapalan, T. (2023). The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial. Nutrients, 15(18), Article 3872. https://doi.org/10.3390/nu15183872

We performed an open-label, randomised controlled trial to compare the effects of a very-low-calorie diet (VLCD) vs. moderate energy deficit approach on body weight, body composition, free androgen index (FAI), and metabolic markers in obese women wi... Read More about The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial.

Effects of Iranian herbal Zofa® syrup for the management of clinical symptoms in patients with COVID-19: A randomized clinical trial (2023)
Journal Article
Ghazvini, A., Vahedian-Azimi, A., Abdoli, M., Rahimibashar, F., Panahi, Y., Sathyapalan, T., & Sahebkar, A. (2023). Effects of Iranian herbal Zofa® syrup for the management of clinical symptoms in patients with COVID-19: A randomized clinical trial. Avicenna Journal of Phytomedicine, 13(5), 500-512. https://doi.org/10.22038/AJP.2023.21909

Objective: The objective of this study was to determine the role of Iranian herbal Zofa® syrup in improving the clinical symptoms of patients with COVID-19. Materials and Methods: This randomized clinical trial was conducted on 105 patients with COVI... Read More about Effects of Iranian herbal Zofa® syrup for the management of clinical symptoms in patients with COVID-19: A randomized clinical trial.

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients (2023)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2023). Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients. Cells, 12(15), Article 2002. https://doi.org/10.3390/cells12152002

Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS. We directly compared complement factors from... Read More about Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients.

Association of flame retardants, polybrominated diethyl ethers (PBDEs), with vitamin D in female subjects (2023)
Journal Article
Butler, A. E., Brennan, E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Association of flame retardants, polybrominated diethyl ethers (PBDEs), with vitamin D in female subjects. Chemosphere, 338, Article 139488. https://doi.org/10.1016/j.chemosphere.2023.139488

Introduction: A class of flame retardants, polybrominated diethyl ethers (PBDEs), are known endocrine disrupters and may induce the hepatic enzymes CYP24 and CYP3A that promote 25-hydroxylation of vitamin D3. Therefore, this study examined the associ... Read More about Association of flame retardants, polybrominated diethyl ethers (PBDEs), with vitamin D in female subjects.

An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review (2023)
Journal Article
Golpour-Hamedani, S., Pourmasoumi, M., Askari, G., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (in press). An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review. Current medicinal chemistry, 30, https://doi.org/10.2174/0929867330666230413093409

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors... Read More about An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review.

Association between Organochlorine Pesticides and Vitamin D in Female Subjects (2023)
Journal Article
Brennan, E., Nandakumar, M., Butler, A. E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Association between Organochlorine Pesticides and Vitamin D in Female Subjects. Biomedicines, 11(5), Article 1451. https://doi.org/10.3390/biomedicines11051451

In human population studies, organochlorine pesticides (OCPs) have been linked to vitamin D deficiency. Therefore, this study examined the association between OCPs, vitamin D3 (cholecalciferol, 25(OH)D3), and the active metabolite 1,25-dihydrovitamin... Read More about Association between Organochlorine Pesticides and Vitamin D in Female Subjects.

High density lipoprotein-associated proteins in non-obese women with and without polycystic ovary syndrome (2023)
Journal Article
Butler, A. E., Moin, A. S. M., Reiner, Ž., Sathyapalan, T., Jamialahmadi, T., Sahebkar, A., & Atkin, S. L. (2023). High density lipoprotein-associated proteins in non-obese women with and without polycystic ovary syndrome. Frontiers in endocrinology, 14, Article 1117761. https://doi.org/10.3389/fendo.2023.1117761

Introduction: Dyslipidemia frequently occurs in women with polycystic ovary syndrome (PCOS), but it is unclear whether dyslipidemia is due to obesity and insulin resistance (IR) or is inherent to PCOS. To address this, proteomic analysis of proteins... Read More about High density lipoprotein-associated proteins in non-obese women with and without polycystic ovary syndrome.

Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity (2023)
Journal Article
Jamialahmadi, T., Bo, S., Abbasifard, M., Sathyapalan, T., Jangjoo, A., Moallem, S. A., …Sahebkar, A. (2023). Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity. Journal of Health, Population and Nutrition, 42(1), Article 30. https://doi.org/10.1186/s41043-023-00372-8

BACKGROUND: Inflammation is critical in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). hs-CRP, an inflammatory marker, is considered one of the prognostic predictors of hepatic damage progression in NAFLD in some studies. METHODS: We... Read More about Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity.

Ethnic disparities in people accessing FreeStyle Libre in the United Kingdom: Insights from the Association of British Clinical Diabetologists audit (2023)
Journal Article
Deshmukh, H., Adeleke, K. A., Ssemmondo, E., Wilmot, E. G., Shah, N., Pieri, B., …Sathyapalan, T. (2023). Ethnic disparities in people accessing FreeStyle Libre in the United Kingdom: Insights from the Association of British Clinical Diabetologists audit. Diabetic medicine, 40(8), Article e15095. https://doi.org/10.1111/dme.15095

Metabolic and endocrine complications of long COVID-19: A review (2023)
Journal Article
Bandara, T., Deshmukh, H. A., Abdalla, M., & Sathyapalan, T. (2023). Metabolic and endocrine complications of long COVID-19: A review. Experimental and Clinical Endocrinology and Diabetes, 131(6), 367-374. https://doi.org/10.1055/a-2063-8697

Over the past two years, the COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), centralized the interest of the health care systems and the scientific world. Majority of the COVID-19 infected individuals fully r... Read More about Metabolic and endocrine complications of long COVID-19: A review.

Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu (2023)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Rizzo, M., & Sahebkar, A. (2024). Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu. Current medicinal chemistry, 31(2), 138-151. https://doi.org/10.2174/0929867330666230202163513

Patients with diabetes are at higher risk of cognitive impairment and memory loss than the normal population. Thus, using hypoglycemic agents to improve brain function is important for diabetic patients. Sodium-glucose cotransporters-2 inhibitors (S-... Read More about Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu.

HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study (2023)
Journal Article
Butler, A. E., Moin, A. S. M., Reiner, Ž., Sathyapalan, T., Jamialahmadi, T., Sahebkar, A., & Atkin, S. L. (2023). HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study. Cells, 12(6), https://doi.org/10.3390/cells12060855

INTRODUCTION: Serum lipoproteins, with the exception of high-density lipoprotein cholesterol (HDL-C), are increased in polycystic ovary syndrome (PCOS) and their levels may reflect the associated obesity and insulin resistance, but the nature of this... Read More about HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study.

The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type 1 diabetes: Insights from the Association of British Clinical Diabetologists national audit (2023)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Christian, P., Barnes, D. J., …Sathyapalan, T. (2023). The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type 1 diabetes: Insights from the Association of British Clinical Diabetologists national audit. Diabetic medicine, 40(6), Article e15070. https://doi.org/10.1111/dme.15070

Aims To investigate the change in glycated haemoglobin (HbA1c), hypoglycaemia awareness and diabetes-related distress in people with type 1 diabetes (T1D) using FreeStyle Libre (FSL) over a 2-year follow-up period. Methods FSL user data from U.K w... Read More about The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type 1 diabetes: Insights from the Association of British Clinical Diabetologists national audit.

A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease (2023)
Journal Article
Sardou, H. S., Vosough, P. R., Abbaspour, M., Akhgari, A., Sathyapalan, T., & Sahebkar, A. (in press). A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease. Inflammopharmacology, https://doi.org/10.1007/s10787-023-01140-0

Synthetic drugs and monoclonal antibodies are the typical treatments to combat inflammatory bowel disease (IBD). However, side effects are present when these treatments are used, and their continued application could be restricted by the high relapse... Read More about A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease.

Modulatory properties of curcumin in cancer: A narrative review on the role of interferons (2023)
Journal Article
Chamani, S., Moossavi, M., Naghizadeh, A., Abbasifard, M., Kesharwani, P., Sathyapalan, T., & Sahebkar, A. (in press). Modulatory properties of curcumin in cancer: A narrative review on the role of interferons. Phytotherapy Research, https://doi.org/10.1002/ptr.7734

The immune network is an effective network of cell types and chemical compounds established to maintain the body's homeostasis from foreign threats and to prevent the risk of a wide range of diseases; hence, its proper functioning and balance are ess... Read More about Modulatory properties of curcumin in cancer: A narrative review on the role of interferons.

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies (2023)
Journal Article
Heidari, H., Bagherniya, M., Majeed, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (in press). Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy Research, https://doi.org/10.1002/ptr.7737

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioava... Read More about Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies.

Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2022). Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D. Frontiers in endocrinology, 13, Article 935750. https://doi.org/10.3389/fendo.2022.935750

Introduction: Women with polycystic ovary syndrome (PCOS) exhibit complement factor expression changes that may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, complement changes have been associated with vitamin D deficiency,... Read More about Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D.

Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery (2022)
Journal Article
Jangjoo, S., Emami, N., Sahranavard, M., Shah, N. Z., Alidadi, M., Baratzadeh, F., …Sahebkar, A. (2023). Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery. Obesity Surgery, 33, 548–554. https://doi.org/10.1007/s11695-022-06416-y

Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe obesity who were referred for... Read More about Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery.

Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial (2022)
Journal Article
Ajjan, R. A., Heller, S. R., Everett, C. C., Vargas-Palacios, A., Higham, R., Sharples, L., …Stocken, D. D. (2023). Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial. Diabetes Care, 46(2), 441-449. https://doi.org/10.2337/dc22-1219

OBJECTIVE To analyze the impact of modern glucose-monitoring strategies on glycemic and patient-related outcomes in individuals with type 2 diabetes (T2D) and recent myocardial infarction (MI) and assess cost effectiveness. RESEARCH DESIGN AND METHOD... Read More about Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial.

MicroRNA Changes Up to 24 h following Induced Hypoglycemia in Type 2 Diabetes (2022)
Journal Article
Ramanjaneya, M., Bettahi, I., Pawar, K., Halabi, N. M., Moin, A. S. M., Sathyapalan, T., …Butler, A. E. (2022). MicroRNA Changes Up to 24 h following Induced Hypoglycemia in Type 2 Diabetes. International Journal of Molecular Sciences, 23(23), Article 14696. https://doi.org/10.3390/ijms232314696

Hypoglycemia, as a complication of type 2 diabetes (T2D), causes increased morbidity and mortality but the physiological response underlying hypoglycemia has not been fully elucidated. Small noncoding microRNA (miRNA) have multiple downstream biologi... Read More about MicroRNA Changes Up to 24 h following Induced Hypoglycemia in Type 2 Diabetes.

Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis (2022)
Journal Article
Deshmukh, H., Akbar, S., Bhaiji, A., Saeed, Y., Shah, N., Adeleke, K., …Sathyapalan, T. (2023). Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis. Clinical Endocrinology, 98(3), 400-406. https://doi.org/10.1111/cen.14847

Introduction: Some but not all women with polycystic ovary syndrome (PCOS) develop the metabolic syndrome (MS). The objective of this study was to determine if a subset of women with PCOS had higher androgen levels predisposing them to MS and whether... Read More about Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis.

Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus (2022)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus. Current medicinal chemistry, 30(25), 2850-2863. https://doi.org/10.2174/0929867329666220831151645

Type 2 diabetes mellitus (T2DM) is one of the main causes of mortality and morbidity worldwide. It leads to various long-term complications such as diabetic nephropathy. Diabetes nephropathy is the leading cause of renal failure in patients with chro... Read More about Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus.

The Role of High-density Lipoprotein in Oral and Dental Diseases (2022)
Journal Article
Sadeghalbanaei, L., Shirban, F., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2023). The Role of High-density Lipoprotein in Oral and Dental Diseases. Current medicinal chemistry, 30(20), 2226-2246. https://doi.org/10.2174/0929867329666220901120654

High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, tr... Read More about The Role of High-density Lipoprotein in Oral and Dental Diseases.

Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (2022). Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Therapeutic Advances in Endocrinology and Metabolism, 13, https://doi.org/10.1177/20420188221127142

Context: Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age, and metformin is a widely used medication in managing this condition. Aim: To review the available literature comprehensively o... Read More about Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians. Cardiovascular Diabetology, 21(1), Article 202. https://doi.org/10.1186/s12933-022-01639-w

Objective: Severe hypoglycemia is associated with increased cardiovascular death risk, and platelet responses to hypoglycemia (hypo) have been described. However, the impact of deep transient hypo (deep-hypo) versus prolonged milder hypo (mild-hypo)... Read More about The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians.

Components of the Complement Cascade Differ in Polycystic Ovary Syndrome (2022)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2022). Components of the Complement Cascade Differ in Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 23(20), Article 12232. https://doi.org/10.3390/ijms232012232

Complement pathway proteins are reported to be increased in polycystic ovary syndrome (PCOS) and may be affected by obesity and insulin resistance. To investigate this, a proteomic analysis of the complement system was undertaken, including inhibitor... Read More about Components of the Complement Cascade Differ in Polycystic Ovary Syndrome.

Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery (2022)
Journal Article
Ganjooei, N. A., Jamialahmadi, T., Nematy, M., Shah, N. Z., Jangjoo, S., Emami, N., …Sahebkar, A. (2022). Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery. Middle East Journal of Digestive Diseases, 14(4), 410-421. https://doi.org/10.34172/mejdd.2022.302

Background: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatic fibrosis have emerged as one of the leading causes of chronic liver disease. The prevalence of the NAFLD spectrum has increased, which can be att... Read More about Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery.

Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus (2022)
Journal Article
Sadeghi, M., Dehnavi, S., Shohan, M., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2023). Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus. Current medicinal chemistry, 30(14), 1623-1637. https://doi.org/10.2174/0929867329666220817142848

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to e... Read More about Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus.

Protective effects of curcumin on ischemia/reperfusion injury (2022)
Journal Article
Mohamadian, M., Parsamanesh, N., Chiti, H., Sathyapalan, T., & Sahebkar, A. (2022). Protective effects of curcumin on ischemia/reperfusion injury. Phytotherapy Research, https://doi.org/10.1002/ptr.7620

Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury. While I/R may result in systemic inflammatory response syndrome or multiple organ d... Read More about Protective effects of curcumin on ischemia/reperfusion injury.

The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis (2022)
Journal Article
Mahdi Seyedzadeh Sani, S., Sahranavard, M., Jannati Yazdanabad, M., Seddigh Shamsi, M., Elyasi, S., Hooshang Mohammadpour, A., …Sahebkar, A. (2022). The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis. International immunopharmacology, 112, Article 109227. https://doi.org/10.1016/j.intimp.2022.109227

Background: Changes in the incidence of bleomycin pulmonary toxicity (BPT) as a result of adding colony-stimulating factors (CSF) to bleomycin regimens has been investigated in numerous studies. We performed a systematic review and meta-analysis to a... Read More about The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis.

Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review (2022)
Journal Article
Javid, H., Karimi-Shahri, M., Khorramdel, M., Mashhad, A. S., Tabrizi, A. T., Sathyapalan, T., …Sahebkar, A. (2023). Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review. Current medicinal chemistry, 30(4), 390-406. https://doi.org/10.2174/0929867329666220511185745

The immune system's role in maintaining the health of the gastrointestinal (GI) system is like a double-edged sword. Simultaneously, it could reduce the risk of pathogen invasion by the inflammatory response. However, if regulated improperly, it coul... Read More about Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review.

Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites. Nutrients, 14(17), Article 3540. https://doi.org/10.3390/nu14173540

INTRODUCTION: Chronic low-grade inflammation is a characteristic of women with polycystic ovary syndrome (PCOS), although this may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, vitamin D deficiency, another common feature of... Read More about Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites.

Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit (2022)
Journal Article
Deshmukh, H., Wilmot, E., Pieri, B., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2022). Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit. Diabetic medicine, Article e14942. https://doi.org/10.1111/dme.14942

Aims: The aim of this study was to understand the relationship between time in range (TIR) achieved using the isCGM with changes in glycaemic control, diabetes-related distress (DRD) and resource utilisation in people living with diabetes. Methods: C... Read More about Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit.

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit (2022)
Journal Article
Pieri, B., Deshmukh, H., Wilmot, E. G., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2023). Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit. Diabetes, Obesity and Metabolism, 25(1), 302-305. https://doi.org/10.1111/dom.14841

MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes (2022)
Journal Article
Ramanjaneya, M., Priyanka, R., Bensila, M., Jerobin, J., Pawar, K., Sathyapalan, T., …Butler, A. E. (2022). MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes. Frontiers in endocrinology, 13, Article 917041. https://doi.org/10.3389/fendo.2022.917041

Objective: Hypoglycemia in type 2 diabetes (T2D) increases morbidity and mortality but the underlying physiological response is still not fully understood, though physiological changes are still apparent 24 hours after the event. Small noncoding micr... Read More about MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes.

The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review (2022)
Journal Article
Vitale, S. G., Fulghesu, A. M., Mikuš, M., Watrowski, R., D’Alterio, M. N., Lin, L. T., …Angioni, S. (2022). The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review. Biomedicines, 10(8), Article 1816. https://doi.org/10.3390/biomedicines10081816

MicroRNAs (miRNAs) are small, non-coding RNAs that are essential for the regulation of post-transcriptional gene expression during tissue development and differentiation. They are involved in the regulation of manifold metabolic and hormonal processe... Read More about The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review.

Therapeutic effects of statins on osteoarthritis: A review (2022)
Journal Article
Saberianpour, S., Abolbashari, S., Modaghegh, M. H., Karimian, M. S., Eid, A. H., Sathyapalan, T., & Sahebkar, A. (2022). Therapeutic effects of statins on osteoarthritis: A review. Journal of Cellular Biochemistry, 123(8), 1285-1297. https://doi.org/10.1002/jcb.30309

Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. Hypercholesterolemia is considered a no... Read More about Therapeutic effects of statins on osteoarthritis: A review.

The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature (2022)
Journal Article
Arab, A., Karimi, E., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2022). The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature. Current medicinal chemistry, 29(33), 5462-5473. https://doi.org/10.2174/0929867329666220415114343

Background: To date, many investigations have employed pro-/synbiotic to examine their effects on chemotherapy-related side effects; nevertheless, their findings are inconclu-sive. To address this issue, we carried out a systematic review to explore... Read More about The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature.

Phytochemicals as Modulators of Paraoxonase‐1 in Health and Diseases (2022)
Journal Article
Arab, Z. N., Khayatan, D., Razavi, S. M., Zare, K., Kheradkhah, E., Momtaz, S., …Sahebkar, A. (2022). Phytochemicals as Modulators of Paraoxonase‐1 in Health and Diseases. Antioxidants, 11(7), Article 1273. https://doi.org/10.3390/antiox11071273

Chronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality. These diseases have gained much attention due to their complications, and therefore novel app... Read More about Phytochemicals as Modulators of Paraoxonase‐1 in Health and Diseases.

Abnormal Uterine Bleeding in Perimenopausal Women: The Role of Hysteroscopy and Its Impact on Quality of Life and Sexuality (2022)
Journal Article
Vitale, S. G., Watrowski, R., Barra, F., D’alterio, M. N., Carugno, J., Sathyapalan, T., …Angioni, S. (2022). Abnormal Uterine Bleeding in Perimenopausal Women: The Role of Hysteroscopy and Its Impact on Quality of Life and Sexuality. Diagnostics, 12(5), Article 1176. https://doi.org/10.3390/diagnostics12051176

Abnormal uterine bleeding (AUB) is a frequent symptom in perimenopausal women. It is defined as uterine bleeding in which the duration, frequency, or amount of bleeding is considered excessive and negatively affects the woman’s quality of life (QoL)... Read More about Abnormal Uterine Bleeding in Perimenopausal Women: The Role of Hysteroscopy and Its Impact on Quality of Life and Sexuality.

Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review (2022)
Journal Article
Babaie, F., Omraninava, M., Gorabi, A. M., Khosrojerdi, A., Aslani, S., Yazdchi, A., …Sahebkar, A. (2022). Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review. Current Genomics, 23(3), 163-174. https://doi.org/10.2174/1389202923666220527111037

Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of... Read More about Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review.

Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Archives of Gynecology and Obstetrics, https://doi.org/10.1007/s00404-022-06549-6

Context: Polycystic ovary syndrome (PCOS) is a complex endocrine disease that affects women of reproductive age and is characterised by biochemical and clinical androgen excess. Aim: To evaluate the efficacy of pharmacological interventions used to d... Read More about Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response (2022)
Journal Article
Nandakumar, M., Moin, A. S. M., Ramanjaneya, M., Qaissi, A. A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response. Diabetes, Obesity and Metabolism, 24(8), 1483-1497. https://doi.org/10.1111/dom.14716

Introduction: There is evidence that fibroblast growth factor (FGF) levels may be implicated in hypoglycaemia, with FGF19 being a potential contributor to insulin-independent pathways driving postprandial hypoglycaemia following bariatric surgery and... Read More about Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response.

Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups (2022)
Journal Article
Yale, J. F., Bodholdt, U., Catarig, A. M., Catrina, S., Clark, A., Ekberg, N. R., …Rudofsky, G. (2022). Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups. BMJ Open Diabetes Research and Care, 10(2), Article e002619. https://doi.org/10.1136/bmjdrc-2021-002619

INTRODUCTION: This post hoc pooled analysis of four real-world studies (SURE Canada, Denmark/Sweden, Switzerland and UK) aimed to characterize the use of once-weekly (OW) semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in patients... Read More about Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups.

Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy (2022)
Journal Article
Bibak, B., Shakeri, F., Keshavarzi, Z., Mollazadeh, H., Javid, H., Jalili-Nik, M., …Sahebkar, A. (2022). Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy. Current medicinal chemistry, 29(26), 4507-4528. https://doi.org/10.2174/0929867329666220224112811

The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by re... Read More about Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy.

FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis (2022)
Journal Article
Blissett, R., Blissett, D., Levrat-Guillen, F., Deshmukh, H., Wilmot, E. G., Ryder, R. E., …Sathyapalan, T. (2022). FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis. BMJ Open Diabetes Research and Care, 10(2), Article e002580. https://doi.org/10.1136/bmjdrc-2021-002580

INTRODUCTION: This study aims to estimate the budget impact of increased uptake of the FreeStyle Libre Flash Glucose Monitoring system in people with type 1 diabetes mellitus (T1DM) in the UK. RESEARCH DESIGN AND METHODS: A budget impact model was de... Read More about FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis.

Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders (2022)
Journal Article
Shakeri, F., Bibak, B., Safdari, M. R., Keshavarzi, Z., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2022). Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders. Current medicinal chemistry, 29(16), 2878-2890. https://doi.org/10.2174/0929867329666220210145033

There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The... Read More about Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders.

A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome (2022)
Journal Article
Brennan, E., Kumar, N., Drage, D. S., Cunningham, T. K., Sathyapalan, T., Mueller, J. F., & Atkin, S. L. (2022). A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome. Journal of Environmental Science and Health , Part C: Toxicology and Carcinogenesis, 40(1), 86-105. https://doi.org/10.1080/26896583.2022.2043135

Polychlorinated biphenyls (PCBs) are a class of environmental pollutants with a long half-life that sequester in fat. Women with polycystic ovarian syndrome (PCOS) may represent a sensitive subgroup to endogenous exposure to PCBs because of associate... Read More about A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome.

Postradioiodine Graves' management: The PRAGMA study (2022)
Journal Article
Perros, P., Basu, A., Boelaert, K., Dayan, C., Vaidya, B., Williams, G. R., …Karavitaki, N. (2022). Postradioiodine Graves' management: The PRAGMA study. Clinical Endocrinology, https://doi.org/10.1111/cen.14719

Objective: Thyroid status in the months following radioiodine (RI) treatment for Graves' disease can be unstable. Our objective was to quantify frequency of abnormal thyroid function post-RI and compare effectiveness of common management strategies.... Read More about Postradioiodine Graves' management: The PRAGMA study.

Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology (2022)
Journal Article
Sahebkar, A., Sathyapalan, T., Guest, P. C., & Barreto, G. E. (2022). Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology. Biomedicine and Pharmacotherapy, 148, Article 112770. https://doi.org/10.1016/j.biopha.2022.112770

Traumatic brain injury (TBI) affects approximately 50% of the world population at some point in their lifetime. To date, there are no effective treatments as most of the damage occurs due to secondary effects through a variety of pathophysiological p... Read More about Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology.

A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging (2022)
Journal Article
Mesgari, M., Aalami, A. H., Sathyapalan, T., & Sahebkar, A. (2022). A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging. Bioinorganic Chemistry and Applications, 2022, Article 7557825. https://doi.org/10.1155/2022/7557825

Background. Food nanopackaging helps maintain food quality against physical, chemical, and storage instability factors. Copper oxide nanoparticles (CuONPs) can improve biopolymers' mechanical features and barrier properties. This will lead to antimic... Read More about A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging.

Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature (2022)
Journal Article
Hatamipour, M., Hadizadeh, F., Jaafari, M. R., Khashyarmanesh, Z., Sathyapalan, T., & Sahebkar, A. (2022). Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature. Current medicinal chemistry, 29(8), 1459-1471. https://doi.org/10.2174/0929867328666210910141316

BACKGROUND: Curcuminoids, flavoring, and coloring agents in food have potent antioxidant, anti-tumor activity, and anti-inflammatory effects. However, they are rapidly metabolized to lesser active metabolites. Therefore, various studies have been con... Read More about Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature.

Effects of the pharmacological interventions and a structured education in the management of polycystic ovary syndrome (PCOS) (2022)
Thesis
Abdalla, M. A. (2022). Effects of the pharmacological interventions and a structured education in the management of polycystic ovary syndrome (PCOS). (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4224300

Introduction Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects women of reproductive age and is associated with an array of metabolic disorders. Insulin resistance, increased body weight, dyslipidaemia and excess an... Read More about Effects of the pharmacological interventions and a structured education in the management of polycystic ovary syndrome (PCOS).

The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery (2022)
Journal Article
Jamialahmadi, T., Nematy, M., Abdalla, M., Jangjoo, A., Goshayeshi, L., Kroh, M., …Sahebkar, A. (2022). The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery. Journal of Nutrition and Metabolism, 2022, Article 7319742. https://doi.org/10.1155/2022/7319742

Background. Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity... Read More about The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery.

Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization. Metabolites, 12(3), Article 196. https://doi.org/10.3390/metabo12030196

Development of type-2 diabetes(T2D) is preceded by β-cell dysfunction and loss. How-ever, accurate measurement of β-cell function remains elusive. Biomarkers have been reported to predict β-cell functional decline but require validation. Therefore, w... Read More about Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization.

Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis (2022)
Journal Article
Akbari, A., Rafiee, M., Sathyapalan, T., & Sahebkar, A. (2022). Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis. Journal of Diabetes Research, 2022, Article 7520632. https://doi.org/10.1155/2022/7520632

Background: Several trials have assessed the antihyperglycemic effects of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in patients with type 2 diabetes mellitus (T2DM). We conducted a quantitative analysis to assess the impact of SGLT2is on ser... Read More about Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis.

Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women (2022)
Journal Article
Ramanjaneya, M., Abdalhakam, I., Bettahi, I., Bensila, M., Jerobin, J., Aye, M. M., …Abou-Samra, A. B. (2022). Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women. Frontiers in endocrinology, 12, Article 740703. https://doi.org/10.3389/fendo.2021.740703

Background: The complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, al... Read More about Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women.

Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer (2022)
Journal Article
Pashirzad, M., Sathyapalan, T., Sheikh, A., Kesharwani, P., & Sahebkar, A. (2022). Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry, 115, 19-29. https://doi.org/10.1016/j.procbio.2022.02.006

Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorect... Read More about Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer.

The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19 (2022)
Journal Article
Saghafi, N., Rezaee, S. A., Momtazi-Borojeni, A. A., Tavasolian, F., Sathyapalan, T., Abdollahi, E., & Sahebkar, A. (2022). The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19. Life Sciences, 294, Article 120392. https://doi.org/10.1016/j.lfs.2022.120392

The SARS coronavirus 2 (SARS CoV-2) causes Coronavirus Disease (COVID-19), is an emerging viral infection. SARS CoV-2 infects target cells by attaching to Angiotensin-Converting Enzyme (ACE2). SARS CoV-2 could cause cardiac damage in patients with se... Read More about The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19.

PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease (2022)
Journal Article
Shahbaz, S. K., Koushki, K., Sathyapalan, T., Majeed, M., & Sahebkar, A. (2022). PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease. Current Neuropharmacology, 20(2), 309-323. https://doi.org/10.2174/1570159X19666210823103020

Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic ne... Read More about PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease.

The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review (2022)
Journal Article
Bagherniya, M., Mahdavi, A., Abbasi, E., Iranshahy, M., Sathyapalan, T., & Sahebkar, A. (2022). The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review. Inflammopharmacology, 30(1), 91-110. https://doi.org/10.1007/s10787-021-00902-y

Obesity is abnormal fat accumulation in the body which acts as a risk factor for various cardiometabolic states. Adipose tissue in excess can release inflammatory factors, including TNF-α and IL-6, and suppress adiponectin production. TNF-α increases... Read More about The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.

Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review (2022)
Journal Article
Gholami, L., Ivari, J. R., Nasab, N. K., Oskuee, R. K., Sathyapalan, T., & Sahebkar, A. (2023). Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review. Current medicinal chemistry, 30(3), 335-355. https://doi.org/10.2174/0929867328666210810160901

Lung cancer is one of the commonest cancers with a significant mortality rate for both genders, particularly in men. Lung cancer is recognized as one of the leading causes of death worldwide, which threatens the lives of over 1.6 million people every... Read More about Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review.

Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs (2022)
Book Chapter
Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases (463-471). Cham: Springer. https://doi.org/10.1007/978-3-030-73234-9_31

MicroRNAs (miRNAs) are endogenous short noncoding RNAs with approximately 22 nucleotides. The primary function of miRNAs is the negative regulation of target gene expression via mRNA degradation or translation inhibition. During recent years, much at... Read More about Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs.

Preface (2021)
Book Chapter
Sahebkar, A., & Sathyapalan, T. (2021). Preface. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases : Pharmacology, Molecular Targets, and Therapeutic Benefits (v). Cham: Springer Verlag. https://doi.org/10.1007/978-3-030-73234-9

Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14663

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age and is associated with increased body weight. Objective: To review the literature on the effect of different pharmacological interventions on t... Read More about Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials.

Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study (2021)
Journal Article
Deshmukh, H., Shah, N., Papageorgiou, M., Abdalla, M. A., Lhaf, F., Aye, M., & Sathyapalan, T. (2022). Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study. Bone, 155, Article 116285. https://doi.org/10.1016/j.bone.2021.116285

Introduction: There is conflicting data on the effect of polycystic ovary syndrome (PCOS) on bone mineral density (BMD) and fracture risk. Recent genetic data suggest that men may also carry genetic risk factors for PCOS; the associations of these fa... Read More about Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study.

Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes. Frontiers in Molecular Biosciences, 8, Article 744459. https://doi.org/10.3389/fmolb.2021.744459

Background and Purpose: Patients with type 2 diabetes (T2D) have increased risk of cardiovascular disease (CVD), encompassing myocardial infarction, stroke, and peripheral vascular disease. We hypothesized that those biomarkers indicative of acute is... Read More about Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes.

Hypoglycemia-induced changes in complement pathways in type 2 diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Diboun, I., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Hypoglycemia-induced changes in complement pathways in type 2 diabetes. Atherosclerosis, 46, 35-45. https://doi.org/10.1016/j.athplu.2021.11.002

Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothes... Read More about Hypoglycemia-induced changes in complement pathways in type 2 diabetes.

Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14636

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD). Ob... Read More about Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis.

Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Kahal, H., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia. Cells, 10(11), Article 3109. https://doi.org/10.3390/cells10113109

Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elic-its a similar response with inflammatory and oxidative-stress responses c... Read More about Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia.

Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14623

Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterized by insulin resistance and is a major risk factor for type 2 diabetes mellitus (T2DM). The objective was to review th... Read More about Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review (2021)
Journal Article
Safarzadeh, S., Shirban, F., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2022). The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review. Phytotherapy Research, 36(1), 243-265. https://doi.org/10.1002/ptr.7308

Cancer therapy-induced oral mucositis (OM) is one of the most troublesome morbidities after radio-chemotherapy. Age, nutritional status, tumor type, oral hygiene, and treatment method are the determinants for OM incidence. In addition, oxygen-free ra... Read More about The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review.

The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease (2021)
Journal Article
Lashgari, N. A., Roudsari, N. M., Momtaz, S., Sathyapalan, T., Abdolghaffari, A. H., & Sahebkar, A. (2021). The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease. Journal of Neuroimmunology, 361, Article 577758. https://doi.org/10.1016/j.jneuroim.2021.577758

Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and oxidative stress play key etiopathological role. The pathology of PD brain is characterized by inclusions of aggregated α-synuclein (α-SYN) in the cytoplasmic region o... Read More about The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease.

Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract (2021)
Journal Article
Korani, S., Rashidi, K., Hamelian, M., Jalalvand, A. R., Tajehmiri, A., Korani, M., …Sahebkar, A. (2021). Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract. Bioinorganic Chemistry and Applications, 2021, Article 7019130. https://doi.org/10.1155/2021/7019130

Background. Wound healing is a complex process of replacing devitalized cellular structures and tissues with healthy cells and tissue. Nanotechnology has been increasingly proposed as a novel platform to treat wounds and skin regeneration. The aim of... Read More about Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract.

Association of microRNAs With Embryo Development and Fertilization in Women Undergoing Subfertility Treatments: A Pilot Study (2021)
Journal Article
Butler, A. E., Cunningham, T. K., Ramachandran, V., Diboun, I., Halama, A., Sathyapalan, T., …Atkin, S. L. (2021). Association of microRNAs With Embryo Development and Fertilization in Women Undergoing Subfertility Treatments: A Pilot Study. Frontiers in Reproductive Health, 3, Article 719326. https://doi.org/10.3389/frph.2021.719326

Objective: Small non-coding RNAs, known as microRNAs (miRNAs), have emerging regulatory functions within the ovary that have been related to fertility. This study was undertaken to determine if circulating miRNAs reflect the changes associated with t... Read More about Association of microRNAs With Embryo Development and Fertilization in Women Undergoing Subfertility Treatments: A Pilot Study.

Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study (2021)
Journal Article
Holmes, P., Bell, H. E., Bozkurt, K., Catarig, A. M., Clark, A., Machell, A., & Sathyapalan, T. (2021). Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study. Diabetes Therapy, https://doi.org/10.1007/s13300-021-01141-8

Introduction: Once-weekly (OW) semaglutide was associated with clinically relevant improvements in glycaemic control and body weight versus comparators in the SUSTAIN randomised controlled trials (RCTs). SURE UK, which is one of a series of individua... Read More about Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study.

Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit (2021)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Choudhary, P., Christian, P., …Sathyapalan, T. (in press). Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit. British Journal of Diabetes, https://doi.org/10.15277/bjd.2021.308

Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Choudhary, P., Narendran, P., Shah, N., Barnes, D., …Sathyapalan, T. (2021). Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit. Diabetes Care, 44(11), e190-e191. https://doi.org/10.2337/dc21-1181

Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders (2021)
Journal Article
Koushki, K., Shahbaz, S. K., Keshavarz, M., Bezsonov, E. E., Sathyapalan, T., & Sahebkar, A. (2021). Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders. Biomolecules, 11(9), Article 1289. https://doi.org/10.3390/biom11091289

Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-lo... Read More about Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders.

Impact of severe hypoglycemia on the heat shock and related protein response (2021)
Journal Article
Atkin, A. S., Moin, A. S. M., Nandakumar, M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Impact of severe hypoglycemia on the heat shock and related protein response. Scientific reports, 11(1), Article 17057. https://doi.org/10.1038/s41598-021-96642-8

Heat shock proteins contribute to diabetes-induced complications and are affected by glycemic control. Our hypothesis was that hypoglycemia-induced heat shock and related protein changes would be amplified in type 2 diabetes (T2D). This prospective,... Read More about Impact of severe hypoglycemia on the heat shock and related protein response.

Implications on the Therapeutic Potential of Statins via Modulation of Autophagy (2021)
Journal Article
Gorabi, A. M., Kiaie, N., Aslani, S., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Implications on the Therapeutic Potential of Statins via Modulation of Autophagy. Oxidative Medicine and Cellular Longevity, 2021, Article 9599608. https://doi.org/10.1155/2021/9599608

Statins, which are functionally known as 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) inhibitors, are lipid-lowering compounds widely prescribed in patients with cardiovascular diseases (CVD). Several biological and therapeutic functions have been attri... Read More about Implications on the Therapeutic Potential of Statins via Modulation of Autophagy.

The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes (2021)
Journal Article
Yaribeygi, H., Farrokhi, F. R., Abdalla, M. A., Sathyapalan, T., Banach, M., Jamialahmadi, T., & Sahebkar, A. (2021). The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes. Journal of Diabetes Research, 2021, Article 6518221. https://doi.org/10.1155/2021/6518221

Glucagon-like peptide-1 receptor (GLP-1R) agonists are a class of newly introduced antidiabetic medications that potentially lower blood glucose by several molecular pathways. DPP-4 inhibitors are the other type of novel antidiabetic medications whic... Read More about The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes.

Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers (2021)
Journal Article
Marsden, A. J., Riley, D. R., Birkett, S., Rodriguez-Barucg, Q., Guinn, B. A., Carroll, S., …Beltran-Alvarez, P. (in press). Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers. Amino acids, https://doi.org/10.1007/s00726-021-03024-5

Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily av... Read More about Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity. Frontiers in endocrinology, 12, Article 658304. https://doi.org/10.3389/fendo.2021.658304

Objective: Detailed proteomic analysis in a cohort of patients with differing severity of COVID-19 disease identified biomarkers within the complement and coagulation cascades as biomarkers for disease severity has been reported; however, it is uncle... Read More about Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection? (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?. Frontiers in endocrinology, 12, Article 665134. https://doi.org/10.3389/fendo.2021.665134

Introduction: Neuropilin-1(NRP1) is a cofactor that enhances SARS-CoV-2 coronavirus cell infectivity when co-expressed with angiotensin-converting enzyme 2(ACE2). The Renin-Angiotensin System (RAS) is activated in type 2 diabetes (T2D); therefore, th... Read More about Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?.

Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., …Sathyapalan, T. (2021). Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study. Diabetes, Obesity and Metabolism, 23(10), 2261-2268. https://doi.org/10.1111/dom.14467

Aim: To identify the baseline demographic and clinical characteristics associated with diabetes-related distress (DRD) and factors associated with improvement in DRD after initiating use of the FreeStyle Libre (FSL) in people living with type 1 diabe... Read More about Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study.

High-fidelity simulation and virtual reality: An evaluation of medical students' experiences (2021)
Journal Article
Macnamara, A. F., Bird, K., Rigby, A., Sathyapalan, T., & Hepburn, D. (2021). High-fidelity simulation and virtual reality: An evaluation of medical students' experiences. BMJ Simulation & Technology Enhanced Learning, 7(6), 528-535. https://doi.org/10.1136/bmjstel-2020-000625

Background: Simulation technology is widely used in medical education, providing an environment in which students can develop and practise a multitude of skills that are relevant to clinical practice, without the risk of harm to patients. Methods: We... Read More about High-fidelity simulation and virtual reality: An evaluation of medical students' experiences.

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype (2021)
Journal Article
Li, J. V., Ashrafian, H., Sarafian, M., Homola, D., Rushton, L., Barker, G., …Holmes, E. (2021). Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype. Microbiome, 9(1), Article 139. https://doi.org/10.1186/s40168-021-01086-x

Background: Bariatric surgery, used to achieve effective weight loss in individuals with severe obesity, modifies the gut microbiota and systemic metabolism in both humans and animal models. The aim of the current study was to understand better the m... Read More about Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype.

The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Mohammed, I., Atkin, S., Reid, M., & Sathyapalan, T. (2021). The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study. Frontiers in Physiology, 12, Article 652559. https://doi.org/10.3389/fphys.2021.652559

Purpose: Free androgen index (FAI) and anti-Mullerian hormone (AMH) are independently associated with polycystic ovary syndrome (PCOS). This study aimed to describe the relationship between these two markers and health-related quality of life (HR-QoL... Read More about The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study.

The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery (2021)
Journal Article
Jamialahmadi, T., Nematy, M., Jangjoo, A., Goshayeshi, L., Abdalla, M. A., Akhlaghi, S., …Sahebkar, A. (in press). The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, https://doi.org/10.1007/s40519-021-01151-2

Background: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hepatic fibrosis are the most detrimental hepatic abnormalities associated with increased body weight with devastating clinical outcomes. Therefore, there... Read More about The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery.

Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches (2021)
Journal Article
Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (in press). Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches. Mini-Reviews in Medicinal Chemistry, 22(2), 312-321. https://doi.org/10.2174/1389557521666210505112834

Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favoura... Read More about Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches.

Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia (2021)
Journal Article
Moin, A. S. M., Kahal, H., Al-Qaissi, A., Kumar, N., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia. BMJ Open Diabetes Research and Care, 9(1), Article e002211. https://doi.org/10.1136/bmjdrc-2021-002211

Introduction Hypoglycemia in type 2 diabetes (T2D) may increase risk for Alzheimer’s disease (AD), but no data on changes in AD-related proteins with differing degrees of hypoglycemia exist. We hypothesized that milder prolonged hypoglycemia would ca... Read More about Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia.

Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials (2021)
Journal Article
Gorabi, A. M., Razi, B., Aslani, S., Abbasifard, M., Imani, D., Sathyapalan, T., & Sahebkar, A. (2021). Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials. Cytokine, 143, Article 155541. https://doi.org/10.1016/j.cyto.2021.155541

It has been suggested that curcumin has the potential for lowering inflammation. In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and... Read More about Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials.

Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms (2021)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms. Oxidative Medicine and Cellular Longevity, 2021, Article 9959320. https://doi.org/10.1155/2021/9959320

Glucagon-like peptide 1 receptor agonists and dipeptidyl-peptidase 4 inhibitors are medications used for managing diabetes, mimicking the metabolic effects of incretin hormones. Recent evidence suggests that these medications have antioxidative poten... Read More about Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms.

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis (2021)
Journal Article
Aalami, A. H., Abdeahad, H., Mesgari, M., Sathyapalan, T., & Sahebkar, A. (2021). Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis. Biomed research international, 2021, Article 5557309. https://doi.org/10.1155/2021/5557309

Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis,... Read More about Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis.

Plasma heat shock protein response to euglycemia in type 2 diabetes (2021)
Journal Article
Atkin, A. S., Moin, A. S., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Plasma heat shock protein response to euglycemia in type 2 diabetes. BMJ Open Diabetes Research and Care, 9(1), Article e002057. https://doi.org/10.1136/bmjdrc-2020-002057

Introduction Glucose variability is associated with mortality and macrovascular diabetes complications. The mechanisms through which glucose variability mediates tissue damage are not well understood, although cellular oxidative stress is likely invo... Read More about Plasma heat shock protein response to euglycemia in type 2 diabetes.

Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training (2021)
Journal Article
Jerobin, J., Ramanjaneya, M., Bettahi, I., Parammal, R., Siveen, K. S., Alkasem, M., …Abou-Samra, A. B. (2021). Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training. Lipids in Health and Disease, 20(1), Article 34. https://doi.org/10.1186/s12944-021-01463-3

Background: Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid ho... Read More about Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training.

The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review (2021)
Book Chapter
Gharibpour, F., Shirban, F., Bagherniya, M., Nosouhian, M., Sathyapalan, T., & Sahebkar, A. (2021). The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review. In G. E. Barreto, & A. Sahebkar (Eds.), Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health (225-248). Cham: Springer Verlag. https://doi.org/10.1007/978-3-030-64872-5_16

Candida albicans is part of the healthy flora in the oral cavity. It can also cause opportunistic infection, which can be deleterious. The most typical type of chronic oral candidiasis is denture stomatitis, and C. albicans is identified as the most... Read More about The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review.

Impact of curcumin on fatty acid metabolism (2021)
Journal Article
Nosrati-Oskouie, M., Aghili-Moghaddam, N. S., Sathyapalan, T., & Sahebkar, A. (in press). Impact of curcumin on fatty acid metabolism. Phytotherapy Research, https://doi.org/10.1002/ptr.7105

Free fatty acids (FFAs) and fatty acid synthesis (FAS) activity have significantly contributed to disease states such as insulin resistance, obesity, type 2 diabetes, myocardial infarction, blood pressure, and several types of cancer. Currently, seve... Read More about Impact of curcumin on fatty acid metabolism.

Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes. Frontiers in endocrinology, 12, Article 651009. https://doi.org/10.3389/fendo.2021.651009

Introduction: Patients with severe COVID-19 infections have coagulation abnormalities indicative of a hypercoagulable state, with thromboembolic complications and increased mortality. Platelets are recognized as mediators of inflammation, releasing p... Read More about Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19 (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Diboun, I., Atkin, S. L., & Butler, A. E. (in press). Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19. Scientific reports, 11(1), Article 6428. https://doi.org/10.1038/s41598-021-85760-y

Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS). The objective was to determine the circulatory biomarkers for macrophage activation at baselin... Read More about Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19.

The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update (2021)
Journal Article
Navashenaq, J. G., Shabgah, A. G., Hedayati-Moghadam, M., Ariaee, N., Mohammadi, H., Hemmatzadeh, M., …Sahebkar, A. (2021). The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update. Life Sciences, 269, https://doi.org/10.1016/j.lfs.2021.119083

© 2021 Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the late stages of the disease, it can be associated with several complications. Although the exact etiology of RA is unknown, various studies have been p... Read More about The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update.

Correction to: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome (Journal of Translational Medicine, (2020), 18, 1, (490), 10.1186/s12967-020-02669-2) (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Correction to: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome (Journal of Translational Medicine, (2020), 18, 1, (490), 10.1186/s12967-020-02669-2). Journal of Translational Medicine, 19(1), Article 106. https://doi.org/10.1186/s12967-021-02782-w

© 2021, The Author(s). An amendment to this paper has been published and can be accessed via the original article.

Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis (2021)
Journal Article
Karimi, L., Makvandi, S., Vahedian-Azimi, A., Sathyapalan, T., & Sahebkar, A. (2021). Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis. Journal of Pregnancy, 2021, 1-33. https://doi.org/10.1155/2021/8870129

Background. Based on what is known at this time, pregnant women are at an increased risk of severe illness from COVID-19 compared to nonpregnant women. Additionally, pregnant women with COVID-19 might have an increased risk of adverse pregnancy outco... Read More about Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis.

Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Diboun, I., Elrayess, M. A., Butler, A. E., & Atkin, S. L. (in press). Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome. Scientific reports, 11(1), Article 5320. https://doi.org/10.1038/s41598-021-84586-y

© 2021, The Author(s). Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulatio... Read More about Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome.

The Immune Response and Effectiveness of COVID-19 Therapies (2021)
Book Chapter
Tavasolian, F., Hatam, G. R., Mosawi, S. H., Saadi, M. I., Abdollahi, E., Jamialahmadi, T., …Sahebkar, A. (2021). The Immune Response and Effectiveness of COVID-19 Therapies. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (115-126). Cham: Springer. https://doi.org/10.1007/978-3-030-59261-5_10

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly pathogenic with r... Read More about The Immune Response and Effectiveness of COVID-19 Therapies.

Depression, Anxiety, and Stress Among Patients with COVID-19: A Cross-Sectional Study (2021)
Book Chapter
Moayed, M. S., Vahedian-Azimi, A., Mirmomeni, G., Rahimi-Bashar, F., Goharimoghadam, K., Pourhoseingholi, M. A., …Sahebkar, A. (2021). Depression, Anxiety, and Stress Among Patients with COVID-19: A Cross-Sectional Study. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (229-236). Cham: Springer. https://doi.org/10.1007/978-3-030-59261-5_19

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Aim: Patients with confirmed COVID-19 infection can develop several psychological consequences. Epidemiological data on mental health... Read More about Depression, Anxiety, and Stress Among Patients with COVID-19: A Cross-Sectional Study.

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2021). Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?. Frontiers in endocrinology, 12, Article 638621. https://doi.org/10.3389/fendo.2021.638621

© Copyright © 2021 Moin, Sathyapalan, Butler and Atkin. Background: Women with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the... Read More about Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?.

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals (2021)
Journal Article
Hosseini, S. A., Zahedipour, F., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (in press). Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals. BioFactors, https://doi.org/10.1002/biof.1713

Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokin... Read More about Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals.

Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models (2021)
Journal Article
Mohammadi, S., Abdollahi, E., Nezamnia, M., Esmaeili, S. A., Tavasolian, F., Sathyapalan, T., & Sahebkar, A. (2021). Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models. International immunopharmacology, 90, Article 107195. https://doi.org/10.1016/j.intimp.2020.107195

Since half of the genes are inherited from the paternal side, the maternal immune system has to tolerate the presence of foreign paternal antigens. Regulatory T cells facilitate the development and maintenance of peripheral tissue tolerance of the fe... Read More about Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models.

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2021). The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/2042018821989238

© The Author(s), 2021. Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Metabolic consequences associated with PCOS include, but are not limited to, insulin resistance (IR), type 2... Read More about The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.

Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme (2021)
Journal Article
Afshari, A. R., Motamed-Sanaye, A., Sabri, H., Soltani, A., Karkon-Shayan, S., Radvar, S., …Sahebkar, A. (2021). Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme. Current medicinal chemistry, 28(24), 4877-4892. https://doi.org/10.2174/0929867328666210113165805

The current standard of care in glioblastoma multiforme (GBM), as the most morbid brain tumor, is not adequate, despite substantial progress in cancer therapy. Among patients receiving current standard treatments, including surgery, irradiation, and... Read More about Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme.

Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms (2021)
Book Chapter
Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases (401-410). Cham: Springer. https://doi.org/10.1007/978-3-030-73234-9_26

Diabetes mellitus is a growing health challenge globally which is increasing in epidemic proportion. Naturally occurring pharmacological agents are more likely to provide beneficial therapeutic effects without undesirable side effects compared to the... Read More about Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms.

Cardiac Injury in COVID-19: A Systematic Review (2021)
Book Chapter
Moayed, M. S., Rahimi-Bashar, F., Vahedian-Azimi, A., Sathyapalan, T., Guest, P. C., Jamialahmadi, T., & Sahebkar, A. (2021). Cardiac Injury in COVID-19: A Systematic Review. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (325-333). Cham: Springer. https://doi.org/10.1007/978-3-030-59261-5_29

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Coronavirus 2019 (COVID-19) is responsible for the current pandemic which has already resulted in considerable mortality worldwide. Th... Read More about Cardiac Injury in COVID-19: A Systematic Review.

Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice (2021)
Journal Article
Shah, N., Abdalla, M. A., Deshmukh, H., & Sathyapalan, T. (2021). Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/20420188211042145

Diabetes mellitus (DM) is a chronic, progressive, and multifaceted illness resulting in significant physical and psychological detriment to patients. As of 2019, 463 million people are estimated to be living with DM worldwide, out of which 90% have t... Read More about Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice.

siRNA Therapeutics: Future Promise for Neurodegenerative Diseases (2021)
Journal Article
Amiri, A., Barreto, G., Sathyapalan, T., & Sahebkar, A. (2021). siRNA Therapeutics: Future Promise for Neurodegenerative Diseases. Current Neuropharmacology, 19(11), 1896-1911. https://doi.org/10.2174/1570159X19666210402104054

Neurodegenerative diseases (ND), as a group of central nervous system (CNS) disorders, are among the most prominent medical problems of the 21st century. They are often associated with considerable disability, motor dysfunction and dementia and are m... Read More about siRNA Therapeutics: Future Promise for Neurodegenerative Diseases.

Association of Differing Qatari Genotypes with Vitamin D Metabolites (2020)
Thesis
Dakroury, Y. (2020). Association of Differing Qatari Genotypes with Vitamin D Metabolites. (Thesis). Hull York Medical School, The University of Hull and The University of York. Retrieved from https://hull-repository.worktribe.com/output/4192858

This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Pers... Read More about Association of Differing Qatari Genotypes with Vitamin D Metabolites.

Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations (2020)
Journal Article
Butler, A. E., Abouseif, A., Dargham, S. R., Sathyapalan, T., & Atkin, S. L. (2020). Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations. Scientific reports, 10(1), Article 18895. https://doi.org/10.1038/s41598-020-75109-2

© 2020, The Author(s). To determine if metabolic characteristics differed in women with and without polycystic ovary syndrome (PCOS) between a Caucasian and Middle East population. Comparative cross-sectional analysis. Demographic and metabolic data... Read More about Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations.

Recent advances in drug discovery for diabetic kidney disease (2020)
Journal Article
Danta, C. C., Boa, A. N., Bhandari, S., Sathyapalan, T., & Xu, S. Z. (2021). Recent advances in drug discovery for diabetic kidney disease. Expert Opinion on Drug Discovery, 16(4), 447-461. https://doi.org/10.1080/17460441.2021.1832077

Introduction: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD), and 40% of patients with diabetes develop DKD. Although some pathophysiological mechanisms and drug targets of DKD have been described, the effectivenes... Read More about Recent advances in drug discovery for diabetic kidney disease.

Curcumin for the management of periodontal diseases: a review (2020)
Journal Article
Forouzanfar, F., Forouzanfar, A., Sathyapalan, T., Orafai, H. M., & Sahebkar, A. (2020). Curcumin for the management of periodontal diseases: a review. Current Pharmaceutical Design, 26(34), 4277-4284. https://doi.org/10.2174/1381612826666200513112607

Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receivi... Read More about Curcumin for the management of periodontal diseases: a review.

Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia (2020)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.14220

Objective Hypoglycemia in diabetes (T2D) may increase the risk for Alzheimer's disease (AD). We hypothesized that hypoglycemia‐induced amyloid‐related protein changes would be exacerbated in T2D. Methods A prospective, parallel study in T2D (n=2... Read More about Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia.

Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study (2020)
Journal Article
Butler, A. E., Ramachandran, V., Cunningham, T. K., David, R., Gooderham, N. J., Benurwar, M., …Atkin, S. L. (2020). Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study. Frontiers in endocrinology, 11, Article 571357. https://doi.org/10.3389/fendo.2020.571357

© Copyright © 2020 Butler, Ramachandran, Cunningham, David, Gooderham, Benurwar, Dargham, Hayat, Sathyapalan, Najafi-Shoushtari and Atkin. Background: Small noncoding microRNA (miRNA) have regulatory functions in polycystic ovary syndrome (PCOS) that... Read More about Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study.

