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Outputs (56)

Evaluating the Role of Ultrasound in Prostate cancer (ERUP) trial – Phase 1 early experience of micro-ultrasound in the UK (2024)
Journal Article
Parker, P., Twiddy, M., Rigby, A., Whybrow, P., & Simms, M. (2024). Evaluating the Role of Ultrasound in Prostate cancer (ERUP) trial – Phase 1 early experience of micro-ultrasound in the UK. Ultrasound, https://doi.org/10.1177/1742271X231226302

Purpose: To evaluate if the use of micro-ultrasound (microUS) can detect significant prostate (csPCa) pathology when compared to histology obtained during a transperineal prostate biopsy. Methods: Patients suspected of having prostate cancer, who h... Read More about Evaluating the Role of Ultrasound in Prostate cancer (ERUP) trial – Phase 1 early experience of micro-ultrasound in the UK.

High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): a qualitative acceptability study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., …Twiddy, M. (2024). High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): a qualitative acceptability study. Annals of vascular surgery, 102, Article 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Introduction A novel high-intensity interval training (HIIT) programme has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT programme to inform refinemen... Read More about High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): a qualitative acceptability study.

How can patients influence service improvement decision-making? A participatory research mixed methods study (2023)
Journal Article
Drinkwater, J., MacFarlane, A., Twiddy, M., Meads, D., Chadwick, R. H., Donnelly, A., …Foy, R. (in press). How can patients influence service improvement decision-making? A participatory research mixed methods study. The British journal of general practice : the journal of the Royal College of General Practitioners, Article BJGP-2023-0263.R2. https://doi.org/10.3399/BJGP.2023.0263

Background Health policy promotes patient participation in decision-making about service organisation. In English general practice this happens through contractually required patient participation groups (PPGs). However, there are problems with the... Read More about How can patients influence service improvement decision-making? A participatory research mixed methods study.

Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study (2023)
Journal Article
Akwa, L. G., Smith, L., Twiddy, M., Abt, G., Garnett, C., Oldham, M., …Herbec, A. (2023). Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study. PLoS ONE, 18(10 October), Article e0287199. https://doi.org/10.1371/journal.pone.0287199

Introduction The COVID-19 pandemic and attendant lockdowns have had a substantial negative effect on alcohol consumption and physical activity globally. Pre-pandemic evidence in the adult population suggests that higher levels of physical activity we... Read More about Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study.

High-intensity interval training in patients with intermittent claudication (2023)
Journal Article
Pymer, S., Harwood, A. E., Prosser, J., Waddell, A., Rhavindhran, B., McGregor, G., …Chetter, I. C. (2023). High-intensity interval training in patients with intermittent claudication. Journal of vascular surgery, 78(4), 1048-1056.e4. https://doi.org/10.1016/j.jvs.2023.05.045

Objective: Provision, uptake, adherence, and completion rates for supervised exercise programs (SEP) for intermittent claudication (IC) are low. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effecti... Read More about High-intensity interval training in patients with intermittent claudication.

Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation (2023)
Journal Article
Gordon, H., Hebenton, J., Davie-Smith, F., Twiddy, M., Smith, G., & Carradice, D. (2023). Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation. Journal of Vascular Societies Great Britain and Ireland, 2(4), 208-214. https://doi.org/10.54522/jvsgbi.2023.081

Background: Through knee amputation (TKA) may offer benefits over above knee amputation (AKA) in patients unsuitable for below knee amputation. This retrospective analysis compared surgical and rehabilitation outcomes post TKA and AKA. Methods: Al... Read More about Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation.

Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales (2023)
Journal Article
Thiery, H., Cook, J., Burchell, J., Wilberforce, M., Twiddy, M., Nikolova, S., …Hulme, C. (2023). Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales. Social Sciences & Humanities Open, 8(1), Article 100714. https://doi.org/10.1016/j.ssaho.2023.100714

Adult Social Care (ASC) in England faces an ‘existential crisis’, caught between increased demand for services and continued cuts to social care and local government budgets. Increasingly, it is argued that this crisis cannot be solved without reform... Read More about Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales.

Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review (2022)
Journal Article
Hitchman, L., Totty, J., Smith, G. E., Carradice, D., Twiddy, M., Iglesias, C., …Chetter, I. C. (2022). Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review. International wound journal, https://doi.org/10.1111/iwj.14035

Emerging evidence suggests that extracorporeal shockwave therapy (ESWT) may improve time to DFU healing. The aim of this review was to appraise the evidence on role of ESWT in DFU healing and impact of different ESWT doses. Databases were searched fo... Read More about Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review.

Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives (2022)
Journal Article
Twiddy, M., Birtwistle, J., Edmondson, A., Croft, J., Gordon, K., Meads, D., …Harji, D. (2022). Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives. BJS Open, 6(6), Article zrac137. https://doi.org/10.1093/bjsopen/zrac137

Background: Undertaking randomized clinical trials (RCTs) in emergency surgical settings is associated with methodological and practical challenges. This study explored patients' and clinicians' perspectives associated with the conduct of an RCT comp... Read More about Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives.

Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study (2022)
Journal Article
Twiddy, M., Trump, B., & Ramsden, S. (2022). Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study. PLoS ONE, 17(9), Article e0274890. https://doi.org/10.1371/journal.pone.0274890

As the effects of climate change become more visible, extreme weather events are becoming more common. The effects of flooding on health are understood but the long-term impact on the well-being of those affected need to be considered. This mixed met... Read More about Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study.

A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation (2022)
Thesis
Crane, H. (2022). A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4312145

Through-knee amputation (TKA) has several theoretical physical advantages over above-knee amputation (AKA), yet AKA remains the preferred level of amputation by UK vascular surgeons when below-knee amputation (BKA) is not feasible. How clinician’s pe... Read More about A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2022)
Journal Article
Pearson, M., Jackson, G., Jackson, C., Boland, J., Featherstone, I., Huang, C., …Johnson, M. (2022). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. BMJ open, 12(7), Article e060450. https://doi.org/10.1136/bmjopen-2021-060450

INTRODUCTION: Delirium is a complex condition in which altered mental state and cognition causes severe distress and poor clinical outcomes for patients and families, anxiety and stress for the health professionals and support staff providing care, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

Emerging environmental contaminants and human health : risk assessment of dietary exposure to microplastics (2022)
Thesis
Ntanopoulos, E. (2022). Emerging environmental contaminants and human health : risk assessment of dietary exposure to microplastics. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4224197

Microplastics (MPs) are an emerging contaminant ubiquitous in the environment. There is growing concern regarding potential human health effects. A major human exposure route is hypothesised to be the dietary pathway via ingestion of contaminated foo... Read More about Emerging environmental contaminants and human health : risk assessment of dietary exposure to microplastics.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations. The Cochrane database of systematic reviews, 2021(12), CD013839. https://doi.org/10.1002/14651858.CD013839.pub2

BACKGROUND: Diabetes and vascular disease are the leading causes of lower limb amputation. Currently, 463 million adults are living with diabetes, and 202 million with peripheral vascular disease, worldwide. When a lower limb amputation is considered... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations.

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. (2021)
Journal Article
Danopoulos, E., Twiddy, M., West, R., & Rotchell, J. M. (in press). A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. Journal of hazardous materials, Article 127861. https://doi.org/10.1016/j.jhazmat.2021.127861

Humans are exposed to microplastics (MPs) daily via ingestion and inhalation. It is not known whether this results in adverse health effects and, if so, at what levels of exposure. Without epidemiological studies, human cell in vitro MP toxicological... Read More about A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells..

The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience (2021)
Journal Article
Chen, H., Twiddy, M., Jones, L., & Johnson, M. J. (2021). The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience. European Journal of Cancer Care, 30(6), Article e13503. https://doi.org/10.1111/ecc.13503

Objective: The objective of this study is to explore the specific information and communication needs of men affected by prostate cancer to inform the development of educational materials for clinicians. Methods: This is a qualitative descriptive stu... Read More about The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience.

A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol (2021)
Journal Article
Twiddy, M., Hazara, A., Bhandari, S., & Allgar, V. (in press). A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol. Clinical and Experimental Nephrology, https://doi.org/10.1007/s10157-021-02072-1

Background: Incremental haemodialysis/haemodiafiltration (HD) may help reduce early mortality rates in patients starting HD. This mixed-method feasibility study aims to test the acceptability, tolerance and safety of a novel incremental HD regime, an... Read More about A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol.

The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review (2021)
Journal Article
Simms, M., Parker, P., Rigby, A., Whybrow, P., & Twiddy, M. (in press). The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review. Ultrasound, https://doi.org/10.1177/1742271X21995212

Background: The use of multiparametric magnetic resonance imaging (mpMRI) within active surveillance of prostate cancer programmes is identified by the UK National Institute for Health and Care Excellence (NICE guideline NG 131 2019) as having a role... Read More about The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review.

The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres (2021)
Journal Article
Burton, W., Sahota, P., Twiddy, M., Brown, J., & Bryant, M. (in press). The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres. Prevention Science, https://doi.org/10.1007/s11121-021-01205-y

Background Poor participant engagement threatens the potential impact and cost effectiveness of public health programmes preventing meaningful evaluation and wider application. Although barriers and levers to engagement with public health programmes... Read More about The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres.

Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study (2021)
Journal Article
Brown, J. M., Croft, J., Poad, H., Bell, R., Collinson, M., Gordon, K., …Goodwin, L. (2021). Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study. Journal of Clinical Oncology, 39(3), 202-214. https://doi.org/10.1200/JCO.20.01665

PURPOSE: High-grade nonmuscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease. Treatments include intravesical maintenance Bacillus Calmette-Guerin (mBCG) and radical cystectomy (RC). We wanted to understand whether a randomized trial co... Read More about Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol) (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol). Cochrane Database of Systematic Reviews, 2021(1), Article CD013839. https://doi.org/10.1002/14651858.CD013839

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of through-knee amputation compared to above-knee amputation on clinical and rehabilitation outcomes and complication rates in... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol).

Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers (2021)
Journal Article
Johnson, M. J., Huang, C., Chen, H., Jones, L., & Twiddy, M. (2021). Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003438

Objectives: Men living with prostate cancer have supportive and palliative needs. However, few studies detail unmet needs (vs quality of life measurement) or include data from those with advanced disease. We aimed to identify unmet needs of people li... Read More about Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers.

Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis. Environmental Health Perspectives, 128(12), 126002-1-126002-32. https://doi.org/10.1289/EHP7171

Background: Microplastics (MPs) have contaminated all compartments of the marine environment including biota such as seafood; ingestion from such sources is one of the two major uptake routes identified for human exposure. Objectives: The objectives... Read More about Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis.

Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis. SN Applied Sciences, 2(12), Article 1950. https://doi.org/10.1007/s42452-020-03749-0

Microplastics (MPs) are an emerging contaminant ubiquitous in the environment. There is growing concern regarding potential human health effects, a major human exposure route being dietary uptake. We have undertaken a systematic review (SR) and meta-... Read More about Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis.

Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services (2020)
Journal Article
Hess, S., Meads, D., Twiddy, M., Mason, S., Czoski-Murray, C., & Minton, J. (2021). Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services. Journal of Choice Modelling, 38, Article 100252. https://doi.org/10.1016/j.jocm.2020.100252

Choice modelling techniques have established themselves as a key analysis tool in health economics and have been used to understand patient and practitioner preferences across a wide variety of settings. A key interest in recent years has been the in... Read More about Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services.

Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search (2020)
Journal Article
Coleman, S., Wright, J. M., Nixon, J., Schoonhoven, L., Twiddy, M., & Greenhalgh, J. (2020). Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search. BMC Medical Research Methodology, 20(1), 217. https://doi.org/10.1186/s12874-020-01084-x

BACKGROUND: Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the first step in a realist eval... Read More about Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search.

