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Dr Michael Crooks

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Michael Crooks

Senior Clinical Lecturer in Respiratory Medicine


Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis (2020)
Journal Article
Fraser, S. D., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2021). Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis. ERJ Open Research, 7(1), https://doi.org/10.1183/23120541.00804-2020

Background: In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 an... Read More about Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis.

Azithromycin for sarcoidosis cough: an open label exploratory clinical trial (2020)
Journal Article
Fraser, S. D., Thackray-Nocera, S., Shepherd, M., Flockton, R., Wright, C., Sheedy, W., …Hart, S. P. (2020). Azithromycin for sarcoidosis cough: an open label exploratory clinical trial. ERJ Open Research, 6(4), https://doi.org/10.1183/23120541.00534-2020

Background Chronic cough is a distressing symptom for many people with pulmonary sarcoidosis. Continuous treatment with a macrolide antibiotic may improve cough. We aimed to assess the potential efficacy of azithromycin in patients with sarcoidosis a... Read More about Azithromycin for sarcoidosis cough: an open label exploratory clinical trial.

Hidden morbidity: the results of a collaborative community chronic obstructive pulmonary disease screening initiative (2018)
Journal Article
Crooks, M. G., Thompson, J. L., Cummings, H., Watkins, K., Jackson, N., Platten, S., …Faruqi, S. (2019). Hidden morbidity: the results of a collaborative community chronic obstructive pulmonary disease screening initiative. Clinical Respiratory Journal, 13(1), 43-49. https://doi.org/10.1111/crj.12978

Chronic obstructive pulmonary disease (COPD) often goes unrecognised resulting in people living with the disease without a diagnosis. We investigated the characteristics, symptom burden and flow of participants in a community COPD screening initiativ... Read More about Hidden morbidity: the results of a collaborative community chronic obstructive pulmonary disease screening initiative.

Agreement between blood draw techniques for assessing platelet activation by flow cytometry (2018)
Journal Article
Welch, E. L., Crooks, M. G., & Hart, S. P. (2019). Agreement between blood draw techniques for assessing platelet activation by flow cytometry. Platelets, 30(4), 530-534. https://doi.org/10.1080/09537104.2018.1535705

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into... Read More about Agreement between blood draw techniques for assessing platelet activation by flow cytometry.

Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis (2018)
Journal Article
Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., …Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesi... Read More about Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis.

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation (2017)
Journal Article
Crooks, M. G., den Brinker, A., Hayman, Y., Williamson, J. D., Innes, A., Wright, C. E., …Morice, A. H. (2017). Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation. Lung, 195(3), 289-294. https://doi.org/10.1007/s00408-017-9996-2

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deteriorat... Read More about Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation.

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin (2016)
Journal Article
Williamson, J. D., Sadofsky, L. R., Crooks, M. G., Greenman, J., & Hart, S. P. (2016). Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin. Experimental Lung Research, 42(8-10), 397-407. https://doi.org/10.1080/01902148.2016.1243742

© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis. The mechanisms unde... Read More about Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin.

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Fahim, A., Crooks, M. G., Morice, A. H., & Hart, S. P. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), 277-284. https://doi.org/10.1007/s00408-013-9546-5

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More about Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis..

Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis (2012)
Journal Article
Fahim, A., Crooks, M., Wilmot, R., Campbell, A. P., Morice, A., & Hart, S. (2012). Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis. Respirology : official journal of the Asian Pacific Society of Respirology, 17(8), 1247-1252. https://doi.org/10.1111/j.1440-1843.2012.02231.x

Background and objective: Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer.... Read More about Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis.

Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies (2012)
Journal Article
Fahim, A., Chong, M. C., Crooks, M. G., & Hart, S. P. (2012). Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies. Lung, 190(4), 451-458. https://doi.org/10.1007/s00408-012-9390-z

PurposeIdiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies... Read More about Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies.