Dr Leigh Madden's Outputs (62)

Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression (2024)
Journal Article
Connolly, D., Madden, L. A., Edwards, V., & Lee, V. (2024). Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression. Aerospace Medicine and Human Performance, 95(9), 667-674. https://doi.org/10.3357/AMHP.6391.2024

INTRODUCTION: Biomarker responses to intensive decompression indicate systemic proinflammatory responses and possible neurological stress. To further investigate responses, 12 additional brain and lung biomarkers were assayed. METHODS: A total of 15... Read More about Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression.

Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis (2024)
Journal Article
Metcalfe, J., Orange, S., Madden, L. A., Marshall, P., & Vince, R. V. (2024). Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 32(9), Article 593. https://doi.org/10.1007/s00520-024-08766-y

Purpose: To systematically review and meta-analyse the efficacy of resistance training on quality of life (QOL), fatigue, physical function, and muscular strength in people diagnosed with cancer undergoing chemotherapy. Methods: Electronic databases... Read More about Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis.

Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations (2024)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (online). Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations. Biomaterials science / Royal Society of Chemistry, https://doi.org/10.1039/d4bm00692e

Here we used a 3D human hepatic tumour cell culture model to assess the in vitro efficacy of “active” metformin-loaded nanoparticles (NPs) as anticancer therapeutics. The metformin nanocarrier design was repurposed from previous studies targeting bac... Read More about Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations.

‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity (2024)
Journal Article
Orange, S., Roebuck, J., Marshall, P., Madden, L. A., Vince, R. V., & Bell, B. (online). ‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity. British Journal of Health Psychology, https://doi.org/10.1111/bjhp.12739

Objectives: Living within a larger body brings unique challenges to exercise participation, which are poorly understood. This qualitative study explored the attitudes towards, and experiences of, exercise participation in adults with class III obesit... Read More about ‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity.

Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products (2024)
Thesis
Doyle, B. Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4587910

Upon entering the body, any given xenobiotic can undergo metabolism which facilitates its excretion from the body. When metabolised, a compound typically has the same effects of the initial drug/nutraceutical, however this is not always the case and... Read More about Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products.

Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram (2023)
Journal Article
Madden, L. A., Vince, R. V., Edwards, V. C., Lee, V. M., & Connolly, D. M. (2023). Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram. Hemato, 4(4), 301-310. https://doi.org/10.3390/hemato4040024

The blood coagulation response to decompression stress in humans has yet to be fully investigated. Here we utilised calibrated automated thrombogram (CAT) on samples from healthy volunteers exposed to decompression stress to investigate real-time thr... Read More about Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram.

Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress (2023)
Journal Article
Connolly, D., Madden, L. A., Edwards, V., D'Oyly, T., Harridge, S., Smith, T., & Lee, V. (2023). Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress. Aerospace Medicine and Human Performance, 94(10), 738-749. https://doi.org/10.3357/AMHP.6247.2023

INTRODUCTION: Consistent blood biomarkers of hypobaric (altitude) decompression stress remain elusive. Recent laboratory investigation of decompression sickness risk at 25,000 ft (7620 m) enabled evaluation of early pathophysiological responses to ex... Read More about Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress.

Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites (2023)
Journal Article
Doyle, B., Madden, L. A., Pamme, N., & Jones, H. (2023). Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites. RSC advances, 13(40), 27696-27704. https://doi.org/10.1039/d3ra03742h

The study of naturally circulating drug metabolites has been a focus of interest, since these metabolites may have different therapeutic and toxicological effects compared to the parent drug. The synthesis of metabolites outside of the human body is... Read More about Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites.

Digital Health Solutions for Weight Loss and Obesity: A Narrative Review (2023)
Journal Article
Irvin, L., Madden, L. A., Marshall, P., & Vince, R. V. (2023). Digital Health Solutions for Weight Loss and Obesity: A Narrative Review. Nutrients, 15(8), Article 1858. https://doi.org/10.3390/nu15081858

Personal exercise programmes have long been used and prescribed for weight loss and the improvement of quality of life in obese patients. While individualised programmes are usually the preferred option, they can be more costly and challenging to del... Read More about Digital Health Solutions for Weight Loss and Obesity: A Narrative Review.

Advanced biomedical applications of cell clusteroids based on aqueous twophase Pickering emulsion systems (2022)
Thesis
Wang, A. Advanced biomedical applications of cell clusteroids based on aqueous twophase Pickering emulsion systems. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4249064

The development of in vitro models for advancing the research of cell biology and cell physiology is of great importance to the fields of biotechnology, cancer study, drug testing, toxicity study. The emerging field includes tissue engineering and re... Read More about Advanced biomedical applications of cell clusteroids based on aqueous twophase Pickering emulsion systems.

Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System (2022)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2022). Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System. ACS Applied Bio Materials, https://doi.org/10.1021/acsabm.2c00168

Tumor cell spheroids and 3D cell culture have generated a lot of interest in the past decade due to their relative ease of production and biomedical research applications. To date, the frontier in tumor 3D models has been pushed to the level of perso... Read More about Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System.

Vascularized Co‐Culture Clusteroids of Primary Endothelial and Hep‐G2 Cells Based on Aqueous Two‐Phase Pickering Emulsions (2022)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2022). Vascularized Co‐Culture Clusteroids of Primary Endothelial and Hep‐G2 Cells Based on Aqueous Two‐Phase Pickering Emulsions. Bioengineering, 9(3), Article 126. https://doi.org/10.3390/bioengineering9030126

Three‐dimensional cell culture has been extensively involved in biomedical applications due to its high availability and relatively mature biochemical properties. However, single 3D cell culture models based on hydrogel or various scaffolds do not me... Read More about Vascularized Co‐Culture Clusteroids of Primary Endothelial and Hep‐G2 Cells Based on Aqueous Two‐Phase Pickering Emulsions.

Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles (2021)
Journal Article
Wang, A., Weldrick, P. J., Madden, L. A., & Paunov, V. N. (2021). Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles. Biomaterials science / Royal Society of Chemistry, 9(20), 6927-6939. https://doi.org/10.1039/d1bm01035b

Candida urinary tract biofilms are increasingly witnessed in nosocomial infections due to reduced immunity of patients and the hospital ecosystem. The indwelling devices utilized to support patients with urethral diseases that connect the unsterilize... Read More about Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles.

Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies (2021)
Journal Article
Wang, A., Weldrick, P., Madden, L. A., & Paunov, V. N. (2021). Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies. ACS Applied Materials & Interfaces, 13(19), 22182-22194. https://doi.org/10.1021/acsami.1c02679

Microbial biofilms are a major concern in wound care, implant devices, and organ infections. Biofilms allow higher tolerance to antimicrobial drugs, can impair wound healing, and potentially lead to sepsis. There has been a recent focus on developing... Read More about Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies.

Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 2 (2021)
Journal Article
Corre, J., Sabbah, M., Schjesvold, F., Zeidan, A. M., Buccisano, F., Sallman, D., Mazzucato, M., Madden, L. A., Martini, M., Van Breda, E., Dolcetti, R., Busca, A., Cook, G., Onida, F., Versari, A., Kiladjian, J. J., Walter, R. B., Garderet, L., Robin, M., & Signore, A. (2021). Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 2. Hemato, 2(1), 79-88. https://doi.org/10.3390/hemato2010004

High-throughput fabrication of hepatic cell clusteroids with enhanced growth and functionality for tissue engineering applications (2020)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2020). High-throughput fabrication of hepatic cell clusteroids with enhanced growth and functionality for tissue engineering applications. Materials Advances, 1(8), 3022-3032. https://doi.org/10.1039/d0ma00635a

Culturing of cells as three-dimensional (3D) clusters can enhance in vitro tests for basic biological research as well as for therapeutics development. Such 3D culture models, however, are often more complicated, cumbersome and expensive than two-dim... Read More about High-throughput fabrication of hepatic cell clusteroids with enhanced growth and functionality for tissue engineering applications.

Advanced biomedical applications based on emerging 3D cell culturing platforms (2020)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2020). Advanced biomedical applications based on emerging 3D cell culturing platforms. Journal of Materials Chemistry B, 8(46), 10487-10501. https://doi.org/10.1039/d0tb01658f

It is of great value to develop reliable in vitro models for cell biology and toxicology. However, ethical issues and the decreasing number of donors restrict the further use of traditional animal models in various fields, including the emerging fiel... Read More about Advanced biomedical applications based on emerging 3D cell culturing platforms.

Resistance training leads to large improvements in strength and moderate improvements in physical function in adults who are overweight or obese: a systematic review (2020)
Journal Article
Orange, S. T., Madden, L. A., & Vince, R. V. (2020). Resistance training leads to large improvements in strength and moderate improvements in physical function in adults who are overweight or obese: a systematic review. Journal of Physiotherapy, 66(4), 214-224. https://doi.org/10.1016/j.jphys.2020.09.009

Questions
What are the effects of resistance training on muscle strength, physical function and muscle power in adults who are overweight or obese? Which factors moderate the effects?

Design
Systematic review of randomised controlled trials, wit... Read More about Resistance training leads to large improvements in strength and moderate improvements in physical function in adults who are overweight or obese: a systematic review.

Bioimprint Mediated Label-Free Isolation of Pancreatic Tumor Cells from a Healthy Peripheral Blood Cell Population (2020)
Journal Article
Pelle, M., Das, A. A. K., Madden, L. A., & Paunov, V. N. (in press). Bioimprint Mediated Label-Free Isolation of Pancreatic Tumor Cells from a Healthy Peripheral Blood Cell Population. Advanced Biosystems, Article 2000054. https://doi.org/10.1002/adbi.202000054

New techniques are required for earlier diagnosis and response to treatment of pancreatic cancer. Here, a label-free approach is reported in which circulating pancreatic tumor cells are isolated from healthy peripheral blood cells via cell bioimprint... Read More about Bioimprint Mediated Label-Free Isolation of Pancreatic Tumor Cells from a Healthy Peripheral Blood Cell Population.

Doxorubicin Enhances Procoagulant Activity of Endothelial Cells after Exposure to Tumour Microparticles on Microfluidic Devices (2020)
Journal Article
Algarni, A., Greenman, J., & Madden, L. A. (2020). Doxorubicin Enhances Procoagulant Activity of Endothelial Cells after Exposure to Tumour Microparticles on Microfluidic Devices. Hemato, 1(1), 23-34. https://doi.org/10.3390/bloods1010006

The majority of cancer patients undergoing chemotherapy have a significantly increased risk of venous thromboembolism via a mechanism not yet fully elucidated but which most probably involves tumour microparticles (MP) combined with damaged/activated... Read More about Doxorubicin Enhances Procoagulant Activity of Endothelial Cells after Exposure to Tumour Microparticles on Microfluidic Devices.