Microplastic contamination of drinking water: a systematic review. (2020)
Journal Article
Danopoulos, E., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of drinking water: a systematic review. PLoS ONE, 15(7 July), Article e0236838. https://doi.org/10.1371/journal.pone.0236838

Background Microplastics (MPs) are omnipresent in the environment, including the human food chain; a likely important contributor to human exposure is drinking water. Objective To undertake a systematic review of MP contamination of drinking water... Read More about Microplastic contamination of drinking water: a systematic review..

high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study (2020)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Twiddy, M., …Chetter, I. C. (2020). high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study. BMJ open, 10(7), Article e038825. https://doi.org/10.1136/bmjopen-2020-038825

Introduction: The first-line recommended treatment for patients with intermittent claudication (IC), is a supervised exercise programme (SEP), which includes a minimum of 2 hours exercise per week over a 12-week period. However, provision, uptake, an... Read More about high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study.

Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial (2020)
Journal Article
Cardozo, W., Baker, R., Berger, C., Chapman, S., Codd, R., Coyne, P., …Brown, J. (in press). Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial. British journal of surgery, https://doi.org/10.1002/bjs.11703

Abstract Background Approximately 30,000 people per annum undergo major, emergency abdominal, gastrointestinal surgery, of which 36% (~10,800) are carried out for emergency colorectal pathology. Approximately 14% of all patients requiring emergency... Read More about Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial.

Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT (2020)
Journal Article
Davidson, B., Gurusamy, K., Corrigan, N., Croft, J., Ruddock, S., Pullan, A., …de Wilt, J. H. (2020). Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT. Health Technology Assessment, 24(21), 1-66. https://doi.org/10.3310/hta24210

Background: Although surgical resection has been considered the only curative option for colorectal liver metastases, thermal ablation has recently been suggested as an alternative curative treatment. There have been no adequately powered trials comp... Read More about Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT.

Information design for bowel cancer detection: The impact of using information visualisation to help patients prepare for colonoscopy screening (2019)
Journal Article
dos Santos Lonsdale, M., Ni, L. C., Gu, C., & Twiddy, M. (2019). Information design for bowel cancer detection: The impact of using information visualisation to help patients prepare for colonoscopy screening. Information Design Journal, 25(2), 125-156. https://doi.org/10.1075/idj.25.2.01lon

© 2019 John Benjamins Publishing Company. All rights reserved. Colorectal cancer is one of the most commonly occurring cancers in the world, and colonoscopy is the most sensitive procedure to detect it. Colonoscopy success depends on the quality of b... Read More about Information design for bowel cancer detection: The impact of using information visualisation to help patients prepare for colonoscopy screening.

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol (2019)
Journal Article
Wright, C., Hart, S. P., Allgar, V., English, A., Swan, F., Dyson, J., …Crooks, M. G. (2019). A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol. ERJ Open Research, 5(4), Article 0186. https://doi.org/10.1183/23120541.00186-2019

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now av... Read More about A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol.

Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study (2019)
Journal Article
Burton, W., Twiddy, M., Sahota, P., Brown, J., & Bryant, M. (2019). Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study. BMC public health, 19(1), Article 1074. https://doi.org/10.1186/s12889-019-7410-0

© 2019 The Author(s). Background: Children's centres in the UK provide a setting for public health programmes; offering support to families living in the most disadvantaged areas where obesity prevalence is at its highest. Health, Exercise and Nutrit... Read More about Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study.

Patient and public involvement in health research in low and middle-income countries: a systematic review (2019)
Journal Article
Cook, N., Siddiqi, N., Twiddy, M., & Kenyon, R. (2019). Patient and public involvement in health research in low and middle-income countries: a systematic review. BMJ open, 9(5), Article e026514. https://doi.org/10.1136/bmjopen-2018-026514

Objectives: Patient and public involvement (PPI) is argued to lead to higher quality health research, which is more relatable to and helps empower the public. We synthesised the evidence to look for examples of PPI in health research in low/middle-in... Read More about Patient and public involvement in health research in low and middle-income countries: a systematic review.

High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis (2018)
Journal Article
Forester, N. D., Lowes, S., Mitchell, E., & Twiddy, M. (2019). High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis. European journal of surgical oncology, 45(4), 519-527. https://doi.org/10.1016/j.ejso.2018.12.008

© 2018 Introduction: Provide evidence to support evolving management strategies for high-risk (B3) breast lesions by assessing risk of carcinoma in subgroups of B3 lesions using systematic review and meta-analysis. Methods: Databases identified obser... Read More about High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis.

TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial (2018)
Journal Article
Edginton, E., Walwyn, R., Twiddy, M., Wright-Hughes, A., Tubeuf, S., Reed, S., …Cottrell, D. (2018). TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial. Journal of Child and Adolescent Mental Health, 30(3), 167-182. https://doi.org/10.2989/17280583.2018.1532433

Background: Parenting programmes are recommended for conduct disorders in 5–11 year olds, but ineffective for 25–33%. A feasibility trial was needed to determine whether a confirmatory trial of second-line, manualised short-term psychoanalytic child... Read More about TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial.

Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial (2018)
Journal Article
Gurusamy, K., Corrigan, N., Croft, J., Twiddy, M., Morris, S., Woodward, N., …Davidson, B. R. (2018). Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial. Trials, 19(1), https://doi.org/10.1186/s13063-018-2499-5

Background:Although surgical resection has been considered the only curative option for colorectal livermetastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment. A prospective randomised trial is required to... Read More about Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial.

Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol (2018)
Journal Article
Harji, D., Marshall, H., Gordon, K., Crow, H., Hiley, V., Burke, D., …Sagar, P. (2018). Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol. BMJ open, 8(2), Article e018618. https://doi.org/10.1136/bmjopen-2017-018618

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Acute colorectal surgery forms a significant prop... Read More about Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol.

A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement (2018)
Journal Article
Twiddy, M., Czoski Murray, C. J., Mason, S. J., Meads, D., Wright, J. M., Mitchell, E. D., & Minton, J. (2018). A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement. BMJ open, 8(1), e019099. https://doi.org/10.1136/bmjopen-2017-019099

Abstract Objective Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation is patchy and a variety of service models are in use. The slow uptake in the UK and Europe is due to... Read More about A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement.

TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial (2017)
Journal Article
Edginton, E., Walwyn, R., Burton, K., Cicero, R., Graham, L., Reed, S., …Cottrell, D. (2017). TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial. Trials, 18(1), Article 431. https://doi.org/10.1186/s13063-017-2166-2

Background: The National Institute for Health and Care Excellence (NICE) recommends evidence-based parenting programmes as a first-line intervention for conduct disorders (CD) in children aged 5–11 years. As these are not effective in 25–33% of cases... Read More about TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial.

Radical cystectomy (bladder removal) against intravesical BCG immunotherapy for high-risk non-muscle invasive bladder cancer (BRAVO): a protocol for a randomised controlled feasibility study (2017)
Journal Article
Noon, A. P., Chahal, R., Dooldeniya, M., Koenig, P., Catto, J. W. F., Oughton, J. B., …Catto, J. (2017). Radical cystectomy (bladder removal) against intravesical BCG immunotherapy for high-risk non-muscle invasive bladder cancer (BRAVO): a protocol for a randomised controlled feasibility study. BMJ open, 7(8), e017913. https://doi.org/10.1136/bmjopen-2017-017913

Introduction High-risk non-muscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease that can be difficult to predict. While around 25% of cancers progress to invasion and metastases, the remaining majority of tumours remain within the blad... Read More about Radical cystectomy (bladder removal) against intravesical BCG immunotherapy for high-risk non-muscle invasive bladder cancer (BRAVO): a protocol for a randomised controlled feasibility study.

Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach (2017)
Journal Article
Vargas-Palacios, A., Meads, D. M., Twiddy, M., Murray, C. C., Hulme, C., Mitchell, E. D., …Minton, J. (2017). Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach. The journal of antimicrobial chemotherapy, 72(8), 2392-2400. https://doi.org/10.1093/jac/dkx123

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. Objectives: In the UK, patients who require intravenous antimicrobial (IVA) treatment may receive this in th... Read More about Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach.