Dynamic Changes in Circulating Endocrine FGF19 Subfamily and Fetuin-A in Response to Intralipid and Insulin Infusions in Healthy and PCOS Women (2020)
Journal Article
Ramanjaneya, M., Bensila, M., Bettahi, I., Jerobin, J., Samra, T. A., Aye, M. M., …Abou-Samra, A. B. (2020). Dynamic Changes in Circulating Endocrine FGF19 Subfamily and Fetuin-A in Response to Intralipid and Insulin Infusions in Healthy and PCOS Women. Frontiers in endocrinology, 11, Article 568500. https://doi.org/10.3389/fendo.2020.568500

© Copyright © 2020 Ramanjaneya, Bensila, Bettahi, Jerobin, Samra, Aye, Alkasem, Siveen, Sathyapalan, Skarulis, Atkin and Abou-Samra. Background: The fibroblast growth factors (FGF) 19 subfamily, also referred to as endocrine FGFs, includes FGF19, FGF... Read More about Dynamic Changes in Circulating Endocrine FGF19 Subfamily and Fetuin-A in Response to Intralipid and Insulin Infusions in Healthy and PCOS Women.

Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients (2020)
Journal Article
Draicchio, F., van Vliet, S., Ancu, O., Paluska, S. A., Wilund, K. R., Mickute, M., …Mackenzie, R. W. (2020). Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients. The Journal of physiology, 598(24), 5701-5716. https://doi.org/10.1113/JP280441

Key points: Patients with renal failure undergoing maintenance haemodialysis are associated with insulin resistance and protein metabolism dysfunction. Novel research suggests that disruption to the transmembrane protein linkage between the cytoskele... Read More about Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients.

Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis (2020)
Journal Article
Deshmukh, H., Papageorgiou, M., Aye, M., England, J., Abdalla, M., & Sathyapalan, T. (in press). Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14330

Introduction Untreated hyperthyroidism is associated with accelerated bone turnover, low bone mineral density (BMD) and increased susceptibility to fragility fractures. Although treatment appears to improve or even reverse some of these adverse skel... Read More about Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis.

Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2021). Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes. Journal of Diabetes, 13(3), 191-199. https://doi.org/10.1111/1753-0407.13111

Background: The effect of postload glucose spikes (PGS), the difference between 2 hour post-load plasma glucose (2hPLPG) and fasting plasma glucose (FPG), on post–myocardial infarction (post-MI) prognosis in nondiabetic patients is unexplored. Method... Read More about Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes.

Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction (2020)
Journal Article
Everett, C. C., Reynolds, C., Fernandez, C., Stocken, D. D., Sharples, L. D., Sathyapalan, T., …Ajjan, R. A. (2020). Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction. Diabetes and Vascular Disease Research, 17(5), https://doi.org/10.1177/1479164120957934

Hyperglycaemia in individuals with type 2 diabetes (T2D) and myocardial infarction (MI) is associated with guarded clinical prognosis. Studies improving glucose levels in T2D following MI relied on HbA1c as the main glycaemic marker, failing to addre... Read More about Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction.

Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2020). Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes. Cardiology, 145(9), 553-561. https://doi.org/10.1159/000509180

© 2020 S. Karger AG, Basel. All rights reserved. Objective: To assess improvement in predictive performance of Global Registry of Acute Coronary Events risk score (GRS) by addition of a glucose matrix. Methods: 1,056 acute coronary syndrome (ACS) sur... Read More about Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes.

Obesity and Insulin Resistance: A Review of Molecular Interactions (2020)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Obesity and Insulin Resistance: A Review of Molecular Interactions. Current Molecular Medicine, 21(3), 182-193. https://doi.org/10.2174/1566524020666200812221527

The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. An increase in sedentary lifestyle and consumption of a more ener... Read More about Obesity and Insulin Resistance: A Review of Molecular Interactions.

miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review (2020)
Journal Article
Abdalla, M., Deshmukh, H., Atkin, S. L., & Sathyapalan, T. (2020). miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review. Life Sciences, 259, https://doi.org/10.1016/j.lfs.2020.118174

© 2020 Elsevier Inc. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of the reproductive age. PCOS is commonly manifested as ovulatory dysfunction, clinical and biochemical excess androgen level, and polycystic ov... Read More about miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review.

Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (Frontiers in Endocrinology, (2020), 11, 10.3389/fendo.2020.00206) (2020)
Journal Article
Butler, A. E., Ramachandran, V., Sathyapalan, T., David, R., Gooderham, N. J., Benurwar, M., …Atkin, S. L. (2020). Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (Frontiers in Endocrinology, (2020), 11, 10.3389/fendo.2020.00206). Frontiers in endocrinology, 11, Article 00515. https://doi.org/10.3389/fendo.2020.00515

Copyright © 2020 Butler, Ramachandran, Sathyapalan, David, Gooderham, Benurwar, Dargham, Hayat, Hani Najafi-Shoushtari and Atkin. An author name was incorrectly spelled as Sathypalan. The correct spelling is Sathyapalan. The authors apologize for thi... Read More about Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (Frontiers in Endocrinology, (2020), 11, 10.3389/fendo.2020.00206).

Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit (2020)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., …Sathyapalan, T. (2020). Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit. Diabetes Care, 43(9), 2153-2160. https://doi.org/10.2337/dc20-0738

OBJECTIVE The FreeStyle Libre (FSL) flash glucose-monitoring device was made available on the U.K. National Health Service (NHS) drug tariff in 2017. This study aims to explore the U.K. real-world experience of FSL and the impact on glycemic control,... Read More about Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit.

Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls (2020)
Journal Article
Butler, A. E., Hayat, S., Dargham, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., …Atkin, S. L. (2020). Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls. Reproductive BioMedicine Online, 41(4), 579-583. https://doi.org/10.1016/j.rbmo.2020.06.018

Research question: Long non-coding RNA (lncRNA) do not show protein translation but do have gene regulatory functions in several disease states. Studies have shown that lncRNA differ in overweight women with polycystic ovary syndrome (PCOS), increase... Read More about Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls.

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome (2020)
Journal Article
Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020). The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome. Endocrine Connections, 9(6), 563-569. https://doi.org/10.1530/EC-20-0173

Context: Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managin... Read More about The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome.

Author Correction: Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (Scientific Reports, (2020), 10, 1, (4750), 10.1038/s41598-020-61531-z) (2020)
Journal Article
Kahal, H., Halama, A., Aburima, A., Bhagwat, A. M., Butler, A. E., Graumann, J., …Atkin, S. L. (2020). Author Correction: Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (Scientific Reports, (2020), 10, 1, (4750), 10.1038/s41598-020-61531-z). Scientific reports, 10(1), Article 10233. https://doi.org/10.1038/s41598-020-66189-1

© 2020, The Author(s). The original version of this Article contained a typographical error in the spelling of the author Johannes Graumann, which was incorrectly given as Johannes Grauman. This has now been corrected in the PDF and HTML versions of... Read More about Author Correction: Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (Scientific Reports, (2020), 10, 1, (4750), 10.1038/s41598-020-61531-z).

Counteracting arsenic toxicity: Curcumin to the rescue? (2020)
Journal Article
Bahrami, A., Sathyapalan, T., Moallem, S. A., & Sahebkar, A. (2020). Counteracting arsenic toxicity: Curcumin to the rescue?. Journal of hazardous materials, 400, Article 123160. https://doi.org/10.1016/j.jhazmat.2020.123160

Arsenicosis leads to various irreversible damages in several organs and is considered to be a carcinogen. The effects of chronic arsenic poisoning are a result of an imbalance between pro- and antioxidant homeostasis, oxidative stress, as well as DNA... Read More about Counteracting arsenic toxicity: Curcumin to the rescue?.

Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu (2020)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020). Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu. Life Sciences, 256, Article 117916. https://doi.org/10.1016/j.lfs.2020.117916

Incretin-based therapies include pharmacologic agents such as glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors which exert potent anti-hyperglycemic effects in the diabetic milieu. They are also shown to have extra-panc... Read More about Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu.

Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery (2020)
Journal Article
Deshmukh, H., Aylward, L. L., Rose, M., Fernandes, A., Sedman, P., Thatcher, N. J., …Sathyapalan, T. (2020). Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery. Clinical Endocrinology, 93(3), 280-287. https://doi.org/10.1111/cen.14257

Introduction The objective of this study was to study associations of a wide range of halogenated biphenyls, dibenzo‐p‐dioxins, dibenzofurans, and diphenylethers with body mass index (BMI) and evaluate changes in their concentration following bariat... Read More about Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery.

microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (2020)
Journal Article
Butler, A. E., Ramachandran, V., Sathyapalan, T., David, R., Gooderham, N. J., Benurwar, M., …Atkin, S. L. (2020). microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index. Frontiers in endocrinology, 11, Article 206. https://doi.org/10.3389/fendo.2020.00206

Background: Despite several authors who have hypothesized that alterations of small noncoding RNAs (miR) are implicated in the etiopathogenesis of polycystic ovarian syndrome (PCOS), contrasting findings have been reported so far. Discrepancies in bo... Read More about microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index.

The role of interleukin-18 in the development and progression of atherosclerosis (2020)
Journal Article
Bahrami, A., Sathyapalan, T., & Sahebkar, A. (2021). The role of interleukin-18 in the development and progression of atherosclerosis. Current medicinal chemistry, 28(9), 1757-1774. https://doi.org/10.2174/0929867327666200427095830

Atherosclerosis (AS), as a chronic inflammatory disorder of the cardiovascular system, is one of the leading causes of ischemic heart disease, stroke and peripheral vascular disease. There is growing evidence on the role of innate and adaptive immuni... Read More about The role of interleukin-18 in the development and progression of atherosclerosis.

The effect of aromatherapy with rose and lavender on anxiety, surgical site pain, and extubation time after open-heart surgery: A double-center randomized controlled trial (2020)
Journal Article
Babatabar Darzi, H., Vahedian-Azimi, A., Ghasemi, S., Ebadi, A., Sathyapalan, T., & Sahebkar, A. (2020). The effect of aromatherapy with rose and lavender on anxiety, surgical site pain, and extubation time after open-heart surgery: A double-center randomized controlled trial. Phytotherapy Research, 34(10), 2675-2684. https://doi.org/10.1002/ptr.6698

To determine the effect of aromatherapy with rose and lavender on the patient outcomes after open‐heart surgery (OHS). In the clinical trial, patients were randomized to four groups. One group received routine care, the placebo group received a cotto... Read More about The effect of aromatherapy with rose and lavender on anxiety, surgical site pain, and extubation time after open-heart surgery: A double-center randomized controlled trial.

Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (2020)
Journal Article
Kahal, H., Halama, A., Aburima, A., Bhagwat, A. M., Butler, A. E., Grauman, J., …Atkin, S. L. (2020). Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects. Scientific reports, 10(1), Article 4750. https://doi.org/10.1038/s41598-020-61531-z

Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); this has been suggested to be due to increased hypoglycemia. We measured hypoglycemia-induced changes in endothelial parameters, oxidative stress marke... Read More about Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects.

A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome (2020)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2020). A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome. Therapeutic Advances in Endocrinology and Metabolism, 11, https://doi.org/10.1177/2042018820938305

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Metabolic sequelae associated with PCOS range from insulin resistance to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Insulin resistanc... Read More about A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome.

Incretins and microRNAs: Interactions and physiological relevance (2020)
Journal Article
Radbakhsh, S., Sathyapalan, T., Banach, M., & Sahebkar, A. (2020). Incretins and microRNAs: Interactions and physiological relevance. Pharmacological research : the official journal of the Italian Pharmacological Society, 153, Article 104662. https://doi.org/10.1016/j.phrs.2020.104662

MicroRNAs (miRNA) are one class of the small regulatory RNAs that can impact the expression of numerous genes including incretin hormones and their G protein-coupled receptors. Incretin peptides, including GLP-1, GLP-2, and GIP, are released from the... Read More about Incretins and microRNAs: Interactions and physiological relevance.

MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress (2020)
Journal Article
Ashrafizadeh, M., Ahmadi, Z., Samarghandian, S., Mohammadinejad, R., Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2020). MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress. Life Sciences, 244, 117329. https://doi.org/10.1016/j.lfs.2020.117329

MicroRNAs (miRs) are small non-coding pieces of RNA that are involved in a variety of physiologic processes such as apoptosis, cell proliferation, cell differentiation, cell cycle and cell survival. These multifunctional nucleotides are also capable... Read More about MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress.

The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review (2020)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Iranpanah, H., Orafai, H. M., Jamialahmadi, T., & Sahebkar, A. (2020). The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review. Life Sciences, 244, Article 117305. https://doi.org/10.1016/j.lfs.2020.117305

Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially am... Read More about The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review.

Newly diagnosed abnormal glucose tolerance determines post-MI prognosis in patients with hospital related hyperglycaemia but without known diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2020). Newly diagnosed abnormal glucose tolerance determines post-MI prognosis in patients with hospital related hyperglycaemia but without known diabetes. Journal of Diabetes and its Complications, 34(4), Article 107518. https://doi.org/10.1016/j.jdiacomp.2019.107518

Aims: Investigate if abnormal glucose tolerance (AGT) affects post-myocardial infarction (MI) prognosis in patients with hospital-related hyperglycaemia (HRH) but without known diabetes mellitus (KDM). Methods: Post-MI survivors without KDM underwent... Read More about Newly diagnosed abnormal glucose tolerance determines post-MI prognosis in patients with hospital related hyperglycaemia but without known diabetes.