NIHR Liver/Renal Biomarker Programme Final Report: Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease (2017)
Report
Selby, P., Banks, R., Gregory, W., Hewison, J., Rosenberg, W., Altman, D., …Hutchinson, M. (2017). NIHR Liver/Renal Biomarker Programme Final Report: Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease. Southampton: NIHR

Protein biomarkers are naturally occurring substances that can be measured, often in fluids such as blood or urine, and which provide information about a patient and their illness. Different diseases have different biomarkers. When people become ill,... Read More about NIHR Liver/Renal Biomarker Programme Final Report: Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease.

Clinical and cost-effectiveness, safety and acceptability of community intravenous antibiotic service models: CIVAS systematic review (2017)
Journal Article
Murray, C. C., Mitchell, E. D., Czoski Murray, C., Meads, D., Minton, J., Wright, J., & Twiddy, M. (2017). Clinical and cost-effectiveness, safety and acceptability of community intravenous antibiotic service models: CIVAS systematic review. BMJ open, 7(4), Article e013560. https://doi.org/10.1136/bmjopen-2016-013560

OBJECTIVE: Evaluate evidence of the efficacy, safety, acceptability and cost-effectiveness of outpatient parenteral antimicrobial therapy (OPAT) models. DESIGN: A systematic review. DATA SOURCES: MEDLINE, EMBASE, CINAHL, Cochrane Library, National He... Read More about Clinical and cost-effectiveness, safety and acceptability of community intravenous antibiotic service models: CIVAS systematic review.

The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence (2017)
Journal Article
Edmondson, A. J., Birtwistle, J. C., Catto, J. W., & Twiddy, M. (2017). The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence. Journal of cancer survivorship : research and practice, 11(4), 453-461. https://doi.org/10.1007/s11764-017-0603-6

© 2017, The Author(s). Purpose: Bladder cancer (BC) is a common disease with disparate treatment options and variable outcomes. Despite the disease’s high prevalence, little is known of the lived experience of affected patients. National patient expe... Read More about The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence.

The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy (2017)
Journal Article
Minton, J., Murray, C. C., Meads, D., Hess, S., Vargas-Palacios, A., Mitchell, E., …Twiddy, M. (2017). The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy. Health Services and Delivery Research, 5(6), 1-272. https://doi.org/10.3310/hsdr05060

Background Outpatient parenteral antimicrobial therapy (OPAT) is widely used in most developed countries, providing considerable opportunities for improved cost savings. However, it is implemented only partially in the UK, using a variety of servi... Read More about The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy.

Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study. (2016)
Journal Article
Arharya, S., Bryant, L. B., & Twiddy, M. (2017). Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study. Journal of Psychosomatic Obstetrics and Gynecology, 38(1), 4 - 11. https://doi.org/10.1080/0167482X.2016.1233171

Introduction: This qualitative study was conducted to explore the motivations and experience of oocyte donors donating to women known to them. Methods: Three women who donated oocytes to a close relative were interviewed and data were analysed usi... Read More about Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study..

Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study (2016)
Journal Article
Acharya, S., Bryant, L., & Twiddy, M. (2016). Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study. Journal of Psychosomatic Obstetrics and Gynecology, 38(1), 4-11. https://doi.org/10.1080/0167482X.2016.1233171

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: This qualitative study was conducted to explore the motivations and experience of oocyte donors donating to women known to them. Methods: Three women who donated oocytes to... Read More about Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study.

Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study (2015)
Journal Article
Allsop, M. J., Twiddy, M., Grant, H., Czoski-Murray, C., Mon-Williams, M., Mushtaq, F., …Pavitt, S. (2015). Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study. Acta Neurochirurgica, 157(11), 1925-1933. https://doi.org/10.1007/s00701-015-2515-4

Background Trigeminal neuralgia (TN) is a serious health problem, causing brief, recurrent episodes of stabbing or burning facial pain, which patients describe as feeling like an electric shock. The consequences of living with the condition are seve... Read More about Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study.

Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services (2015)
Journal Article
Czoski Murray, C., Twiddy, M., Meads, D., Hess, S., Wright, J., Mitchell, E. D., …Minton, J. (2015). Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services. BMJ open, 5(8), Article e008965. https://doi.org/10.1136/bmjopen-2015-008965

Introduction: Outpatient parenteral antimicrobial therapy (OPAT) is used to treat a wide range of infections, and is common practice in countries such as the USA and Australia. In the UK, national guidelines (standards of care) for OPAT services have... Read More about Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services.