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., …Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes (2019)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020). Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes. Life Sciences, 241, Article 117152. https://doi.org/10.1016/j.lfs.2019.117152

GLP-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase 4 inhibitors (DPP-4i) are two classes of antidiabetic agents used in the management of diabetes based on incretin hormones. There is emerging evidence that they have anti-inflammatory effects... Read More about Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes.

Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review (2019)
Journal Article
Yaribeygi, H., Sathyapalan, T., Maleki, M., Jamialahmadi, T., & Sahebkar, A. (2020). Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review. Life Sciences, 240, Article 117090. https://doi.org/10.1016/j.lfs.2019.117090

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are a relatively newer class of anti-hyperglycemic medications that reduce blood glucose by inhibition of renal glucose re-uptake, thereby increasing urinary glucose excretion. Although glycosuria i... Read More about Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review.

Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet (2019)
Journal Article
Ganie, M. A., Sahar, T., Rashid, A., Wani, I. A., Nisar, S., Sathyapalan, T., …Geer, I. (2019). Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet. Frontiers in endocrinology, 10, Article 699. https://doi.org/10.3389/fendo.2019.00699

Background: Sub-inflammation and insulin resistance characterize women with PCOS. Data on dietary modulation of inflammation among PCOS women is scant, particularly from Indian subcontinent. The present study aimed to assess the effect of plant based... Read More about Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet.

Expression of microRNA in follicular fluid in women with and without PCOS (2019)
Journal Article
Butler, A. E., Ramachandran, V., Hayat, S., Dargham, S. R., Cunningham, T. K., Benurwar, M., …Atkin, S. L. (2019). Expression of microRNA in follicular fluid in women with and without PCOS. Scientific reports, 9(1), Article 16306. https://doi.org/10.1038/s41598-019-52856-5

© 2019, The Author(s). Several studies have shown the expression of small non-coding microRNA (miRNA) changes in PCOS and their expression in follicular fluid has been described, though the number of studies remains small. In this prospective cohort... Read More about Expression of microRNA in follicular fluid in women with and without PCOS.

The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms (2019)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., & Sahebkar, A. (2019). The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sciences, 237, Article 116950. https://doi.org/10.1016/j.lfs.2019.116950

C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated before the release of insulin. It is secreted in an equimolar amount to insulin from the pancreatic beta-cells into the circulation. Recent evidence demonstr... Read More about The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms.

Effects of curcumin on mitochondria in neurodegenerative diseases (2019)
Journal Article
Bagheri, H., Ghasemi, F., Barreto, G. E., Rafiee, R., Sathyapalan, T., & Sahebkar, A. (2020). Effects of curcumin on mitochondria in neurodegenerative diseases. BioFactors, 46(1), 5-20. https://doi.org/10.1002/biof.1566

Neurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., p... Read More about Effects of curcumin on mitochondria in neurodegenerative diseases.

Anti-fibrotic effects of curcumin and some of its analogues in the heart (2019)
Journal Article
Gorabi, A. M., Hajighasemi, S., Kiaie, N., Rosano, G. M. C., Sathyapalan, T., Al-Rasadi, K., & Sahebkar, A. (2020). Anti-fibrotic effects of curcumin and some of its analogues in the heart. Heart Failure Reviews, 25(5), 731-743. https://doi.org/10.1007/s10741-019-09854-6

Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, wh... Read More about Anti-fibrotic effects of curcumin and some of its analogues in the heart.

Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome (2019)
Journal Article
Butler, A. E., Hayat, S., Dargam, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., …Atkin, S. L. (2019). Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome. Clinical Endocrinology, 91(6), 793-797. https://doi.org/10.1111/cen.14087

Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides long that are not translated into protein; however, there is increasing evidence of their regulatory functions. To date, there are few studies measuring lncRNA in control women or... Read More about Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

Therapeutic effects of Crocin in autoimmune diseases: A review (2019)
Journal Article
Korani, S., Korani, M., Sathyapalan, T., & Sahebkar, A. (2019). Therapeutic effects of Crocin in autoimmune diseases: A review. BioFactors, 45(6), 835-843. https://doi.org/10.1002/biof.1557

The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple... Read More about Therapeutic effects of Crocin in autoimmune diseases: A review.

A review of the pharmacological and therapeutic effects of auraptene (2019)
Journal Article
Bibak, B., Shakeri, F., Barreto, G. E., Keshavarzi, Z., Sathyapalan, T., & Sahebkar, A. (2019). A review of the pharmacological and therapeutic effects of auraptene. BioFactors, 45(6), 867-879. https://doi.org/10.1002/biof.1550

There is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the th... Read More about A review of the pharmacological and therapeutic effects of auraptene.

Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity (2019)
Journal Article
Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity. Life Sciences, 234, Article 116776. https://doi.org/10.1016/j.lfs.2019.116776

Glucagon-like peptide-1 is a peptide of incretin family which is used in the management of diabetes as glucagon-like peptide-1 receptor agonist (GLP-1RA). Dipeptidyl peptidase-4 enzyme metabolizes glucagon-like peptide-1 and various dipeptidyl peptid... Read More about Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity.

Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom (2019)
Journal Article
Drage, D. S., Heffernan, A. L., Cunningham, T. K., Aylward, L. L., Mueller, J. F., Sathyapalan, T., & Atkin, S. L. (2019). Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom. Environmental Research, 177, Article 108631. https://doi.org/10.1016/j.envres.2019.108631

We investigated the serum concentrations of two brominated flame retardants (BFRs) – polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD) –in 59 women aged between 23 and 42 from the United Kingdom. We also collected demographic... Read More about Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom.

Is weight loss harmful for skeletal health in obese older adults? (2019)
Journal Article
Papageorgiou, M., Kerschan-Schindl, K., Sathyapalan, T., & Pietschmann, P. (2020). Is weight loss harmful for skeletal health in obese older adults?. Gerontology, 66(1), 2-14. https://doi.org/10.1159/000500779

Purpose of Review: In view of the existing uncertainty about the implications of intentional weight loss in older obese adults, the present review (a) summarizes the available evidence from epidemiological and interventional studies concerning the ef... Read More about Is weight loss harmful for skeletal health in obese older adults?.

The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome (2019)
Journal Article
Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A. M., Pemberton, P., …Atkin, S. L. (2019). The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome. Frontiers in endocrinology, 10(JUN), Article 394. https://doi.org/10.3389/fendo.2019.00394

Copyright © 2019 Sathyapalan, Hobkirk, Javed, Carroll, Coady, Pemberton, Smith, Cianflone and Atkin. Background: Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chroni... Read More about The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome.

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited (2019)
Journal Article
Keshavarzi, Z., Shakeri, F., Barreto, G. E., Bibak, B., Sathyapalan, T., & Sahebkar, A. (2019). Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited. BioFactors, 45(4), 517-535. https://doi.org/10.1002/biof.1516

Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI... Read More about Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited.

Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial (2019)
Journal Article
Mosenzon, O., Blicher, T. M., Rosenlund, S., Eriksson, J., Heller, S., Hels, O. H., …Zhdanova, E. (2019). Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. Lancet Diabetes and Endocrinology, 7(7), 515-527. https://doi.org/10.1016/S2213-8587%2819%2930192-5

Background: Oral semaglutide is the first oral glucagon-like peptide-1 (GLP-1) receptor agonist for glycaemic control in patients with type 2 diabetes. Type 2 diabetes is commonly associated with renal impairment, restricting treatment options. We ai... Read More about Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial.

Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage (2019)
Journal Article
Sathyapalan, T., Yaribeygi, H., Sahebkar, A., & Lhaf, F. (2019). Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage. Life Sciences, 231, Article 116538. https://doi.org/10.1016/j.lfs.2019.06.013

Apoptosis is a complicated process that involves activation of a series of intracellular signaling. Tissue injuries from diabetes mellitus mostly occur as a consequence of higher rate of apoptosis process due to activation of a series of molecular me... Read More about Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage.

Curcumin: a modulator of inflammatory signaling pathways in the immune system (2019)
Journal Article
Kahkhaie, K. R., Mirhosseini, A., Aliabadi, A., Mohammadi, A., Mousavi, M. J., Haftcheshmeh, S. M., …Sahebkar, A. (2019). Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology, 27(5), 885-900. https://doi.org/10.1007/s10787-019-00607-3

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflamma... Read More about Curcumin: a modulator of inflammatory signaling pathways in the immune system.

Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes (2019)
Journal Article
Yaribeygi, H., Yaribeygi, A., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(3), 2214-2218. https://doi.org/10.1016/j.dsx.2019.05.023

Diabetes mellitus is the most prevalent metabolic disorder contributing to significant morbidity and mortality in humans. Many preventative and therapeutic agents have been developed for normalizing glycemic profile in patients with diabetes. In addi... Read More about Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes.

Bariatric surgery modulates urinary levels of microRNAs involved in the regulation of renal function (2019)
Journal Article
Alkandari, A., Ashrafian, H., Sathyapalan, T., Darzi, A., Holmes, E., Athanasiou, T., …Gooderham, N. J. (2019). Bariatric surgery modulates urinary levels of microRNAs involved in the regulation of renal function. Frontiers in endocrinology, 10(MAY), Article 319. https://doi.org/10.3389/fendo.2019.00319

Background: Obesity and diabetes cause chronic kidney disease with a common pathophysiology that is characterized by the accumulation of collagen in the extracellular matrix. Recent evidence has implicated the epithelial-to-mesenchymal transition (EM... Read More about Bariatric surgery modulates urinary levels of microRNAs involved in the regulation of renal function.

The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study (2019)
Journal Article
Konya, J., Sathyapalan, T., Kilpatrick, E. S., & Atkin, S. L. (2019). The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study. Frontiers in endocrinology, 10(MAY), Article 296. https://doi.org/10.3389/fendo.2019.00296

Objective: Soy and cocoa have been suggested to be beneficial for diabetes. The aim of this study was to identify the effects of soy protein, isoflavones, and cocoa on glycemic control parameters. Research design and methods: The study was a paral... Read More about The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study.

Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects (2019)
Journal Article
Ramanjaneya, M., Jerobin, J., Bettahi, I., Bensila, M., Aye, M., Siveen, K. S., …Atkin, S. L. (2019). Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects. Clinical Endocrinology, 91(2), 278-287. https://doi.org/10.1111/cen.14007

Objective: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS-c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and A... Read More about Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states (2019)
Journal Article
Rahimi, K., Ahmadi, A., Hassanzadeh, K., Soleimani, Z., Sathyapalan, T., Mohammadi, A., & Sahebkar, A. (2019). Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states. Autoimmunity Reviews, 18(7), 738-748. https://doi.org/10.1016/j.autrev.2019.05.012

CD4+ T helper (Th) cells are a crucial player in host defense but under certain conditions can contribute to the pathogenesis of inflammatory and autoimmune diseases. Beside the Th1/Th2 subset, several additional Th subsets have been identified, each... Read More about Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states.

Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes (2019)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2019). Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes. Diabetes and Vascular Disease Research, 16(6), 489-497. https://doi.org/10.1177/1479164119845561

© The Author(s) 2019. Background: Effect of pre-diabetes mellitus on post-myocardial infarction prognosis is unclear. Methods: Retrospective cohort analysis of 1056 myocardial infarction survivors with fasting plasma glucose and 2-h post-load plasma... Read More about Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes.

Effects of curcumin on ion channels and pumps: A review (2019)
Journal Article
Tabeshpour, J., Banaeeyeh, S., Eisvand, F., Sathyapalan, T., Hashemzaei, M., & Sahebkar, A. (2019). Effects of curcumin on ion channels and pumps: A review. IUBMB Life, 71(7), 812-820. https://doi.org/10.1002/iub.2054

Curcumin, an orange‐yellow lipophilic polyphenolic molecule, is the active component of Curcuma longa, which is extensively used as a spice in most of the Asian countries. This natural compound is able to interact with a large number of molecular str... Read More about Effects of curcumin on ion channels and pumps: A review.

The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome (2019)
Journal Article
Dawson, A. J., Sathyapalan, T., Vince, R., Coady, A. M., Ajjan, R. A., Kilpatrick, E. S., & Atkin, S. L. (2019). The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(APR), Article 189. https://doi.org/10.3389/fendo.2019.00189

Background: Polycystic ovary syndrome (PCOS) is associated with an adverse cardiovascular risk profile including a prothrombotic state. Exenatide has been shown to be effective at improving insulin sensitivity and weight loss in PCOS; therefore this... Read More about The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome.

The effect of soy isoflavones on steroid metabolism (2019)
Journal Article
Swart, A. C., Johannes, I. D., Sathyapalan, T., & Atkin, S. L. (2019). The effect of soy isoflavones on steroid metabolism. Frontiers in endocrinology, 10(APR), Article 229. https://doi.org/10.3389/fendo.2019.00229

Objective: This study is a post-hoc analysis of steroid hormones before and after administration of pharmacological doses of soy isoflavones in a large cohort of men and women from two independent studies. Isoflavones are reported to inhibit mineralo... Read More about The effect of soy isoflavones on steroid metabolism.

Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus (2019)
Journal Article
Paseban, M., Mohebbati, R., Niazmand, S., Sathyapalan, T., & Sahebkar, A. (2019). Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus. Biomolecules, 9(4), 118. https://doi.org/10.3390/biom9040118

Objective: The aim of this study was to investigate the effect of combined intake of a high dose of aspirin, atorvastatin, captopril and metformin on oxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats.... Read More about Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus.

Harnessing CRISPR/Cas9 technology in cardiovascular disease (2019)
Journal Article
Rezaei, H., khadempar, S., Farahani, N., Hosseingholi, E. Z., hayat, S. M. G., Sathyapalan, T., & Sahebkar, A. H. (2020). Harnessing CRISPR/Cas9 technology in cardiovascular disease. Trends in Cardiovascular Medicine, 30(2), 93-101. https://doi.org/10.1016/j.tcm.2019.03.005

The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compa... Read More about Harnessing CRISPR/Cas9 technology in cardiovascular disease.