Measuring patient-perceived continuity of care for patients with long-term conditions in primary care (2014)
Journal Article
Hill, K. M., Twiddy, M., Hewison, J., & House, A. O. (2014). Measuring patient-perceived continuity of care for patients with long-term conditions in primary care. BMC family practice, 15(1), Article 191. https://doi.org/10.1186/s12875-014-0191-8

Background: Continuity of care is widely acknowledged as important for patients with multi-morbidity but simple, service-orientated indices cannot capture the full impact of continuity in complex care delivery systems. The patient’s perspective is im... Read More about Measuring patient-perceived continuity of care for patients with long-term conditions in primary care.

Variability in clinicians' opinions regarding fitness to drive in patients with obstructive sleep apnoea syndrome (OSAS) (2014)
Journal Article
Dwarakanath, A., Twiddy, M., Ghosh, D., Jamson, S. L., Baxter, P. D., & Elliott, M. W. (2015). Variability in clinicians' opinions regarding fitness to drive in patients with obstructive sleep apnoea syndrome (OSAS). Thorax, 70(5), 495-497. https://doi.org/10.1136/thoraxjnl-2014-206180

We evaluated clinicians' current practice for giving advice to patients with obstructive sleep apnoea syndrome. Clinicians were invited to complete a web-based survey and indicate the advice they would give to patients in a number of scenarios about... Read More about Variability in clinicians' opinions regarding fitness to drive in patients with obstructive sleep apnoea syndrome (OSAS).

Understanding causal associations between self-rated health and personal relationships in older adults: a review of evidence from longitudinal studies (2014)
Journal Article
Craigs, C. L., Twiddy, M., Parker, S. G., & West, R. M. (2014). Understanding causal associations between self-rated health and personal relationships in older adults: a review of evidence from longitudinal studies. Archives of Gerontology and Geriatrics, 59(2), 211-226. https://doi.org/10.1016/j.archger.2014.06.009

Abstract Background As we age we experience many life changes in our health, personal relationships, work, or home life which can impact on other aspects of our life. There is compelling evidence that how we feel about our health influences, or is i... Read More about Understanding causal associations between self-rated health and personal relationships in older adults: a review of evidence from longitudinal studies.

Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS) (2013)
Journal Article
Boote, J. D., Twiddy, M., Baird, W., Birks, Y., Clarke, C., & Beever, D. (2015). Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS). Health Expectations, 18(5), 1481-1493. https://doi.org/10.1111/hex.12130

BACKGROUND: It is good practice for the public to be involved in developing health research. Resources should be available for researchers to fund the involvement of the public in the development of their grants. OBJECTIVE: To describe a funding awar... Read More about Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS).

The association between discrepancy in illness representations on distress in stroke patients and carers (2012)
Journal Article
Twiddy, M., House, A., & Jones, F. (2012). The association between discrepancy in illness representations on distress in stroke patients and carers. Journal of psychosomatic research, 72(3), 220-225. https://doi.org/10.1016/j.jpsychores.2011.12.004

Background: To investigate the association between the illness representations of recently diagnosed stroke patients and their carers and distress in the months after stroke. Method: Forty-two stroke survivors and their carers were assessed at 3 m... Read More about The association between discrepancy in illness representations on distress in stroke patients and carers.

Lessons learned from a family-focused weight management intervention for obese and overweight children (2012)
Journal Article
Twiddy, M., Wilson, I., Bryant, M., & Rudolf, M. (2012). Lessons learned from a family-focused weight management intervention for obese and overweight children. Public health nutrition, 15(07), 1310-1317. https://doi.org/10.1017/s1368980011003211

Treatment for childhood obesity is characterised by high attrition rates and failure to achieve weight maintenance. It is therefore important to develop more effective programmes. The aim of the present qualitative study was to explore the views of p... Read More about Lessons learned from a family-focused weight management intervention for obese and overweight children.