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., …Sathyapalan, T. (2019). Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study. Clinical Endocrinology, 90(6), 805-813. https://doi.org/10.1111/cen.13968

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascu... Read More about Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study.

Systematic review and meta-analysis on the effect of soy on thyroid function (2019)
Journal Article
Otun, J., Sahebkar, A., Östlundh, L., Atkin, S. L., & Sathyapalan, T. (2019). Systematic review and meta-analysis on the effect of soy on thyroid function. Scientific reports, 9(1), Article 3964. https://doi.org/10.1038/s41598-019-40647-x

© 2019, The Author(s). Soy foods have had an important dietary role in Asian countries for centuries, and in recent years they have become increasingly popular in Western countries as a result of their suggested health benefits. Nevertheless, there... Read More about Systematic review and meta-analysis on the effect of soy on thyroid function.

Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment (2019)
Journal Article
Cunningham, T. K., Allgar, V., Dargham, S. R., Kilpatrick, E., Sathyapalan, T., Maguiness, S., …Atkin, S. L. (2019). Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment. Frontiers in endocrinology, 10(JAN), Article 13. https://doi.org/10.3389/fendo.2019.00013

Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)2D3), 25-hydroxyvitamin D2 (25(OH)D2), 25-hydroxyvitamin D3 (25(OH)D3), 24,25-dihydroxyvitamin D (24,25(OH)2D3), and 25-hydroxy-3epi-Vitamin D3 (3epi25(OH)D3... Read More about Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment.

A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Kilpatrick, E., Mann, V., Corless, L., …Sathyapalan, T. (2019). A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome. Nutrients, 11(1), 188. https://doi.org/10.3390/nu11010188

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemis... Read More about A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome.

Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes (2018)
Journal Article
Halama, A., Kahal, H., Bhagwat, A. M., Zierer, J., Sathyapalan, T., Grauman, J., …Atkin, S. (2019). Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes. Diabetes, Obesity and Metabolism, 21(4), 909-919. https://doi.org/10.1111/dom.13602

Aims: To determine the biochemical changes that underlie hypoglycaemia in a healthy control group and in people with type 2 diabetes (T2D). Materials and methods: We report a hypoglycaemic clamp study in seven healthy controls and 10 people with T2D.... Read More about Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes.

The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women (2018)
Journal Article
Sathyapalan, T., Köhrle, J., Rijntjes, E., Rigby, A. S., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women. Frontiers in endocrinology, 9, Article 698. https://doi.org/10.3389/fendo.2018.00698

Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action. Materials and Methods: We examined the effect of soy isoflavones on rever... Read More about The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women.

Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS) (2018)
Journal Article
Deshmukh, H., Papageorgiou, M., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (in press). Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS). Clinical Endocrinology, 90(1), 162-169. https://doi.org/10.1111/cen.13879

Objective The aim of this study was to develop a simple phenotypic algorithm that can capture the underlying clinical and hormonal abnormalities to help in the diagnosis and risk stratification of polycystic ovary syndrome (PCOS). Methods The study... Read More about Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS).

Cardiovascular profile of pharmacological agents used for the management of polycystic ovary syndrome (2018)
Journal Article
Alalami, H., Sathyapalan, T., & Atkin, S. L. (2019). Cardiovascular profile of pharmacological agents used for the management of polycystic ovary syndrome. Therapeutic Advances in Endocrinology and Metabolism, 10, 1-10. https://doi.org/10.1177/2042018818805674

Women with polycystic ovary syndrome (PCOS) have an adverse metabolic profile with an increased risk of prediabetes and type 2 diabetes (T2DM); however, it is unclear if PCOS is associated with increased cardiovascular events in later years independe... Read More about Cardiovascular profile of pharmacological agents used for the management of polycystic ovary syndrome.

Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women (2018)
Journal Article
Papageorgiou, M., Sathyapalan, T., & Schutte, R. (2019). Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women. Journal of Cachexia, Sarcopenia and Muscle, 10(1), 131-139. https://doi.org/10.1002/jcsm.12359

© 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders Background: Despite several muscle mass measures being used in the current defi... Read More about Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women.

Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Deshmukh, H., Madden, L. A., Rigby, A., Kilpatrick, E. S., …Sathyapalan, T. (2019). Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 533-540. https://doi.org/10.1111/dom.13548

Aims Endothelial microparticles (EMPs) are novel surrogate markers of endothelial injury and dysfunction that may be differentially produced in response to acute insulin‐induced hypoglycaemia in adults with and without type 2 diabetes.

Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Javed, Z., Heise, T., Rigby, A. S., Garrett, A. T., …Sathyapalan, T. (2019). Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus. Diabetes, Obesity and Metabolism, 21(3), 569-574. https://doi.org/10.1111/dom.13555

Objective This study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes. Research Design A 3‐way, cross‐over, randomised study was performed in adults with type 1 diab... Read More about Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus.

Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques—A Literature Review (2018)
Journal Article
Reyes-Muñoz, E., Sathyapalan, T., Rossetti, P., Shah, M., Long, M., Buscema, M., …Vitale, S. G. (2018). Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques—A Literature Review. Advances in Therapy, 35(11), 1805-1815. https://doi.org/10.1007/s12325-018-0810-1

Polycystic ovary syndrome (PCOS) affects 6–10% of women and could be considered one of the most common endocrine alterations in women of reproductive age. The syndrome is characterized by several hormonal and metabolic alterations, including insulin... Read More about Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques—A Literature Review.

The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study (2018)
Journal Article
Sathyapalan, T., Dawson, A. J., Rigby, A. S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study. Frontiers in endocrinology, 9(SEP), Article 531. https://doi.org/10.3389/fendo.2018.00531

Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on... Read More about The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study.

Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach (2018)
Journal Article
Papageorgiou, M., Wells, L., Williams, C., White, K. L., De Santis, B., Liu, Y., …Sathyapalan, T. (2018). Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach. Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment, 35(10), 2032-2044. https://doi.org/10.1080/19440049.2018.1508890

Deoxynivalenol (DON) is a Fusarium toxin, to which humans are frequently exposed via diet. Although the elderly are speculated to be sensitive to the toxic effects of DON as a result of age-related conditions, disease and altered DON metabolism, ther... Read More about Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach.

Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters (2018)
Journal Article
Heffernan, A., Cunningham, T., Drage, D., Aylward, L., Thompson, K., Vijayasarathy, S., …Sathyapalan, T. (2018). Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters. International Journal of Hygiene and Environmental Health, 221(7), 1068-1075. https://doi.org/10.1016/j.ijheh.2018.07.009

© 2018 Women with polycystic ovarian syndrome (PCOS) undergoing treatment for infertility could be a sensitive subpopulation for endocrine effects of exposure to perfluorinated alkyl acids (PFAAs), persistent organic pollutants with potential endocri... Read More about Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters.

Investigation of pituitary disease (2018)
Book Chapter
Sathyapalan, T., & Atkin, S. L. (2018). Investigation of pituitary disease. In J. Watkinson, & R. Clarke (Eds.), Scott-Brown's Otorhinolaryngology and Head and Neck Surgery, vol.1 (915-921). (8th ed.). Boca Raton, Fla.: CRC Press. https://doi.org/10.1201/9780203731031

The close relationship between the upper respiratory tract (nose and paranasal sinuses) and the lower respiratory tract (tracheobronchial tree) is something that is manifestly observed by all practising rhinologists. There is strong epidemiological e... Read More about Investigation of pituitary disease.

Clinical evaluation of hypercalcaemia (2018)
Book Chapter
Aye, M., & Sathyapalan, T. (2018). Clinical evaluation of hypercalcaemia. In J. Watkinson, & R. Clarke (Eds.), Scott-Brown's Otorhinolaryngology and Head and Neck Surgery Volume 1: Basic Sciences, Endocrine Surgery, Rhinology (827-832). (8th ed.). Boca Raton, Fla.: CRC Press. https://doi.org/10.1201/9780203731031

Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: A longitudinal study in humans (2018)
Journal Article
Alkandari, A., Ashrafian, H., Sathyapalan, T., Sedman, P., Darzi, A., Holmes, E., …Gooderham, N. J. (2018). Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: A longitudinal study in humans. BMC obesity, 5(1), Article 20. https://doi.org/10.1186/s40608-018-0199-z

Background The global pandemic of obesity and the metabolic syndrome are leading causes of mortality and morbidity. Bariatric surgery leads to sustained weight loss and improves obesity-associated morbidity including remission of type 2 diabetes. Mic... Read More about Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: A longitudinal study in humans.

Platelet function following induced hypoglycaemia in type 2 diabetes (2018)
Journal Article
Kahal, H., Aburima, A., Spurgeon, B., Wraith, K. S., Rigby, A. S., Sathyapalan, T., …Atkin, S. L. (2018). Platelet function following induced hypoglycaemia in type 2 diabetes. Diabetes & metabolism, 44(5), 431-436. https://doi.org/10.1016/j.diabet.2018.04.004

Aim Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes comp... Read More about Platelet function following induced hypoglycaemia in type 2 diabetes.

Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-term major adverse cardiac events in acute coronary syndrome in patients without known diabetes (2018)
Journal Article
George, A., John, J., Sathyapalan, T., & Chattopadhyay, S. (2018). Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-term major adverse cardiac events in acute coronary syndrome in patients without known diabetes. European Heart Journal, 39(29), 2740-2745. https://doi.org/10.1093/eurheartj/ehy233

Aims Global Registry of Acute Coronary Events (GRACE) risk score (GRS), a powerful predictor of prognosis after ACE, does not include a glucometabolic measure. We investigate whether 2 hour post-load plasma glucose (2h-PG) could improve GRS based pro... Read More about Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-term major adverse cardiac events in acute coronary syndrome in patients without known diabetes.

Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1 (2018)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Thatcher, N. J., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1. Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(7), 691-697. https://doi.org/10.1016/j.numecd.2018.03.007

Background Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones... Read More about Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1.

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause (2018)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Thatcher, N. J., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause. Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(7), 691-697. https://doi.org/10.1016/j.numecd.2018.03.007

© 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University Background: Hormone replacement thera... Read More about Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause.

Novel interventional therapies to improve cardiovascular risk in women with polycystic ovary syndrome (2018)
Thesis
Javed, Z. (2018). Novel interventional therapies to improve cardiovascular risk in women with polycystic ovary syndrome. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4220685

Introduction: Polycystic ovary syndrome (PCOS) is associated with a diverse range of endocrine, metabolic and cardiovascular risk factors. Low vitamin D in PCOS is associated with multiple cardiovascular risk factors and vitamin D replacement therap... Read More about Novel interventional therapies to improve cardiovascular risk in women with polycystic ovary syndrome.

Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome (2018)
Journal Article
Sathyapalan, T., Al-Qaissi, A., Kilpatrick, E. S., Dargham, S. R., Keevil, B., & Atkin, S. L. (2018). Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome. Scientific reports, 8(1), Article 3795. https://doi.org/10.1038/s41598-018-22176-1

To determine the predictive value of a raised androgen level with an elevated anti-Müllerian hormone (AMH) for the diagnosis or exclusion of polycystic ovary syndrome (PCOS), a prospective cross-sectional study of 170 women (105 with PCOS type A and... Read More about Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome.

Effects of growth hormone replacement on peripheral muscle and exercise capacity in severe growth hormone deficiency (2018)
Journal Article
Gonzalez, S., Sathyapalan, T., Javed, Z., & Atkin, S. L. (2018). Effects of growth hormone replacement on peripheral muscle and exercise capacity in severe growth hormone deficiency. Frontiers in endocrinology, 9(FEB), 56. https://doi.org/10.3389/fendo.2018.00056

Aims We evaluate prevalence of new abnormal glucose tolerance (AGT) in post-MI survivors without known diabetes (DM) if guidelines are followed and compare the ability of admission (APG), fasting (FPG) and 2-h post-load plasma glucose (2h-PG) to pred... Read More about Effects of growth hormone replacement on peripheral muscle and exercise capacity in severe growth hormone deficiency.

Two-hour post-challenge glucose is a better predictor of adverse outcome after myocardial infarction than fasting or admission glucose in patients without diabetes (2018)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2018). Two-hour post-challenge glucose is a better predictor of adverse outcome after myocardial infarction than fasting or admission glucose in patients without diabetes. Acta Diabetologica, 55(5), 449–458. https://doi.org/10.1007/s00592-018-1114-2

Aims We evaluate prevalence of new abnormal glucose tolerance (AGT) in post-MI survivors without known diabetes (DM) if guidelines are followed and compare the ability of admission (APG), fasting (FPG) and 2-h post-load plasma glucose (2h-PG) to pred... Read More about Two-hour post-challenge glucose is a better predictor of adverse outcome after myocardial infarction than fasting or admission glucose in patients without diabetes.

The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study (2018)
Journal Article
Konya, J., Spurgeon, B. E. J., Al Qaissi, A., Sathyapalan, T., Ajjan, R., Madden, L., …Atkin, S. L. (2018). The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study. Frontiers in endocrinology, 9(FEB), Article 26. https://doi.org/10.3389/fendo.2018.00026

© 2018 Konya, Al Qaissi, Sathyapalan, Ajjan, Madden, Naseem, Garrett, Kilpatrick and Atkin. Aims: To determine if clotting, platelet, and endothelial function were affected by simulated short-haul commercial air flight conditions (SF) in participants... Read More about The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study.

Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents (2018)
Journal Article
Papageorgiou, M., Wells, L., Williams, C., White, K., De Santis, B., Liu, Y., …Sathyapalan, T. (2018). Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents. Toxins, 10(2), 50. https://doi.org/10.3390/toxins10020050

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Deoxynivalenol (DON), the mycotoxin produced mainly by Fusarium graminearum and found in contaminated cereal-based foodstuff, has been consistently detected in body fluids in adults. Available... Read More about Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents.

Anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome (2017)
Journal Article
Sathyapalan, T., Al-Qaissi, A., Kilpatrick, E. S., Dargham, S. R., & Atkin, S. L. (2018). Anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome. Clinical Endocrinology, 88(2), 258-262. https://doi.org/10.1111/cen.13517

Objective: Anti-Müllerian hormone (AMH) is derived from the small antral follicles, and an elevated level has been suggested to add value to the Rotterdam criteria for the diagnosis of PCOS in cases of diagnostic uncertainty. Therefore, the role of A... Read More about Anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome.

Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study (2017)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study. Scientific reports, 7(1), Article ARTN 15366. https://doi.org/10.1038/s41598-017-15402-9

© 2017 The Author(s). Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementa... Read More about Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study.

The effects of acute interval exercise and strawberry intake on postprandial lipemia (2017)
Journal Article
O’Doherty, A., Jones, H. S., Sathyapalan, T., Ingle, L., & Carroll, S. (2017). The effects of acute interval exercise and strawberry intake on postprandial lipemia. Medicine and Science in Sports and Exercise, 49(11), 2315-2323. https://doi.org/10.1249/MSS.0000000000001341

Purpose: Raised postprandial triglycerides (TAG) and related oxidative stresses are strongly associated with increased cardiovascular disease (CVD) risk. Acute exercise and strawberry ingestion independently ameliorate postprandial lipid excursions a... Read More about The effects of acute interval exercise and strawberry intake on postprandial lipemia.

The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome (2017)
Journal Article
Sathyapalan, T., Atkin, S. L., Coady, A. M., & Kilpatrick, E. S. (2017). The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome. Endocrine Connections, 6(8), 811-816. https://doi.org/10.1530/EC-17-0217

Background There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients. However, there is some data to show that statins increase the r... Read More about The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome.

Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency (2017)
Journal Article
Gonzalez, S., Windram, J. D., Sathyapalan, T., Javed, Z., Clark, A., & Atkin, S. L. (2017). Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency. Journal of International Medical Research, 45(6), 1708-1719. https://doi.org/10.1177/0300060517723798

Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followe... Read More about Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency.

Deoxynivalenol biomarkers in the urine of UK vegetarians (2017)
Journal Article
Wells, L., Hardie, L., Williams, C., White, K., Liu, Y., De Santis, B., …Sathyapalan, T. (2017). Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins, 9(7), 196. https://doi.org/10.3390/toxins9070196

Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycoto... Read More about Deoxynivalenol biomarkers in the urine of UK vegetarians.

Salivary testosterone measurement in women with and without polycystic ovary syndrome (2017)
Journal Article
Sathyapalan, T., Al-Qaissi, A., Kilpatrick, E. S., Dargham, S. R., Adaway, J., Keevil, B., & Atkin, S. L. (2017). Salivary testosterone measurement in women with and without polycystic ovary syndrome. Scientific reports, 7(1), Article ARTN 3589. https://doi.org/10.1038/s41598-017-03945-w

Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involvin... Read More about Salivary testosterone measurement in women with and without polycystic ovary syndrome.

Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome (2017)
Journal Article
Cho, L. W., Sathyapalan, T., Kilpatrick, E. S., Keevil, B. G., Miller, A. G., Coady, A. M., …Atkin, S. L. (2017). Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome. BMC Endocrine Disorders, 17(1), Article 26. https://doi.org/10.1186/s12902-017-0177-3

BACKGROUND: Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may diffe... Read More about Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome.

Effects of dietary polyphenols on vascular endothelium and cardiovascular health (2017)
Thesis
Ehtesham, E. (2017). Effects of dietary polyphenols on vascular endothelium and cardiovascular health. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4219556

Introduction: Polyphenols have been suggested as being able to modulate the risk of cardiovascular disease. However, the molecular mechanisms underlying these effects are unclear and the literature lacks consistency and reproducibility, with in vitro... Read More about Effects of dietary polyphenols on vascular endothelium and cardiovascular health.

Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study (2017)
Journal Article
Sathyapalan, T., Javed, Z., Rigby, A. S., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study. Journal of the Endocrine Society, 1(5), 423-430. https://doi.org/10.1210/js.2016-1068

© 2017 Endocrine Society. Background: Soy protein with isoflavones appears to have an adverse effect on thyroid function, but it is not known whether it is the protein or isoflavone component that is deleterious. The effect of isoflavone-free soy on... Read More about Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study.

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study (2016)
Journal Article
Sathyapalan, T., Rigby, A. S., Bhasin, S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study. Journal of Clinical Endocrinology and Metabolism, 102(2), 425-433. https://doi.org/10.1210/jc.2016-2875

Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to h... Read More about Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study.

Determination of deoxynivalenol in the urine of pregnant women in the UK (2016)
Journal Article
Rigby, A., Sathyapalan, T., Wells, L., Atkin, S., Brera, C., De Santis, B., …Williams, C. (2016). Determination of deoxynivalenol in the urine of pregnant women in the UK. Toxins, 8(11), 306. https://doi.org/10.3390/toxins8110306

Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provi... Read More about Determination of deoxynivalenol in the urine of pregnant women in the UK.

The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise (2016)
Journal Article
O’Doherty, A. F., Sathyapalan, T., Rigby, A. S., Ingle, L., & Carroll, S. (2018). The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise. European Journal of Nutrition, 57(1), 309-318. https://doi.org/10.1007/s00394-016-1320-z

© 2016 The Author(s) Purpose: The Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention... Read More about The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise.

Modelling aspects of oviduct fluid formation in vitro (2016)
Journal Article
Simintiras, C. A., Arnold, G. J., Ulbrich, S. E., Leese, H. J., Sturmey, R. G., Froehlich, T., …Ulbrich, S. (2017). Modelling aspects of oviduct fluid formation in vitro. Reproduction, 153(1), 23-33. https://doi.org/10.1530/REP-15-0508

© 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation. However, the composition and regulation of this critical e... Read More about Modelling aspects of oviduct fluid formation in vitro.

Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome (2016)
Journal Article
Javed, Z., Sathyapalan, T., Atkin, S. L., Coady, A., & Kilpatrick, E. S. (2017). Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome. Clinical Endocrinology, 86(3), 384-387. https://doi.org/10.1111/cen.13239

© 2016 John Wiley & Sons Ltd Context: Animal studies suggest that cannabinoid receptor-1 (CB-1) blockade reduces inflammation and neovascularization by decreasing vascular endothelial growth factor (VEGF) levels associated with a reduction in infla... Read More about Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome.

Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial (2016)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial. Journal of Bone and Mineral Research, 32(1), 157-164. https://doi.org/10.1002/jbmr.2927

Menopausal estrogen loss leads to an increased bone loss. Soy isoflavones can act as selective estrogen receptor modulators, their role in bone turnover is unclear. The primary outcome was assessing changes in plasma bone turnover markers. The second... Read More about Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial.

Pilot investigation of a virtual gastric band hypnotherapy intervention (2016)
Journal Article
Greetham, S., Goodwin, S., Wells, L., Whitham, C., Jones, H., Rigby, A., …Atkin, S. (2016). Pilot investigation of a virtual gastric band hypnotherapy intervention. International Journal of Clinical and Experimental Hypnosis, 64(4), 419-433. https://doi.org/10.1080/00207144.2016.1209037

This was a pilot investigation of 30 men and women with a BMI > 27kg/m² over a 24 week period. It aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherap... Read More about Pilot investigation of a virtual gastric band hypnotherapy intervention.

Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome (2016)
Journal Article
Sathyapalan, T., Dakroury, Y., Ahmed, L., Elshewehy, A. M. M., Kilpatrick, E. S., Coady, A., & Atkin, S. L. (2016). Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome. Clinical Endocrinology, 85(4), 671-673. https://doi.org/10.1111/cen.13120

There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabin... Read More about Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome.

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis (2015)
Journal Article
Sathyapalan, T., Atkin, S. L., David, R., & Gooderham, N. J. (2015). Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis. Scientific reports, 5(1), 16890-1-16890-8. https://doi.org/10.1038/srep16890

MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and m... Read More about Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis.

Sporopollenin, the least known yet toughest natural biopolymer (2015)
Journal Article
Mackenzie, G., Boa, A. N., Diego-Taboada, A., Atkin, S. L., & Sathyapalan, T. (2015). Sporopollenin, the least known yet toughest natural biopolymer. Frontiers in Materials, 2, 1-5. https://doi.org/10.3389/fmats.2015.00066

© 2015 Mackenzie, Boa, Diego-Taboada, Atkin and Sathyapalan. Sporopollenin is highly cross-linked polymer composed of carbon, hydrogen, and oxygen that is extraordinarily stable and has been found chemically intact in sedimentary rocks some 500 milli... Read More about Sporopollenin, the least known yet toughest natural biopolymer.

Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study (2015)
Journal Article
George, A., Bhatia, R. T., Buchanan, G. L., Whiteside, A., Moisey, R. S., Beer, S. F., …John, J. (2015). Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study. PLoS ONE, 10(11), e0142045. https://doi.org/10.1371/journal.pone.0142045

Objective To investigate the prognostic effect of newly diagnosed diabetes mellitus (NDM) and impaired glucose tolerance (IGT) post myocardial infarction (MI). Research Design and Methods Retrospective cohort study of 768 patients without preexisting... Read More about Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study.

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., …Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Sedman, P., Ajjan, R., Kilpatrick, E. S., & Atkin, S. L. (2014). Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls. Obesity Surgery, 24(3), 349-358. https://doi.org/10.1007/s11695-013-1100-2

Background Insulin resistance (IR) after bariatric surgery is significantly lower than controls matched for bodymass index (BMI) and is indistinguishable from lean subjects however it is not known if this is the same for associated cardiovascular ris... Read More about Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls.

GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS (2013)
Thesis
Kahal, H. (2013). GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4215983

Studies investigating atherothrombotic risk in women with polycystic ovary syndrome (PCOS), in particular platelet function and carotid intima-media wall thickness (cIMT), have been confounded by not adequately accounting for obesity. Liraglutide is... Read More about GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS.

A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Smithson, J. A. J., Vince, R. V., Coady, A. M., Ajjan, R., …Atkin, S. L. (2014). A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clinical Endocrinology, 80(6), 843-849. https://doi.org/10.1111/cen.12258

Background Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile. Objectiv... Read More about A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease.

Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome (2012)
Journal Article
Sathyapalan, T., Shepherd, J., Coady, A., Kilpatrick, E. S., & Atkin, S. L. (2012). Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 97(11), 3951-3955. https://doi.org/10.1210/jc.2012-2279

Background: It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome (PCOS). Statins are considered to have a pleiotropic effect other than their lipid-lowering effect. These effects may be mediated in part by redu... Read More about Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome.

The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms (2012)
Journal Article
Kahal, H., Aye, M., Rigby, A. S., Sathyapalan, T., England, R. J. A., & Atkin, S. L. (2012). The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms. Clinical Endocrinology, 76(2), 196-200. https://doi.org/10.1111/j.1365-2265.2011.04197.x

Background With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic. Objective To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical... Read More about The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms.

The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study (2011)
Journal Article
Sathyapalan, T., Manuchehri, A. M., Thatcher, N. J., Rigby, A. S., Chapman, T., Kilpatrick, E. S., & Atkin, S. L. (2011). The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study. Journal of Clinical Endocrinology and Metabolism, 96(5), 1442-1449. https://doi.org/10.1210/jc.2010-2255

Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect... Read More about The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study.

Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome (2010)
Journal Article
Sathyapalan, T., Shepherd, J., Arnett, C., Coady, A., Kilpatrick, E. S., & Atkin, S. L. (2010). Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome. Clinical Chemistry, 56(11), 1696-1700. https://doi.org/10.1373/clinchem.2010.144014

BACKGROUND: It has been shown that many women with polycystic ovary syndrome (PCOS) are 25-hydroxyvitamin D (25OHD) insufficient. Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin re... Read More about Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome.

Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes (2010)
Journal Article
Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes. Diabetes Care, 33(9), 1948-1950. https://doi.org/10.2337/dc10-0201

OBJECTIVE - Reduction in LDL and high sensitivity (hs) C-reactive protein (CRP) are independent indicators of successful cardiovascular risk reduction with statins. This study compared the effect of equivalent LDL-lowering doses of simvastatin and at... Read More about Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes.

Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement? (2009)
Journal Article
Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement?. Diabetes, Obesity and Metabolism, 12(6), 540-544. https://doi.org/10.1111/j.1463-1326.2009.01190.x

Aim: The benefit of direct, as opposed to calculated, low density lipoprotein - cholesterol (LDL-C) measurement remains unclear. This study compared the biological variability of direct LDL in patients with type 2 diabetes (T2DM) on equivalent doses... Read More about Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement?.

Cardiovascular risk reduction in insulin resistant states (2009)
Thesis
Sathyapalan, T. (2009). Cardiovascular risk reduction in insulin resistant states. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212907

Introduction: Insulin resistance is the hall mark of a number of pathological conditions and is thought to play a major role in the cardiovascular risk associated with them. This thesis critically evaluates two insulin resistant conditions - polycyst... Read More about Cardiovascular risk reduction in insulin resistant states.

The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study (2009)
Journal Article
Sathyapalan, T., Kilpatrick, E. S., Coady, A. M., & Atkin, S. L. (2009). The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study. Journal of Clinical Endocrinology and Metabolism, 94(1), 103-108. https://doi.org/10.1210/jc.2008-1750

CONTEXT: Polycystic ovary syndrome (PCOS) is associated with increased risk of cardiovascular morbidity, whereas statins are proven to reduce cardiovascular mortality and morbidity through lipid-lowering and perhaps through their pleiotropic effects.... Read More about The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study.